The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
SH3 Domains
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 19357: Formin-binding protein 1 homolog

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 9 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
16 A8JNK4 (/IPI) M9ND42 (/IPI) M9ND44 (/IPI) M9NDH6 (/IPI) M9NE16 (/IPI) M9NF07 (/IPI) M9NF10 (/IPI) M9PBP3 (/IPI) M9PE52 (/IPI) P97531 (/IPI)
(6 more)
Phospholipid binding GO:0005543
Interacting selectively and non-covalently with phospholipids, a class of lipids containing phosphoric acid as a mono- or diester.
10 A8JNK4 (/ISM) M9ND42 (/ISM) M9ND44 (/ISM) M9NDH6 (/ISM) M9NE16 (/ISM) M9NF07 (/ISM) M9NF10 (/ISM) M9PBP3 (/ISM) M9PE52 (/ISM) Q9VZD7 (/ISM)
Lipid binding GO:0008289
Interacting selectively and non-covalently with a lipid.
10 A8JNK4 (/IDA) M9ND42 (/IDA) M9ND44 (/IDA) M9NDH6 (/IDA) M9NE16 (/IDA) M9NF07 (/IDA) M9NF10 (/IDA) M9PBP3 (/IDA) M9PE52 (/IDA) Q9VZD7 (/IDA)
GTPase activating protein binding GO:0032794
Interacting selectively and non-covalently with a GTPase activating protein.
10 A8JNK4 (/IPI) M9ND42 (/IPI) M9ND44 (/IPI) M9NDH6 (/IPI) M9NE16 (/IPI) M9NF07 (/IPI) M9NF10 (/IPI) M9PBP3 (/IPI) M9PE52 (/IPI) Q9VZD7 (/IPI)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
2 Q15642 (/IPI) Q96RU3 (/IPI)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
2 Q80TY0 (/ISO) Q8CJ53 (/ISO)
GTPase activator activity GO:0005096
Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP.
1 Q15642 (/TAS)
Cadherin binding GO:0045296
Interacting selectively and non-covalently with cadherin, a type I membrane protein involved in cell adhesion.
1 Q5T0N5 (/IDA)
GTPase binding GO:0051020
Interacting selectively and non-covalently with a GTPase, any enzyme that catalyzes the hydrolysis of GTP.
1 Q5T0N5 (/IPI)

There are 33 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Plasma membrane tubulation GO:0097320
A membrane tubulation process occurring in a plasma membrane.
11 A8JNK4 (/IDA) M9ND42 (/IDA) M9ND44 (/IDA) M9NDH6 (/IDA) M9NE16 (/IDA) M9NF07 (/IDA) M9NF10 (/IDA) M9PBP3 (/IDA) M9PE52 (/IDA) Q5T0N5 (/IDA)
(1 more)
Plasma membrane organization GO:0007009
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the plasma membrane.
10 A8JNK4 (/IMP) M9ND42 (/IMP) M9ND44 (/IMP) M9NDH6 (/IMP) M9NE16 (/IMP) M9NF07 (/IMP) M9NF10 (/IMP) M9PBP3 (/IMP) M9PE52 (/IMP) Q9VZD7 (/IMP)
Cellularization GO:0007349
The separation of a multi-nucleate cell or syncytium into individual cells. An example of this is found in Drosophila melanogaster embryo development.
10 A8JNK4 (/IMP) M9ND42 (/IMP) M9ND44 (/IMP) M9NDH6 (/IMP) M9NE16 (/IMP) M9NF07 (/IMP) M9NF10 (/IMP) M9PBP3 (/IMP) M9PE52 (/IMP) Q9VZD7 (/IMP)
Mesoderm development GO:0007498
The process whose specific outcome is the progression of the mesoderm over time, from its formation to the mature structure. The mesoderm is the middle germ layer that develops into muscle, bone, cartilage, blood and connective tissue.
10 A8JNK4 (/IEP) M9ND42 (/IEP) M9ND44 (/IEP) M9NDH6 (/IEP) M9NE16 (/IEP) M9NF07 (/IEP) M9NF10 (/IEP) M9PBP3 (/IEP) M9PE52 (/IEP) Q9VZD7 (/IEP)
Protein localization GO:0008104
Any process in which a protein is transported to, or maintained in, a specific location.
10 A8JNK4 (/IMP) M9ND42 (/IMP) M9ND44 (/IMP) M9NDH6 (/IMP) M9NE16 (/IMP) M9NF07 (/IMP) M9NF10 (/IMP) M9PBP3 (/IMP) M9PE52 (/IMP) Q9VZD7 (/IMP)
Regulation of synaptic growth at neuromuscular junction GO:0008582
Any process that modulates the frequency, rate or extent of synaptic growth at neuromuscular junctions.
10 A8JNK4 (/IDA) M9ND42 (/IDA) M9ND44 (/IDA) M9NDH6 (/IDA) M9NE16 (/IDA) M9NF07 (/IDA) M9NF10 (/IDA) M9PBP3 (/IDA) M9PE52 (/IDA) Q9VZD7 (/IDA)
Germarium-derived female germ-line cyst encapsulation GO:0030708
Formation of a single follicular epithelium around the germ-line derived cells of a cyst formed in the germarium. An example of this process is found in Drosophila melanogaster.
10 A8JNK4 (/IMP) M9ND42 (/IMP) M9ND44 (/IMP) M9NDH6 (/IMP) M9NE16 (/IMP) M9NF07 (/IMP) M9NF10 (/IMP) M9PBP3 (/IMP) M9PE52 (/IMP) Q9VZD7 (/IMP)
Negative regulation of actin filament polymerization GO:0030837
Any process that stops, prevents, or reduces the frequency, rate or extent of actin polymerization.
10 A8JNK4 (/IDA) M9ND42 (/IDA) M9ND44 (/IDA) M9NDH6 (/IDA) M9NE16 (/IDA) M9NF07 (/IDA) M9NF10 (/IDA) M9PBP3 (/IDA) M9PE52 (/IDA) Q9VZD7 (/IDA)
Cellular protein localization GO:0034613
Any process in which a protein is transported to, and/or maintained in, a specific location at the level of a cell. Localization at the cellular level encompasses movement within the cell, from within the cell to the cell surface, or from one location to another at the surface of a cell.
10 A8JNK4 (/IMP) M9ND42 (/IMP) M9ND44 (/IMP) M9NDH6 (/IMP) M9NE16 (/IMP) M9NF07 (/IMP) M9NF10 (/IMP) M9PBP3 (/IMP) M9PE52 (/IMP) Q9VZD7 (/IMP)
Imaginal disc-derived wing hair organization GO:0035317
A process that is carried out at the cellular level that results in the assembly, arrangement of constituent parts, or disassembly of an imaginal disc-derived wing hair. A wing hair is an actin-rich, polarized, non-sensory apical projection that protrudes from each of the approximately 30,000 wing epithelial cells. An example of this is found in Drosophila melanogaster.
10 A8JNK4 (/IMP) M9ND42 (/IMP) M9ND44 (/IMP) M9NDH6 (/IMP) M9NE16 (/IMP) M9NF07 (/IMP) M9NF10 (/IMP) M9PBP3 (/IMP) M9PE52 (/IMP) Q9VZD7 (/IMP)
Negative regulation of synaptic growth at neuromuscular junction GO:0045886
Any process that stops, prevents, or reduces the frequency, rate or extent of synaptic growth at neuromuscular junction.
10 A8JNK4 (/IMP) M9ND42 (/IMP) M9ND44 (/IMP) M9NDH6 (/IMP) M9NE16 (/IMP) M9NF07 (/IMP) M9NF10 (/IMP) M9PBP3 (/IMP) M9PE52 (/IMP) Q9VZD7 (/IMP)
Negative regulation of actin nucleation GO:0051126
Any process that stops, prevents, or reduces the frequency, rate or extent of actin nucleation, the initial step in the formation of an actin filament in which actin monomers combine to form a new filament.
10 A8JNK4 (/IDA) M9ND42 (/IDA) M9ND44 (/IDA) M9NDH6 (/IDA) M9NE16 (/IDA) M9NF07 (/IDA) M9NF10 (/IDA) M9PBP3 (/IDA) M9PE52 (/IDA) Q9VZD7 (/IDA)
Plasma membrane tubulation GO:0097320
A membrane tubulation process occurring in a plasma membrane.
10 A8JNK4 (/IMP) M9ND42 (/IMP) M9ND44 (/IMP) M9NDH6 (/IMP) M9NE16 (/IMP) M9NF07 (/IMP) M9NF10 (/IMP) M9PBP3 (/IMP) M9PE52 (/IMP) Q9VZD7 (/IMP)
Regulation of adherens junction organization GO:1903391
Any process that modulates the frequency, rate or extent of adherens junction organization.
10 A8JNK4 (/IMP) M9ND42 (/IMP) M9ND44 (/IMP) M9NDH6 (/IMP) M9NE16 (/IMP) M9NF07 (/IMP) M9NF10 (/IMP) M9PBP3 (/IMP) M9PE52 (/IMP) Q9VZD7 (/IMP)
Membrane organization GO:0061024
A process which results in the assembly, arrangement of constituent parts, or disassembly of a membrane. A membrane is a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.
3 Q15642 (/TAS) Q5T0N5 (/TAS) Q96RU3 (/TAS)
Epithelial to mesenchymal transition GO:0001837
A transition where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell.
1 P97531 (/IMP)
Membrane budding GO:0006900
The evagination of a membrane, resulting in formation of a vesicle.
1 Q5T0N5 (/IDA)
Cell communication GO:0007154
Any process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment.
1 Q15642 (/NAS)
Signal transduction GO:0007165
The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.
1 Q15642 (/TAS)
Nervous system development GO:0007399
The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state.
1 Q8R511 (/IDA)
Membrane invagination GO:0010324
The infolding of a membrane.
1 Q5T0N5 (/IDA)
Negative regulation of cardiac muscle cell apoptotic process GO:0010667
Any process that decreases the rate or extent of cardiac cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a cardiac muscle cell and result in its death.
1 P97531 (/IMP)
Vesicle organization GO:0016050
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a vesicle.
1 Q5T0N5 (/IDA)
Actin cytoskeleton organization GO:0030036
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins.
1 Q15642 (/NAS)
Vesicle transport along actin filament GO:0030050
Movement of a vesicle along an actin filament, mediated by motor proteins.
1 Q5T0N5 (/IDA)
Response to food GO:0032094
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a food stimulus; food is anything which, when taken into the body, serves to nourish or build up the tissues or to supply body heat.
1 P97531 (/IEP)
Hyperosmotic salinity response GO:0042538
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, an increase in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment.
1 P97531 (/IDA)
Regulation of small GTPase mediated signal transduction GO:0051056
Any process that modulates the frequency, rate or extent of small GTPase mediated signal transduction.
1 Q15642 (/TAS)
Positive regulation of filopodium assembly GO:0051491
Any process that activates or increases the frequency, rate or extent of the assembly of a filopodium, a thin, stiff protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal growth cone.
1 Q5T0N5 (/IDA)
Cilium assembly GO:0060271
The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole.
1 Q5T0N5 (/IMP)
Cilium assembly GO:0060271
The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole.
1 Q8K012 (/ISO)
Positive regulation of cell growth involved in cardiac muscle cell development GO:0061051
Any process that increases the rate, frequency, or extent of the growth of a cardiac muscle cell, where growth contributes to the progression of the cell over time from its initial formation to its mature state.
1 P97531 (/IMP)
Clathrin-dependent endocytosis GO:0072583
An endocytosis process that begins when material is taken up into clathrin-coated pits, which then pinch off to form clathrin-coated endocytic vesicles.
1 Q5T0N5 (/IDA)

There are 17 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
10 A8JNK4 (/IDA) M9ND42 (/IDA) M9ND44 (/IDA) M9NDH6 (/IDA) M9NE16 (/IDA) M9NF07 (/IDA) M9NF10 (/IDA) M9PBP3 (/IDA) M9PE52 (/IDA) Q9VZD7 (/IDA)
Vesicle membrane GO:0012506
The lipid bilayer surrounding any membrane-bounded vesicle in the cell.
10 A8JNK4 (/IDA) M9ND42 (/IDA) M9ND44 (/IDA) M9NDH6 (/IDA) M9NE16 (/IDA) M9NF07 (/IDA) M9NF10 (/IDA) M9PBP3 (/IDA) M9PE52 (/IDA) Q9VZD7 (/IDA)
Midbody GO:0030496
A thin cytoplasmic bridge formed between daughter cells at the end of cytokinesis. The midbody forms where the contractile ring constricts, and may persist for some time before finally breaking to complete cytokinesis.
10 A8JNK4 (/IDA) M9ND42 (/IDA) M9ND44 (/IDA) M9NDH6 (/IDA) M9NE16 (/IDA) M9NF07 (/IDA) M9NF10 (/IDA) M9PBP3 (/IDA) M9PE52 (/IDA) Q9VZD7 (/IDA)
Neuromuscular junction GO:0031594
The junction between the axon of a motor neuron and a muscle fiber. In response to the arrival of action potentials, the presynaptic button releases molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane of the muscle fiber, leading to a change in post-synaptic potential.
10 A8JNK4 (/IDA) M9ND42 (/IDA) M9ND44 (/IDA) M9NDH6 (/IDA) M9NE16 (/IDA) M9NF07 (/IDA) M9NF10 (/IDA) M9PBP3 (/IDA) M9PE52 (/IDA) Q9VZD7 (/IDA)
Cleavage furrow GO:0032154
The cleavage furrow is a plasma membrane invagination at the cell division site. The cleavage furrow begins as a shallow groove and eventually deepens to divide the cytoplasm.
10 A8JNK4 (/IDA) M9ND42 (/IDA) M9ND44 (/IDA) M9NDH6 (/IDA) M9NE16 (/IDA) M9NF07 (/IDA) M9NF10 (/IDA) M9PBP3 (/IDA) M9PE52 (/IDA) Q9VZD7 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
3 Q15642 (/TAS) Q5T0N5 (/TAS) Q96RU3 (/TAS)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
2 M0R0F9 (/IDA) Q15642 (/IDA)
Intracellular membrane-bounded organelle GO:0043231
Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
2 M0R0F9 (/IDA) Q15642 (/IDA)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
2 Q15642 (/IDA) Q5T0N5 (/IDA)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
1 Q8CJ53 (/ISO)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 Q5T0N5 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 Q8K012 (/ISO)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 Q15642 (/NAS)
Microtubule GO:0005874
Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle.
1 Q8CJ53 (/TAS)
Cytoplasmic vesicle GO:0031410
A vesicle found in the cytoplasm of a cell.
1 Q5T0N5 (/IDA)
Intracellular membrane-bounded organelle GO:0043231
Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
1 Q8CJ53 (/ISO)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
1 Q8CJ53 (/ISO)