The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Cystine-knot cytokines
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Browse Functional Families

ID Function Family (FunFam) Name Total Sequences Enzyme? Structure? Structural Representative PDB Sites? Alignment Diversity (0-100)
2838
4608
EC
3D
4n1dA00 - 88.4
2916
2534
EC
3D
1bj1V00 - 90.6
2857
1468
3D
1betA00 - 88.3
2754
790
3D
1klaA00 - 87.4
2648
516
3D
3hh2A00 - 84.1
2797
339
EC
3D
3mjkA00 - 71.0
2829
330
3D
1dz7A00 - 81.8
2018
320
3D
5aejA00 - 61.4
2885
293
3D
2askA00 - 92.6
2841
262
3D
1fl7B00 - 96.8
2704
255
3D
1nysB00 - 77.6
1721
Human Predicted
241
3D
5bpuA00 - 69.7
2774
231
3D
2v5eB00 - 75.9
2749
207
3D
4jphB00 - 55.5
2839
200 - - 95.5
2762
173
3D
1hcnB00 - 83.7
2628
153 - - 50.9
328
148 - - 29.4
2738
144
3D
4x1jA00 - 49.8
1719
142 - - 79.4
2825
127
3D
2vxsA00 - 88.3
2771
102 - - 64.0
2781
99 - - 66.9
2701
98 - - 56.9
2816
84 - - 88.7
803
82 - - 83.5
1444
80 - - 33.7
309
73 - - 44.8
1236
71 - - 74.9
121
67 - - 41.2
2654
64 - - 39.9
213
64 - - 41.7
2792
53 - - 71.5
1614
52 - - 23.3
2686
48 - - 42.8
2854
48 - - 74.7
1853
35 - - 13.6
699
30 - - 19.8
1357
25 - - 22.1
1351
24
3D
3e07A00 - 14.6
1174
24 - - 24.1
2886
23 - - 61.8
1316
23 - - 30.2
2663
21 - - 40.1
2622
21
3D
1jpyA00 - 25.1
2664
18 - - 41.2
2834
14 - - 74.5
974
13 - - 42.2
2192
12 - - 22.7
2808
11 - - 31.6
879
11 - - 6.8
1414
9 - - 17.2
1371
8 - - 8.7
2842
8 - - 65.7
440
6 - - 1.1
2632
6
3D
1aocA00 - 35.2
2244
6 - - 19.7
1320
5 - - 11.4
2147
5 - - 3.3
176
4 - - 0.9
153
4 - - 0.0
1926
4
3D
2gnnA00 - 10.5
1826
3 - - 5.0
1615
3 - - 23.7
2776
3 - - 32.9
2751
3 - - 22.7
1443
3 - - 8.9
1017
3 - - 1.9
1973
2 - - 16.7
1972
2 - - 0.0
1318
1 - - 0.0
804
1 - - 0.0
2372
1 - - 0.0
2093
1 - - 0.0
1601
1 - - 0.0
1127
1 - - 0.0
1472
1 - - 0.0
1353
1 - - 0.0