The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Cytochrome P450
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 29449: Steroid 21-hydroxylase, CYP21

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 19 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Steroid hydroxylase activity GO:0008395
Catalysis of the formation of a hydroxyl group on a steroid by incorporation of oxygen from O2.
7 P00191 (/ISS) P03940 (/ISS) P15540 (/ISS) Q2LA59 (/ISS) Q2LA60 (/ISS) Q2LCM1 (/ISS) Q8WNW0 (/ISS)
Monooxygenase activity GO:0004497
Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water.
2 G4N3P7 (/IGC) Q2KGW4 (/IGC)
Steroid 21-monooxygenase activity GO:0004509
Catalysis of the reaction: a steroid + donor-H2 + O2 = a 21-hydroxysteroid + acceptor + H2O.
2 P08686 (/IDA) Q64562 (/IDA)
Iron ion binding GO:0005506
Interacting selectively and non-covalently with iron (Fe) ions.
2 G4N3P7 (/IGC) Q2KGW4 (/IGC)
Heme binding GO:0020037
Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring.
2 G4N3P7 (/IGC) Q2KGW4 (/IGC)
Monooxygenase activity GO:0004497
Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water.
1 Q6UEG2 (/IDA)
Steroid 21-monooxygenase activity GO:0004509
Catalysis of the reaction: a steroid + donor-H2 + O2 = a 21-hydroxysteroid + acceptor + H2O.
1 P03940 (/ISO)
Steroid 21-monooxygenase activity GO:0004509
Catalysis of the reaction: a steroid + donor-H2 + O2 = a 21-hydroxysteroid + acceptor + H2O.
1 P08686 (/TAS)
Steroid hydroxylase activity GO:0008395
Catalysis of the formation of a hydroxyl group on a steroid by incorporation of oxygen from O2.
1 P08686 (/IMP)
Steroid hydroxylase activity GO:0008395
Catalysis of the formation of a hydroxyl group on a steroid by incorporation of oxygen from O2.
1 P03940 (/ISO)
Steroid hydroxylase activity GO:0008395
Catalysis of the formation of a hydroxyl group on a steroid by incorporation of oxygen from O2.
1 P08686 (/TAS)
Oxidoreductase activity GO:0016491
Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.
1 Q2KGW4 (/IGC)
Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen GO:0016705
Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor.
1 Q6UEG2 (/IDA)
Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen GO:0016705
Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor.
1 Q00714 (/RCA)
Phenylacetate hydroxylase activity GO:0018631
Catalysis of the reaction: phenylacetate + NADH + O2 = NAD+ + OH- + 2-hydroxyphenylacetate.
1 Q9Y7G5 (/IMP)
Heme binding GO:0020037
Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring.
1 P08686 (/IDA)
Heme binding GO:0020037
Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring.
1 P03940 (/ISO)
Versicolorin reductase activity GO:0042469
Catalysis of the reduction of versicolorin A to sterigmatocystin.
1 Q00714 (/IMP)
Metal ion binding GO:0046872
Interacting selectively and non-covalently with any metal ion.
1 Q2KGW4 (/IGC)

There are 19 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Steroid metabolic process GO:0008202
The chemical reactions and pathways involving steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus.
7 P00191 (/ISS) P03940 (/ISS) P15540 (/ISS) Q2LA59 (/ISS) Q2LA60 (/ISS) Q2LCM1 (/ISS) Q8WNW0 (/ISS)
Steroid biosynthetic process GO:0006694
The chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus; includes de novo formation and steroid interconversion by modification.
1 P08686 (/IDA)
Steroid biosynthetic process GO:0006694
The chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus; includes de novo formation and steroid interconversion by modification.
1 P03940 (/ISO)
C21-steroid hormone biosynthetic process GO:0006700
The chemical reactions and pathways resulting in the formation of C21-steroid hormones, steroid compounds containing 21 carbons which function as hormones.
1 Q64562 (/IMP)
Glucocorticoid biosynthetic process GO:0006704
The chemical reactions and pathways resulting in the formation of glucocorticoids, hormonal C21 corticosteroids synthesized from cholesterol.
1 P08686 (/TAS)
Mineralocorticoid biosynthetic process GO:0006705
The chemical reactions and pathways resulting in the formation of mineralocorticoids, hormonal C21 corticosteroids synthesized from cholesterol.
1 Q64562 (/IDA)
Mineralocorticoid biosynthetic process GO:0006705
The chemical reactions and pathways resulting in the formation of mineralocorticoids, hormonal C21 corticosteroids synthesized from cholesterol.
1 P08686 (/TAS)
Steroid metabolic process GO:0008202
The chemical reactions and pathways involving steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus.
1 P08686 (/IMP)
Steroid metabolic process GO:0008202
The chemical reactions and pathways involving steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus.
1 P03940 (/ISO)
Phenylacetate catabolic process GO:0010124
The chemical reactions and pathways resulting in the breakdown of phenylacetate.
1 Q9Y7G5 (/IMP)
Positive regulation of sterigmatocystin biosynthetic process GO:0010914
Any process that increases the rate, frequency, or extent of sterigmatocystin biosynthesis. Sterigmatocystin biosynthetic processes are the chemical reactions and pathways resulting in the formation of sterigmatocystin, a carcinogenic mycotoxin produced in high yields by strains of the common molds.
1 Q00714 (/IMP)
Sterol metabolic process GO:0016125
The chemical reactions and pathways involving sterols, steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule.
1 P08686 (/TAS)
Secondary metabolic process GO:0019748
The chemical reactions and pathways resulting in many of the chemical changes of compounds that are not necessarily required for growth and maintenance of cells, and are often unique to a taxon. In multicellular organisms secondary metabolism is generally carried out in specific cell types, and may be useful for the organism as a whole. In unicellular organisms, secondary metabolism is often used for the production of antibiotics or for the utilization and acquisition of unusual nutrients.
1 Q00714 (/RCA)
Penicillin biosynthetic process GO:0042318
The chemical reactions and pathways resulting in the formation of any antibiotic that contains the condensed beta-lactamthiazolidine ring system.
1 Q9Y7G5 (/IMP)
Progesterone metabolic process GO:0042448
The chemical reactions and pathways involving progesterone, a steroid hormone produced in the ovary which prepares and maintains the uterus for pregnancy. Also found in plants.
1 Q64562 (/IDA)
Aflatoxin biosynthetic process GO:0045122
The chemical reactions and pathways resulting in the formation of aflatoxin, a fungal metabolite found as a contaminant in moldy grains that induces liver cancer. Aflatoxin induces a G to T transversion at codon 249 of p53, leading to its inactivation. Aflatoxin is converted to a chemical carcinogen by P450.
1 Q6UEG2 (/IDA)
Sterigmatocystin biosynthetic process GO:0045461
The chemical reactions and pathways resulting in the formation of sterigmatocystin, a carcinogenic mycotoxin produced in high yields by strains of the common molds.
1 Q00714 (/IMP)
Response to antibiotic GO:0046677
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antibiotic stimulus. An antibiotic is a chemical substance produced by a microorganism which has the capacity to inhibit the growth of or to kill other microorganisms.
1 Q64562 (/IEP)
Cellular response to peptide hormone stimulus GO:0071375
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide hormone stimulus. A peptide hormone is any of a class of peptides that are secreted into the blood stream and have endocrine functions in living animals.
1 Q64562 (/IEP)

There are 2 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Endoplasmic reticulum membrane GO:0005789
The lipid bilayer surrounding the endoplasmic reticulum.
1 P08686 (/TAS)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
1 Q2KGW4 (/IGC)