The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
SH3 Domains
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 19466: C-Jun-amino-terminal kinase-interacting protein 1

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 15 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
4 Q9R237 (/IPI) Q9UQF2 (/IPI) Q9W0K0 (/IPI) Q9WVI9 (/IPI)
Kinesin binding GO:0019894
Interacting selectively and non-covalently and stoichiometrically with kinesin, a member of a superfamily of microtubule-based motor proteins that perform force-generating tasks such as organelle transport and chromosome segregation.
3 Q9UQF2 (/IPI) Q9W0K0 (/IPI) Q9WVI9 (/IPI)
MAP-kinase scaffold activity GO:0005078
The binding activity of a molecule that functions as a physical support for the assembly of a multiprotein mitogen-activated protein kinase (MAPK) complex. Binds multiple kinases of the MAPKKK cascade, and also upstream signaling proteins, permitting those molecules to function in a coordinated way. Bringing together multiple enzymes and their substrates enables the signal to be transduced quickly and efficiently.
2 Q9UQF2 (/IPI) Q9W0K0 (/IPI)
Protein kinase binding GO:0019901
Interacting selectively and non-covalently with a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.
2 Q9W0K0 (/IPI) Q9WVI9 (/IPI)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
2 Q9R237 (/IPI) Q9W0K0 (/IPI)
Protein kinase inhibitor activity GO:0004860
Stops, prevents or reduces the activity of a protein kinase, an enzyme which phosphorylates a protein.
1 Q9UQF2 (/TAS)
MAP-kinase scaffold activity GO:0005078
The binding activity of a molecule that functions as a physical support for the assembly of a multiprotein mitogen-activated protein kinase (MAPK) complex. Binds multiple kinases of the MAPKKK cascade, and also upstream signaling proteins, permitting those molecules to function in a coordinated way. Bringing together multiple enzymes and their substrates enables the signal to be transduced quickly and efficiently.
1 Q9R237 (/IMP)
MAP-kinase scaffold activity GO:0005078
The binding activity of a molecule that functions as a physical support for the assembly of a multiprotein mitogen-activated protein kinase (MAPK) complex. Binds multiple kinases of the MAPKKK cascade, and also upstream signaling proteins, permitting those molecules to function in a coordinated way. Bringing together multiple enzymes and their substrates enables the signal to be transduced quickly and efficiently.
1 Q9WVI9 (/ISO)
MAP-kinase scaffold activity GO:0005078
The binding activity of a molecule that functions as a physical support for the assembly of a multiprotein mitogen-activated protein kinase (MAPK) complex. Binds multiple kinases of the MAPKKK cascade, and also upstream signaling proteins, permitting those molecules to function in a coordinated way. Bringing together multiple enzymes and their substrates enables the signal to be transduced quickly and efficiently.
1 Q9WVI9 (/NAS)
JUN kinase binding GO:0008432
Interacting selectively and non-covalently with JUN kinase, an enzyme that catalyzes the phosphorylation and activation of members of the JUN family.
1 Q9R237 (/IPI)
Kinesin binding GO:0019894
Interacting selectively and non-covalently and stoichiometrically with kinesin, a member of a superfamily of microtubule-based motor proteins that perform force-generating tasks such as organelle transport and chromosome segregation.
1 Q9WVI9 (/ISO)
Kinesin binding GO:0019894
Interacting selectively and non-covalently and stoichiometrically with kinesin, a member of a superfamily of microtubule-based motor proteins that perform force-generating tasks such as organelle transport and chromosome segregation.
1 Q9R237 (/ISS)
Protein kinase binding GO:0019901
Interacting selectively and non-covalently with a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.
1 Q9R237 (/ISS)
Mitogen-activated protein kinase kinase binding GO:0031434
Interacting selectively and non-covalently with a mitogen-activated protein kinase kinase, any protein that can phosphorylate a MAP kinase.
1 Q9R237 (/IPI)
Mitogen-activated protein kinase kinase kinase binding GO:0031435
Interacting selectively and non-covalently with a mitogen-activated protein kinase kinase kinase, any protein that can phosphorylate a MAP kinase kinase.
1 Q9R237 (/IPI)

There are 19 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Regulation of JNK cascade GO:0046328
Any process that modulates the frequency, rate or extent of signal transduction mediated by the JNK cascade.
3 Q9R237 (/ISS) Q9UQF2 (/ISS) Q9W0K0 (/ISS)
Signal transduction GO:0007165
The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.
2 Q9R237 (/IDA) Q9WVI9 (/IDA)
Regulation of transcription, DNA-templated GO:0006355
Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
1 Q9WVI9 (/IDA)
Signal transduction GO:0007165
The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.
1 Q9R237 (/TAS)
JNK cascade GO:0007254
An intracellular protein kinase cascade containing at least a JNK (a MAPK), a JNKK (a MAPKK) and a JUN3K (a MAP3K). The cascade can also contain two additional tiers: the upstream MAP4K and the downstream MAP Kinase-activated kinase (MAPKAPK). The kinases in each tier phosphorylate and activate the kinases in the downstream tier to transmit a signal within a cell.
1 Q9W0K0 (/ISA)
JUN phosphorylation GO:0007258
The process of introducing a phosphate group into a JUN protein.
1 Q9WVI9 (/IDA)
Vesicle-mediated transport GO:0016192
A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane.
1 Q9WVI9 (/IDA)
Vesicle-mediated transport GO:0016192
A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane.
1 Q9UQF2 (/ISS)
Axonal transport of mitochondrion GO:0019896
The directed movement of mitochondria along microtubules in nerve cell axons.
1 Q9W0K0 (/IMP)
Negative regulation of apoptotic process GO:0043066
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
1 Q9R237 (/IDA)
Negative regulation of JUN kinase activity GO:0043508
Any process that stops, prevents, or reduces the frequency, rate or extent of JUN kinase activity.
1 Q9R237 (/IMP)
Regulation of JNK cascade GO:0046328
Any process that modulates the frequency, rate or extent of signal transduction mediated by the JNK cascade.
1 Q9WVI9 (/IMP)
Regulation of JNK cascade GO:0046328
Any process that modulates the frequency, rate or extent of signal transduction mediated by the JNK cascade.
1 Q9W0K0 (/IPI)
Negative regulation of JNK cascade GO:0046329
Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the JNK cascade.
1 Q9R237 (/IMP)
Anterograde synaptic vesicle transport GO:0048490
The directed movement of synaptic vesicle along axonal microtubules from the cell body to the presynapse.
1 Q9W0K0 (/IMP)
Retrograde synaptic vesicle transport GO:0048491
The directed movement of synaptic vesicle along axonal microtubules from the presynapse to the cell body.
1 Q9W0K0 (/IMP)
Neuron projection morphogenesis GO:0048812
The process in which the anatomical structures of a neuron projection are generated and organized. A neuron projection is any process extending from a neural cell, such as axons or dendrites.
1 Q9W0K0 (/IMP)
Regulation of terminal button organization GO:2000331
Any process that modulates the frequency, rate or extent of terminal button organization.
1 Q9W0K0 (/IMP)
Negative regulation of intrinsic apoptotic signaling pathway GO:2001243
Any process that stops, prevents or reduces the frequency, rate or extent of intrinsic apoptotic signaling pathway.
1 Q9WVI9 (/IDA)

There are 15 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
3 Q9R237 (/IDA) Q9UQF2 (/IDA) Q9WVI9 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
2 Q9R237 (/IDA) Q9WVI9 (/IDA)
Axon GO:0030424
The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter.
2 Q9W0K0 (/IDA) Q9WVI9 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 Q9WVI9 (/ISO)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
1 Q9WVI9 (/IDA)
Dendrite GO:0030425
A neuron projection that has a short, tapering, often branched, morphology, receives and integrates signals from other neurons or from sensory stimuli, and conducts a nerve impulse towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body.
1 Q9WVI9 (/IDA)
Neuron projection GO:0043005
A prolongation or process extending from a nerve cell, e.g. an axon or dendrite.
1 Q9WVI9 (/IDA)
Dendritic growth cone GO:0044294
The migrating motile tip of a growing nerve cell dendrite.
1 Q9R237 (/IDA)
Dendritic growth cone GO:0044294
The migrating motile tip of a growing nerve cell dendrite.
1 Q9WVI9 (/ISO)
Axonal growth cone GO:0044295
The migrating motile tip of a growing nerve cell axon.
1 Q9R237 (/IDA)
Axonal growth cone GO:0044295
The migrating motile tip of a growing nerve cell axon.
1 Q9WVI9 (/ISO)
Cell body GO:0044297
The portion of a cell bearing surface projections such as axons, dendrites, cilia, or flagella that includes the nucleus, but excludes all cell projections.
1 Q9WVI9 (/IDA)
Dentate gyrus mossy fiber GO:0044302
Distinctive, unmyelinated axons produced by granule cells.
1 Q9WVI9 (/IDA)
Synapse GO:0045202
The junction between a nerve fiber of one neuron and another neuron, muscle fiber or glial cell. As the nerve fiber approaches the synapse it enlarges into a specialized structure, the presynaptic nerve ending, which contains mitochondria and synaptic vesicles. At the tip of the nerve ending is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic nerve ending secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane.
1 Q9WVI9 (/IDA)
Perinuclear region of cytoplasm GO:0048471
Cytoplasm situated near, or occurring around, the nucleus.
1 Q9R237 (/IDA)