The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
SH3 Domains
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 19652: Intersectin 1 isoform ITSN-l (Predicted)

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 11 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
14 M9ND00 (/IPI) M9PBF6 (/IPI) M9PDC7 (/IPI) Q15811 (/IPI) Q1WWC9 (/IPI) Q8INU2 (/IPI) Q8T068 (/IPI) Q9C865 (/IPI) Q9NZM3 (/IPI) Q9U2T9 (/IPI)
(4 more)
SH3/SH2 adaptor activity GO:0005070
Interacting selectively and non-covalently and simultaneously with one or more signal transduction molecules, usually acting as a scaffold to bring these molecules into close proximity either using their own SH2/SH3 domains (e.g. Grb2) or those of their target molecules (e.g. SAM68).
1 Q9NZM3 (/TAS)
Guanyl-nucleotide exchange factor activity GO:0005085
Stimulates the exchange of guanyl nucleotides associated with a GTPase. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase.
1 Q15811 (/NAS)
Guanyl-nucleotide exchange factor activity GO:0005085
Stimulates the exchange of guanyl nucleotides associated with a GTPase. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase.
1 Q15811 (/TAS)
Rho guanyl-nucleotide exchange factor activity GO:0005089
Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rho family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase.
1 Q15811 (/TAS)
Calcium ion binding GO:0005509
Interacting selectively and non-covalently with calcium ions (Ca2+).
1 Q15811 (/NAS)
Kinase activator activity GO:0019209
Binds to and increases the activity of a kinase, an enzyme which catalyzes of the transfer of a phosphate group, usually from ATP, to a substrate molecule.
1 Q9Z0R4 (/IDA)
Protein complex scaffold GO:0032947
A structural molecule activity that provides a physical support for the assembly of a multiprotein complex. The scaffold may or may not be part of the final complex.
1 Q15811 (/IDA)
Protein complex scaffold GO:0032947
A structural molecule activity that provides a physical support for the assembly of a multiprotein complex. The scaffold may or may not be part of the final complex.
1 Q9Z0R4 (/ISO)
Proline-rich region binding GO:0070064
Interacting selectively and non-covalently with a proline-rich region, i.e. a region that contains a high proportion of proline residues, in a protein.
1 Q15811 (/IPI)
Proline-rich region binding GO:0070064
Interacting selectively and non-covalently with a proline-rich region, i.e. a region that contains a high proportion of proline residues, in a protein.
1 Q9Z0R4 (/ISO)

There are 19 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Synaptic vesicle endocytosis GO:0048488
Clathrin-mediated endocytosis of presynaptic membrane that recycles synaptic vesicle membrane and its components following synaptic vesicle exocytosis. This process starts with coating of the membrane with adaptor proteins and clathrin prior to invagination and ends when uncoating has finished.
8 M9ND00 (/TAS) M9PBF6 (/TAS) M9PDC7 (/TAS) Q15811 (/TAS) Q1WWC9 (/TAS) Q8INU2 (/TAS) Q8T068 (/TAS) Q9VIF7 (/TAS)
Positive regulation of neuroblast proliferation GO:0002052
Any process that activates or increases the rate of neuroblast proliferation.
7 M9ND00 (/IMP) M9PBF6 (/IMP) M9PDC7 (/IMP) Q1WWC9 (/IMP) Q8INU2 (/IMP) Q8T068 (/IMP) Q9VIF7 (/IMP)
Neurotransmitter secretion GO:0007269
The regulated release of neurotransmitter from the presynapse into the synaptic cleft via calcium regualated exocytosis during synaptic transmission.
7 M9ND00 (/NAS) M9PBF6 (/NAS) M9PDC7 (/NAS) Q1WWC9 (/NAS) Q8INU2 (/NAS) Q8T068 (/NAS) Q9VIF7 (/NAS)
Protein localization GO:0008104
Any process in which a protein is transported to, or maintained in, a specific location.
7 M9ND00 (/IMP) M9PBF6 (/IMP) M9PDC7 (/IMP) Q1WWC9 (/IMP) Q8INU2 (/IMP) Q8T068 (/IMP) Q9VIF7 (/IMP)
Negative regulation of Notch signaling pathway GO:0045746
Any process that stops, prevents, or reduces the frequency, rate or extent of the Notch signaling pathway.
7 M9ND00 (/IMP) M9PBF6 (/IMP) M9PDC7 (/IMP) Q1WWC9 (/IMP) Q8INU2 (/IMP) Q8T068 (/IMP) Q9VIF7 (/IMP)
Positive regulation of protein kinase activity GO:0045860
Any process that activates or increases the frequency, rate or extent of protein kinase activity.
7 M9ND00 (/IDA) M9PBF6 (/IDA) M9PDC7 (/IDA) Q1WWC9 (/IDA) Q8INU2 (/IDA) Q8T068 (/IDA) Q9VIF7 (/IDA)
Synaptic vesicle endocytosis GO:0048488
Clathrin-mediated endocytosis of presynaptic membrane that recycles synaptic vesicle membrane and its components following synaptic vesicle exocytosis. This process starts with coating of the membrane with adaptor proteins and clathrin prior to invagination and ends when uncoating has finished.
7 M9ND00 (/IMP) M9PBF6 (/IMP) M9PDC7 (/IMP) Q1WWC9 (/IMP) Q8INU2 (/IMP) Q8T068 (/IMP) Q9VIF7 (/IMP)
Synaptic growth at neuromuscular junction GO:0051124
The growth of a synapse at a neuromuscular junction, the site of apposition of a motor end plate and the subneural cleft of the skeletal muscle fiber that it innervates.
7 M9ND00 (/IMP) M9PBF6 (/IMP) M9PDC7 (/IMP) Q1WWC9 (/IMP) Q8INU2 (/IMP) Q8T068 (/IMP) Q9VIF7 (/IMP)
Ephrin receptor signaling pathway GO:0048013
The series of molecular signals generated as a consequence of an ephrin receptor binding to an ephrin.
2 Q15811 (/TAS) Q9Z0R4 (/TAS)
Exocytosis GO:0006887
A process of secretion by a cell that results in the release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle by fusion of the vesicle with the plasma membrane of a cell. This process begins with steps that prepare vesicles for fusion with the membrane (tethering and docking) and ends when vesicle fusion is complete. This is the process in which most molecules are secreted from eukaryotic cells.
1 Q9WVE9 (/TAS)
Small GTPase mediated signal transduction GO:0007264
Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals.
1 Q9Z0R4 (/IDA)
Positive regulation of apoptotic process GO:0043065
Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process.
1 Q15811 (/TAS)
Negative regulation of neuron apoptotic process GO:0043524
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process in neurons.
1 Q9Z0R4 (/IMP)
Regulation of small GTPase mediated signal transduction GO:0051056
Any process that modulates the frequency, rate or extent of small GTPase mediated signal transduction.
1 Q15811 (/TAS)
Positive regulation of protein kinase B signaling GO:0051897
Any process that activates or increases the frequency, rate or extent of protein kinase B signaling, a series of reactions mediated by the intracellular serine/threonine kinase protein kinase B.
1 Q9Z0R4 (/IDA)
Membrane organization GO:0061024
A process which results in the assembly, arrangement of constituent parts, or disassembly of a membrane. A membrane is a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.
1 Q15811 (/TAS)
Positive regulation of synaptic vesicle endocytosis GO:1900244
Any process that activates or increases the frequency, rate or extent of synaptic vesicle endocytosis.
1 Q9U2T9 (/IMP)
Positive regulation of dendrite extension GO:1903861
Any process that activates or increases the frequency, rate or extent of dendrite extension.
1 Q9NZM3 (/IDA)
Positive regulation of dendrite extension GO:1903861
Any process that activates or increases the frequency, rate or extent of dendrite extension.
1 Q9Z0R6 (/ISO)

There are 17 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
10 M9ND00 (/IDA) M9PBF6 (/IDA) M9PDC7 (/IDA) Q15811 (/IDA) Q1WWC9 (/IDA) Q8INU2 (/IDA) Q8T068 (/IDA) Q9C865 (/IDA) Q9U2T9 (/IDA) Q9VIF7 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
7 M9ND00 (/IDA) M9PBF6 (/IDA) M9PDC7 (/IDA) Q1WWC9 (/IDA) Q8INU2 (/IDA) Q8T068 (/IDA) Q9VIF7 (/IDA)
Synaptic vesicle GO:0008021
A secretory organelle, typically 50 nm in diameter, of presynaptic nerve terminals; accumulates in high concentrations of neurotransmitters and secretes these into the synaptic cleft by fusion with the 'active zone' of the presynaptic plasma membrane.
7 M9ND00 (/IDA) M9PBF6 (/IDA) M9PDC7 (/IDA) Q1WWC9 (/IDA) Q8INU2 (/IDA) Q8T068 (/IDA) Q9VIF7 (/IDA)
Apical cortex GO:0045179
The region that lies just beneath the plasma membrane on the apical edge of a cell.
7 M9ND00 (/IDA) M9PBF6 (/IDA) M9PDC7 (/IDA) Q1WWC9 (/IDA) Q8INU2 (/IDA) Q8T068 (/IDA) Q9VIF7 (/IDA)
Endocytic vesicle GO:0030139
A membrane-bounded intracellular vesicle formed by invagination of the plasma membrane around an extracellular substance. Endocytic vesicles fuse with early endosomes to deliver the cargo for further sorting.
4 E6N0W0 (/IDA) E6N0W1 (/IDA) Q9U2T9 (/IDA) Q9Z0R4 (/IDA)
Presynaptic periactive zone GO:0036062
A region that surrounds the active zone of the presynaptic plasma membrane, and is specialized for the control of synaptic development.
3 E6N0W0 (/IDA) E6N0W1 (/IDA) Q9U2T9 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
2 Q15811 (/TAS) Q9Z0R4 (/TAS)
Centrosome GO:0005813
A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle.
1 Q9NZM3 (/IDA)
Centrosome GO:0005813
A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle.
1 Q9Z0R6 (/ISO)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 Q8VWF1 (/IDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 Q9Z0R4 (/ISO)
Clathrin-coated pit GO:0005905
A part of the endomembrane system in the form of an invagination of a membrane upon which a clathrin coat forms, and that can be converted by vesicle budding into a clathrin-coated vesicle. Coated pits form on the plasma membrane, where they are involved in receptor-mediated selective transport of many proteins and other macromolecules across the cell membrane, in the trans-Golgi network, and on some endosomes.
1 Q15811 (/IDA)
Clathrin-coated pit GO:0005905
A part of the endomembrane system in the form of an invagination of a membrane upon which a clathrin coat forms, and that can be converted by vesicle budding into a clathrin-coated vesicle. Coated pits form on the plasma membrane, where they are involved in receptor-mediated selective transport of many proteins and other macromolecules across the cell membrane, in the trans-Golgi network, and on some endosomes.
1 Q9Z0R4 (/ISO)
Lamellipodium GO:0030027
A thin sheetlike process extended by the leading edge of a migrating cell or extending cell process; contains a dense meshwork of actin filaments.
1 Q9Z0R4 (/IDA)
Terminal bouton GO:0043195
Terminal inflated portion of the axon, containing the specialized apparatus necessary to release neurotransmitters. The axon terminus is considered to be the whole region of thickening and the terminal bouton is a specialized region of it.
1 Q9WVE9 (/IDA)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
1 Q9NZM3 (/IDA)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
1 Q9Z0R6 (/ISO)