The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:
"Trypsin-like serine proteases
".
FunFam 20014: Replicase polyprotein 1a
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 8 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
3'-5'-exoribonuclease activity GO:0000175
Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of an RNA molecule.
|
1 | P0C6X7 (/IDA) |
|
Double-stranded RNA binding GO:0003725
Interacting selectively and non-covalently with double-stranded RNA.
|
1 | P0C6X7 (/IDA) |
|
Single-stranded RNA binding GO:0003727
Interacting selectively and non-covalently with single-stranded RNA.
|
1 | P0C6X7 (/IDA) |
|
RNA-directed 5'-3' RNA polymerase activity GO:0003968
Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1); uses an RNA template, i.e. the catalysis of RNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time.
|
1 | P0C6X7 (/IDA) |
|
Helicase activity GO:0004386
Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA or RNA helix.
|
1 | P0C6X7 (/IDA) |
|
MRNA (guanine-N7-)-methyltransferase activity GO:0004482
Catalysis of the reaction: S-adenosyl-L-methionine + G(5')pppR-RNA = S-adenosyl-L-homocysteine + m7G(5')pppR-RNA. m7G(5')pppR-RNA is mRNA containing an N7-methylguanine cap; R may be guanosine or adenosine.
|
1 | P0C6X7 (/IDA) |
|
MRNA (nucleoside-2'-O-)-methyltransferase activity GO:0004483
Catalysis of the reaction: S-adenosyl-L-methionine + m7G(5')pppR-RNA = S-adenosyl-L-homocysteine + m7G(5')pppRm-RNA. R may be guanosine or adenosine.
|
1 | P0C6X7 (/IDA) |
|
Lys48-specific deubiquitinase activity GO:1990380
Hydrolysis of Lys48-linked ubiquitin unit(s) from a ubiquitinated protein.
|
1 | P0C6X7 (/IDA) |
There are 14 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Transcription, RNA-templated GO:0001172
The cellular synthesis of RNA on a template of RNA.
|
1 | P0C6X7 (/IDA) |
|
7-methylguanosine mRNA capping GO:0006370
Addition of the 7-methylguanosine cap to the 5' end of a nascent messenger RNA transcript.
|
1 | P0C6X7 (/IDA) |
|
Viral transcription GO:0019083
The process by which a viral genome, or part of a viral genome, is transcribed within the host cell.
|
1 | P0C6X7 (/IMP) |
|
Suppression by virus of host type I interferon-mediated signaling pathway GO:0039502
Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of type I interferon-mediated signaling in the host organism. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families.
|
1 | P0C6X7 (/IDA) |
|
Modulation by virus of host autophagy GO:0039519
Any process in which a virus effect a change in the frequency, rate or extent of autophagy in the host.
|
1 | P0C6X7 (/IDA) |
|
Suppression by virus of host IRF3 activity by inhibition of IRF3 phosphorylation GO:0039549
Any process in which a virus stops, prevents, or reduces the rate or extent of the phosphorylation of IRF3 (interferon regulatory factor-3), thereby inhibiting IRF3 activation. In response to signaling from RIG-1/MDA-5 receptors, IRF3 is phosphorylated on multiple serine and threonine residues; phosphorylation results in the cytoplasm-to-nucleus translocation of IRF3, DNA binding, and increased transcriptional activation of interferon-encoding genes.
|
1 | P0C6X7 (/IDA) |
|
Suppression by virus of host ISG15 activity GO:0039579
Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host ubiquitin-like protein ISG15 activity. ISG15 is a ubiquitin-like protein that is conjugated to lysine residues on various target proteins. Viruses escape from the antiviral activity of ISG15 by using different mechanisms; the influenza B virus NS1 protein for instance blocks the covalent linkage of ISG15 to its target proteins by directly interacting with ISG15. The papain-like protease from the coronavirus cleaves ISG15 derivatives.
|
1 | P0C6X7 (/IDA) |
|
Suppression by virus of host translation GO:0039604
Any process in which a virus prevents or reduces the frequency, rate or extent of translation of host mRNA.
|
1 | P0C6X7 (/IDA) |
|
Suppression by virus of host NF-kappaB transcription factor activity GO:0039644
Any process in which a virus stops, prevents, or reduces the activity of host NF-kappaB activity.
|
1 | P0C6X7 (/IDA) |
|
Modulation by virus of host protein ubiquitination GO:0039648
Any process in which a virus modulates the frequency, rate or extent of protein ubiquitination in the host organism. Ubiquitination is the process in which one or more ubiquitin groups are added to a protein.
|
1 | P0C6X7 (/IDA) |
|
Positive stranded viral RNA replication GO:0039690
A viral genome replication process where the template genome is positive stranded, single stranded RNA ((+)ssRNA). Replication of the positive strand leads to dsRNA formation, which in turn is transcribed into positive single stranded RNA.
|
1 | P0C6X7 (/IDA) |
|
MRNA methylation GO:0080009
The posttranscriptional addition of methyl groups to specific residues in an mRNA molecule.
|
1 | P0C6X7 (/IDA) |
|
RNA phosphodiester bond hydrolysis, exonucleolytic GO:0090503
The chemical reactions and pathways involving the hydrolysis of terminal 3',5'-phosphodiester bonds in one or two strands of ribonucleotides.
|
1 | P0C6X7 (/IDA) |
|
Positive regulation of ubiquitin-specific protease activity GO:2000158
Any process that activates or increases the frequency, rate or extent of ubiquitin-specific protease (deubiquitinase) activity.
|
1 | P0C6X7 (/IDA) |
There are 1 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Cytoplasmic viral factory GO:0039714
A viral factory located in the cytoplasm of a host cell.
|
2 | P0C6U8 (/IDA) P0C6X7 (/IDA) |