The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:
"Cystine-knot cytokines
".
FunFam 2749: Gremlin
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 4 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Heparin binding GO:0008201
Interacting selectively and non-covalently with heparin, any member of a group of glycosaminoglycans found mainly as an intracellular component of mast cells and which consist predominantly of alternating alpha-(1->4)-linked D-galactose and N-acetyl-D-glucosamine-6-sulfate residues.
|
1 | O88273 (/IDA) |
|
Heparin binding GO:0008201
Interacting selectively and non-covalently with heparin, any member of a group of glycosaminoglycans found mainly as an intracellular component of mast cells and which consist predominantly of alternating alpha-(1->4)-linked D-galactose and N-acetyl-D-glucosamine-6-sulfate residues.
|
1 | Q9H772 (/ISS) |
|
BMP binding GO:0036122
Interacting selectively and non-covalently with a member of the bone morphogenetic protein (BMP) family.
|
1 | O88273 (/IMP) |
|
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
|
1 | O88273 (/IMP) |
There are 16 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Cardiac chamber development GO:0003205
The progression of a cardiac chamber over time, from its formation to the mature structure. A cardiac chamber is an enclosed cavity within the heart.
|
2 | A0A0R4ICD7 (/IMP) Q566Z5 (/IMP) |
|
Cardiac atrium development GO:0003230
The process whose specific outcome is the progression of a cardiac atrium over time, from its formation to the mature structure. A cardiac atrium receives blood from a vein and pumps it to a cardiac ventricle.
|
2 | A0A0R4ICD7 (/IDA) Q566Z5 (/IDA) |
|
Cardiac atrium development GO:0003230
The process whose specific outcome is the progression of a cardiac atrium over time, from its formation to the mature structure. A cardiac atrium receives blood from a vein and pumps it to a cardiac ventricle.
|
2 | A0A0R4ICD7 (/IMP) Q566Z5 (/IMP) |
|
Cartilage development GO:0051216
The process whose specific outcome is the progression of a cartilage element over time, from its formation to the mature structure. Cartilage elements are skeletal elements that consist of connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate.
|
2 | A0A0R4ICD7 (/IMP) Q566Z5 (/IMP) |
|
Cartilage morphogenesis GO:0060536
The process in which the anatomical structures of cartilage are generated and organized.
|
2 | A0A0R4ICD7 (/IMP) Q566Z5 (/IMP) |
|
BMP signaling pathway involved in heart development GO:0061312
A series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, which contributes to the progression of the heart over time.
|
2 | A0A0R4ICD7 (/IMP) Q566Z5 (/IMP) |
|
Embryonic body morphogenesis GO:0010172
The process in which the anatomical structures of the embryonic soma are generated and organized.
|
1 | O88273 (/IMP) |
|
Embryonic body morphogenesis GO:0010172
The process in which the anatomical structures of the embryonic soma are generated and organized.
|
1 | Q9H772 (/ISS) |
|
Cytokine-mediated signaling pathway GO:0019221
A series of molecular signals initiated by the binding of a cytokine to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
|
1 | O88273 (/IMP) |
|
Cytokine-mediated signaling pathway GO:0019221
A series of molecular signals initiated by the binding of a cytokine to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
|
1 | Q9H772 (/ISS) |
|
BMP signaling pathway GO:0030509
A series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
|
1 | Q9H772 (/TAS) |
|
Negative regulation of BMP signaling pathway GO:0030514
Any process that stops, prevents, or reduces the frequency, rate or extent of the BMP signaling pathway.
|
1 | O88273 (/IMP) |
|
Sequestering of BMP from receptor via BMP binding GO:0038098
Binding to a bone morphogenetic protein (BMP) in the extracellular region, and inhibiting BMP signaling by preventing BMP from binding to its cell surface receptor.
|
1 | O88273 (/IMP) |
|
Determination of dorsal identity GO:0048263
Determination of the identity of part of an organism or organ where those parts are of the type that occur in the dorsal region. Identity is considered to be the aggregate of characteristics by which a structure is recognized.
|
1 | O88273 (/IMP) |
|
Regulation of cytokine activity GO:0060300
Any process that modulates the rate, frequency or extent of the activity of a molecule that controls the survival, growth, differentiation and effector function of tissues and cells.
|
1 | O88273 (/IMP) |
|
Regulation of cytokine activity GO:0060300
Any process that modulates the rate, frequency or extent of the activity of a molecule that controls the survival, growth, differentiation and effector function of tissues and cells.
|
1 | Q9H772 (/ISS) |
There are 2 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
|
1 | Q9H772 (/TAS) |
|
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
|
1 | O88273 (/IMP) |
