The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
SH3 Domains
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 19370: PIX-1, isoform a

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 2 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Guanyl-nucleotide exchange factor activity GO:0005085
Stimulates the exchange of guanyl nucleotides associated with a GTPase. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase.
6 A8DZ19 (/ISS) A8DZ20 (/ISS) C3KGL5 (/ISS) M9PBE8 (/ISS) M9PGB1 (/ISS) Q9VIN1 (/ISS)
Protein complex scaffold GO:0032947
A structural molecule activity that provides a physical support for the assembly of a multiprotein complex. The scaffold may or may not be part of the final complex.
6 A8DZ19 (/IMP) A8DZ20 (/IMP) C3KGL5 (/IMP) M9PBE8 (/IMP) M9PGB1 (/IMP) Q9VIN1 (/IMP)

There are 9 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Positive regulation of hippo signaling GO:0035332
Any process that activates or increases the frequency, rate or extent of hippo signaling.
6 A8DZ19 (/IGI) A8DZ20 (/IGI) C3KGL5 (/IGI) M9PBE8 (/IGI) M9PGB1 (/IGI) Q9VIN1 (/IGI)
Positive regulation of GTPase activity GO:0043547
Any process that activates or increases the activity of a GTPase.
6 A8DZ19 (/ISS) A8DZ20 (/ISS) C3KGL5 (/ISS) M9PBE8 (/ISS) M9PGB1 (/ISS) Q9VIN1 (/ISS)
Regulation of organ growth GO:0046620
Any process that modulates the frequency, rate or extent of growth of an organ of an organism.
6 A8DZ19 (/IGI) A8DZ20 (/IGI) C3KGL5 (/IGI) M9PBE8 (/IGI) M9PGB1 (/IGI) Q9VIN1 (/IGI)
Regulation of synapse organization GO:0050807
Any process that modulates the physical form of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell).
6 A8DZ19 (/IMP) A8DZ20 (/IMP) C3KGL5 (/IMP) M9PBE8 (/IMP) M9PGB1 (/IMP) Q9VIN1 (/IMP)
Neuron migration GO:0001764
The characteristic movement of an immature neuron from germinal zones to specific positions where they will reside as they mature.
2 E3W735 (/IGI) Q21430 (/IGI)
Neuron migration GO:0001764
The characteristic movement of an immature neuron from germinal zones to specific positions where they will reside as they mature.
2 E3W735 (/IMP) Q21430 (/IMP)
Gonad morphogenesis GO:0035262
The process in which the anatomical structures of the gonads are generated and organized. A gonad is an animal organ producing gametes, e.g. the testes or the ovary in mammals.
2 E3W735 (/IGI) Q21430 (/IGI)
Gonad morphogenesis GO:0035262
The process in which the anatomical structures of the gonads are generated and organized. A gonad is an animal organ producing gametes, e.g. the testes or the ovary in mammals.
2 E3W735 (/IMP) Q21430 (/IMP)
Inductive cell migration GO:0040039
Migration of a cell in a multicellular organism that, having changed its location, is required to induce normal properties in one or more cells at its new location. An example of this would be the distal tip cells of Caenorhabditis elegans.
2 E3W735 (/IMP) Q21430 (/IMP)

There are 5 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Muscle cell postsynaptic density GO:0097482
A postsynaptic specialization that is part of a neuromuscular junction.
6 A8DZ19 (/IDA) A8DZ20 (/IDA) C3KGL5 (/IDA) M9PBE8 (/IDA) M9PGB1 (/IDA) Q9VIN1 (/IDA)
Hemidesmosome GO:0030056
A cell-substrate junction (attachment structure) found in epithelial cells that links intermediate filaments to extracellular matrices via transmembrane complexes. In vertebrates, hemidesmosomes mediate contact between the basal side of epithelial cells and the basal lamina. In C. elegans, hemidesmosomes connect epithelial cells to distinct extracellular matrices on both the apical and basal cell surfaces.
2 E3W735 (/IDA) Q21430 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 Q21430 (/IDA)
Cell-cell adherens junction GO:0005913
An adherens junction which connects a cell to another cell.
1 Q21430 (/IDA)
Cell periphery GO:0071944
The part of a cell encompassing the cell cortex, the plasma membrane, and any external encapsulating structures.
1 Q21430 (/IDA)