The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
SH3 Domains
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
« Back to all FunFams

FunFam 2635: Guanine nucleotide exchange factor UNC-73A

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 4 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Rho guanyl-nucleotide exchange factor activity GO:0005089
Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rho family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase.
5 C4ALD5 (/IDA) H2KYM2 (/IDA) O61528 (/IDA) Q7JNG6 (/IDA) Q7KPP4 (/IDA)
Rho GTPase binding GO:0017048
Interacting selectively and non-covalently with Rho protein, any member of the Rho subfamily of the Ras superfamily of monomeric GTPases. Proteins in the Rho subfamily are involved in relaying signals from cell-surface receptors to the actin cytoskeleton.
5 C4ALD5 (/IPI) H2KYM2 (/IPI) O61528 (/IPI) Q7JNG6 (/IPI) Q7KPP4 (/IPI)
Rac guanyl-nucleotide exchange factor activity GO:0030676
Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rac family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase.
5 C4ALD5 (/IDA) H2KYM2 (/IDA) O61528 (/IDA) Q7JNG6 (/IDA) Q7KPP4 (/IDA)
Rac GTPase binding GO:0048365
Interacting selectively and non-covalently with Rac protein, any member of the Rac subfamily of the Ras superfamily of monomeric GTPases.
5 C4ALD5 (/IPI) H2KYM2 (/IPI) O61528 (/IPI) Q7JNG6 (/IPI) Q7KPP4 (/IPI)

There are 20 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Neuron migration GO:0001764
The characteristic movement of an immature neuron from germinal zones to specific positions where they will reside as they mature.
5 C4ALD5 (/IMP) H2KYM2 (/IMP) O61528 (/IMP) Q7JNG6 (/IMP) Q7KPP4 (/IMP)
Neuron migration GO:0001764
The characteristic movement of an immature neuron from germinal zones to specific positions where they will reside as they mature.
5 C4ALD5 (/TAS) H2KYM2 (/TAS) O61528 (/TAS) Q7JNG6 (/TAS) Q7KPP4 (/TAS)
Nematode larval development GO:0002119
The process whose specific outcome is the progression of the nematode larva over time, from its formation to the mature structure. Nematode larval development begins with the newly hatched first-stage larva (L1) and ends with the end of the last larval stage (for example the fourth larval stage (L4) in C. elegans). Each stage of nematode larval development is characterized by proliferation of specific cell lineages and an increase in body size without alteration of the basic body plan. Nematode larval stages are separated by molts in which each stage-specific exoskeleton, or cuticle, is shed and replaced anew.
5 C4ALD5 (/NAS) H2KYM2 (/NAS) O61528 (/NAS) Q7JNG6 (/NAS) Q7KPP4 (/NAS)
Mesodermal cell migration GO:0008078
The orderly movement of mesodermal cells from one site to another.
5 C4ALD5 (/TAS) H2KYM2 (/TAS) O61528 (/TAS) Q7JNG6 (/TAS) Q7KPP4 (/TAS)
Embryo development ending in birth or egg hatching GO:0009792
The process whose specific outcome is the progression of an embryo over time, from zygote formation until the end of the embryonic life stage. The end of the embryonic life stage is organism-specific and may be somewhat arbitrary; for mammals it is usually considered to be birth, for insects the hatching of the first instar larva from the eggshell.
5 C4ALD5 (/NAS) H2KYM2 (/NAS) O61528 (/NAS) Q7JNG6 (/NAS) Q7KPP4 (/NAS)
Cell migration GO:0016477
The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues. Cell migration is a central process in the development and maintenance of multicellular organisms.
5 C4ALD5 (/TAS) H2KYM2 (/TAS) O61528 (/TAS) Q7JNG6 (/TAS) Q7KPP4 (/TAS)
Rac protein signal transduction GO:0016601
A series of molecular signals within the cell that are mediated by a member of the Rac family of proteins switching to a GTP-bound active state.
5 C4ALD5 (/IC) H2KYM2 (/IC) O61528 (/IC) Q7JNG6 (/IC) Q7KPP4 (/IC)
Oviposition GO:0018991
The deposition of eggs (either fertilized or not) upon a surface or into a medium such as water.
5 C4ALD5 (/TAS) H2KYM2 (/TAS) O61528 (/TAS) Q7JNG6 (/TAS) Q7KPP4 (/TAS)
Positive regulation of actin filament polymerization GO:0030838
Any process that activates or increases the frequency, rate or extent of actin polymerization.
5 C4ALD5 (/IDA) H2KYM2 (/IDA) O61528 (/IDA) Q7JNG6 (/IDA) Q7KPP4 (/IDA)
Positive regulation of Rac protein signal transduction GO:0035022
Any process that activates or increases the frequency, rate or extent of Rac protein signal transduction.
5 C4ALD5 (/IC) H2KYM2 (/IC) O61528 (/IC) Q7JNG6 (/IC) Q7KPP4 (/IC)
Positive regulation of Rho protein signal transduction GO:0035025
Any process that activates or increases the frequency, rate or extent of Rho protein signal transduction.
5 C4ALD5 (/IC) H2KYM2 (/IC) O61528 (/IC) Q7JNG6 (/IC) Q7KPP4 (/IC)
Regulation of locomotion GO:0040012
Any process that modulates the frequency, rate or extent of locomotion of a cell or organism.
5 C4ALD5 (/IMP) H2KYM2 (/IMP) O61528 (/IMP) Q7JNG6 (/IMP) Q7KPP4 (/IMP)
Regulation of vulval development GO:0040028
Any process that modulates the frequency, rate or extent of development of the vulva. Vulval development is the process whose specific outcome is the progression of the egg-laying organ of female and hermaphrodite nematodes over time, from its formation to the mature structure. In nematodes, the vulva is formed from ventral epidermal cells during larval stages to give rise to a fully formed vulva in the adult.
5 C4ALD5 (/TAS) H2KYM2 (/TAS) O61528 (/TAS) Q7JNG6 (/TAS) Q7KPP4 (/TAS)
Engulfment of apoptotic cell GO:0043652
The removal of the apoptotic cell by phagocytosis, by a neighboring cell or by a phagocyte.
5 C4ALD5 (/IGI) H2KYM2 (/IGI) O61528 (/IGI) Q7JNG6 (/IGI) Q7KPP4 (/IGI)
Positive regulation of axon extension GO:0045773
Any process that activates or increases the frequency, rate or extent of axon extension.
5 C4ALD5 (/IMP) H2KYM2 (/IMP) O61528 (/IMP) Q7JNG6 (/IMP) Q7KPP4 (/IMP)
Male genitalia morphogenesis GO:0048808
The process in which the anatomical structures of male genitalia are generated and organized.
5 C4ALD5 (/IMP) H2KYM2 (/IMP) O61528 (/IMP) Q7JNG6 (/IMP) Q7KPP4 (/IMP)
Neuron migration GO:0001764
The characteristic movement of an immature neuron from germinal zones to specific positions where they will reside as they mature.
1 C4ALD5 (/IPI)
Positive regulation of acetylcholine secretion, neurotransmission GO:0014057
Any process that activates or increases the frequency, rate or extent of the regulated release of acetylcholine.
1 O61528 (/IMP)
Regulation of synaptic transmission, GABAergic GO:0032228
Any process that modulates the frequency, rate or extent of GABAergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter gamma-aminobutyric acid (GABA).
1 Q7KPP4 (/IMP)
Positive regulation of protein localization to synapse GO:1902474
Any process that activates or increases the frequency, rate or extent of protein localization to synapse.
1 O61528 (/IMP)

There are 3 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
5 C4ALD5 (/IDA) H2KYM2 (/IDA) O61528 (/IDA) Q7JNG6 (/IDA) Q7KPP4 (/IDA)
Axon GO:0030424
The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter.
5 C4ALD5 (/IDA) H2KYM2 (/IDA) O61528 (/IDA) Q7JNG6 (/IDA) Q7KPP4 (/IDA)
Muscle cell projection GO:0036194
A prolongation or process extending from a muscle cell. A muscle cell is a mature contractile cell, commonly known as a myocyte. This cell has as part of its cytoplasm myofibrils organized in various patterns.
5 C4ALD5 (/IDA) H2KYM2 (/IDA) O61528 (/IDA) Q7JNG6 (/IDA) Q7KPP4 (/IDA)