The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Cytochrome P450
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 29449: Steroid 21-hydroxylase, CYP21

There are 4 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Transferred entry: 1.14.14.16. [EC: 1.14.99.10]
    14 C7DTU9 Q16746 Q16748 Q1EM51 Q1EM52 Q1EM53 Q1H8Y2 Q1H8Y3 Q1H8Y4 Q1H8Y5
    (4 more...)
    Steroid 21-monooxygenase. [EC: 1.14.14.16]
    A C(21) steroid + [reduced NADPH--hemoprotein reductase] + O(2) = a 21-hydroxy-C(21)-steroid + [oxidized NADPH--hemoprotein reductase] + H(2)O.
    • For the conversion of progesterone and 17-alpha-hydroxyprogesterone to their respective 21-hydroxylated derivatives, 11-deoxycorticosterone and 11-deoxycortisol.
    • Involved in the biosynthesis of the hormones aldosterone and cortisol.
    • The electron donor is EC 1.6.2.4.
    • Formerly EC 1.14.1.8, EC 1.14.99.10 and EC 1.99.1.11.
    10 K9LHU1 P00191 P03940 P08686 P15540 Q2LA59 Q2LA60 Q2LCM1 Q64562 Q8WNW0
    Unspecific monooxygenase. [EC: 1.14.14.1]
    RH + [reduced NADPH--hemoprotein reductase] + O(2) = ROH + [oxidized NADPH--hemoprotein reductase] + H(2)O.
    • Acts on a wide range of substrates including many xenobiotics, steroids, fatty acids, vitamins and prostaglandins; reactions catalyzed include hydroxylation, epoxidation, N-oxidation, sulfooxidation, N-, S- and O-dealkylations, desulfation, deamination, and reduction of azo, nitro and N-oxide groups.
    • Together with EC 1.6.2.4, it forms a system in which two reducing equivalents are supplied by NADPH.
    • Some of the reactions attributed to EC 1.14.15.3 belong here.
    • Formerly EC 1.14.1.1, EC 1.14.14.2, EC 1.14.99.8 and EC 1.99.1.1.
    6 A0A0F4YNZ5 A2R6S7 B6HHQ0 Q9URR5 Q9URR6 Q9URR7
    Sterol 14-alpha-demethylase. [EC: 1.14.13.70]
    A 14-alpha-methylsteroid + 3 O(2) + 3 NADPH = a Delta(14)-steroid + formate + 3 NADP(+) + 4 H(2)O.
    • This heme-thiolate (P450) enzyme acts on a range of steroids with a 14-alpha-methyl group, such as obtusifoliol and lanosterol.
    • The enzyme catalyzes two successive hydroxylations of the 14-alpha- methyl group, followed by elimination as formate, leaving a 14(15) double bond.
    1 A0A0L1I0X9