The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:
"Complement Module, domain 1
".
FunFam 16898: E-selectin
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 9 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Transmembrane signaling receptor activity GO:0004888
Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity or state as part of signal transduction.
|
2 | P16581 (/IMP) P16581 (/IMP) |
Transmembrane signaling receptor activity GO:0004888
Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity or state as part of signal transduction.
|
2 | Q00690 (/ISO) Q00690 (/ISO) |
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
2 | P16581 (/IPI) P16581 (/IPI) |
Sialic acid binding GO:0033691
Interacting selectively and non-covalently with sialic acid, any of a variety of N- or O- substituted derivatives of neuraminic acid, a nine carbon monosaccharide. Sialic acids often occur in polysaccharides, glycoproteins, and glycolipids in animals and bacteria.
|
2 | P16581 (/IDA) P16581 (/IDA) |
Sialic acid binding GO:0033691
Interacting selectively and non-covalently with sialic acid, any of a variety of N- or O- substituted derivatives of neuraminic acid, a nine carbon monosaccharide. Sialic acids often occur in polysaccharides, glycoproteins, and glycolipids in animals and bacteria.
|
2 | Q00690 (/ISO) Q00690 (/ISO) |
Phospholipase binding GO:0043274
Interacting selectively and non-covalently with any phospholipase, enzymes that catalyze of the hydrolysis of a glycerophospholipid.
|
2 | P16581 (/IDA) P16581 (/IDA) |
Phospholipase binding GO:0043274
Interacting selectively and non-covalently with any phospholipase, enzymes that catalyze of the hydrolysis of a glycerophospholipid.
|
2 | Q00690 (/ISO) Q00690 (/ISO) |
Oligosaccharide binding GO:0070492
Interacting selectively and non-covalently with any oligosaccharide, a molecule with between two and (about) 20 monosaccharide residues connected by glycosidic linkages.
|
2 | P16581 (/IDA) P16581 (/IDA) |
Oligosaccharide binding GO:0070492
Interacting selectively and non-covalently with any oligosaccharide, a molecule with between two and (about) 20 monosaccharide residues connected by glycosidic linkages.
|
2 | Q00690 (/ISO) Q00690 (/ISO) |
There are 26 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Inflammatory response GO:0006954
The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages.
|
3 | P16581 (/TAS) P16581 (/TAS) P98105 (/TAS) |
Positive regulation of receptor internalization GO:0002092
Any process that activates or increases the frequency, rate or extent of receptor internalization.
|
2 | P16581 (/IDA) P16581 (/IDA) |
Positive regulation of receptor internalization GO:0002092
Any process that activates or increases the frequency, rate or extent of receptor internalization.
|
2 | Q00690 (/ISO) Q00690 (/ISO) |
Leukocyte migration involved in inflammatory response GO:0002523
The movement of a leukocyte within or between different tissues and organs of the body contributing to an inflammatory response.
|
2 | P16581 (/TAS) P16581 (/TAS) |
Positive regulation of leukocyte migration GO:0002687
Any process that activates or increases the frequency, rate, or extent of leukocyte migration.
|
2 | Q00690 (/IGI) Q00690 (/IGI) |
Heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules GO:0007157
The attachment of an adhesion molecule in one cell to a nonidentical adhesion molecule in an adjacent cell.
|
2 | P16581 (/IMP) P16581 (/IMP) |
Heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules GO:0007157
The attachment of an adhesion molecule in one cell to a nonidentical adhesion molecule in an adjacent cell.
|
2 | Q00690 (/ISO) Q00690 (/ISO) |
Leukocyte cell-cell adhesion GO:0007159
The attachment of a leukocyte to another cell via adhesion molecules.
|
2 | P16581 (/IDA) P16581 (/IDA) |
Leukocyte cell-cell adhesion GO:0007159
The attachment of a leukocyte to another cell via adhesion molecules.
|
2 | Q00690 (/ISO) Q00690 (/ISO) |
Activation of phospholipase C activity GO:0007202
The initiation of the activity of the inactive enzyme phospolipase C as the result of a series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand.
|
2 | P16581 (/IMP) P16581 (/IMP) |
Activation of phospholipase C activity GO:0007202
The initiation of the activity of the inactive enzyme phospolipase C as the result of a series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand.
|
2 | Q00690 (/ISO) Q00690 (/ISO) |
Calcium-mediated signaling GO:0019722
Any intracellular signal transduction in which the signal is passed on within the cell via calcium ions.
|
2 | P16581 (/TAS) P16581 (/TAS) |
Actin filament-based process GO:0030029
Any cellular process that depends upon or alters the actin cytoskeleton, that part of the cytoskeleton comprising actin filaments and their associated proteins.
|
2 | P16581 (/IDA) P16581 (/IDA) |
Actin filament-based process GO:0030029
Any cellular process that depends upon or alters the actin cytoskeleton, that part of the cytoskeleton comprising actin filaments and their associated proteins.
|
2 | Q00690 (/ISO) Q00690 (/ISO) |
Response to lipopolysaccharide GO:0032496
Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria.
|
2 | P16581 (/TAS) P16581 (/TAS) |
Response to tumor necrosis factor GO:0034612
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tumor necrosis factor stimulus.
|
2 | P16581 (/TAS) P16581 (/TAS) |
Regulation of inflammatory response GO:0050727
Any process that modulates the frequency, rate or extent of the inflammatory response, the immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents.
|
2 | P16581 (/TAS) P16581 (/TAS) |
Leukocyte migration GO:0050900
The movement of a leukocyte within or between different tissues and organs of the body.
|
2 | P16581 (/TAS) P16581 (/TAS) |
Leukocyte tethering or rolling GO:0050901
Transient adhesive interactions between leukocytes and endothelial cells lining blood vessels. Carbohydrates on circulating leukocytes bind selectins on the vessel wall causing the leukocytes to slow down and roll along the inner surface of the vessel wall. During this rolling motion, transitory bonds are formed and broken between selectins and their ligands. Typically the first step in cellular extravasation (the movement of leukocytes out of the circulatory system, towards the site of tissue damage or infection).
|
2 | P16581 (/IMP) P16581 (/IMP) |
Leukocyte tethering or rolling GO:0050901
Transient adhesive interactions between leukocytes and endothelial cells lining blood vessels. Carbohydrates on circulating leukocytes bind selectins on the vessel wall causing the leukocytes to slow down and roll along the inner surface of the vessel wall. During this rolling motion, transitory bonds are formed and broken between selectins and their ligands. Typically the first step in cellular extravasation (the movement of leukocytes out of the circulatory system, towards the site of tissue damage or infection).
|
2 | Q00690 (/ISO) Q00690 (/ISO) |
Response to interleukin-1 GO:0070555
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-1 stimulus.
|
2 | P16581 (/IDA) P16581 (/IDA) |
Response to interleukin-1 GO:0070555
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-1 stimulus.
|
2 | Q00690 (/ISO) Q00690 (/ISO) |
Inflammatory response GO:0006954
The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages.
|
1 | P98105 (/IMP) |
Cell adhesion GO:0007155
The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules.
|
1 | P98105 (/TAS) |
Response to cytokine GO:0034097
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytokine stimulus.
|
1 | P98105 (/IEP) |
Leukocyte migration GO:0050900
The movement of a leukocyte within or between different tissues and organs of the body.
|
1 | P98105 (/IEP) |
There are 13 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
|
2 | P16581 (/IDA) P16581 (/IDA) |
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
|
2 | Q00690 (/ISO) Q00690 (/ISO) |
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
2 | P16581 (/TAS) P16581 (/TAS) |
Caveola GO:0005901
A membrane raft that forms small pit, depression, or invagination that communicates with the outside of a cell and extends inward, indenting the cytoplasm and the cell membrane. Examples include flask-shaped invaginations of the plasma membrane in adipocytes associated with caveolin proteins, and minute pits or incuppings of the cell membrane formed during pinocytosis. Caveolae may be pinched off to form free vesicles within the cytoplasm.
|
2 | P16581 (/IDA) P16581 (/IDA) |
Caveola GO:0005901
A membrane raft that forms small pit, depression, or invagination that communicates with the outside of a cell and extends inward, indenting the cytoplasm and the cell membrane. Examples include flask-shaped invaginations of the plasma membrane in adipocytes associated with caveolin proteins, and minute pits or incuppings of the cell membrane formed during pinocytosis. Caveolae may be pinched off to form free vesicles within the cytoplasm.
|
2 | Q00690 (/ISO) Q00690 (/ISO) |
Clathrin-coated pit GO:0005905
A part of the endomembrane system in the form of an invagination of a membrane upon which a clathrin coat forms, and that can be converted by vesicle budding into a clathrin-coated vesicle. Coated pits form on the plasma membrane, where they are involved in receptor-mediated selective transport of many proteins and other macromolecules across the cell membrane, in the trans-Golgi network, and on some endosomes.
|
2 | P16581 (/IDA) P16581 (/IDA) |
Clathrin-coated pit GO:0005905
A part of the endomembrane system in the form of an invagination of a membrane upon which a clathrin coat forms, and that can be converted by vesicle budding into a clathrin-coated vesicle. Coated pits form on the plasma membrane, where they are involved in receptor-mediated selective transport of many proteins and other macromolecules across the cell membrane, in the trans-Golgi network, and on some endosomes.
|
2 | Q00690 (/ISO) Q00690 (/ISO) |
Cortical cytoskeleton GO:0030863
The portion of the cytoskeleton that lies just beneath the plasma membrane.
|
2 | P16581 (/IDA) P16581 (/IDA) |
Cortical cytoskeleton GO:0030863
The portion of the cytoskeleton that lies just beneath the plasma membrane.
|
2 | Q00690 (/ISO) Q00690 (/ISO) |
Membrane raft GO:0045121
Any of the small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes. Small rafts can sometimes be stabilized to form larger platforms through protein-protein and protein-lipid interactions.
|
2 | P16581 (/IDA) P16581 (/IDA) |
Membrane raft GO:0045121
Any of the small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes. Small rafts can sometimes be stabilized to form larger platforms through protein-protein and protein-lipid interactions.
|
2 | Q00690 (/ISO) Q00690 (/ISO) |
Perinuclear region of cytoplasm GO:0048471
Cytoplasm situated near, or occurring around, the nucleus.
|
2 | P16581 (/IDA) P16581 (/IDA) |
Perinuclear region of cytoplasm GO:0048471
Cytoplasm situated near, or occurring around, the nucleus.
|
2 | Q00690 (/ISO) Q00690 (/ISO) |