The modification of histone H3 by addition of one or more methyl groups to lysine at position 4 of the histone.

The process aimed at the progression of a glial cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell.

Generation of cells within the nervous system.

The process whose specific outcome is the progression of the myeloid and lymphoid derived organ/tissue systems of the blood and other parts of the body over time, from formation to the mature structure. The site of hemopoiesis is variable during development, but occurs primarily in bone marrow or kidney in many adult vertebrates.

The process whose specific outcome is the progression of the paraxial mesoderm over time, from its formation to the mature structure. The paraxial mesoderm is the mesoderm located bilaterally adjacent to the notochord and neural tube.

The process aimed at the progression of a nucleate erythrocyte over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell.

The modification of histone H3 by addition of one or more methyl groups to lysine at position 4 of the histone.

The modification of histone H3 by addition of three methyl groups to lysine at position 4 of the histone.

The process by which an organism or tissue maintains a population of stem cells of a single type. This can be achieved by a number of mechanisms: stem cell asymmetric division maintains stem cell numbers; stem cell symmetric division increases them; maintenance of a stem cell niche maintains the conditions for commitment to the stem cell fate for some types of stem cell; stem cells may arise de novo from other cell types.

Any process that modulates the frequency, rate or extent of hematopoietic stem cell differentiation.

Any process that modulates the frequency, rate or extent of chromatin organization.

Any process that activates or increases the frequency, rate or extent of neural precursor cell proliferation.

Any process that activates or increases the frequency, rate or extent of stem cell proliferation.

The modification of histone H3 by addition of one or more methyl groups to lysine at position 36 of the histone.

The modification of histone H3 by addition of two methyl groups to lysine at position 4 of the histone.

Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.

Maintenance of transcription by remodelling of chromatin into an 'open configuration'. Once established, this regulation is mitotically stable and is maintained over many cell divisions. It is also heritable.

The modification of histone H3 by addition of one or more methyl groups to lysine at position 4 of the histone.

The modification of histone H3 by addition of one or more methyl groups to lysine at position 4 of the histone.

Any process that modulates the frequency, rate or extent of the covalent addition of a methyl group to the lysine at position 4 of histone H3.

The modification of histone H3 by addition of three methyl groups to lysine at position 4 of the histone.

Any process that modulates the frequency, rate or extent of chromatin organization.

Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter.

Any process that contributes to the maintenance of proper telomeric length and structure by affecting and monitoring the activity of telomeric proteins, the length of telomeric DNA and the replication and repair of the DNA. These processes includes those that shorten, lengthen, replicate and repair the telomeric DNA sequences.

The process whose specific outcome is the progression of the ovarian follicle over time, from its formation to the mature structure.

The process whose specific outcome is the progression of the eye over time, from its formation to the mature structure. The eye is the organ of sight.

The process whose specific outcome is the progression of the eye over time, from its formation to the mature structure. The eye is the organ of sight.

The process in which precursor cell type acquires the specialized features of a hematopoietic progenitor cell, a class of cell types including myeloid progenitor cells and lymphoid progenitor cells.

The covalent transfer of a methyl group to either N-6 of adenine or C-5 or N-4 of cytosine.

Repression of transcription of telomeric DNA by altering the structure of chromatin.

Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.

The synthesis of RNA from a DNA template by RNA polymerase II, originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs).

The aggregation, arrangement and bonding together of a set of components to form a protein complex.

The aggregation, arrangement and bonding together of a set of components to form a protein complex.

The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues.

The process whose specific outcome is the progression of the haltere over time, from its formation to the mature structure. The haltere is the club-shaped 'balancers' found on each side of the metathorax among the true flies (Diptera). They are the much-modified hind wings.

The activities involved in the mental information processing system that receives (registers), modifies, stores, and retrieves informational stimuli. The main stages involved in the formation and retrieval of memory are encoding (processing of received information by acquisition), storage (building a permanent record of received information as a result of consolidation) and retrieval (calling back the stored information and use it in a suitable way to execute a given task).

Any process that stops, prevents or reduces the rate or extent of cell proliferation.

The control of viability and duration in the adult phase of the life-cycle.

The orderly movement of a cell specialized to produce haploid gametes through the embryo from its site of production to the place where the gonads will form.

The orderly movement of a cell specialized to produce haploid gametes through the embryo from its site of production to the place where the gonads will form.

Any process in an organism in which a change in behavior of an individual occurs in response to repeated exposure to a visual cue.

The set of specific processes that generate the ability of an organism to induce an abnormal, generally detrimental state in another organism.

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light.

The process whose specific outcome is the progression of the organism over time, from the completion of embryonic development to the mature structure. See embryonic development.

Any process that modulates the frequency, rate or extent of flower development.

The regionalization process in which specific areas of cell differentiation are determined along the anterior-posterior axis. The anterior-posterior axis is defined by a line that runs from the head or mouth of an organism to the tail or opposite end of the organism.

The regionalization process in which specific areas of cell differentiation are determined along the anterior-posterior axis. The anterior-posterior axis is defined by a line that runs from the head or mouth of an organism to the tail or opposite end of the organism.

The process in which a relatively unspecialized immature germ cell acquires the specialized features of a mature female gamete.

The process involved in transforming a meristem that produces vegetative structures, such as leaves, into a meristem that produces reproductive structures, such as a flower or an inflorescence.

Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.

Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.

Any process carried out at the cellular level that results in either long-term transcriptional repression via action on chromatin structure or RNA mediated, post-transcriptional repression of gene expression.

The modification of histones by addition of methyl groups.

The modification of histones by addition of methyl groups.

The modification of histones by addition of methyl groups.

The modification of a histone by the addition of an acetyl group.

The methylation of peptidyl-lysine to form peptidyl-N6-methyl-L-lysine.

The methylation of peptidyl-lysine to form peptidyl-N6,N6-dimethyl-L-lysine.

The methylation of peptidyl-lysine to form peptidyl-N6,N6-dimethyl-L-lysine.

Any process, either active or passive, by which an organism avoids the effects of the host organism's immune response. The host is defined as the larger of the organisms involved in a symbiotic interaction.

Any process involved in the biological strategy of changing antigenic determinants on the surface that are exposed to another organism's immune system.

The process in which cells that are products of meiosis acquire the specialized features of ascospores. Ascospores are generally found in clusters of four or eight spores within a single mother cell, the ascus, and are characteristic of the ascomycete fungi (phylum Ascomycota).

The process in which a multicellular organism, a unicellular organism or a group of unicellular organisms grow in a threadlike, filamentous shape.

Repression of transcription at silent mating-type loci by alteration of the structure of chromatin.

The release of a mature ovum/oocyte from an ovary.

The process whose specific outcome is the progression of the aggregate over time, from its formation to the point when a slug is formed. Aggregate development begins in response to starvation and continues by the chemoattractant-mediated movement of cells toward each other. The aggregate is a multicellular structure that gives rise to the slug.

Any process that activates or increases the activity of a transporter.

Any process that activates or increases the activity of a transporter.

Any process that modulates the frequency, rate or extent of gene expression such that an expression pattern recurs with a regularity of approximately 24 hours.

Any process that modulates the frequency, rate or extent of gene expression such that an expression pattern recurs with a regularity of approximately 24 hours.

Any process that activates or increases the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides, catalyzed by RNA polymerase II.

Any process that activates or increases the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides, catalyzed by RNA polymerase II.

The modification of a histone by addition of one or more methyl groups to a lysine residue.

Any process that activates or increases the frequency, rate or extent of the addition of an acetyl group to a histone protein.

The stages of blood cell formation that take place within the embryo.

The stages of blood cell formation that take place within the embryo.

The specific behavior of an organism in response to a novel environment or stimulus.

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a potassium ion stimulus.

A reversible switch of a cell from one cell type or form to another, at a frequency above the expected frequency for somatic mutations. Phenotypic switching involves changes in cell morphology and altered gene expression patterns. For example, Candida albicans switches from white cells to opaque cells for sexual mating. Phenotypic switching also occurs in multicellular organisms; smooth muscle cells (SMCs) exhibit phenotypic transitions to allow rapid adaption to fluctuating environmental cues.

Any process that modulates the frequency, rate or extent of gene expression; the process is mitotically or meiotically heritable, or is stably self-propagated in the cytoplasm of a resting cell, and does not entail a change in DNA sequence.

Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation).

Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation).

The modification of histone H3 by the addition of an acetyl group.

The modification of histone H4 by the addition of an acetyl group to a lysine residue at position 16 of the histone.

The modification of histone H4 by the addition of an acetyl group to a lysine residue at position 16 of the histone.

The modification of histone H4 by the addition of an acetyl group to a lysine residue at position 16 of the histone.

The activation by an organism of the defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction.

The modification of histone H3 by addition of two methyl groups to lysine at position 4 of the histone.

Any process that modulates the frequency, rate or extent of erythrocyte differentiation.

Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.

Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.

Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.

Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.

Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.

Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.

Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.

Any process that activates or increases the frequency, rate or extent of the JAK-STAT signaling pathway activity.

A process that modulates short-term neuronal synaptic plasticity, the ability of neuronal synapses to change in the short-term as circumstances require. Short-term neuronal synaptic plasticity generally involves increasing or decreasing synaptic sensitivity.

The process whose specific outcome is the progression of the spleen over time, from its formation to the mature structure. The spleen is a large vascular lymphatic organ composed of white and red pulp, involved both in hemopoietic and immune system functions.

Any process that activates, maintains or increases long-day photoperiodism, where the response associated with the photoperiodism is flowering. Flowering is defined by the switch from the vegetative to the reproductive phase.

A biological process whose specific outcome is the progression of a cell over time from an initial condition to a later condition.

Any biological process involved in the maintenance of the steady-state number of cells within a population of cells in a tissue.

The operation of the mind by which an organism becomes aware of objects of thought or perception; it includes the mental activities associated with thinking, learning, and memory.

The modification of histone H3 by addition of one or more methyl groups to lysine at position 4 of the histone.

The modification of histone H3 by addition of one or more methyl groups to lysine at position 4 of the histone.

The modification of histone H3 by addition of one or more methyl groups to lysine at position 4 of the histone.

Any process that activates or increases the frequency, rate or extent of the covalent addition of a methyl group to the lysine at position 4 of histone H3.

Any process that activates or increases the frequency, rate or extent of the covalent addition of a methyl group to the lysine at position 4 of histone H3.

The process in which membrane potential decreases with respect to its steady-state potential, usually from negative potential to a more positive potential. For example, the initial depolarization during the rising phase of an action potential is in the direction from the negative steady-state resting potential towards the positive membrane potential that will be the peak of the action potential.

A second wave of blood cell production that, in vertebrates, generates long-term hemopoietic stem cells that continously provide erythroid, myeloid and lymphoid lineages throughout adulthood.

The conversion of a differentiated cell of one fate into a differentiated cell of another fate without first undergoing cell division or reversion to a more primitive or stem cell-like fate.

The conversion of a differentiated cell of one fate into a differentiated cell of another fate without first undergoing cell division or reversion to a more primitive or stem cell-like fate.

Any process that results in the assembly of chromatin into heterochromatin and contributes to chromatin silencing.

Any process that modulates the frequency, rate or extent of the addition of an acetyl group to histone H3 at position 14 of the histone.

Any process that modulates the frequency, rate or extent of the addition of an acetyl group to histone H3 at position 14 of the histone.

The modification of histone H3 by addition of three methyl groups to lysine at position 4 of the histone.

The modification of histone H3 by addition of three methyl groups to lysine at position 36 of the histone.

Any process that modulates the frequency, rate or extent of histone H3-K27 acetylation.

Any process that modulates the frequency, rate or extent of hematopoietic stem cell differentiation.

Any process that modulates the frequency, rate or extent of chromatin organization.

Any process that modulates the frequency, rate or extent of meiotic DNA double-strand break formation.

Any process that modulates the frequency, rate or extent of histone H3-K9 acetylation.

Any process that modulates the frequency, rate or extent of histone H3-K9 acetylation.

Any process that modulates the frequency, rate or extent of response to DNA damage stimulus.

Any process that activates or increases the frequency, rate or extent of cellular response to drug.

Any process that activates or increases the frequency, rate or extent of cellular response to drug.

A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

A multimeric complex that is able to catalyze the addition of methyl groups to histone proteins.

A multimeric complex that is able to catalyze the addition of methyl groups to histone proteins.

That part of the nuclear content other than the chromosomes or the nucleolus.

A conserved protein complex that catalyzes methylation of histone H3. In Saccharomyces the complex contains Shg1p, Sdc1p, Swd1p, Swd2p, Swd3p, Spp1p, Bre2p, and the trithorax-related Set1p; in mammals it contains the catalytic subunit (SETD1A or SETD1B), WDR5, WDR82, RBBP5, ASH2L/ASH2, CXXC1/CFP1, HCFC1 and DPY30.

The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome in the nucleus.

That part of the nuclear content other than the chromosomes or the nucleolus.

The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy.

A conserved protein complex that catalyzes methylation of histone H3. In Saccharomyces the complex contains Shg1p, Sdc1p, Swd1p, Swd2p, Swd3p, Spp1p, Bre2p, and the trithorax-related Set1p; in mammals it contains the catalytic subunit (SETD1A or SETD1B), WDR5, WDR82, RBBP5, ASH2L/ASH2, CXXC1/CFP1, HCFC1 and DPY30.

A type of chromosome in a polyploid cell, formed when multiple copies of homologous chromosomes are aligned side by side to give a giant chromosome in which distinct chromosome bands are readily visible.

All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

A conserved protein complex that catalyzes methylation of histone H3. In Saccharomyces the complex contains Shg1p, Sdc1p, Swd1p, Swd2p, Swd3p, Spp1p, Bre2p, and the trithorax-related Set1p; in mammals it contains the catalytic subunit (SETD1A or SETD1B), WDR5, WDR82, RBBP5, ASH2L/ASH2, CXXC1/CFP1, HCFC1 and DPY30.

A protein complex that possesses histone acetyltransferase activity.

The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome in the nucleus.

The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome in the nucleus.

A dispersed and relatively uncompacted form of chromatin.

A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

That part of the nuclear content other than the chromosomes or the nucleolus.

A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information.

The dispersed less dense form of chromatin in the interphase nucleus. It exists in at least two forms, a some being in the form of transcriptionally active chromatin which is the least condensed, while the rest is inactive euchromatin which is more condensed than active chromatin but less condensed than heterochromatin.

The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

Any protein complex that interacts with RNA polymerase II to increase (positive transcription elongation factor) or reduce (negative transcription elongation factor) the rate of transcription elongation.

A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy.

The portion of the nuclear lumen proximal to the inner nuclear membrane.

A multimeric complex that is able to catalyze the addition of methyl groups to histone proteins.

A multimeric complex that is able to catalyze the addition of methyl groups to histone proteins.

The ordered and organized complex of DNA and protein that forms regions of the chromosome that are being actively transcribed.

A protein complex that can methylate lysine-4 of histone H3, and which contains either of the protein subunits MLL1 or MLL2 in human, or equivalent in other species.

A conserved protein complex that catalyzes methylation of histone H3. In Saccharomyces the complex contains Shg1p, Sdc1p, Swd1p, Swd2p, Swd3p, Spp1p, Bre2p, and the trithorax-related Set1p; in mammals it contains the catalytic subunit (SETD1A or SETD1B), WDR5, WDR82, RBBP5, ASH2L/ASH2, CXXC1/CFP1, HCFC1 and DPY30.

A conserved protein complex that catalyzes methylation of histone H3. In Saccharomyces the complex contains Shg1p, Sdc1p, Swd1p, Swd2p, Swd3p, Spp1p, Bre2p, and the trithorax-related Set1p; in mammals it contains the catalytic subunit (SETD1A or SETD1B), WDR5, WDR82, RBBP5, ASH2L/ASH2, CXXC1/CFP1, HCFC1 and DPY30.

A protein complex that can methylate lysine-4 of histone H3. MLL1/MLL is the catalytic methyltransferase subunit, and the complex also contains the core components ASH2L, HCFC1/HCF1 WDR5 and RBBP5.

A protein complex that can methylate lysine-4 of histone H3. MLL1/MLL is the catalytic methyltransferase subunit, and the complex also contains the core components ASH2L, HCFC1/HCF1 WDR5 and RBBP5.

A protein complex that can methylate lysine-4 of histone H3. MLL1/MLL is the catalytic methyltransferase subunit, and the complex also contains the core components ASH2L, HCFC1/HCF1 WDR5 and RBBP5.