The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:
"Trypsin-like serine proteases
".
FunFam 46570: Genome polyprotein
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 44 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
15 |
K7Y1A2 (/IPI)
O92972 (/IPI)
O93077 (/IPI)
P26660 (/IPI)
P26662 (/IPI)
P26663 (/IPI)
P26664 (/IPI)
P27958 (/IPI)
P29846 (/IPI)
Q03463 (/IPI)
(5 more) |
|
RNA-directed 5'-3' RNA polymerase activity GO:0003968
Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1); uses an RNA template, i.e. the catalysis of RNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time.
|
2 | P27958 (/IDA) Q9WMX2 (/IDA) |
|
Serine-type peptidase activity GO:0008236
Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine).
|
2 | P26663 (/IDA) P27958 (/IDA) |
|
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
|
2 | P26663 (/IPI) P27958 (/IPI) |
|
Protease binding GO:0002020
Interacting selectively and non-covalently with any protease or peptidase.
|
1 | P26663 (/IPI) |
|
P53 binding GO:0002039
Interacting selectively and non-covalently with one of the p53 family of proteins.
|
1 | P27958 (/IPI) |
|
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
|
1 | P26662 (/IMP) |
|
RNA binding GO:0003723
Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
|
1 | Q9WMX2 (/IDA) |
|
RNA binding GO:0003723
Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
|
1 | P26662 (/IMP) |
|
RNA helicase activity GO:0003724
Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a RNA helix.
|
1 | P26662 (/IDA) |
|
Actin binding GO:0003779
Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments.
|
1 | Q9WMX2 (/IPI) |
|
Serine-type endopeptidase activity GO:0004252
Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine).
|
1 | P27958 (/IDA) |
|
Protein kinase C binding GO:0005080
Interacting selectively and non-covalently with protein kinase C.
|
1 | O92972 (/IPI) |
|
Scavenger receptor binding GO:0005124
Interacting selectively and non-covalently with scavenger receptors, a family of proteins that are expressed on myeloid cells and are involved in the uptake of effete cellular components and foreign particles.
|
1 | P27958 (/IPI) |
|
Transforming growth factor beta receptor binding GO:0005160
Interacting selectively and non-covalently with the transforming growth factor beta receptor.
|
1 | Q99IB8 (/IPI) |
|
Transcription factor binding GO:0008134
Interacting selectively and non-covalently with a transcription factor, any protein required to initiate or regulate transcription.
|
1 | P27958 (/IPI) |
|
Peptidase activity GO:0008233
Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid.
|
1 | P27958 (/IDA) |
|
Serine-type peptidase activity GO:0008236
Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine).
|
1 | Q91RS4 (/IMP) |
|
Zinc ion binding GO:0008270
Interacting selectively and non-covalently with zinc (Zn) ions.
|
1 | P27958 (/IDA) |
|
Zinc ion binding GO:0008270
Interacting selectively and non-covalently with zinc (Zn) ions.
|
1 | Q9WMX2 (/IMP) |
|
ATPase activity GO:0016887
Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction.
|
1 | P27958 (/IMP) |
|
Rab GTPase binding GO:0017137
Interacting selectively and non-covalently with Rab protein, any member of the Rab subfamily of the Ras superfamily of monomeric GTPases.
|
1 | P27958 (/IPI) |
|
DEAD/H-box RNA helicase binding GO:0017151
Interacting selectively and non-covalently with the enzyme DEAD/H-box RNA helicase.
|
1 | P27958 (/IPI) |
|
Enzyme binding GO:0019899
Interacting selectively and non-covalently with any enzyme.
|
1 | P27958 (/IPI) |
|
Kinase binding GO:0019900
Interacting selectively and non-covalently with a kinase, any enzyme that catalyzes the transfer of a phosphate group.
|
1 | P27958 (/IDA) |
|
Kinase binding GO:0019900
Interacting selectively and non-covalently with a kinase, any enzyme that catalyzes the transfer of a phosphate group.
|
1 | P27958 (/IPI) |
|
Protein kinase binding GO:0019901
Interacting selectively and non-covalently with a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.
|
1 | O92972 (/IPI) |
|
Protein phosphatase binding GO:0019903
Interacting selectively and non-covalently with any protein phosphatase.
|
1 | P27958 (/IPI) |
|
Heat shock protein binding GO:0031072
Interacting selectively and non-covalently with a heat shock protein, any protein synthesized or activated in response to heat shock.
|
1 | P27958 (/IPI) |
|
Translation initiation factor binding GO:0031369
Interacting selectively and non-covalently with a translation initiation factor, any polypeptide factor involved in the initiation of ribosome-mediated translation.
|
1 | P27958 (/IPI) |
|
Ubiquitin protein ligase binding GO:0031625
Interacting selectively and non-covalently with a ubiquitin protein ligase enzyme, any of the E3 proteins.
|
1 | Q99IB8 (/IPI) |
|
RNA strand annealing activity GO:0033592
Facilitates the base-pairing of complementary single-stranded RNA.
|
1 | P26662 (/IMP) |
|
Toll-like receptor 2 binding GO:0035663
Interacting selectively and non-covalently with a Toll-like 2 protein, a pattern recognition receptor that binds microbial pattern motifs to initiate an innate immune response.
|
1 | P27958 (/IMP) |
|
MHC class I protein binding GO:0042288
Interacting selectively and non-covalently with major histocompatibility complex class I molecules; a set of molecules displayed on cell surfaces that are responsible for lymphocyte recognition and antigen presentation.
|
1 | P27958 (/IPI) |
|
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
|
1 | Q9WMX2 (/IMP) |
|
SMAD binding GO:0046332
Interacting selectively and non-covalently with a SMAD signaling protein.
|
1 | O92972 (/IPI) |
|
Retinoid X receptor binding GO:0046965
Interacting selectively and non-covalently with a retinoid X receptor.
|
1 | Q03463 (/IPI) |
|
Calcium-dependent protein binding GO:0048306
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules), in the presence of calcium.
|
1 | Q03463 (/IPI) |
|
NFAT protein binding GO:0051525
Interacting selectively and non-covalently with NFAT (nuclear factor of activated T cells) proteins, a family of transcription factors. NFAT proteins have crucial roles in the development and function of the immune system.
|
1 | Q913V3 (/IPI) |
|
ATPase regulator activity GO:0060590
Modulates the rate of ATP hydrolysis by an ATPase.
|
1 | P27958 (/IDA) |
|
14-3-3 protein binding GO:0071889
Interacting selectively and non-covalently with a 14-3-3 protein. A 14-3-3 protein is any of a large family of approximately 30kDa acidic proteins which exist primarily as homo- and heterodimers within all eukaryotic cells, and have been implicated in the modulation of distinct biological processes by binding to specific phosphorylated sites on diverse target proteins, thereby forcing conformational changes or influencing interactions between their targets and other molecules. Each 14-3-3 protein sequence can be roughly divided into three sections: a divergent amino terminus, the conserved core region and a divergent carboxyl terminus. The conserved middle core region of the 14-3-3s encodes an amphipathic groove that forms the main functional domain, a cradle for interacting with client proteins.
|
1 | O92972 (/IPI) |
|
STAT family protein binding GO:0097677
Interacting selectively and non-covalently with any member of the signal transducers and activators of transcription (STAT) protein family. STATs are, as the name indicates, both signal transducers and transcription factors. STATs are activated by cytokines and some growth factors and thus control important biological processes including cell growth, cell differentiation, apoptosis and immune responses.
|
1 | P27958 (/IPI) |
|
Keratin filament binding GO:1990254
Interacting selectively and non-covalently with a keratin filament, an intermediate filament composed of acidic and basic keratins (types I and II), typically expressed in epithelial cells.
|
1 | P27958 (/IPI) |
|
DNA/DNA annealing activity GO:1990814
A nucleic acid binding activity that brings together complementary sequences of ssDNA so that they pair by hydrogen bonds to form a double-stranded DNA.
|
1 | P26662 (/IMP) |
There are 97 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Positive regulation by symbiont of host protein levels GO:1990219
Any process in which an organism activates, maintains or increases the frequency, rate or extent of protein levels in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction.
|
4 | P27958 (/IDA) Q03463 (/IDA) Q99IB8 (/IDA) Q9WMX2 (/IDA) |
|
Negative regulation of interleukin-6 production GO:0032715
Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-6 production.
|
3 | P27958 (/IDA) Q03463 (/IDA) Q99IB8 (/IDA) |
|
Negative regulation of toll-like receptor 2 signaling pathway GO:0034136
Any process that stops, prevents, or reduces the frequency, rate, or extent of toll-like receptor 2 signaling pathway.
|
3 | P27958 (/IDA) Q03463 (/IDA) Q99IB8 (/IDA) |
|
Negative regulation of toll-like receptor 4 signaling pathway GO:0034144
Any process that stops, prevents, or reduces the frequency, rate, or extent of toll-like receptor 4 signaling pathway.
|
3 | P27958 (/IDA) Q03463 (/IDA) Q99IB8 (/IDA) |
|
Negative regulation of toll-like receptor 7 signaling pathway GO:0034156
Any process that stops, prevents, or reduces the frequency, rate, or extent of toll-like receptor 7 signaling pathway.
|
3 | P27958 (/IDA) Q03463 (/IDA) Q99IB8 (/IDA) |
|
Negative regulation of toll-like receptor 9 signaling pathway GO:0034164
Any process that stops, prevents, or reduces the frequency, rate, or extent of toll-like receptor 9 signaling pathway.
|
3 | P27958 (/IDA) Q03463 (/IDA) Q99IB8 (/IDA) |
|
Suppression by virus of host transcription GO:0039653
Any process in which a virus stops, prevents, or reduces the activity of host DNA-dependent transcription; the cellular synthesis of RNA on a template of DNA. Viral proteins can interfere with either host RNA polymerase or with transcription factors.
|
3 | P27958 (/IDA) Q03463 (/IDA) Q99IB8 (/IDA) |
|
Negative regulation by symbiont of host protein levels GO:1990214
Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of protein levels in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction.
|
3 | P27958 (/IDA) Q03463 (/IDA) Q99IB8 (/IDA) |
|
Positive regulation by symbiont of host transcription GO:1990216
Any process in which an organism activates, maintains or increases the frequency, rate or extent of transcription in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction.
|
3 | P27958 (/IDA) Q03463 (/IDA) Q913V3 (/IDA) |
|
Suppression by virus of host PKR activity GO:0039580
Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host PKR (protein kinase regulated by RNA) activity. Activation of PKR involves dsRNA binding followed by autophosphorylation. Phosphorylated PKR can then phosphorylate downstream targets such as the translation initiation factor eIF2 to inhibit protein synthesis. Viruses encode a number of mechanisms to inhibit the host antiviral response via PKR, including direct interaction with PKR, promoting degradation of PKR or altering the subcellular location of PKR.
|
2 | P27958 (/IDA) Q03463 (/IDA) |
|
Negative regulation of transcription from RNA polymerase II promoter GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter.
|
1 | P27958 (/IDA) |
|
Stimulatory C-type lectin receptor signaling pathway GO:0002223
Any series of molecular signals generated as a consequence of binding to a C-type lectin receptor capable of cellular activation.
|
1 | Q99IB8 (/TAS) |
|
Negative regulation of acute inflammatory response GO:0002674
Any process that stops, prevents, or reduces the frequency, rate, or extent of an acute inflammatory response.
|
1 | P27958 (/IMP) |
|
Positive regulation of cell proliferation GO:0008284
Any process that activates or increases the rate or extent of cell proliferation.
|
1 | P27958 (/IMP) |
|
Negative regulation of autophagy GO:0010507
Any process that stops, prevents, or reduces the frequency, rate or extent of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm.
|
1 | Q99IB8 (/IDA) |
|
Positive regulation of gene expression GO:0010628
Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
|
1 | P27958 (/IDA) |
|
Positive regulation of gene expression GO:0010628
Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
|
1 | P27958 (/IMP) |
|
Positive regulation of alkaline phosphatase activity GO:0010694
Any process that increases the frequency, rate or extent of alkaline phosphatase activity, the catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an alkaline pH optimum.
|
1 | P27958 (/IDA) |
|
Negative regulation of tumor necrosis factor-mediated signaling pathway GO:0010804
Any process that decreases the rate or extent of the tumor necrosis factor-mediated signaling pathway. The tumor necrosis factor-mediated signaling pathway is the series of molecular signals generated as a consequence of tumor necrosis factor binding to a cell surface receptor.
|
1 | P27958 (/IMP) |
|
Positive regulation of triglyceride biosynthetic process GO:0010867
Any process that increases the rate, frequency, or extent of triglyceride biosynthesis. Triglyceride biosynthesis is the collection of chemical reactions and pathways resulting in the formation of triglyceride, any triester of glycerol.
|
1 | Q03463 (/IDA) |
|
Negative regulation of SMAD protein complex assembly GO:0010991
Any process that decreases the rate, frequency, or extent of SMAD protein complex assembly. SMAD protein complex assembly is the aggregation, arrangement and bonding together of a set of components to form a protein complex that contains SMAD proteins.
|
1 | O92972 (/IMP) |
|
Viral process GO:0016032
A multi-organism process in which a virus is a participant. The other participant is the host. Includes infection of a host cell, replication of the viral genome, and assembly of progeny virus particles. In some cases the viral genetic material may integrate into the host genome and only subsequently, under particular circumstances, 'complete' its life cycle.
|
1 | P26660 (/IMP) |
|
Suppression by virus of host apoptotic process GO:0019050
Any viral process that inhibits apoptosis of infected host cells, facilitating prolonged cell survival during viral replication.
|
1 | P27958 (/IDA) |
|
Modulation by virus of host transcription GO:0019056
Any process in which a virus modulates the frequency, rate or extent of its host's transcription.
|
1 | P27958 (/IMP) |
|
Viral protein processing GO:0019082
Any protein maturation process achieved by the cleavage of a peptide bond or bonds within a viral protein.
|
1 | P27958 (/TAS) |
|
Positive regulation of cell growth GO:0030307
Any process that activates or increases the frequency, rate, extent or direction of cell growth.
|
1 | P27958 (/IDA) |
|
Negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512
Any process that stops, prevents, or reduces the frequency, rate or extent of any TGF-beta receptor signaling pathway.
|
1 | O92972 (/IMP) |
|
Negative regulation of B cell proliferation GO:0030889
Any process that stops, prevents or reduces the rate or extent of B cell proliferation.
|
1 | P27958 (/IMP) |
|
Negative regulation of protein ubiquitination GO:0031397
Any process that stops, prevents, or reduces the frequency, rate or extent of the addition of ubiquitin groups to a protein.
|
1 | Q99IB8 (/IDA) |
|
Negative regulation of protein autophosphorylation GO:0031953
Any process that stops, prevents or decreases the rate of the phosphorylation by a protein of one or more of its own residues.
|
1 | P27958 (/IDA) |
|
Negative regulation of protein binding GO:0032091
Any process that stops, prevents, or reduces the frequency, rate or extent of protein binding.
|
1 | O92972 (/IDA) |
|
Activation of protein kinase activity GO:0032147
Any process that initiates the activity of an inactive protein kinase.
|
1 | O92972 (/IDA) |
|
Positive regulation of cytokinesis GO:0032467
Any process that activates or increases the frequency, rate or extent of the division of the cytoplasm of a cell, and its separation into two daughter cells.
|
1 | P27958 (/IMP) |
|
Negative regulation of interferon-alpha production GO:0032687
Any process that stops, prevents, or reduces the frequency, rate, or extent of interferon-alpha production.
|
1 | Q03463 (/IEP) |
|
Positive regulation of interferon-beta production GO:0032728
Any process that activates or increases the frequency, rate, or extent of interferon-beta production.
|
1 | Q03463 (/IEP) |
|
Negative regulation of ATPase activity GO:0032780
Any process that stops or reduces the rate of ATP hydrolysis by an ATPase.
|
1 | P27958 (/IDA) |
|
Positive regulation of transforming growth factor beta1 production GO:0032914
Any process that activates or increases the frequency, rate, or extent of production of transforming growth factor-beta1.
|
1 | Q99IB8 (/IDA) |
|
Positive regulation of collagen biosynthetic process GO:0032967
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals.
|
1 | Q99IB8 (/IDA) |
|
Negative regulation by symbiont of host defense-related protein level GO:0033663
Any process in which the symbiont stops or reduces of the levels of defense-related proteins in its host. The host is defined as the larger of the organisms involved in a symbiotic interaction.
|
1 | P27958 (/IMP) |
|
Negative regulation of kinase activity GO:0033673
Any process that stops, prevents, or reduces the frequency, rate or extent of kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule.
|
1 | P27958 (/IMP) |
|
Negative regulation of MyD88-dependent toll-like receptor signaling pathway GO:0034125
Any process that stops, prevents, or reduces the frequency, rate, or extent of MyD88-dependent toll-like receptor signaling pathway.
|
1 | Q03463 (/TAS) |
|
Positive regulation of histone acetylation GO:0035066
Any process that activates or increases the frequency, rate or extent of the addition of an acetyl group to a histone protein.
|
1 | Q913V3 (/IDA) |
|
Suppression by virus of host type I interferon-mediated signaling pathway GO:0039502
Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of type I interferon-mediated signaling in the host organism. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families.
|
1 | P27958 (/IDA) |
|
Suppression by virus of host MAVS activity by MAVS proteolysis GO:0039546
The chemical reactions and pathways performed by a virus resulting in the hydrolysis of the host MAVS (mitochondrial inhibitor of viral signaling) protein by cleavage of peptide bonds, thereby inhibiting the host innate immune response. For example, MAVS harbors a C-terminal transmembrane domain that targets it to the mitochondrial outer membrane; cleavage within this domain removes MAVS from the membrane, thus preventing it from signaling.
|
1 | P27958 (/TAS) |
|
Suppression by virus of host TRAF activity GO:0039547
Any process in which a virus stops, prevents, or reduces the activity of a host TRAF (tumor necrosis factor receptor-associated factor) protein. TRAFs are intracellular signal transducers that lie downstream of receptors including RIG-I, MDA-5 and Toll-like receptors (TLR) and transfer the signal to other intracellular signaling components.
|
1 | P27958 (/IDA) |
|
Suppression by virus of host IRF9 activity GO:0039560
Any process in which a virus stops, prevents, or reduces the activity of host IRF9 (interferon regulatory factor-9), a transcription factor involved in the innate immune response. Viral infection triggers binding of IRF9 to phosphorylated STAT1 and STAT2, forming the ISGF3 complex. The ISGF3 complex migrates to the nucleus and activates transcription of IFN-responsive genes.
|
1 | P27958 (/IMP) |
|
Suppression by virus of host STAT1 activity by positive regulation of STAT1 catabolic process GO:0039565
Any process in which a virus stops, prevents, or reduces the activity of host STAT1 (signal transducer and activator of transcription-1) by promoting the ubiquitin-dependent degradation of STAT1, mediated by the proteasome.
|
1 | P27958 (/IDA) |
|
Suppression by virus of host STAT1 activity by negative regulation of STAT1 tyrosine phosphorylation GO:0039571
Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host STAT1 (signal transducer and activator of transcription-1) activity by stopping, preventing, or reducing the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a STAT1 protein. For example, the measles virus V protein inhibits tyrosine phosphorylation of STAT1, thereby preventing STAT1 activation.
|
1 | Q03463 (/IDA) |
|
Suppression by virus of host translation initiation factor activity by induction of host protein dephosphorylation GO:0039608
Any process in which a virus prevents or reduces the frequency, rate or extent of activity of a host translation initiation factor by promoting dephosphorylation of a host protein.
|
1 | P27958 (/IDA) |
|
Suppression by virus of host protein phosphorylation GO:0039613
Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of phosphorylation of viral or host proteins in a host.
|
1 | P27958 (/IDA) |
|
Suppression by virus of host protein phosphorylation GO:0039613
Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of phosphorylation of viral or host proteins in a host.
|
1 | P27958 (/IMP) |
|
Induction by virus of host protein phosphorylation GO:0039614
Any process in which a virus activates or increases the frequency, rate or extent of phosphorylation of viral or host proteins in a host.
|
1 | Q99IB8 (/IDA) |
|
Suppression by virus of host NF-kappaB transcription factor activity GO:0039644
Any process in which a virus stops, prevents, or reduces the activity of host NF-kappaB activity.
|
1 | P27958 (/IDA) |
|
Suppression by virus of host NF-kappaB transcription factor activity GO:0039644
Any process in which a virus stops, prevents, or reduces the activity of host NF-kappaB activity.
|
1 | P27958 (/IMP) |
|
Positive stranded viral RNA replication GO:0039690
A viral genome replication process where the template genome is positive stranded, single stranded RNA ((+)ssRNA). Replication of the positive strand leads to dsRNA formation, which in turn is transcribed into positive single stranded RNA.
|
1 | Q9WMX2 (/IMP) |
|
Viral RNA genome replication GO:0039694
The replication of a viral RNA genome.
|
1 | Q9WMX2 (/IMP) |
|
Negative regulation of tyrosine phosphorylation of STAT protein GO:0042532
Any process that stops, prevents, or reduces the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a STAT (Signal Transducer and Activator of Transcription) protein.
|
1 | P27958 (/IMP) |
|
Negative regulation of apoptotic process GO:0043066
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
|
1 | P26662 (/IDA) |
|
Positive regulation of DNA binding GO:0043388
Any process that increases the frequency, rate or extent of DNA binding. DNA binding is any process in which a gene product interacts selectively with DNA (deoxyribonucleic acid).
|
1 | Q03463 (/IDA) |
|
Negative regulation of sequence-specific DNA binding transcription factor activity GO:0043433
Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of a transcription factor, any factor involved in the initiation or regulation of transcription.
|
1 | P29846 (/IDA) |
|
RNA stabilization GO:0043489
Prevention of degradation of RNA molecules.
|
1 | P26662 (/IMP) |
|
Translocation of peptides or proteins into host cell cytoplasm GO:0044053
The directed movement of peptides or proteins produced by a symbiont organism to a location within the host cell cytoplasm.
|
1 | P27958 (/IMP) |
|
Modulation by virus of host protein transport GO:0044833
Any viral process that modulates the frequency, rate or extent of protein transport in its host organism.
|
1 | P27958 (/IMP) |
|
Positive regulation of translation GO:0045727
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA.
|
1 | P27958 (/IMP) |
|
Positive regulation of proteolysis GO:0045862
Any process that activates or increases the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein.
|
1 | P27958 (/IDA) |
|
Viral budding from ER membrane GO:0046762
A viral budding that starts with formation of a membrane curvature in the host ER membrane.
|
1 | P27958 (/IDA) |
|
Suppression by virus of host intracellular interferon activity GO:0046774
Any viral process that results in the inhibition of interferon activity within the host cell.
|
1 | P27958 (/IMP) |
|
Positive regulation of viral process GO:0048524
Any process that activates or increases the frequency, rate or extent of a multi-organism process in which a virus is a participant.
|
1 | P27958 (/IDA) |
|
Negative regulation of defense response to virus by host GO:0050689
Any host process that results in the inhibition of antiviral immune response mechanisms, thereby facilitating viral replication. The host is defined as the larger of the organisms involved in a symbiotic interaction.
|
1 | P27958 (/TAS) |
|
Negative regulation of protein secretion GO:0050709
Any process that stops, prevents, or reduces the frequency, rate or extent of the controlled release of a protein from a cell.
|
1 | P27958 (/IDA) |
|
Positive regulation of secretion GO:0051047
Any process that activates or increases the frequency, rate or extent of the controlled release of a substance from a cell or a tissue.
|
1 | P27958 (/IDA) |
|
Positive regulation by symbiont of defense-related host reactive oxygen species production GO:0052369
Any process in which an organism activates, maintains or increases the frequency, rate or extent of the production of reactive oxygen species as part of the defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction.
|
1 | Q99IB8 (/IDA) |
|
Positive regulation of apoptotic process by virus GO:0060139
Any viral process that activates or increases the frequency, rate or extent of cell death by apoptotic process.
|
1 | P26662 (/IDA) |
|
Negative regulation of cell death GO:0060548
Any process that decreases the rate or frequency of cell death. Cell death is the specific activation or halting of processes within a cell so that its vital functions markedly cease, rather than simply deteriorating gradually over time, which culminates in cell death.
|
1 | P27958 (/IDA) |
|
Negative regulation of endoribonuclease activity GO:0060702
Any process that decreases the rate, frequency or extent of the catalysis of the hydrolysis of ester linkages within ribonucleic acid by creating internal breaks.
|
1 | P27958 (/IMP) |
|
Membrane organization GO:0061024
A process which results in the assembly, arrangement of constituent parts, or disassembly of a membrane. A membrane is a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.
|
1 | P27958 (/TAS) |
|
Negative regulation of interleukin-6-mediated signaling pathway GO:0070104
Any process that decreases the rate, frequency or extent of the series of molecular events generated as a consequence of interleukin-6 binding to a cell surface receptor.
|
1 | P27958 (/IMP) |
|
Negative regulation of ERK1 and ERK2 cascade GO:0070373
Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade.
|
1 | Q03463 (/IDA) |
|
Lymphocyte aggregation GO:0071593
The adhesion of one lymphocyte to one or more other lymphocytes via adhesion molecules.
|
1 | P27958 (/IMP) |
|
Microtubule-dependent intracellular transport of viral material GO:0075519
The directed movement of the viral genome or viral particle within the host cell cytoplasm along host microtubules. Microtubule-dependent transport involves motor proteins like dynein and kinesin and is mostly used by viruses that target their genomes to the nucleus.
|
1 | Q9WMX2 (/IDA) |
|
Actin-dependent intracellular transport of virus GO:0075520
The directed movement of a virus, or part of a virus, within the host cell cytoplasm via the host's actin filaments. Actin-dependent transport is induced by viral proteins that interact with actin and/or host cell motor proteins like myosins or that promotes actin polymerization/depolymerization reactions.
|
1 | Q9WMX2 (/IDA) |
|
Negative regulation of release of cytochrome c from mitochondria GO:0090201
Any process that decreases the rate, frequency or extent of release of cytochrome c from mitochondria, the process in which cytochrome c is enabled to move from the mitochondrial intermembrane space into the cytosol, which is an early step in apoptosis and leads to caspase activation.
|
1 | P27958 (/IDA) |
|
Self proteolysis GO:0097264
The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their own peptide bonds.
|
1 | Q91RS4 (/IDA) |
|
Regulation of endoplasmic reticulum unfolded protein response GO:1900101
Any process that modulates the frequency, rate or extent of endoplasmic reticulum unfolded protein response.
|
1 | P27958 (/IDA) |
|
Negative regulation of endoplasmic reticulum unfolded protein response GO:1900102
Any process that stops, prevents or reduces the frequency, rate or extent of endoplasmic reticulum unfolded protein response.
|
1 | P27958 (/IDA) |
|
Negative regulation of execution phase of apoptosis GO:1900118
Any process that stops, prevents or reduces the frequency, rate or extent of execution phase of apoptosis.
|
1 | P27958 (/IMP) |
|
Negative regulation of RNA interference GO:1900369
Any process that stops, prevents or reduces the frequency, rate or extent of RNA interference.
|
1 | P27958 (/IDA) |
|
Positive regulation of transforming growth factor beta2 activation GO:1901397
Any process that activates or increases the frequency, rate or extent of transforming growth factor beta2 activation.
|
1 | Q99IB8 (/IDA) |
|
Negative regulation of cell cycle G1/S phase transition GO:1902807
Any process that stops, prevents or reduces the frequency, rate or extent of cell cycle G1/S phase transition.
|
1 | P26662 (/IDA) |
|
Negative regulation of autophagosome assembly GO:1902902
Any process that stops, prevents or reduces the frequency, rate or extent of autophagosome assembly.
|
1 | Q99IB8 (/IDA) |
|
Negative regulation of mitophagy GO:1903147
Any process that stops, prevents or reduces the frequency, rate or extent of mitochondrion degradation (mitophagy).
|
1 | Q99IB8 (/IDA) |
|
Negative regulation of protein targeting to mitochondrion GO:1903215
Any process that stops, prevents or reduces the frequency, rate or extent of protein targeting to mitochondrion.
|
1 | Q99IB8 (/IDA) |
|
Positive regulation of tumor necrosis factor-mediated signaling pathway GO:1903265
Any process that activates or increases the frequency, rate or extent of tumor necrosis factor-mediated signaling pathway.
|
1 | P27958 (/IDA) |
|
Negative regulation of protein import into mitochondrial outer membrane GO:1903637
Any process that stops, prevents or reduces the frequency, rate or extent of protein import into mitochondrial outer membrane.
|
1 | Q99IB8 (/IDA) |
|
Positive regulation of I-kappaB phosphorylation GO:1903721
Any process that activates or increases the frequency, rate or extent of I-kappaB phosphorylation.
|
1 | P27958 (/IDA) |
|
Protein localization to lipid particle GO:1990044
A process in which a protein is transported to, or maintained in, a location on or within a lipid particle.
|
1 | P27958 (/IDA) |
|
Positive regulation by symbiont of host protein levels GO:1990219
Any process in which an organism activates, maintains or increases the frequency, rate or extent of protein levels in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction.
|
1 | P27958 (/IMP) |
There are 23 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Host cell cytoplasm GO:0030430
The cytoplasm of a host cell.
|
7 | O92972 (/IDA) P26662 (/IDA) P26663 (/IDA) P27958 (/IDA) Q03463 (/IDA) Q99IB8 (/IDA) Q9WMX2 (/IDA) |
|
Host cell nucleus GO:0042025
A membrane-bounded organelle as it is found in the host cell in which chromosomes are housed and replicated. The host is defined as the larger of the organisms involved in a symbiotic interaction.
|
5 | O92972 (/IDA) P26662 (/IDA) P27958 (/IDA) Q03463 (/IDA) Q913V3 (/IDA) |
|
Host cell endoplasmic reticulum GO:0044165
The irregular network of unit membranes, visible only by electron microscopy, that occurs in the host cell cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The host ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
|
4 | P27958 (/IDA) Q03463 (/IDA) Q99IB8 (/IDA) Q9WMX2 (/IDA) |
|
Host cell cytosol GO:0044164
The part of the host cell cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
3 | O92972 (/IDA) P26662 (/IDA) P27958 (/IDA) |
|
Host cell perinuclear region of cytoplasm GO:0044220
The host cell cytoplasm situated near, or occurring around, the host nucleus.
|
3 | O92972 (/IDA) P27958 (/IDA) Q9WMX2 (/IDA) |
|
Host cell cytoplasm GO:0030430
The cytoplasm of a host cell.
|
2 | P26663 (/IMP) P27958 (/IMP) |
|
Host cell membrane GO:0033644
Double layer of lipid molecules as it encloses host cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. The host is defined as the larger of the organisms involved in a symbiotic interaction.
|
2 | O92972 (/IDA) P27958 (/IDA) |
|
Host cell nucleus GO:0042025
A membrane-bounded organelle as it is found in the host cell in which chromosomes are housed and replicated. The host is defined as the larger of the organisms involved in a symbiotic interaction.
|
2 | P26663 (/IMP) P27958 (/IMP) |
|
Host cell cytosol GO:0044164
The part of the host cell cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
2 | P26663 (/IMP) P27958 (/IMP) |
|
Viral envelope GO:0019031
The lipid bilayer of a virion that surrounds the protein capsid. May also contain glycoproteins.
|
1 | Q99IB8 (/TAS) |
|
Protein-DNA complex GO:0032993
A macromolecular complex containing both protein and DNA molecules.
|
1 | P26662 (/IMP) |
|
Endoplasmic reticulum-Golgi intermediate compartment membrane GO:0033116
The lipid bilayer surrounding any of the compartments of the endoplasmic reticulum (ER)-Golgi intermediate compartment system.
|
1 | P27958 (/TAS) |
|
Host cell membrane GO:0033644
Double layer of lipid molecules as it encloses host cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. The host is defined as the larger of the organisms involved in a symbiotic interaction.
|
1 | P27958 (/IMP) |
|
Host intracellular organelle GO:0033647
Organized structure of distinctive morphology and function, occurring within the host cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane. The host is defined as the larger of the organisms involved in a symbiotic interaction.
|
1 | P27958 (/IMP) |
|
Host intracellular membrane-bounded organelle GO:0033648
Organized structure of distinctive morphology and function, as found in host cells, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane. The host is defined as the larger of the organisms involved in a symbiotic interaction.
|
1 | Q03463 (/IDA) |
|
Host cell mitochondrion GO:0033650
A semiautonomous, self replicating organelle as found in host cells that occurs in varying numbers, shapes, and sizes in the cell cytoplasm. The host is defined as the larger of the organisms involved in a symbiotic interaction.
|
1 | Q9WMX2 (/IDA) |
|
Cytoplasmic viral factory GO:0039714
A viral factory located in the cytoplasm of a host cell.
|
1 | P27958 (/IDA) |
|
Protein complex GO:0043234
A stable macromolecular complex composed (only) of two or more polypeptide subunits along with any covalently attached molecules (such as lipid anchors or oligosaccharide) or non-protein prosthetic groups (such as nucleotides or metal ions). Prosthetic group in this context refers to a tightly bound cofactor. The component polypeptide subunits may be identical.
|
1 | Q9WMX2 (/IMP) |
|
Host cell endoplasmic reticulum GO:0044165
The irregular network of unit membranes, visible only by electron microscopy, that occurs in the host cell cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The host ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
|
1 | P27958 (/IMP) |
|
Host cell endoplasmic reticulum membrane GO:0044167
The lipid bilayer surrounding the host cell endoplasmic reticulum.
|
1 | Q9WMX2 (/IDA) |
|
Host cell Golgi apparatus GO:0044177
A compound membranous cytoplasmic organelle of eukaryotic host cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack.
|
1 | P27958 (/IDA) |
|
Host cell lipid particle GO:0044186
Any particle of coalesced lipids in the cytoplasm of a host cell. May include associated proteins.
|
1 | P27958 (/IDA) |
|
Ribonucleoprotein complex GO:1990904
A macromolecular complex containing both protein and RNA molecules.
|
1 | P26662 (/IMP) |