The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
SET domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 5059: Probable histone-lysine N-methyltransferase set-2

There are 2 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Histone-lysine N-methyltransferase. [EC: 2.1.1.43]
S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].
    2316 A0A010Q432 A0A010SAA2 A0A014MXN9 A0A015IIK1 A0A016V2S4 A0A016WYM2 A0A016WZJ6 A0A016X0A7 A0A017SBD4 A0A017SGW1
    (2306 more...)
    DNA-(apurinic or apyrimidinic site) lyase. [EC: 4.2.99.18]
    The C-O-P bond 3' to the apurinic or apyrimidinic site in DNA is broken by a beta-elimination reaction, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.
    • 'Nicking' of the phosphodiester bond is due to a lyase-type reaction, not hydrolysis.
    • This group of enzymes was previously listed as endonucleases, under the number EC 3.1.25.2.
    1 M4EUG8