The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
SH3 Domains
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 19404: Chromosome 2 SCAF14738, whole genome shotgun seque...

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 27 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
7 Q4ACU6 (/IPI) Q9BYB0 (/IPI) Q9JLU4 (/IPI) Q9QX74 (/IPI) Q9UPX8 (/IPI) Q9WV48 (/IPI) Q9Y566 (/IPI)
Ionotropic glutamate receptor binding GO:0035255
Interacting selectively and non-covalently with an ionotropic glutamate receptor. Ionotropic glutamate receptors bind glutamate and exert an effect through the regulation of ion channels.
5 Q9BYB0 (/ISS) Q9JLU4 (/ISS) Q9QX74 (/ISS) Q9UPX8 (/ISS) Q9Y566 (/ISS)
Protein C-terminus binding GO:0008022
Interacting selectively and non-covalently with a protein C-terminus, the end of any peptide chain at which the 1-carboxy function of a constituent amino acid is not attached in peptide linkage to another amino-acid residue.
4 Q4ACU6 (/IPI) Q9JLU4 (/IPI) Q9QX74 (/IPI) Q9WV48 (/IPI)
SH3 domain binding GO:0017124
Interacting selectively and non-covalently with a SH3 domain (Src homology 3) of a protein, small protein modules containing approximately 50 amino acid residues found in a great variety of intracellular or membrane-associated proteins.
4 D3YZU1 (/ISS) Q4ACU6 (/ISS) Q9BYB0 (/ISS) Q9Y566 (/ISS)
Ionotropic glutamate receptor binding GO:0035255
Interacting selectively and non-covalently with an ionotropic glutamate receptor. Ionotropic glutamate receptors bind glutamate and exert an effect through the regulation of ion channels.
4 D3YZU1 (/IPI) Q4ACU6 (/IPI) Q80Z38 (/IPI) Q9WV48 (/IPI)
Protein C-terminus binding GO:0008022
Interacting selectively and non-covalently with a protein C-terminus, the end of any peptide chain at which the 1-carboxy function of a constituent amino acid is not attached in peptide linkage to another amino-acid residue.
3 D3YZU1 (/ISS) Q9BYB0 (/ISS) Q9Y566 (/ISS)
SH3 domain binding GO:0017124
Interacting selectively and non-covalently with a SH3 domain (Src homology 3) of a protein, small protein modules containing approximately 50 amino acid residues found in a great variety of intracellular or membrane-associated proteins.
3 Q9JLU4 (/IPI) Q9QX74 (/IPI) Q9WV48 (/IPI)
GKAP/Homer scaffold activity GO:0030160
Functions as a physical support bridging the N-methyl-D-aspartate receptor-PSD-95-GKAP complex and the mGluR-Homer complex, which are involved in receptor signaling in synapses.
3 Q4ACU6 (/ISS) Q9BYB0 (/ISS) Q9Y566 (/ISS)
Scaffold protein binding GO:0097110
Interacting selectively and non-covalently with a scaffold protein. Scaffold proteins are crucial regulators of many key signaling pathways. Although not strictly defined in function, they are known to interact and/or bind with multiple members of a signaling pathway, tethering them into complexes.
3 Q4ACU6 (/IPI) Q9JLU4 (/IPI) Q9WV48 (/IPI)
Scaffold protein binding GO:0097110
Interacting selectively and non-covalently with a scaffold protein. Scaffold proteins are crucial regulators of many key signaling pathways. Although not strictly defined in function, they are known to interact and/or bind with multiple members of a signaling pathway, tethering them into complexes.
3 D3YZU1 (/ISS) Q9BYB0 (/ISS) Q9Y566 (/ISS)
Structural constituent of postsynaptic density GO:0098919
The action of a molecule that contributes to the structural integrity of a postsynaptic density.
3 D3YZU1 (/IC) Q9JLU4 (/IC) Q9QX74 (/IC)
Zinc ion binding GO:0008270
Interacting selectively and non-covalently with zinc (Zn) ions.
2 Q4ACU6 (/ISS) Q9BYB0 (/ISS)
GKAP/Homer scaffold activity GO:0030160
Functions as a physical support bridging the N-methyl-D-aspartate receptor-PSD-95-GKAP complex and the mGluR-Homer complex, which are involved in receptor signaling in synapses.
2 Q9JLU4 (/IDA) Q9WV48 (/IDA)
Somatostatin receptor binding GO:0031877
Interacting selectively and non-covalently with a somatostatin receptor.
2 D3YZU1 (/ISS) Q9Y566 (/ISS)
Protein complex binding GO:0032403
Interacting selectively and non-covalently with any protein complex (a complex of two or more proteins that may include other nonprotein molecules).
2 D3YZU1 (/ISS) Q9Y566 (/ISS)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
2 Q9JLU4 (/IPI) Q9WV48 (/IPI)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
2 D3YZU1 (/ISS) Q9Y566 (/ISS)
Protein self-association GO:0043621
Interacting selectively and non-covalently with a domain within the same polypeptide.
2 Q4ACU6 (/ISS) Q9BYB0 (/ISS)
Ankyrin repeat binding GO:0071532
Interacting selectively and non-covalently with an ankyrin repeat of a protein. Ankyrin repeats are tandemly repeated modules of about 33 amino acids; each repeat folds into a helix-loop-helix structure with a beta-hairpin/loop region projecting out from the helices at a 90-degree angle, and repeats stack to form an L-shaped structure.
2 D3YZU1 (/ISS) Q9Y566 (/ISS)
Zinc ion binding GO:0008270
Interacting selectively and non-covalently with zinc (Zn) ions.
1 Q9JLU4 (/IDA)
Receptor signaling complex scaffold activity GO:0030159
Functions to provide a physical support for the assembly of a multiprotein receptor signaling complex.
1 Q9WV48 (/IDA)
GKAP/Homer scaffold activity GO:0030160
Functions as a physical support bridging the N-methyl-D-aspartate receptor-PSD-95-GKAP complex and the mGluR-Homer complex, which are involved in receptor signaling in synapses.
1 D3YZU1 (/IMP)
GKAP/Homer scaffold activity GO:0030160
Functions as a physical support bridging the N-methyl-D-aspartate receptor-PSD-95-GKAP complex and the mGluR-Homer complex, which are involved in receptor signaling in synapses.
1 Q9UPX8 (/NAS)
Somatostatin receptor binding GO:0031877
Interacting selectively and non-covalently with a somatostatin receptor.
1 Q9WV48 (/IPI)
Protein complex binding GO:0032403
Interacting selectively and non-covalently with any protein complex (a complex of two or more proteins that may include other nonprotein molecules).
1 Q9WV48 (/IPI)
Protein self-association GO:0043621
Interacting selectively and non-covalently with a domain within the same polypeptide.
1 Q9JLU4 (/IDA)
Ankyrin repeat binding GO:0071532
Interacting selectively and non-covalently with an ankyrin repeat of a protein. Ankyrin repeats are tandemly repeated modules of about 33 amino acids; each repeat folds into a helix-loop-helix structure with a beta-hairpin/loop region projecting out from the helices at a 90-degree angle, and repeats stack to form an L-shaped structure.
1 Q9WV48 (/IPI)

There are 110 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Social behavior GO:0035176
Behavior directed towards society, or taking place between members of the same species. Occurs predominantly, or only, in individuals that are part of a group.
6 D3YZU1 (/IMP) Q4ACU6 (/IMP) Q80Z38 (/IMP) Q9BYB0 (/IMP) Q9UPX8 (/IMP) Q9Y566 (/IMP)
Vocalization behavior GO:0071625
The behavior in which an organism produces sounds by a mechanism involving its respiratory system.
6 D3YZU1 (/IMP) Q4ACU6 (/IMP) Q80Z38 (/IMP) Q9BYB0 (/IMP) Q9UPX8 (/IMP) Q9Y566 (/IMP)
Synapse assembly GO:0007416
The aggregation, arrangement and bonding together of a set of components to form a synapse. This process ends when the synapse is mature (functional).
4 Q9BYB0 (/ISS) Q9JLU4 (/ISS) Q9QX74 (/ISS) Q9UPX8 (/ISS)
Learning GO:0007612
Any process in an organism in which a relatively long-lasting adaptive behavioral change occurs as the result of experience.
4 Q4ACU6 (/IMP) Q80Z38 (/IMP) Q9BYB0 (/IMP) Q9UPX8 (/IMP)
Adult behavior GO:0030534
Behavior in a fully developed and mature organism.
4 Q80Z38 (/IMP) Q9BYB0 (/IMP) Q9UPX8 (/IMP) Q9Y566 (/IMP)
Negative regulation of actin filament bundle assembly GO:0032232
Any process that stops, prevents, or reduces the frequency, rate or extent of the assembly of actin filament bundles.
4 Q9BYB0 (/ISS) Q9JLU4 (/ISS) Q9WV48 (/ISS) Q9Y566 (/ISS)
Dendritic spine morphogenesis GO:0060997
The process in which the anatomical structures of a dendritic spine are generated and organized. A dendritic spine is a protrusion from a dendrite and a specialized subcellular compartment involved in synaptic transmission.
4 Q9BYB0 (/ISS) Q9JLU4 (/ISS) Q9WV48 (/ISS) Q9Y566 (/ISS)
Positive regulation of dendritic spine development GO:0060999
Any process that increases the rate, frequency, or extent of dendritic spine development, the process whose specific outcome is the progression of the dendritic spine over time, from its formation to the mature structure.
4 D3YZU1 (/ISS) Q9BYB0 (/ISS) Q9JLU4 (/ISS) Q9Y566 (/ISS)
Positive regulation of excitatory postsynaptic potential GO:2000463
Any process that enhances the establishment or increases the extent of the excitatory postsynaptic potential (EPSP) which is a temporary increase in postsynaptic potential due to the flow of positively charged ions into the postsynaptic cell. The flow of ions that causes an EPSP is an excitatory postsynaptic current (EPSC) and makes it easier for the neuron to fire an action potential.
4 Q9BYB0 (/ISS) Q9JLU4 (/ISS) Q9WV48 (/ISS) Q9Y566 (/ISS)
Learning GO:0007612
Any process in an organism in which a relatively long-lasting adaptive behavioral change occurs as the result of experience.
3 Q9BYB0 (/ISS) Q9JLU4 (/ISS) Q9QX74 (/ISS)
Memory GO:0007613
The activities involved in the mental information processing system that receives (registers), modifies, stores, and retrieves informational stimuli. The main stages involved in the formation and retrieval of memory are encoding (processing of received information by acquisition), storage (building a permanent record of received information as a result of consolidation) and retrieval (calling back the stored information and use it in a suitable way to execute a given task).
3 Q9BYB0 (/ISS) Q9JLU4 (/ISS) Q9QX74 (/ISS)
Adult behavior GO:0030534
Behavior in a fully developed and mature organism.
3 D3YZU1 (/ISO) Q4ACU6 (/ISO) Q80Z38 (/ISO)
Social behavior GO:0035176
Behavior directed towards society, or taking place between members of the same species. Occurs predominantly, or only, in individuals that are part of a group.
3 D3YZU1 (/ISO) Q4ACU6 (/ISO) Q80Z38 (/ISO)
Social behavior GO:0035176
Behavior directed towards society, or taking place between members of the same species. Occurs predominantly, or only, in individuals that are part of a group.
3 Q9BYB0 (/ISS) Q9JLU4 (/ISS) Q9QX74 (/ISS)
Brain morphogenesis GO:0048854
The process in which the anatomical structures of the brain are generated and organized. The brain is one of the two components of the central nervous system and is the center of thought and emotion. It is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.).
3 F1QCQ3 (/IMP) F1QY89 (/IMP) Q4ACU6 (/IMP)
Neuromuscular process controlling balance GO:0050885
Any process that an organism uses to control its balance, the orientation of the organism (or the head of the organism) in relation to the source of gravity. In humans and animals, balance is perceived through visual cues, the labyrinth system of the inner ears and information from skin pressure receptors and muscle and joint receptors.
3 Q9JLU4 (/ISS) Q9WV48 (/ISS) Q9Y566 (/ISS)
Vocalization behavior GO:0071625
The behavior in which an organism produces sounds by a mechanism involving its respiratory system.
3 D3YZU1 (/ISO) Q4ACU6 (/ISO) Q80Z38 (/ISO)
Vocalization behavior GO:0071625
The behavior in which an organism produces sounds by a mechanism involving its respiratory system.
3 Q9BYB0 (/ISS) Q9JLU4 (/ISS) Q9QX74 (/ISS)
MAPK cascade GO:0000165
An intracellular protein kinase cascade containing at least a MAPK, a MAPKK and a MAP3K. The cascade can also contain two additional tiers: the upstream MAP4K and the downstream MAP Kinase-activated kinase (MAPKAPK). The kinases in each tier phosphorylate and activate the kinases in the downstream tier to transmit a signal within a cell.
2 Q9BYB0 (/ISS) Q9JLU4 (/ISS)
Protein complex assembly GO:0006461
The aggregation, arrangement and bonding together of a set of components to form a protein complex.
2 D3YZU1 (/ISS) Q9Y566 (/ISS)
Cytoskeletal anchoring at plasma membrane GO:0007016
A cytoskeleton organization process that directly or indirectly links cytoskeletal filaments to the plasma membrane.
2 Q9WV48 (/NAS) Q9Y566 (/NAS)
Synapse assembly GO:0007416
The aggregation, arrangement and bonding together of a set of components to form a synapse. This process ends when the synapse is mature (functional).
2 Q4ACU6 (/IMP) Q80Z38 (/IMP)
Learning GO:0007612
Any process in an organism in which a relatively long-lasting adaptive behavioral change occurs as the result of experience.
2 Q4ACU6 (/ISO) Q80Z38 (/ISO)
Memory GO:0007613
The activities involved in the mental information processing system that receives (registers), modifies, stores, and retrieves informational stimuli. The main stages involved in the formation and retrieval of memory are encoding (processing of received information by acquisition), storage (building a permanent record of received information as a result of consolidation) and retrieval (calling back the stored information and use it in a suitable way to execute a given task).
2 Q4ACU6 (/IMP) Q80Z38 (/IMP)
Long-term memory GO:0007616
The memory process that deals with the storage, retrieval and modification of information a long time (typically weeks, months or years) after receiving that information. This type of memory is typically dependent on gene transcription regulated by second messenger activation.
2 Q9WV48 (/ISS) Q9Y566 (/ISS)
Associative learning GO:0008306
Learning by associating a stimulus (the cause) with a particular outcome (the effect).
2 Q9WV48 (/ISS) Q9Y566 (/ISS)
Striatal medium spiny neuron differentiation GO:0021773
The process in which a relatively unspecialized cell acquires specialized features of a medium spiny neuron residing in the striatum.
2 Q9BYB0 (/ISS) Q9JLU4 (/ISS)
Negative regulation of actin filament bundle assembly GO:0032232
Any process that stops, prevents, or reduces the frequency, rate or extent of the assembly of actin filament bundles.
2 D3YZU1 (/IDA) Q4ACU6 (/IDA)
Protein localization to synapse GO:0035418
Any process in which a protein is transported to, and/or maintained at the synapse, the junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell.
2 Q9WV48 (/ISS) Q9Y566 (/ISS)
Exploration behavior GO:0035640
The specific behavior of an organism in response to a novel environment or stimulus.
2 Q4ACU6 (/IMP) Q80Z38 (/IMP)
Swimming behavior GO:0036269
The response to external or internal stimuli that results in the locomotory process of swimming. Swimming is the self-propelled movement of an organism through the water.
2 F1QCQ3 (/IGI) F1QY89 (/IGI)
Swimming behavior GO:0036269
The response to external or internal stimuli that results in the locomotory process of swimming. Swimming is the self-propelled movement of an organism through the water.
2 F1QCQ3 (/IMP) F1QY89 (/IMP)
Negative regulation of cell volume GO:0045794
Any process that decreases cell volume.
2 Q9BYB0 (/ISS) Q9JLU4 (/ISS)
Positive regulation of long-term neuronal synaptic plasticity GO:0048170
A process that increases long-term neuronal synaptic plasticity, the ability of neuronal synapses to change long-term as circumstances require. Long-term neuronal synaptic plasticity generally involves increase or decrease in actual synapse numbers.
2 Q9BYB0 (/ISS) Q9JLU4 (/ISS)
Brain morphogenesis GO:0048854
The process in which the anatomical structures of the brain are generated and organized. The brain is one of the two components of the central nervous system and is the center of thought and emotion. It is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.).
2 F1QCQ3 (/IGI) F1QY89 (/IGI)
Brain morphogenesis GO:0048854
The process in which the anatomical structures of the brain are generated and organized. The brain is one of the two components of the central nervous system and is the center of thought and emotion. It is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.).
2 Q9BYB0 (/ISS) Q9JLU4 (/ISS)
Neuromuscular process controlling balance GO:0050885
Any process that an organism uses to control its balance, the orientation of the organism (or the head of the organism) in relation to the source of gravity. In humans and animals, balance is perceived through visual cues, the labyrinth system of the inner ears and information from skin pressure receptors and muscle and joint receptors.
2 D3YZU1 (/IMP) Q4ACU6 (/IMP)
Positive regulation of synapse structural plasticity GO:0051835
Any process that activates, maintains or increases the frequency, rate or extent of synaptic structural plasticity.
2 Q9BYB0 (/ISS) Q9JLU4 (/ISS)
Positive regulation of synaptic transmission, glutamatergic GO:0051968
Any process that activates, maintains or increases the frequency, rate or extent of glutamatergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter glutamate.
2 Q4ACU6 (/IMP) Q80Z38 (/IMP)
Positive regulation of synaptic transmission, glutamatergic GO:0051968
Any process that activates, maintains or increases the frequency, rate or extent of glutamatergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter glutamate.
2 Q9BYB0 (/ISS) Q9JLU4 (/ISS)
Synapse maturation GO:0060074
The process that organizes a synapse so that it attains its fully functional state. Synaptic maturation plays a critical role in the establishment of effective synaptic connections in early development.
2 D3YZU1 (/ISS) Q9Y566 (/ISS)
Long-term synaptic potentiation GO:0060291
A process that modulates synaptic plasticity such that synapses are changed resulting in the increase in the rate, or frequency of synaptic transmission at the synapse.
2 Q4ACU6 (/IMP) Q80Z38 (/IMP)
Long-term synaptic potentiation GO:0060291
A process that modulates synaptic plasticity such that synapses are changed resulting in the increase in the rate, or frequency of synaptic transmission at the synapse.
2 Q9QX74 (/ISS) Q9UPX8 (/ISS)
Long term synaptic depression GO:0060292
A process that modulates synaptic plasticity such that synapses are changed resulting in the decrease in the rate, or frequency of synaptic transmission at the synapse.
2 Q4ACU6 (/IMP) Q80Z38 (/IMP)
Long term synaptic depression GO:0060292
A process that modulates synaptic plasticity such that synapses are changed resulting in the decrease in the rate, or frequency of synaptic transmission at the synapse.
2 Q9QX74 (/ISS) Q9UPX8 (/ISS)
Dendritic spine morphogenesis GO:0060997
The process in which the anatomical structures of a dendritic spine are generated and organized. A dendritic spine is a protrusion from a dendrite and a specialized subcellular compartment involved in synaptic transmission.
2 D3YZU1 (/IMP) Q4ACU6 (/IMP)
Regulation of dendritic spine morphogenesis GO:0061001
Any process that modulates the rate, frequency, or extent of dendritic spine morphogenesis, the process in which the anatomical structures of a dendritic spine are generated and organized. A dendritic spine is a protrusion from a dendrite and a specialized subcellular compartment involved in synaptic transmission.
2 Q9BYB0 (/ISS) Q9JLU4 (/ISS)
Postsynaptic density assembly GO:0097107
The aggregation, arrangement and bonding together of a set of components to form a postsynaptic density, a region that lies adjacent to the cytoplasmic face of the postsynaptic membrane at excitatory synapse.
2 Q9BYB0 (/ISS) Q9JLU4 (/ISS)
AMPA glutamate receptor clustering GO:0097113
The glutamate receptor clustering process in which alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) receptors are localized to distinct domains in the cell membrane.
2 Q9BYB0 (/ISS) Q9JLU4 (/ISS)
NMDA glutamate receptor clustering GO:0097114
The receptor clustering process in which N-methyl-D-aspartate (NMDA) receptors are localized to distinct domains in the cell membrane.
2 Q9BYB0 (/ISS) Q9JLU4 (/ISS)
Guanylate kinase-associated protein clustering GO:0097117
The clustering process in which guanylate kinase-associated proteins (GKAPs) are localized to distinct domains in the cell membrane. GKAP facilitates assembly of the post synaptic density of neurons.
2 Q9BYB0 (/ISS) Q9JLU4 (/ISS)
Maintenance of postsynaptic density structure GO:0099562
A process which maintains the organization and the arrangement of proteins in the presynaptic density.
2 Q9JLU4 (/IC) Q9QX74 (/IC)
Regulation of long-term synaptic potentiation GO:1900271
Any process that modulates the frequency, rate or extent of long-term synaptic potentiation.
2 Q9BYB0 (/ISS) Q9JLU4 (/ISS)
Positive regulation of long-term synaptic potentiation GO:1900273
Any process that activates or increases the frequency, rate or extent of long-term synaptic potentiation.
2 Q9BYB0 (/ISS) Q9JLU4 (/ISS)
Positive regulation of glutamate receptor signaling pathway GO:1900451
Any process that activates or increases the frequency, rate or extent of glutamate receptor signaling pathway.
2 Q4ACU6 (/IMP) Q9JLU4 (/IMP)
Positive regulation of glutamate receptor signaling pathway GO:1900451
Any process that activates or increases the frequency, rate or extent of glutamate receptor signaling pathway.
2 Q9BYB0 (/ISS) Q9JLU4 (/ISS)
Regulation of long term synaptic depression GO:1900452
Any process that modulates the frequency, rate or extent of long term synaptic depression.
2 Q9BYB0 (/ISS) Q9JLU4 (/ISS)
Regulation of AMPA receptor activity GO:2000311
Any process that modulates the frequency, rate or extent of AMPA selective glutamate receptor activity.
2 Q9WV48 (/ISS) Q9Y566 (/ISS)
Positive regulation of excitatory postsynaptic potential GO:2000463
Any process that enhances the establishment or increases the extent of the excitatory postsynaptic potential (EPSP) which is a temporary increase in postsynaptic potential due to the flow of positively charged ions into the postsynaptic cell. The flow of ions that causes an EPSP is an excitatory postsynaptic current (EPSC) and makes it easier for the neuron to fire an action potential.
2 D3YZU1 (/IMP) Q4ACU6 (/IMP)
Positive regulation of AMPA receptor activity GO:2000969
Any process that activates or increases the frequency, rate or extent of AMPA selective glutamate receptor activity.
2 Q9BYB0 (/ISS) Q9JLU4 (/ISS)
MAPK cascade GO:0000165
An intracellular protein kinase cascade containing at least a MAPK, a MAPKK and a MAP3K. The cascade can also contain two additional tiers: the upstream MAP4K and the downstream MAP Kinase-activated kinase (MAPKAPK). The kinases in each tier phosphorylate and activate the kinases in the downstream tier to transmit a signal within a cell.
1 Q4ACU6 (/IGI)
Embryonic epithelial tube formation GO:0001838
The morphogenesis of an embryonic epithelium into a tube-shaped structure.
1 Q4ACU6 (/IGI)
Protein complex assembly GO:0006461
The aggregation, arrangement and bonding together of a set of components to form a protein complex.
1 Q9WV48 (/IDA)
Axon guidance GO:0007411
The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues.
1 Q9BYB0 (/TAS)
Brain development GO:0007420
The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. Brain development begins with patterning events in the neural tube and ends with the mature structure that is the center of thought and emotion. The brain is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.).
1 Q9QX74 (/IEP)
Response to nutrient GO:0007584
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nutrient stimulus.
1 Q9QX74 (/IEP)
Learning or memory GO:0007611
The acquisition and processing of information and/or the storage and retrieval of this information over time.
1 Q4ACU6 (/IMP)
Long-term memory GO:0007616
The memory process that deals with the storage, retrieval and modification of information a long time (typically weeks, months or years) after receiving that information. This type of memory is typically dependent on gene transcription regulated by second messenger activation.
1 D3YZU1 (/IMP)
Locomotory behavior GO:0007626
The specific movement from place to place of an organism in response to external or internal stimuli. Locomotion of a whole organism in a manner dependent upon some combination of that organism's internal state and external conditions.
1 Q4ACU6 (/IMP)
Associative learning GO:0008306
Learning by associating a stimulus (the cause) with a particular outcome (the effect).
1 D3YZU1 (/IMP)
Striatal medium spiny neuron differentiation GO:0021773
The process in which a relatively unspecialized cell acquires specialized features of a medium spiny neuron residing in the striatum.
1 Q4ACU6 (/IMP)
Adult behavior GO:0030534
Behavior in a fully developed and mature organism.
1 Q9QX74 (/ISS)
Protein localization to synapse GO:0035418
Any process in which a protein is transported to, and/or maintained at the synapse, the junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell.
1 D3YZU1 (/IMP)
Exploration behavior GO:0035640
The specific behavior of an organism in response to a novel environment or stimulus.
1 Q9QX74 (/ISS)
Locomotory exploration behavior GO:0035641
The specific movement from place to place of an organism in response to a novel environment.
1 Q4ACU6 (/IMP)
Locomotory exploration behavior GO:0035641
The specific movement from place to place of an organism in response to a novel environment.
1 Q9JLU4 (/ISS)
Locomotion GO:0040011
Self-propelled movement of a cell or organism from one location to another.
1 Q4ACU6 (/IMP)
Olfactory behavior GO:0042048
The behavior of an organism in response to an odor.
1 D3YZU1 (/IMP)
Olfactory behavior GO:0042048
The behavior of an organism in response to an odor.
1 Q9WV48 (/ISS)
Vocal learning GO:0042297
A behavioral process whose outcome is a relatively long-lasting behavioral change whereby an organism modifies innate vocalizations to imitate sounds produced by others.
1 Q9BYB0 (/IMP)
Vocal learning GO:0042297
A behavioral process whose outcome is a relatively long-lasting behavioral change whereby an organism modifies innate vocalizations to imitate sounds produced by others.
1 Q4ACU6 (/ISO)
Negative regulation of cell volume GO:0045794
Any process that decreases cell volume.
1 Q4ACU6 (/IMP)
Habituation GO:0046959
A decrease in a behavioral response to a repeated stimulus. This is exemplified by the failure of a person to show a startle response to a loud noise that has been repeatedly presented.
1 D3YZU1 (/IMP)
Habituation GO:0046959
A decrease in a behavioral response to a repeated stimulus. This is exemplified by the failure of a person to show a startle response to a loud noise that has been repeatedly presented.
1 Q9WV48 (/ISS)
Regulation of synaptic plasticity GO:0048167
A process that modulates synaptic plasticity, the ability of synapses to change as circumstances require. They may alter function, such as increasing or decreasing their sensitivity, or they may increase or decrease in actual numbers.
1 Q4ACU6 (/IMP)
Positive regulation of long-term neuronal synaptic plasticity GO:0048170
A process that increases long-term neuronal synaptic plasticity, the ability of neuronal synapses to change long-term as circumstances require. Long-term neuronal synaptic plasticity generally involves increase or decrease in actual synapse numbers.
1 Q4ACU6 (/IMP)
Determination of affect GO:0050894
Any process in which an emotional response is associated with a particular sensory stimulation.
1 Q9Y566 (/IMP)
Determination of affect GO:0050894
Any process in which an emotional response is associated with a particular sensory stimulation.
1 D3YZU1 (/ISO)
Protein oligomerization GO:0051259
The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of component monomers; protein oligomers may be composed of different or identical monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer.
1 Q9JLU4 (/IDA)
Positive regulation of synapse structural plasticity GO:0051835
Any process that activates, maintains or increases the frequency, rate or extent of synaptic structural plasticity.
1 Q4ACU6 (/IMP)
Righting reflex GO:0060013
A reflex process in which an animal immediately tries to turn over after being placed in a supine position.
1 D3YZU1 (/IMP)
Righting reflex GO:0060013
A reflex process in which an animal immediately tries to turn over after being placed in a supine position.
1 Q9WV48 (/ISS)
Synapse maturation GO:0060074
The process that organizes a synapse so that it attains its fully functional state. Synaptic maturation plays a critical role in the establishment of effective synaptic connections in early development.
1 Q9WV48 (/IDA)
Positive regulation of dendritic spine development GO:0060999
Any process that increases the rate, frequency, or extent of dendritic spine development, the process whose specific outcome is the progression of the dendritic spine over time, from its formation to the mature structure.
1 Q9WV48 (/IDA)
Positive regulation of dendritic spine development GO:0060999
Any process that increases the rate, frequency, or extent of dendritic spine development, the process whose specific outcome is the progression of the dendritic spine over time, from its formation to the mature structure.
1 Q4ACU6 (/IMP)
Regulation of dendritic spine morphogenesis GO:0061001
Any process that modulates the rate, frequency, or extent of dendritic spine morphogenesis, the process in which the anatomical structures of a dendritic spine are generated and organized. A dendritic spine is a protrusion from a dendrite and a specialized subcellular compartment involved in synaptic transmission.
1 Q4ACU6 (/IMP)
Postsynaptic density assembly GO:0097107
The aggregation, arrangement and bonding together of a set of components to form a postsynaptic density, a region that lies adjacent to the cytoplasmic face of the postsynaptic membrane at excitatory synapse.
1 Q4ACU6 (/IMP)
AMPA glutamate receptor clustering GO:0097113
The glutamate receptor clustering process in which alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) receptors are localized to distinct domains in the cell membrane.
1 Q4ACU6 (/IMP)
NMDA glutamate receptor clustering GO:0097114
The receptor clustering process in which N-methyl-D-aspartate (NMDA) receptors are localized to distinct domains in the cell membrane.
1 Q4ACU6 (/IMP)
Guanylate kinase-associated protein clustering GO:0097117
The clustering process in which guanylate kinase-associated proteins (GKAPs) are localized to distinct domains in the cell membrane. GKAP facilitates assembly of the post synaptic density of neurons.
1 Q4ACU6 (/IMP)
Regulation of long-term synaptic potentiation GO:1900271
Any process that modulates the frequency, rate or extent of long-term synaptic potentiation.
1 Q4ACU6 (/IMP)
Positive regulation of long-term synaptic potentiation GO:1900273
Any process that activates or increases the frequency, rate or extent of long-term synaptic potentiation.
1 Q4ACU6 (/IMP)
Regulation of long term synaptic depression GO:1900452
Any process that modulates the frequency, rate or extent of long term synaptic depression.
1 Q4ACU6 (/IMP)
Regulation of AMPA glutamate receptor clustering GO:1904717
Any process that modulates the frequency, rate or extent of AMPA glutamate receptor clustering.
1 Q4ACU6 (/IMP)
Regulation of AMPA receptor activity GO:2000311
Any process that modulates the frequency, rate or extent of AMPA selective glutamate receptor activity.
1 D3YZU1 (/IMP)
Regulation of grooming behavior GO:2000821
Any process that modulates the frequency, rate or extent of grooming behavior.
1 Q4ACU6 (/IMP)
Regulation of grooming behavior GO:2000821
Any process that modulates the frequency, rate or extent of grooming behavior.
1 Q9JLU4 (/ISS)
Regulation of behavioral fear response GO:2000822
Any process that modulates the frequency, rate or extent of behavioral fear response.
1 Q4ACU6 (/IMP)
Regulation of behavioral fear response GO:2000822
Any process that modulates the frequency, rate or extent of behavioral fear response.
1 Q9JLU4 (/ISS)
Positive regulation of AMPA receptor activity GO:2000969
Any process that activates or increases the frequency, rate or extent of AMPA selective glutamate receptor activity.
1 Q4ACU6 (/IMP)

There are 40 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
6 Q9BYB0 (/ISS) Q9JLU4 (/ISS) Q9QX74 (/ISS) Q9UPX8 (/ISS) Q9WV48 (/ISS) Q9Y566 (/ISS)
Postsynaptic density GO:0014069
An electron dense network of proteins within and adjacent to the postsynaptic membrane in asymetric synapses. Its major components include neurotransmitter receptors and the proteins that spatially and functionally organize them such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components.
6 Q4ACU6 (/ISS) Q80Z38 (/ISS) Q9BYB0 (/ISS) Q9UPX8 (/ISS) Q9WV48 (/ISS) Q9Y566 (/ISS)
Neuron projection GO:0043005
A prolongation or process extending from a nerve cell, e.g. an axon or dendrite.
6 Q9BYB0 (/ISS) Q9JLU4 (/ISS) Q9QX74 (/ISS) Q9UPX8 (/ISS) Q9WV48 (/ISS) Q9Y566 (/ISS)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
5 D3YZU1 (/IDA) H9KV90 (/IDA) Q4ACU6 (/IDA) Q80Z38 (/IDA) Q9Y566 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
4 Q9BYB0 (/TAS) Q9UPX8 (/TAS) Q9WV48 (/TAS) Q9Y566 (/TAS)
Ciliary membrane GO:0060170
The portion of the plasma membrane surrounding a cilium.
4 Q4ACU6 (/ISS) Q80Z38 (/ISS) Q9BYB0 (/ISS) Q9UPX8 (/ISS)
Postsynaptic density GO:0014069
An electron dense network of proteins within and adjacent to the postsynaptic membrane in asymetric synapses. Its major components include neurotransmitter receptors and the proteins that spatially and functionally organize them such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components.
3 D3YZU1 (/IDA) Q9JLU4 (/IDA) Q9QX74 (/IDA)
Neuron projection GO:0043005
A prolongation or process extending from a nerve cell, e.g. an axon or dendrite.
3 D3YZU1 (/IDA) Q4ACU6 (/IDA) Q80Z38 (/IDA)
Dendritic spine GO:0043197
A small, membranous protrusion from a dendrite that forms a postsynaptic compartment - typically receiving input from a single presynapse. They function as partially isolated biochemical and an electrical compartments. Spine morphology is variable including \thin\, \stubby\, \mushroom\, and \branched\, with a continuum of intermediate morphologies. They typically terminate in a bulb shape, linked to the dendritic shaft by a restriction. Spine remodeling is though to be involved in synaptic plasticity.
3 D3YZU1 (/IDA) Q80Z38 (/IDA) Q9WV48 (/IDA)
Dendritic spine GO:0043197
A small, membranous protrusion from a dendrite that forms a postsynaptic compartment - typically receiving input from a single presynapse. They function as partially isolated biochemical and an electrical compartments. Spine morphology is variable including \thin\, \stubby\, \mushroom\, and \branched\, with a continuum of intermediate morphologies. They typically terminate in a bulb shape, linked to the dendritic shaft by a restriction. Spine remodeling is though to be involved in synaptic plasticity.
3 Q9QX74 (/ISS) Q9UPX8 (/ISS) Q9Y566 (/ISS)
Photoreceptor outer segment GO:0001750
The outer segment of a vertebrate photoreceptor that contains discs of photoreceptive membranes.
2 Q9QX74 (/ISS) Q9UPX8 (/ISS)
Photoreceptor inner segment GO:0001917
The inner segment of a vertebrate photoreceptor containing mitochondria, ribosomes and membranes where opsin molecules are assembled and passed to be part of the outer segment discs.
2 Q9QX74 (/ISS) Q9UPX8 (/ISS)
Intracellular GO:0005622
The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.
2 Q9WV48 (/NAS) Q9Y566 (/NAS)
Apical plasma membrane GO:0016324
The region of the plasma membrane located at the apical end of the cell.
2 Q80Z38 (/ISS) Q9UPX8 (/ISS)
Dendrite GO:0030425
A neuron projection that has a short, tapering, often branched, morphology, receives and integrates signals from other neurons or from sensory stimuli, and conducts a nerve impulse towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body.
2 Q9WV48 (/NAS) Q9Y566 (/NAS)
Growth cone GO:0030426
The migrating motile tip of a growing nerve cell axon or dendrite.
2 Q80Z38 (/ISS) Q9UPX8 (/ISS)
Brush border membrane GO:0031526
The portion of the plasma membrane surrounding the brush border.
2 Q80Z38 (/ISS) Q9UPX8 (/ISS)
Neuronal cell body GO:0043025
The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.
2 Q80Z38 (/ISS) Q9UPX8 (/ISS)
Neuron spine GO:0044309
A small membranous protrusion, often ending in a bulbous head and attached to the neuron by a narrow stalk or neck.
2 Q9BYB0 (/ISS) Q9JLU4 (/ISS)
Synapse GO:0045202
The junction between a nerve fiber of one neuron and another neuron, muscle fiber or glial cell. As the nerve fiber approaches the synapse it enlarges into a specialized structure, the presynaptic nerve ending, which contains mitochondria and synaptic vesicles. At the tip of the nerve ending is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic nerve ending secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane.
2 Q9JLU4 (/IDA) Q9WV48 (/IDA)
Postsynaptic membrane GO:0045211
A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters cross the synaptic cleft and transmit the signal to the postsynaptic membrane.
2 D3YZU1 (/IDA) Q9WV48 (/IDA)
Excitatory synapse GO:0060076
A synapse in which an action potential in the presynaptic cell increases the probability of an action potential occurring in the postsynaptic cell.
2 Q9WV48 (/ISS) Q9Y566 (/ISS)
Ciliary membrane GO:0060170
The portion of the plasma membrane surrounding a cilium.
2 Q9JLU4 (/IDA) Q9QX74 (/IDA)
Photoreceptor outer segment GO:0001750
The outer segment of a vertebrate photoreceptor that contains discs of photoreceptive membranes.
1 Q80Z38 (/IDA)
Photoreceptor inner segment GO:0001917
The inner segment of a vertebrate photoreceptor containing mitochondria, ribosomes and membranes where opsin molecules are assembled and passed to be part of the outer segment discs.
1 Q80Z38 (/IDA)
Neurofilament GO:0005883
A type of intermediate filament found in the core of neuronal axons. Neurofilaments are heteropolymers composed of three type IV polypeptides: NF-L, NF-M, and NF-H (for low, middle, and high molecular weight). Neurofilaments are responsible for the radial growth of an axon and determine axonal diameter.
1 Q80Z38 (/IDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 D3YZU1 (/ISO)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
1 Q9Y566 (/IDA)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
1 D3YZU1 (/ISO)
Apical plasma membrane GO:0016324
The region of the plasma membrane located at the apical end of the cell.
1 Q9QX74 (/IDA)
Dendrite GO:0030425
A neuron projection that has a short, tapering, often branched, morphology, receives and integrates signals from other neurons or from sensory stimuli, and conducts a nerve impulse towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body.
1 D3YZU1 (/IDA)
Growth cone GO:0030426
The migrating motile tip of a growing nerve cell axon or dendrite.
1 Q9QX74 (/IDA)
Brush border membrane GO:0031526
The portion of the plasma membrane surrounding the brush border.
1 Q9QX74 (/IDA)
Neuronal cell body GO:0043025
The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.
1 Q9QX74 (/IDA)
Neuron spine GO:0044309
A small membranous protrusion, often ending in a bulbous head and attached to the neuron by a narrow stalk or neck.
1 Q4ACU6 (/IDA)
Postsynaptic membrane GO:0045211
A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters cross the synaptic cleft and transmit the signal to the postsynaptic membrane.
1 Q9Y566 (/ISS)
Presynaptic active zone GO:0048786
A specialized region of the plasma membrane and cell cortex of a presynaptic neuron; encompasses a region of the plasma membrane where synaptic vesicles dock and fuse, and a specialized cortical cytoskeletal matrix.
1 Q9QX74 (/IDA)
Presynaptic active zone GO:0048786
A specialized region of the plasma membrane and cell cortex of a presynaptic neuron; encompasses a region of the plasma membrane where synaptic vesicles dock and fuse, and a specialized cortical cytoskeletal matrix.
1 Q80Z38 (/ISO)
Excitatory synapse GO:0060076
A synapse in which an action potential in the presynaptic cell increases the probability of an action potential occurring in the postsynaptic cell.
1 Q4ACU6 (/IC)
Excitatory synapse GO:0060076
A synapse in which an action potential in the presynaptic cell increases the probability of an action potential occurring in the postsynaptic cell.
1 D3YZU1 (/IDA)