The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:
"Trypsin-like serine proteases
".
FunFam 46581: Genome polyprotein
There are 3 EC terms in this cluster
Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
EC Term | Annotations | Evidence |
---|---|---|
Helper-component proteinase.
[EC: 3.4.22.45]
Hydrolyzes a Gly-|-Gly bond at its own C-terminus, commonly in the sequence -Tyr-Xaa-Val-Gly-|-Gly, in the processing of the potyviral polyprotein.
|
8 | O36979 O56075 P18479 P21231 Q65399 Q6XW15 Q89330 Q90069 |
Nuclear-inclusion-a endopeptidase.
[EC: 3.4.22.44]
Hydrolyzes glutaminyl bonds, and activity is further restricted by preferences for the amino acids in P6 - P1' that vary with the species of potyvirus, e.g. Glu-Xaa-Xaa-Tyr-Xaa-Gln-|-(Ser or Gly) for the enzyme from tobacco etch virus. The natural substrate is the viral polyprotein, but other proteins and oligopeptides containing the appropriate consensus sequence are also cleaved.
|
8 | O36979 O56075 P18479 P21231 Q65399 Q6XW15 Q89330 Q90069 |
RNA-directed RNA polymerase.
[EC: 2.7.7.48]
Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).
|
8 | O36979 O56075 P18479 P21231 Q65399 Q6XW15 Q89330 Q90069 |