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CATH Superfamily 1.50.10.20

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 6352: Protein farnesyltransferase subunit beta

There are 2 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Protein farnesyltransferase. [EC: 2.5.1.58]
Farnesyl diphosphate + protein-cysteine = S-farnesyl protein + diphosphate.
  • This enzyme, along with EC 2.5.1.59 and EC 2.5.1.60, constitutes the protein prenyltransferase family of enzymes.
  • Catalyzes the formation of a thioether linkage between the C-1 of an isoprenyl group and a cysteine residue fourth from the C-terminus of the protein.
  • These protein acceptors have the C-terminal sequence CA(1)A(2)X, where the terminal residue, X, is preferably serine, methionine, alanine or glutamine; leucine makes the protein a substrate for EC 2.5.1.59.
  • The enzymes are relaxed in specificity for A(1), but cannot act if A(2) is aromatic.
  • Substrates of the prenyltransferases include Ras, Rho, Rab, other Ras-related small GTP-binding proteins, gamma-subunits of heterotrimeric G-proteins, nuclear lamins, centromeric proteins and many proteins involved in visual signal transduction.
 22 A0A060RVH6 A0A061I0S5 A0A0B2QCL4 A0A1J1H620 A0A1K9YAR6 B3L5S6 B7PKD0 B9RUT5 E0VV79 H2Q8G7
(12 more...)
Squalene synthase. [EC: 2.5.1.21]
2 farnesyl diphosphate + NAD(P)H = squalene + 2 diphosphate + NAD(P)(+).
  • This microsomal enzyme catalyzes the first committed step in the biosynthesis of sterols.
  • In the absence of NAD(P)H, presqualene diphosphate (PSPP) is accumulated.
  • When NAD(P)H is present, presqualene diphosphate does not dissociate from the enzyme during the synthesis of squalene from farnesyl diphosphate (FPP).
  • High concentrations of FPP inhibit the production of squalene but not of PSPP.
 1 O24448