The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:
"Dbl homology (DH) domain
".
FunFam 3390: Rho guanine nucleotide exchange factor gef1
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 4 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Rho guanyl-nucleotide exchange factor activity GO:0005089
Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rho family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase.
|
2 | O59679 (/IDA) Q09763 (/IDA) |
|
Rho guanyl-nucleotide exchange factor activity GO:0005089
Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rho family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase.
|
1 | Q09763 (/EXP) |
|
Rho guanyl-nucleotide exchange factor activity GO:0005089
Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rho family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase.
|
1 | O59679 (/IGI) |
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
1 | Q09763 (/IPI) |
There are 10 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Vesicle-mediated transport GO:0016192
A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane.
|
1 | O59679 (/IMP) |
|
Cdc42 protein signal transduction GO:0032488
A series of molecular signals within the cell that are mediated by the Cdc42 protein switching to a GTP-bound active state.
|
1 | Q09763 (/NAS) |
|
Regulation of barrier septum assembly GO:0032955
Any process that modulates the frequency, rate or extent of barrier septum formation. Barrier septum formation is the assembly and arrangement of a septum that spans the plasma membrane interface between progeny cells following cytokinesis.
|
1 | Q09763 (/IMP) |
|
Regulation of GTPase activity GO:0043087
Any process that modulates the rate of GTP hydrolysis by a GTPase.
|
1 | O59679 (/IC) |
|
Regulation of protein localization to cell division site involved in cell separation after cytokinesis GO:1905391
Any regulation of protein localization to cell division site that is involved in cell separation after cytokinesis.
|
1 | O59679 (/IMP) |
|
Regulation of establishment or maintenance of bipolar cell polarity regulating cell shape GO:2000100
Any process that modulates the frequency, rate or extent of establishment or maintenance of bipolar cell polarity regulating cell shape.
|
1 | Q09763 (/IGI) |
|
Regulation of establishment or maintenance of bipolar cell polarity regulating cell shape GO:2000100
Any process that modulates the frequency, rate or extent of establishment or maintenance of bipolar cell polarity regulating cell shape.
|
1 | Q09763 (/IMP) |
|
Positive regulation of establishment of cell polarity regulating cell shape GO:2000784
Any process that activates or increases the frequency, rate or extent of establishment of cell polarity regulating cell shape.
|
1 | Q09763 (/EXP) |
|
Positive regulation of establishment of cell polarity regulating cell shape GO:2000784
Any process that activates or increases the frequency, rate or extent of establishment of cell polarity regulating cell shape.
|
1 | Q09763 (/IC) |
|
Positive regulation of cell separation after cytokinesis GO:2001043
Any process that activates or increases the frequency, rate or extent of cell separation involved after cell cycle cytokinesis.
|
1 | O59679 (/EXP) |
There are 11 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
2 | O59679 (/IDA) Q09763 (/IDA) |
|
Cell division site GO:0032153
The eventual plane of cell division (also known as cell cleavage or cytokinesis) in a dividing cell. In Eukaryotes, the cleavage apparatus, composed of septin structures and the actomyosin contractile ring, forms along this plane, and the mitotic, or meiotic, spindle is aligned perpendicular to the division plane. In bacteria, the cell division site is generally located at mid-cell and is the site at which the cytoskeletal structure, the Z-ring, assembles.
|
2 | O59679 (/IDA) Q09763 (/IDA) |
|
Barrier septum GO:0000935
A septum which spans a cell and does not allow exchange of organelles or cytoplasm between compartments.
|
1 | Q09763 (/IDA) |
|
Intracellular GO:0005622
The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.
|
1 | Q09763 (/IDA) |
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
1 | Q09763 (/IDA) |
|
Medial cortex GO:0031097
A medial cortical band overlaying the nucleus which acts as a landmark for contractile ring positioning and plays a role in cell cycle regulation.
|
1 | Q09763 (/IDA) |
|
Medial cortex septin ring GO:0036391
A ring-shaped structure that forms at the medial cortex of a symmetrically dividing cell at the onset of cytokinesis; composed of members of the conserved family of filament forming proteins called septins as well as septin-associated proteins.
|
1 | O59679 (/EXP) |
|
Medial cortex septin ring GO:0036391
A ring-shaped structure that forms at the medial cortex of a symmetrically dividing cell at the onset of cytokinesis; composed of members of the conserved family of filament forming proteins called septins as well as septin-associated proteins.
|
1 | O59679 (/IDA) |
|
Cell cortex of cell tip GO:0051285
The region directly beneath the plasma membrane at the cell tip. The cell tip is the region at either end of the longest axis of a cylindrical or elongated cell.
|
1 | Q09763 (/IDA) |
|
Cell tip GO:0051286
The region at the end of the longest axis of a cylindrical or elongated cell.
|
1 | Q09763 (/IDA) |
|
Cell cortex of growing cell tip GO:1902716
Any cell cortex that is part of a growing cell tip.
|
1 | Q09763 (/IDA) |
