The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:
"SH3 Domains
".
FunFam 19333: cDNA FLJ51309, highly similar to Nebulin
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 14 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Cytoskeletal protein binding GO:0008092
Interacting selectively and non-covalently with any protein component of any cytoskeleton (actin, microtubule, or intermediate filament cytoskeleton).
|
15 |
B7ZCI2 (/ISS)
D4A164 (/ISS)
E2RQ93 (/ISS)
F1MF57 (/ISS)
F1RVG6 (/ISS)
F6YZ84 (/ISS)
F7BZ05 (/ISS)
F7CGV7 (/ISS)
F7CK56 (/ISS)
G1LHM9 (/ISS)
(5 more) |
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
9 | A2AQA9 (/IPI) A2AQB2 (/IPI) E9Q1W3 (/IPI) F6X9B6 (/IPI) O76041 (/IPI) P20929 (/IPI) Q14847 (/IPI) Q61792 (/IPI) Q9JL90 (/IPI) |
|
Ion transmembrane transporter activity GO:0015075
Enables the transfer of an ion from one side of a membrane to the other.
|
2 | Q14847 (/ISS) Q61792 (/ISS) |
|
Actin filament binding GO:0051015
Interacting selectively and non-covalently with an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits.
|
2 | O76041 (/IDA) Q61792 (/IDA) |
|
SH3/SH2 adaptor activity GO:0005070
Interacting selectively and non-covalently and simultaneously with one or more signal transduction molecules, usually acting as a scaffold to bring these molecules into close proximity either using their own SH2/SH3 domains (e.g. Grb2) or those of their target molecules (e.g. SAM68).
|
1 | Q14847 (/TAS) |
|
Tropomyosin binding GO:0005523
Interacting selectively and non-covalently with tropomyosin, a protein associated with actin filaments both in cytoplasm and, in association with troponin, in the thin filament of striated muscle.
|
1 | O76041 (/IPI) |
|
Cytoskeletal protein binding GO:0008092
Interacting selectively and non-covalently with any protein component of any cytoskeleton (actin, microtubule, or intermediate filament cytoskeleton).
|
1 | O76041 (/IDA) |
|
Cytoskeletal protein binding GO:0008092
Interacting selectively and non-covalently with any protein component of any cytoskeleton (actin, microtubule, or intermediate filament cytoskeleton).
|
1 | O76041 (/IPI) |
|
Structural constituent of muscle GO:0008307
The action of a molecule that contributes to the structural integrity of a muscle fiber.
|
1 | O76041 (/NAS) |
|
Structural constituent of muscle GO:0008307
The action of a molecule that contributes to the structural integrity of a muscle fiber.
|
1 | P20929 (/TAS) |
|
Ion transmembrane transporter activity GO:0015075
Enables the transfer of an ion from one side of a membrane to the other.
|
1 | Q99MZ8 (/IDA) |
|
Filamin binding GO:0031005
Interacting selectively and non-covalently with a filamin, any member of a family of high molecular mass cytoskeletal proteins that crosslink actin filaments to form networks and stress fibers. Filamins contain an amino-terminal alpha-actinin-like actin binding domain, which is followed by a rod-domain composed of 4 to 24 100-residue repetitive segments including a carboxy-terminal dimerization domain.
|
1 | O76041 (/IPI) |
|
Cadherin binding GO:0045296
Interacting selectively and non-covalently with cadherin, a type I membrane protein involved in cell adhesion.
|
1 | Q14847 (/IDA) |
|
Cadherin binding GO:0045296
Interacting selectively and non-covalently with cadherin, a type I membrane protein involved in cell adhesion.
|
1 | Q61792 (/ISO) |
There are 11 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Cardiac muscle thin filament assembly GO:0071691
The aggregation, arrangement and bonding together of proteins to form the actin-based thin filaments of myofibrils in cardiac muscle.
|
15 |
B7ZCI2 (/ISS)
D4A164 (/ISS)
E2RQ93 (/ISS)
F1MF57 (/ISS)
F1RVG6 (/ISS)
F6YZ84 (/ISS)
F7BZ05 (/ISS)
F7CGV7 (/ISS)
F7CK56 (/ISS)
G1LHM9 (/ISS)
(5 more) |
|
Muscle fiber development GO:0048747
The process whose specific outcome is the progression of the muscle fiber over time, from its formation to the mature structure. In skeletal muscle, fibers are formed by the maturation of myotubes. They can be classed as slow, intermediate/fast or fast.
|
6 | B0UY61 (/IMP) F1Q6R4 (/IMP) F1Q824 (/IMP) Q1MSX9 (/IMP) Q1MSY0 (/IMP) Q5BLE1 (/IMP) |
|
Regulation of actin filament length GO:0030832
Any process that controls the length of actin filaments in a cell.
|
5 | A2AQA9 (/TAS) A2AQB2 (/TAS) E9Q1W3 (/TAS) F6X9B6 (/TAS) Q9JL90 (/TAS) |
|
Sarcomere organization GO:0045214
The myofibril assembly process that results in the organization of muscle actomyosin into sarcomeres. The sarcomere is the repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs.
|
5 | A2AQA9 (/TAS) A2AQB2 (/TAS) E9Q1W3 (/TAS) F6X9B6 (/TAS) Q9JL90 (/TAS) |
|
Ion transport GO:0006811
The directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
|
2 | Q14847 (/ISS) Q61792 (/ISS) |
|
Ion transport GO:0006811
The directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
|
1 | Q99MZ8 (/IDA) |
|
Muscle organ development GO:0007517
The process whose specific outcome is the progression of the muscle over time, from its formation to the mature structure. The muscle is an organ consisting of a tissue made up of various elongated cells that are specialized to contract and thus to produce movement and mechanical work.
|
1 | P20929 (/TAS) |
|
Somatic muscle development GO:0007525
The process whose specific outcome is the progression of the somatic muscle over time, from its formation to the mature structure. Somatic muscles are striated muscle structures that connect to the exoskeleton or cuticle.
|
1 | P20929 (/NAS) |
|
Muscle filament sliding GO:0030049
The sliding of actin thin filaments and myosin thick filaments past each other in muscle contraction. This involves a process of interaction of myosin located on a thick filament with actin located on a thin filament. During this process ATP is split and forces are generated.
|
1 | P20929 (/TAS) |
|
Regulation of actin filament length GO:0030832
Any process that controls the length of actin filaments in a cell.
|
1 | P20929 (/NAS) |
|
Cardiac muscle thin filament assembly GO:0071691
The aggregation, arrangement and bonding together of proteins to form the actin-based thin filaments of myofibrils in cardiac muscle.
|
1 | O76041 (/IMP) |
There are 27 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Stress fiber GO:0001725
A contractile actin filament bundle that consists of short actin filaments with alternating polarity, cross-linked by alpha-actinin and possibly other actin bundling proteins, and with myosin present in a periodic distribution along the fiber.
|
15 |
B7ZCI2 (/ISS)
D4A164 (/ISS)
E2RQ93 (/ISS)
F1MF57 (/ISS)
F1RVG6 (/ISS)
F6YZ84 (/ISS)
F7BZ05 (/ISS)
F7CGV7 (/ISS)
F7CK56 (/ISS)
G1LHM9 (/ISS)
(5 more) |
|
Z disc GO:0030018
Platelike region of a muscle sarcomere to which the plus ends of actin filaments are attached.
|
15 |
B7ZCI2 (/ISS)
D4A164 (/ISS)
E2RQ93 (/ISS)
F1MF57 (/ISS)
F1RVG6 (/ISS)
F6YZ84 (/ISS)
F7BZ05 (/ISS)
F7CGV7 (/ISS)
F7CK56 (/ISS)
G1LHM9 (/ISS)
(5 more) |
|
Z disc GO:0030018
Platelike region of a muscle sarcomere to which the plus ends of actin filaments are attached.
|
7 | A2AQA9 (/IDA) A2AQB2 (/IDA) E9Q1W3 (/IDA) F6X9B6 (/IDA) O76041 (/IDA) P20929 (/IDA) Q9JL90 (/IDA) |
|
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
|
6 | A2AQA9 (/ISO) A2AQB2 (/ISO) E9Q1W3 (/ISO) F6X9B6 (/ISO) Q61792 (/ISO) Q9JL90 (/ISO) |
|
Striated muscle thin filament GO:0005865
Filaments formed of actin and associated proteins; attached to Z discs at either end of sarcomeres in myofibrils.
|
5 | A2AQA9 (/TAS) A2AQB2 (/TAS) E9Q1W3 (/TAS) F6X9B6 (/TAS) Q9JL90 (/TAS) |
|
Z disc GO:0030018
Platelike region of a muscle sarcomere to which the plus ends of actin filaments are attached.
|
5 | A2AQA9 (/ISO) A2AQB2 (/ISO) E9Q1W3 (/ISO) F6X9B6 (/ISO) Q9JL90 (/ISO) |
|
Protein complex GO:0043234
A stable macromolecular complex composed (only) of two or more polypeptide subunits along with any covalently attached molecules (such as lipid anchors or oligosaccharide) or non-protein prosthetic groups (such as nucleotides or metal ions). Prosthetic group in this context refers to a tightly bound cofactor. The component polypeptide subunits may be identical.
|
5 | A2AQA9 (/ISO) A2AQB2 (/ISO) E9Q1W3 (/ISO) F6X9B6 (/ISO) Q9JL90 (/ISO) |
|
Contractile fiber GO:0043292
Fibers, composed of actin, myosin, and associated proteins, found in cells of smooth or striated muscle.
|
5 | A2AQA9 (/IDA) A2AQB2 (/IDA) E9Q1W3 (/IDA) F6X9B6 (/IDA) Q9JL90 (/IDA) |
|
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
|
3 | O76041 (/IDA) P20929 (/IDA) Q14847 (/IDA) |
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
2 | Q14847 (/IDA) Q61792 (/IDA) |
|
Focal adhesion GO:0005925
Small region on the surface of a cell that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments.
|
2 | Q14847 (/IDA) Q61792 (/IDA) |
|
Myofibril GO:0030016
The contractile element of skeletal and cardiac muscle; a long, highly organized bundle of actin, myosin, and other proteins that contracts by a sliding filament mechanism.
|
2 | A0A096MK15 (/IDA) F1M1J2 (/IDA) |
|
Sarcomere GO:0030017
The repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs.
|
2 | G1TDU6 (/IDA) Q9DEH4 (/IDA) |
|
Cortical actin cytoskeleton GO:0030864
The portion of the actin cytoskeleton, comprising filamentous actin and associated proteins, that lies just beneath the plasma membrane.
|
2 | Q14847 (/ISS) Q61792 (/ISS) |
|
Stress fiber GO:0001725
A contractile actin filament bundle that consists of short actin filaments with alternating polarity, cross-linked by alpha-actinin and possibly other actin bundling proteins, and with myosin present in a periodic distribution along the fiber.
|
1 | O76041 (/IDA) |
|
Cell GO:0005623
The basic structural and functional unit of all organisms. Includes the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope.
|
1 | F1MF57 (/IDA) |
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
1 | Q61792 (/ISO) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
1 | P20929 (/TAS) |
|
Striated muscle thin filament GO:0005865
Filaments formed of actin and associated proteins; attached to Z discs at either end of sarcomeres in myofibrils.
|
1 | Q9Y5Z1 (/NAS) |
|
Focal adhesion GO:0005925
Small region on the surface of a cell that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments.
|
1 | Q61792 (/ISO) |
|
Actin cytoskeleton GO:0015629
The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes.
|
1 | P20929 (/TAS) |
|
Cell junction GO:0030054
A cellular component that forms a specialized region of connection between two or more cells or between a cell and the extracellular matrix. At a cell junction, anchoring proteins extend through the plasma membrane to link cytoskeletal proteins in one cell to cytoskeletal proteins in neighboring cells or to proteins in the extracellular matrix.
|
1 | P34416 (/IDA) |
|
Cortical actin cytoskeleton GO:0030864
The portion of the actin cytoskeleton, comprising filamentous actin and associated proteins, that lies just beneath the plasma membrane.
|
1 | Q99MZ8 (/IDA) |
|
I band GO:0031674
A region of a sarcomere that appears as a light band on each side of the Z disc, comprising a region of the sarcomere where thin (actin) filaments are not overlapped by thick (myosin) filaments; contains actin, troponin, and tropomyosin; each sarcomere includes half of an I band at each end.
|
1 | O76041 (/NAS) |
|
Protein complex GO:0043234
A stable macromolecular complex composed (only) of two or more polypeptide subunits along with any covalently attached molecules (such as lipid anchors or oligosaccharide) or non-protein prosthetic groups (such as nucleotides or metal ions). Prosthetic group in this context refers to a tightly bound cofactor. The component polypeptide subunits may be identical.
|
1 | Q6P516 (/IDA) |
|
Striated muscle dense body GO:0055120
A vinculin-containing myofibril attachment structure of striated muscle that connects sarcomeres to the extracellular matrix. In nematode body wall muscle, the dense body performs the dual role of Z-disk and costamere.
|
1 | P34416 (/IDA) |
|
Skeletal muscle myofibril GO:0098723
A myofibril of a skeletal muscle fiber.
|
1 | G1TDU6 (/IDA) |