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CATH Superfamily 1.10.630.10

Cytochrome P450

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Cytochrome P450
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 29452: Cytochrome P450 19A1

There are 9 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Aromatase. [EC: 1.14.14.14]
(1) Testosterone + 3 [reduced NADPH--hemoprotein reductase] + 3 O(2) = 17-beta-estradiol + formate + 4 H(2)O + 3 [oxidized NADPH--hemoprotein reductase]. (2) Androst-4-ene-3,17-dione + 3 [reduced NADPH--hemoprotein reductase] + 3 O(2) = estrone + formate + 4 H(2)O + 3 [oxidized NADPH--hemoprotein reductase].
  • The enzyme catalyzes three sequential hydroxylations of the androgens androst-4-ene-3,17-dione and testosterone, resulting in their aromatization and forming the estrogens estrone and 17-beta- estradiol, respectively.
 26 A0A024R5S8 O42145 O46512 O73686 P11511 P19098 P22443 P28649 P46194 P70091
(16 more...)
Prostaglandin-I synthase. [EC: 5.3.99.4]
(5Z,13E)-(15S)-9-alpha,11-alpha-epidioxy-15-hydroxyprosta-5,13-dienoate = (5Z,13E)-(15S)-6,9-alpha-epoxy-11-alpha,15-dihydroxyprosta-5,13-dienoate.
  • Converts prostaglandin H(2) into prostaglandin I(2) (prostacyclin).
 15 A9LLA5 F6YMG4 G1R5M7 G3HET1 H0X615 K7C397 O35074 Q16647 Q29626 Q62969
(5 more...)
Unspecific monooxygenase. [EC: 1.14.14.1]
RH + [reduced NADPH--hemoprotein reductase] + O(2) = ROH + [oxidized NADPH--hemoprotein reductase] + H(2)O.
  • Acts on a wide range of substrates including many xenobiotics, steroids, fatty acids, vitamins and prostaglandins; reactions catalyzed include hydroxylation, epoxidation, N-oxidation, sulfooxidation, N-, S- and O-dealkylations, desulfation, deamination, and reduction of azo, nitro and N-oxide groups.
  • Together with EC 1.6.2.4, it forms a system in which two reducing equivalents are supplied by NADPH.
  • Some of the reactions attributed to EC 1.14.15.3 belong here.
  • Formerly EC 1.14.1.1, EC 1.14.14.2, EC 1.14.99.8 and EC 1.99.1.1.
 12 A0A061IC63 A0A191Y1Z3 C9WPI9 K7N9Z5 K7NAC7 K7NAI8 K7NAJ2 Q45RG7 Q7T1M6 Q7T1M7
(2 more...)
Cholesterol 7-alpha-monooxygenase. [EC: 1.14.14.23]
Cholesterol + [reduced NADPH--hemoprotein reductase] + O(2) = 7-alpha- hydroxycholesterol + [oxidized NADPH--hemoprotein reductase] + H(2)O.
  • Catalyzes the first step in the biosynthesis of bile acids.
  • The direct electron donor to the enzyme is EC 1.6.2.4.
  • Formerly EC 1.14.13.17.
 7 A0A0B8RT12 O46491 P18125 P22680 P46634 P51542 Q64505
Transferred entry: 1.14.14.23. [EC: 1.14.13.17]
    		3 A0A140H636 A2QPL7 C1K3N8
    25/26-hydroxycholesterol 7-alpha-hydroxylase. [EC: 1.14.14.29]
    (1) Cholest-5-ene-3-beta,25-diol + [reduced NADPH--hemoprotein reductase] + O(2) = cholest-5-ene-3-beta,7-alpha,25-triol + [oxidized NADPH- -hemoprotein reductase] + H(2)O. (2) (25R)-cholest-5-ene-3-beta,26-diol + [reduced NADPH--hemoprotein reductase] + O(2) = (25R)-cholest-5-ene-3-beta,7-alpha,26-triol + [oxidized NADPH--hemoprotein reductase] + H(2)O.
    • Unlike EC 1.14.14.26, which is specific for its oxysterol substrate, this enzyme can also metabolize the oxysterols 24,25- epoxycholesterol, 22-hydroxycholesterol and 24-hydroxycholesterol, but to a lesser extent.
    • The direct electron donor to the enzyme is EC 1.6.2.4.
    • Formerly EC 1.14.13.60 and EC 1.14.13.100.
    		 3 O75881 Q60991 Q63688
    7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase. [EC: 1.14.18.8]
    7-alpha-hydroxycholest-4-en-3-one + 2 ferrocytochrome b5 + 2 H(+) + O(2) = 7-alpha,12-alpha-dihydroxycholest-4-en-3-one + 2 ferricytochrome b5 + + H(2)O.
    • Requires EC 1.6.2.4 and cytochrome b5 for maximal activity.
    • Important in bile acid biosynthesis, being responsible for the balance between the formation of cholic acid and chenodeoxycholic acid.
    • Formerly EC 1.14.13.95.
    		 3 O02766 O88962 Q9UNU6
    Transferred entry: 1.14.18.8. [EC: 1.14.13.95]
      		1 G3H978
      5-beta-cholestane-3-alpha,7-alpha-diol 12-alpha-hydroxylase. [EC: 1.14.13.96]
      5-beta-cholestane-3-alpha,7-alpha-diol + NADPH + O(2) = 5-beta- cholestane-3-alpha,7-alpha,12-alpha-triol + NADP(+) + H(2)O.
      • Key enzyme in the biosynthesis of the bile acid cholic acid (3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholanoic acid).
      • The activity determines the biosynthetic ratio between cholic acid and chenodeoxycholic acid.
      • Can also hydroxylate the substrate at the 25 and 26 position, but to a lesser extent.
      		 1 Q7YRB2