The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:
"SH3 Domains
".
FunFam 19379: NCK-1, isoform a
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 6 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
4 | Q24218 (/IPI) Q8IPW2 (/IPI) Q95PW9 (/IPI) Q9VPU1 (/IPI) |
|
SH3/SH2 adaptor activity GO:0005070
Interacting selectively and non-covalently and simultaneously with one or more signal transduction molecules, usually acting as a scaffold to bring these molecules into close proximity either using their own SH2/SH3 domains (e.g. Grb2) or those of their target molecules (e.g. SAM68).
|
3 | Q24218 (/ISS) Q8IPW2 (/ISS) Q9VPU1 (/ISS) |
|
SH3/SH2 adaptor activity GO:0005070
Interacting selectively and non-covalently and simultaneously with one or more signal transduction molecules, usually acting as a scaffold to bring these molecules into close proximity either using their own SH2/SH3 domains (e.g. Grb2) or those of their target molecules (e.g. SAM68).
|
3 | Q24218 (/TAS) Q8IPW2 (/TAS) Q9VPU1 (/TAS) |
|
Insulin receptor binding GO:0005158
Interacting selectively and non-covalently with the insulin receptor.
|
3 | Q24218 (/IPI) Q8IPW2 (/IPI) Q9VPU1 (/IPI) |
|
Protein kinase binding GO:0019901
Interacting selectively and non-covalently with a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.
|
3 | Q24218 (/IPI) Q8IPW2 (/IPI) Q9VPU1 (/IPI) |
|
Cell adhesion molecule binding GO:0050839
Interacting selectively and non-covalently with a cell adhesion molecule.
|
3 | Q24218 (/IPI) Q8IPW2 (/IPI) Q9VPU1 (/IPI) |
There are 7 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Axonogenesis GO:0007409
De novo generation of a long process of a neuron, that carries efferent (outgoing) action potentials from the cell body towards target cells. Refers to the morphogenesis or creation of shape or form of the developing axon.
|
3 | Q24218 (/TAS) Q8IPW2 (/TAS) Q9VPU1 (/TAS) |
|
Axon guidance GO:0007411
The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues.
|
3 | Q24218 (/IGI) Q8IPW2 (/IGI) Q9VPU1 (/IGI) |
|
Axon guidance GO:0007411
The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues.
|
3 | Q24218 (/IMP) Q8IPW2 (/IMP) Q9VPU1 (/IMP) |
|
Axon guidance GO:0007411
The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues.
|
3 | Q24218 (/TAS) Q8IPW2 (/TAS) Q9VPU1 (/TAS) |
|
Myoblast fusion GO:0007520
A process in which non-proliferating myoblasts fuse to existing fibers or to myotubes to form new fibers. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers.
|
3 | Q24218 (/IGI) Q8IPW2 (/IGI) Q9VPU1 (/IGI) |
|
Insulin receptor signaling pathway GO:0008286
The series of molecular signals generated as a consequence of the insulin receptor binding to insulin.
|
3 | Q24218 (/IPI) Q8IPW2 (/IPI) Q9VPU1 (/IPI) |
|
Negative regulation of insulin receptor signaling pathway GO:0046627
Any process that stops, prevents, or reduces the frequency, rate or extent of insulin receptor signaling.
|
3 | Q24218 (/IGI) Q8IPW2 (/IGI) Q9VPU1 (/IGI) |
There are 4 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
3 | Q24218 (/NAS) Q8IPW2 (/NAS) Q9VPU1 (/NAS) |
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
1 | Q95PW9 (/IDA) |
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
1 | Q95PW9 (/IDA) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
1 | Q9VPU1 (/TAS) |