The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:
"Complement Module, domain 1
".
FunFam 17427: Chordin-like 2, isoform CRA_c
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 7 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
4 | O57472 (/IPI) Q8VEA6 (/IPI) Q91713 (/IPI) Q9H2X0 (/IPI) |
|
Collagen binding GO:0005518
Interacting selectively and non-covalently with collagen, a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals. Collagen is highly enriched in glycine (some regions are 33% glycine) and proline, occurring predominantly as 3-hydroxyproline (about 20%).
|
1 | Q24025 (/IDA) |
|
Heparin binding GO:0008201
Interacting selectively and non-covalently with heparin, any member of a group of glycosaminoglycans found mainly as an intracellular component of mast cells and which consist predominantly of alternating alpha-(1->4)-linked D-galactose and N-acetyl-D-glucosamine-6-sulfate residues.
|
1 | Q9Z0E2 (/IDA) |
|
Heparin binding GO:0008201
Interacting selectively and non-covalently with heparin, any member of a group of glycosaminoglycans found mainly as an intracellular component of mast cells and which consist predominantly of alternating alpha-(1->4)-linked D-galactose and N-acetyl-D-glucosamine-6-sulfate residues.
|
1 | Q91713 (/ISS) |
|
Cytokine binding GO:0019955
Interacting selectively and non-covalently with a cytokine, any of a group of proteins that function to control the survival, growth and differentiation of tissues and cells, and which have autocrine and paracrine activity.
|
1 | Q9H2X0 (/NAS) |
|
Syndecan binding GO:0045545
Interacting selectively and non-covalently with syndecan, an integral membrane proteoglycan (250-300 kDa) associated largely with epithelial cells.
|
1 | Q9Z0E2 (/IDA) |
|
Syndecan binding GO:0045545
Interacting selectively and non-covalently with syndecan, an integral membrane proteoglycan (250-300 kDa) associated largely with epithelial cells.
|
1 | Q91713 (/ISS) |
There are 75 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Negative regulation of BMP signaling pathway GO:0030514
Any process that stops, prevents, or reduces the frequency, rate or extent of the BMP signaling pathway.
|
5 | O57472 (/IDA) Q8VEA6 (/IDA) Q920C1 (/IDA) Q920C1 (/IDA) Q9Z0E2 (/IDA) |
|
Eye development GO:0001654
The process whose specific outcome is the progression of the eye over time, from its formation to the mature structure. The eye is the organ of sight.
|
4 | Q76LD0 (/ISS) Q76LD0 (/ISS) Q920C1 (/ISS) Q920C1 (/ISS) |
|
Dorsal/ventral pattern formation GO:0009953
The regionalization process in which the areas along the dorsal/ventral axis are established that will lead to differences in cell differentiation. The dorsal/ventral axis is defined by a line that runs orthogonal to both the anterior/posterior and left/right axes. The dorsal end is defined by the upper or back side of an organism. The ventral end is defined by the lower or front side of an organism.
|
4 | B4XEZ3 (/IMP) B4XEZ3 (/IMP) O57472 (/IMP) Q9Z0E2 (/IMP) |
|
Compound eye development GO:0048749
The process whose specific outcome is the progression of the compound eye over time, from its formation to the mature structure. The compound eye is an organ of sight that contains multiple repeating units, often arranged hexagonally. Each unit has its own lens and photoreceptor cell(s) and can generate either a single pixelated image or multiple images, per eye.
|
4 | Q76LD0 (/ISS) Q76LD0 (/ISS) Q920C1 (/ISS) Q920C1 (/ISS) |
|
Dorsal/ventral pattern formation GO:0009953
The regionalization process in which the areas along the dorsal/ventral axis are established that will lead to differences in cell differentiation. The dorsal/ventral axis is defined by a line that runs orthogonal to both the anterior/posterior and left/right axes. The dorsal end is defined by the upper or back side of an organism. The ventral end is defined by the lower or front side of an organism.
|
3 | B4XEZ3 (/IGI) B4XEZ3 (/IGI) O57472 (/IGI) |
|
Eye development GO:0001654
The process whose specific outcome is the progression of the eye over time, from its formation to the mature structure. The eye is the organ of sight.
|
2 | Q9BU40 (/IMP) Q9BU40 (/IMP) |
|
Eye development GO:0001654
The process whose specific outcome is the progression of the eye over time, from its formation to the mature structure. The eye is the organ of sight.
|
2 | Q920C1 (/ISO) Q920C1 (/ISO) |
|
Cell fate determination GO:0001709
A process involved in cell fate commitment. Once determination has taken place, a cell becomes committed to differentiate down a particular pathway regardless of its environment.
|
2 | Q76LD0 (/IMP) Q76LD0 (/IMP) |
|
Neuron differentiation GO:0030182
The process in which a relatively unspecialized cell acquires specialized features of a neuron.
|
2 | Q76LD0 (/IMP) Q76LD0 (/IMP) |
|
BMP signaling pathway GO:0030509
A series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
|
2 | Q9BU40 (/TAS) Q9BU40 (/TAS) |
|
Negative regulation of BMP signaling pathway GO:0030514
Any process that stops, prevents, or reduces the frequency, rate or extent of the BMP signaling pathway.
|
2 | O57472 (/IMP) Q9H2X0 (/IMP) |
|
Post-translational protein modification GO:0043687
The process of covalently altering one or more amino acids in a protein after the protein has been completely translated and released from the ribosome.
|
2 | Q9BU40 (/TAS) Q9BU40 (/TAS) |
|
Cellular protein metabolic process GO:0044267
The chemical reactions and pathways involving a specific protein, rather than of proteins in general, occurring at the level of an individual cell. Includes cellular protein modification.
|
2 | Q9BU40 (/TAS) Q9BU40 (/TAS) |
|
Compound eye development GO:0048749
The process whose specific outcome is the progression of the compound eye over time, from its formation to the mature structure. The compound eye is an organ of sight that contains multiple repeating units, often arranged hexagonally. Each unit has its own lens and photoreceptor cell(s) and can generate either a single pixelated image or multiple images, per eye.
|
2 | Q9BU40 (/IMP) Q9BU40 (/IMP) |
|
Compound eye development GO:0048749
The process whose specific outcome is the progression of the compound eye over time, from its formation to the mature structure. The compound eye is an organ of sight that contains multiple repeating units, often arranged hexagonally. Each unit has its own lens and photoreceptor cell(s) and can generate either a single pixelated image or multiple images, per eye.
|
2 | Q920C1 (/ISO) Q920C1 (/ISO) |
|
Skeletal system development GO:0001501
The process whose specific outcome is the progression of the skeleton over time, from its formation to the mature structure. The skeleton is the bony framework of the body in vertebrates (endoskeleton) or the hard outer envelope of insects (exoskeleton or dermoskeleton).
|
1 | Q9Z0E2 (/IMP) |
|
Skeletal system development GO:0001501
The process whose specific outcome is the progression of the skeleton over time, from its formation to the mature structure. The skeleton is the bony framework of the body in vertebrates (endoskeleton) or the hard outer envelope of insects (exoskeleton or dermoskeleton).
|
1 | Q9H2X0 (/TAS) |
|
Osteoblast differentiation GO:0001649
The process whereby a relatively unspecialized cell acquires the specialized features of an osteoblast, a mesodermal or neural crest cell that gives rise to bone.
|
1 | Q9Z0E2 (/IDA) |
|
Gastrulation with mouth forming second GO:0001702
A gastrulation process in which the initial invagination becomes the anus and the mouth forms second.
|
1 | Q9Z0E2 (/IMP) |
|
Mesoderm formation GO:0001707
The process that gives rise to the mesoderm. This process pertains to the initial formation of the structure from unspecified parts.
|
1 | Q9Z0E2 (/IMP) |
|
Somitogenesis GO:0001756
The formation of mesodermal clusters that are arranged segmentally along the anterior posterior axis of an embryo.
|
1 | O57472 (/IGI) |
|
Somitogenesis GO:0001756
The formation of mesodermal clusters that are arranged segmentally along the anterior posterior axis of an embryo.
|
1 | O57472 (/IMP) |
|
Heart looping GO:0001947
The tube morphogenesis process in which the primitive heart tube loops asymmetrically. This looping brings the primitive heart chambers into alignment preceding their future integration. Heart looping begins with dextral-looping and ends when the main regional divisions of the mature heart and primordium of the great arterial trunks become established preceeding septation.
|
1 | O57472 (/IMP) |
|
Positive regulation of mesenchymal cell proliferation GO:0002053
The process of activating or increasing the rate or extent of mesenchymal cell proliferation. Mesenchymal cells are loosely organized embryonic cells.
|
1 | Q9H2X0 (/IMP) |
|
Positive regulation of mesenchymal cell proliferation GO:0002053
The process of activating or increasing the rate or extent of mesenchymal cell proliferation. Mesenchymal cells are loosely organized embryonic cells.
|
1 | Q9Z0E2 (/ISO) |
|
Embryonic heart tube morphogenesis GO:0003143
The process in which the anatomical structures of the embryonic heart tube are generated and organized. The embryonic heart tube is an epithelial tube that will give rise to the mature heart.
|
1 | O57472 (/IMP) |
|
Maternal specification of dorsal/ventral axis, oocyte, soma encoded GO:0007313
Polarization of the oocyte along the dorsal-ventral axis, by a gene product encoded by somatic cells. An example of this is found in Drosophila melanogaster.
|
1 | Q24025 (/IMP) |
|
Zygotic determination of anterior/posterior axis, embryo GO:0007354
The specification of the anterior/posterior axis of the embryo by products of genes expressed in the zygote; exemplified in insects by the gap genes, pair rule genes and segment polarity gene cascade.
|
1 | Q24025 (/NAS) |
|
Terminal region determination GO:0007362
Specification of the terminal regions (the two non-segmented ends) of the embryo by the gap genes; exemplified in insects by the actions of huckebein and tailless gene products.
|
1 | Q24025 (/IGI) |
|
Determination of left/right symmetry GO:0007368
The establishment of an organism's body plan or part of an organism with respect to the left and right halves. The pattern can either be symmetric, such that the halves are mirror images, or asymmetric where the pattern deviates from this symmetry.
|
1 | O57472 (/IMP) |
|
Amnioserosa formation GO:0007378
Formation of the amnioserosa, an epithelium that occupies a hole in the embryonic dorsal epidermis. This occurs by the transformation of a narrow strip of cells at the dorsal midline of the blastoderm from columnar to squamous cells, accompanied by a lateral shift.
|
1 | Q24025 (/TAS) |
|
Pattern specification process GO:0007389
Any developmental process that results in the creation of defined areas or spaces within an organism to which cells respond and eventually are instructed to differentiate.
|
1 | Q9Z0E2 (/IMP) |
|
Ectoderm development GO:0007398
The process whose specific outcome is the progression of the ectoderm over time, from its formation to the mature structure. In animal embryos, the ectoderm is the outer germ layer of the embryo, formed during gastrulation.
|
1 | Q24025 (/NAS) |
|
Ectoderm development GO:0007398
The process whose specific outcome is the progression of the ectoderm over time, from its formation to the mature structure. In animal embryos, the ectoderm is the outer germ layer of the embryo, formed during gastrulation.
|
1 | Q24025 (/TAS) |
|
Central nervous system development GO:0007417
The process whose specific outcome is the progression of the central nervous system over time, from its formation to the mature structure. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain and spinal cord. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord.
|
1 | Q9Z0E2 (/IMP) |
|
Torso signaling pathway GO:0008293
A series of molecular signals initiated by the binding of an extracellular ligand to torso (a receptor tyrosine kinase) on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
|
1 | Q24025 (/IGI) |
|
Imaginal disc-derived wing vein morphogenesis GO:0008586
The process in which anatomical structures of the veins on an imaginal disc-derived wing are generated and organized.
|
1 | Q24025 (/IMP) |
|
Axis specification GO:0009798
The establishment, maintenance and elaboration of a pattern along a line or around a point.
|
1 | Q91713 (/IMP) |
|
Anterior/posterior axis specification GO:0009948
The establishment, maintenance and elaboration of the anterior/posterior axis. The anterior-posterior axis is defined by a line that runs from the head or mouth of an organism to the tail or opposite end of the organism.
|
1 | O57472 (/IDA) |
|
Anterior/posterior axis specification GO:0009948
The establishment, maintenance and elaboration of the anterior/posterior axis. The anterior-posterior axis is defined by a line that runs from the head or mouth of an organism to the tail or opposite end of the organism.
|
1 | O57472 (/IMP) |
|
Specification of animal organ position GO:0010159
The regionalization process in which information that determines the correct position at which animal organ primordia are formed is generated and perceived resulting in correct positioning of the new animal organ.
|
1 | O57472 (/IMP) |
|
BMP signaling pathway involved in spinal cord dorsal/ventral patterning GO:0021919
A series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, which contributes to the spatial identity of regions along the dorsal-ventral axis of the spinal cord.
|
1 | Q9H2X0 (/IMP) |
|
BMP signaling pathway involved in spinal cord dorsal/ventral patterning GO:0021919
A series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, which contributes to the spatial identity of regions along the dorsal-ventral axis of the spinal cord.
|
1 | Q9Z0E2 (/ISO) |
|
Cell differentiation GO:0030154
The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state.
|
1 | Q8VEA6 (/IDA) |
|
Negative regulation of cell migration GO:0030336
Any process that stops, prevents, or reduces the frequency, rate or extent of cell migration.
|
1 | Q9H2X0 (/IDA) |
|
Negative regulation of cell migration GO:0030336
Any process that stops, prevents, or reduces the frequency, rate or extent of cell migration.
|
1 | Q9Z0E2 (/ISO) |
|
BMP signaling pathway GO:0030509
A series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
|
1 | Q24025 (/NAS) |
|
Regulation of BMP signaling pathway GO:0030510
Any process that modulates the frequency, rate or extent of the activity of any BMP receptor signaling pathway.
|
1 | Q24025 (/TAS) |
|
Positive regulation of transforming growth factor beta receptor signaling pathway GO:0030511
Any process that activates or increases the frequency, rate or extent of TGF-beta receptor signaling pathway activity.
|
1 | Q24025 (/TAS) |
|
Negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512
Any process that stops, prevents, or reduces the frequency, rate or extent of any TGF-beta receptor signaling pathway.
|
1 | Q24025 (/TAS) |
|
Negative regulation of BMP signaling pathway GO:0030514
Any process that stops, prevents, or reduces the frequency, rate or extent of the BMP signaling pathway.
|
1 | O57472 (/IGI) |
|
Negative regulation of BMP signaling pathway GO:0030514
Any process that stops, prevents, or reduces the frequency, rate or extent of the BMP signaling pathway.
|
1 | Q9Z0E2 (/ISO) |
|
Negative regulation of BMP signaling pathway GO:0030514
Any process that stops, prevents, or reduces the frequency, rate or extent of the BMP signaling pathway.
|
1 | Q643S1 (/ISS) |
|
Forebrain development GO:0030900
The process whose specific outcome is the progression of the forebrain over time, from its formation to the mature structure. The forebrain is the anterior of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes especially the cerebral hemispheres, the thalamus, and the hypothalamus and especially in higher vertebrates is the main control center for sensory and associative information processing, visceral functions, and voluntary motor functions).
|
1 | Q9Z0E2 (/IMP) |
|
Floor plate development GO:0033504
The progression of the floor plate over time from its initial formation until its mature state.
|
1 | Q9H2X0 (/TAS) |
|
Caudal fin morphogenesis GO:0035143
The process in which the anatomical structures of the caudal fin are generated and organized. A caudal fin is an unpaired medial fin mounted at the caudal end of the fish, and is the main fin used for propulsion.
|
1 | O57472 (/IMP) |
|
Embryonic hemopoiesis GO:0035162
The stages of blood cell formation that take place within the embryo.
|
1 | O57472 (/IGI) |
|
Embryonic hemopoiesis GO:0035162
The stages of blood cell formation that take place within the embryo.
|
1 | O57472 (/IMP) |
|
Ring gland development GO:0035271
Progression of the ring gland over time, from its formation to a mature structure. The ring gland is a neuroendocrine organ found in higher Dipterans, which is composed of the prothoracic gland, the corpus allatum, and the corpora cardiacum. The ring gland is the site of production and release of ecdysteroids and juvenile hormones.
|
1 | Q24025 (/IMP) |
|
Post-anal tail morphogenesis GO:0036342
The process in which a post-anal tail is generated and organized. A post-anal tail is a muscular region of the body that extends posterior to the anus. The post-anal tail may aid locomotion and balance.
|
1 | Q91713 (/IMP) |
|
Chordate embryonic development GO:0043009
The process whose specific outcome is the progression of the embryo over time, from zygote formation through a stage including a notochord and neural tube until birth or egg hatching.
|
1 | Q91713 (/IMP) |
|
Otic placode formation GO:0043049
The initial developmental process that will lead to the formation of the vertebrate inner ear. The otic placode forms as a thickening of the head ectoderm adjacent to the developing hindbrain.
|
1 | O57472 (/IGI) |
|
Negative regulation of osteoblast differentiation GO:0045668
Any process that stops, prevents, or reduces the frequency, rate or extent of osteoblast differentiation.
|
1 | Q9Z0E2 (/IDA) |
|
Negative regulation of osteoblast differentiation GO:0045668
Any process that stops, prevents, or reduces the frequency, rate or extent of osteoblast differentiation.
|
1 | Q9H2X0 (/IMP) |
|
Negative regulation of osteoblast differentiation GO:0045668
Any process that stops, prevents, or reduces the frequency, rate or extent of osteoblast differentiation.
|
1 | Q9Z0E2 (/ISO) |
|
Positive regulation of cell adhesion GO:0045785
Any process that activates or increases the frequency, rate or extent of cell adhesion.
|
1 | Q9H2X0 (/IDA) |
|
Positive regulation of cell adhesion GO:0045785
Any process that activates or increases the frequency, rate or extent of cell adhesion.
|
1 | Q9Z0E2 (/ISO) |
|
Determination of ventral identity GO:0048264
The regionalization process that results in the determination of the identity of part of an organism or organ where those parts are of the type that occur in the ventral region. Identity is considered to be the aggregate of characteristics by which a structure is recognized.
|
1 | O57472 (/IGI) |
|
Determination of ventral identity GO:0048264
The regionalization process that results in the determination of the identity of part of an organism or organ where those parts are of the type that occur in the ventral region. Identity is considered to be the aggregate of characteristics by which a structure is recognized.
|
1 | O57472 (/IMP) |
|
Pronephros development GO:0048793
The process whose specific outcome is the progression of the pronephros over time, from its formation to the mature structure. In mammals, the pronephros is the first of the three embryonic kidneys to be established and exists only transiently. In lower vertebrates such as fish and amphibia, the pronephros is the fully functional embryonic kidney and is indispensable for larval life.
|
1 | Q91713 (/IMP) |
|
Dorsal convergence GO:0060030
The directed migration of individual cells and small groups of cells toward the dorsal midline during gastrulation. This process does not require cell rearrangement.
|
1 | O57472 (/IGI) |
|
Posterior Malpighian tubule development GO:0061328
The process whose specific outcome is the progression of the posterior Malpighian tubule over time, from its formation to the mature structure. The pair of posterior tubules arise from a ventrolateral region of the embryonic hindgut and project backwards through the body cavity. A Malpighian tubule is a fine, thin-walled excretory tubule in insects which connects with the posterior part of the gut.
|
1 | Q24025 (/IMP) |
|
Determination of heart left/right asymmetry GO:0061371
Determination of the asymmetric location of the heart with respect to the left and right halves of the organism.
|
1 | O57472 (/IMP) |
|
Kupffer's vesicle development GO:0070121
The progression of the Kupffer's vesicle over time from its initial formation until its mature state. The Kupffer's vesicle is a small but distinctive epithelial sac containing fluid, located midventrally posterior to the yolk cell or its extension, and transiently present during most of the segmentation period.
|
1 | O57472 (/IMP) |
|
Regulation of BMP signaling pathway involved in heart jogging GO:2000223
Any process that modulates the frequency, rate or extent of BMP signaling pathway involved in heart jogging.
|
1 | O57472 (/IMP) |
There are 8 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
|
4 | Q76LD0 (/TAS) Q76LD0 (/TAS) Q9BU40 (/TAS) Q9BU40 (/TAS) |
|
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
|
3 | Q6WN34 (/IDA) Q6WN34 (/IDA) Q9Z0E2 (/IDA) |
|
Endoplasmic reticulum lumen GO:0005788
The volume enclosed by the membranes of the endoplasmic reticulum.
|
2 | Q9BU40 (/TAS) Q9BU40 (/TAS) |
|
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
|
1 | Q643S1 (/ISS) |
|
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
|
1 | Q91713 (/NAS) |
|
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
|
1 | Q8VEA6 (/ISO) |
|
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
|
1 | Q9H2X0 (/NAS) |
|
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
1 | Q24025 (/ISS) |
