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CATH Superfamily 1.50.40.10

Mitochondrial carrier domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Mitochondrial carrier domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 9458: Mitochondrial Carrier (MC) Family

There are 4 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
TRNA (guanine(46)-N(7))-methyltransferase. [EC: 2.1.1.33]
S-adenosyl-L-methionine + guanine(46) in tRNA = S-adenosyl-L-homocysteine + N(7)-methylguanine(46) in tRNA.
  • The enzyme specifically methylates guanine(46) at N(7) in tRNA.
 3 A0A0K0DF25 U6NGC0 U6NXV1
Adenosylhomocysteinase. [EC: 3.3.1.1]
S-adenosyl-L-homocysteine + H(2)O = L-homocysteine + adenosine.
  • The NAD(+) cofactor appears to bring about a transient oxidation at C-3' of the 5'-deoxyadenosine residue, thus labilizing the thioether bond cf. EC 5.5.1.4.
 1 A0A0G4MBQ6
Microtubule-severing ATPase. [EC: 3.6.4.3]
ATP + H(2)O = ADP + phosphate.
  • Another member of the AAA-ATPase family, active in splitting microtubules into tubulin dimers in the centrosome.
 1 A0A0F4YXI2
Complement subcomponent C1r. [EC: 3.4.21.41]
Selective cleavage of Lys(or Arg)-|-Ile bond in complement subcomponent C1s to form the active form of C1s (EC 3.4.21.42).
  • Activates C1s by proteolytic cleavage so that it can, in turn, activate C2 and C4.
  • Activated from proenzyme C1r in plasma by autocatalytic mechanism during activation of the complement system by the 'classical' route.
  • Belongs to peptidase family S1.
 1 G0R2K3