The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
SH3 Domains
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 18995: SLIT-ROBO Rho GTPase-activating protein 2

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 14 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
5 O43295 (/IPI) O75044 (/IPI) Q7Z6B7 (/IPI) Q812A2 (/IPI) Q91Z69 (/IPI)
GTPase activator activity GO:0005096
Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP.
3 O75044 (/IDA) Q91Z67 (/IDA) Q91Z69 (/IDA)
GTPase activator activity GO:0005096
Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP.
3 O43295 (/TAS) O75044 (/TAS) Q7Z6B7 (/TAS)
GTPase activator activity GO:0005096
Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP.
2 A1KXK6 (/ISS) D4A208 (/ISS)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
2 O75044 (/IDA) Q91Z67 (/IDA)
Rac GTPase binding GO:0048365
Interacting selectively and non-covalently with Rac protein, any member of the Rac subfamily of the Ras superfamily of monomeric GTPases.
2 O75044 (/IDA) Q91Z67 (/IDA)
GTPase activator activity GO:0005096
Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP.
1 O75044 (/IMP)
GTPase activator activity GO:0005096
Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP.
1 Q91Z67 (/ISO)
Rho GTPase binding GO:0017048
Interacting selectively and non-covalently with Rho protein, any member of the Rho subfamily of the Ras superfamily of monomeric GTPases. Proteins in the Rho subfamily are involved in relaying signals from cell-surface receptors to the actin cytoskeleton.
1 Q91Z69 (/IDA)
Rho GTPase binding GO:0017048
Interacting selectively and non-covalently with Rho protein, any member of the Rho subfamily of the Ras superfamily of monomeric GTPases. Proteins in the Rho subfamily are involved in relaying signals from cell-surface receptors to the actin cytoskeleton.
1 A1KXK6 (/ISS)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
1 Q91Z67 (/ISO)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
1 D4A208 (/ISS)
Rac GTPase binding GO:0048365
Interacting selectively and non-covalently with Rac protein, any member of the Rac subfamily of the Ras superfamily of monomeric GTPases.
1 Q91Z67 (/ISO)
Rac GTPase binding GO:0048365
Interacting selectively and non-covalently with Rac protein, any member of the Rac subfamily of the Ras superfamily of monomeric GTPases.
1 D4A208 (/ISS)

There are 30 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Regulation of small GTPase mediated signal transduction GO:0051056
Any process that modulates the frequency, rate or extent of small GTPase mediated signal transduction.
3 O43295 (/TAS) O75044 (/TAS) Q7Z6B7 (/TAS)
Extension of a leading process involved in cell motility in cerebral cortex radial glia guided migration GO:0021816
The rearrangements of the microtubule cytoskeleton that result in the extension of a leading process, where this process is involved in the movement of cells along radial glial cells.
2 D4A208 (/ISS) O75044 (/ISS)
Positive regulation of GTPase activity GO:0043547
Any process that activates or increases the activity of a GTPase.
2 O75044 (/IDA) Q91Z67 (/IDA)
Filopodium assembly GO:0046847
The assembly of a filopodium, a thin, stiff protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal growth cone.
2 O75044 (/IDA) Q91Z67 (/IDA)
Neuron projection morphogenesis GO:0048812
The process in which the anatomical structures of a neuron projection are generated and organized. A neuron projection is any process extending from a neural cell, such as axons or dendrites.
2 D4A208 (/ISS) O75044 (/ISS)
Actin filament severing GO:0051014
The process in which an actin filament is broken down into smaller filaments.
2 D4A208 (/ISS) Q91Z67 (/ISS)
Negative regulation of neuron migration GO:2001223
Any process that stops, prevents or reduces the frequency, rate or extent of neuron migration.
2 D4A208 (/ISS) Q91Z67 (/ISS)
Lamellipodium assembly involved in ameboidal cell migration GO:0003363
Formation of a lamellipodium, a thin sheetlike extension of the surface of a migrating cell that contributes to the directed self propelled movement of a cell.
1 O75044 (/IMP)
Lamellipodium assembly involved in ameboidal cell migration GO:0003363
Formation of a lamellipodium, a thin sheetlike extension of the surface of a migrating cell that contributes to the directed self propelled movement of a cell.
1 Q91Z67 (/ISO)
Rho protein signal transduction GO:0007266
A series of molecular signals within the cell that are mediated by a member of the Rho family of proteins switching to a GTP-bound active state.
1 Q91Z69 (/IDA)
Rho protein signal transduction GO:0007266
A series of molecular signals within the cell that are mediated by a member of the Rho family of proteins switching to a GTP-bound active state.
1 A1KXK6 (/ISS)
Cell migration GO:0016477
The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues. Cell migration is a central process in the development and maintenance of multicellular organisms.
1 Q91Z69 (/IDA)
Cell migration GO:0016477
The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues. Cell migration is a central process in the development and maintenance of multicellular organisms.
1 A1KXK6 (/ISS)
Extension of a leading process involved in cell motility in cerebral cortex radial glia guided migration GO:0021816
The rearrangements of the microtubule cytoskeleton that result in the extension of a leading process, where this process is involved in the movement of cells along radial glial cells.
1 Q91Z67 (/IMP)
Substrate adhesion-dependent cell spreading GO:0034446
The morphogenetic process that results in flattening of a cell as a consequence of its adhesion to a substrate.
1 O75044 (/IMP)
Substrate adhesion-dependent cell spreading GO:0034446
The morphogenetic process that results in flattening of a cell as a consequence of its adhesion to a substrate.
1 Q91Z67 (/ISO)
Positive regulation of GTPase activity GO:0043547
Any process that activates or increases the activity of a GTPase.
1 O75044 (/IMP)
Positive regulation of GTPase activity GO:0043547
Any process that activates or increases the activity of a GTPase.
1 Q91Z67 (/ISO)
Positive regulation of GTPase activity GO:0043547
Any process that activates or increases the activity of a GTPase.
1 D4A208 (/ISS)
Filopodium assembly GO:0046847
The assembly of a filopodium, a thin, stiff protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal growth cone.
1 Q91Z67 (/ISO)
Filopodium assembly GO:0046847
The assembly of a filopodium, a thin, stiff protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal growth cone.
1 D4A208 (/ISS)
Neuron projection morphogenesis GO:0048812
The process in which the anatomical structures of a neuron projection are generated and organized. A neuron projection is any process extending from a neural cell, such as axons or dendrites.
1 Q91Z67 (/IMP)
Actin filament severing GO:0051014
The process in which an actin filament is broken down into smaller filaments.
1 O75044 (/IDA)
Actin filament severing GO:0051014
The process in which an actin filament is broken down into smaller filaments.
1 Q91Z67 (/ISO)
Dendritic spine development GO:0060996
The process whose specific outcome is the progression of the dendritic spine over time, from its formation to the mature structure. A dendritic spine is a protrusion from a dendrite and a specialized subcellular compartment involved in synaptic transmission.
1 O75044 (/IDA)
Dendritic spine development GO:0060996
The process whose specific outcome is the progression of the dendritic spine over time, from its formation to the mature structure. A dendritic spine is a protrusion from a dendrite and a specialized subcellular compartment involved in synaptic transmission.
1 Q91Z67 (/IMP)
Dendritic spine development GO:0060996
The process whose specific outcome is the progression of the dendritic spine over time, from its formation to the mature structure. A dendritic spine is a protrusion from a dendrite and a specialized subcellular compartment involved in synaptic transmission.
1 Q91Z67 (/ISO)
Dendritic spine development GO:0060996
The process whose specific outcome is the progression of the dendritic spine over time, from its formation to the mature structure. A dendritic spine is a protrusion from a dendrite and a specialized subcellular compartment involved in synaptic transmission.
1 D4A208 (/ISS)
Negative regulation of neuron migration GO:2001223
Any process that stops, prevents or reduces the frequency, rate or extent of neuron migration.
1 O75044 (/IDA)
Negative regulation of neuron migration GO:2001223
Any process that stops, prevents or reduces the frequency, rate or extent of neuron migration.
1 Q91Z67 (/ISO)

There are 23 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
6 A0A075B7E6 (/IDA) A0A075B7E9 (/IDA) A2RUF3 (/IDA) B7ZM87 (/IDA) Q5VZB4 (/IDA) Q91Z67 (/IDA)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
5 A0A075B7E6 (/IDA) A0A075B7E9 (/IDA) A2RUF3 (/IDA) B7ZM87 (/IDA) Q5VZB4 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
3 O43295 (/TAS) O75044 (/TAS) Q7Z6B7 (/TAS)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
2 D4A208 (/ISS) O75044 (/ISS)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
2 O75044 (/IDA) Q91Z67 (/IDA)
Postsynaptic density GO:0014069
An electron dense network of proteins within and adjacent to the postsynaptic membrane in asymetric synapses. Its major components include neurotransmitter receptors and the proteins that spatially and functionally organize them such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components.
2 D4A208 (/ISS) O75044 (/ISS)
Dendritic spine head GO:0044327
Distal part of the dendritic spine, that carries the post-synaptic density.
2 D4A208 (/ISS) Q91Z67 (/ISS)
Postsynaptic membrane GO:0045211
A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters cross the synaptic cleft and transmit the signal to the postsynaptic membrane.
2 D4A208 (/ISS) O75044 (/ISS)
Phagocytic vesicle GO:0045335
A membrane-bounded intracellular vesicle that arises from the ingestion of particulate material by phagocytosis.
2 D4A208 (/ISS) O75044 (/ISS)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 D4A208 (/IDA)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
1 Q91Z67 (/ISO)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 D4A208 (/IDA)
Mitochondrial inner membrane GO:0005743
The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae.
1 Q91Z67 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 Q91Z67 (/ISO)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 Q91Z67 (/ISO)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 D4A208 (/ISS)
Postsynaptic density GO:0014069
An electron dense network of proteins within and adjacent to the postsynaptic membrane in asymetric synapses. Its major components include neurotransmitter receptors and the proteins that spatially and functionally organize them such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components.
1 Q91Z67 (/IDA)
Lamellipodium GO:0030027
A thin sheetlike process extended by the leading edge of a migrating cell or extending cell process; contains a dense meshwork of actin filaments.
1 O75044 (/IDA)
Lamellipodium GO:0030027
A thin sheetlike process extended by the leading edge of a migrating cell or extending cell process; contains a dense meshwork of actin filaments.
1 Q91Z67 (/ISO)
Dendritic spine head GO:0044327
Distal part of the dendritic spine, that carries the post-synaptic density.
1 O75044 (/IDA)
Dendritic spine head GO:0044327
Distal part of the dendritic spine, that carries the post-synaptic density.
1 Q91Z67 (/ISO)
Postsynaptic membrane GO:0045211
A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters cross the synaptic cleft and transmit the signal to the postsynaptic membrane.
1 Q91Z67 (/IDA)
Phagocytic vesicle GO:0045335
A membrane-bounded intracellular vesicle that arises from the ingestion of particulate material by phagocytosis.
1 Q91Z67 (/IDA)