The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Death Domain, Fas
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 5221: Baculoviral IAP repeat-containing 2

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 62 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
16 A0A0G2QC28 (/IPI) D9I2F9 (/IPI) G3V8L1 (/IPI) O08863 (/IPI) P29452 (/IPI) P29466 (/IPI) P43527 (/IPI) Q13489 (/IPI) Q13490 (/IPI) Q2LKU9 (/IPI)
(6 more)
ATP binding GO:0005524
Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
4 A1Z198 (/ISO) Q2LKV5 (/ISO) Q2LKW6 (/ISO) Q3UP24 (/ISO)
Enzyme binding GO:0019899
Interacting selectively and non-covalently with any enzyme.
4 A1Z198 (/ISO) Q2LKV5 (/ISO) Q2LKW6 (/ISO) Q9EPB4 (/ISO)
Protein domain specific binding GO:0019904
Interacting selectively and non-covalently with a specific domain of a protein.
3 A1Z198 (/ISO) Q2LKV5 (/ISO) Q2LKW6 (/ISO)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
3 Q9NPP4 (/IDA) Q9ULZ3 (/IDA) Q9Y2G2 (/IDA)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
3 Q3UP24 (/ISS) Q8HXK9 (/ISS) Q9EPB4 (/ISS)
Scaffold protein binding GO:0097110
Interacting selectively and non-covalently with a scaffold protein. Scaffold proteins are crucial regulators of many key signaling pathways. Although not strictly defined in function, they are known to interact and/or bind with multiple members of a signaling pathway, tethering them into complexes.
3 A0A0G2QC28 (/IPI) D9I2F9 (/IPI) P43527 (/IPI)
Protease binding GO:0002020
Interacting selectively and non-covalently with any protease or peptidase.
2 G3V8L1 (/IPI) Q9ULZ3 (/IPI)
Ubiquitin-protein transferase activity GO:0004842
Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages.
2 Q13489 (/EXP) Q13490 (/EXP)
Ubiquitin-protein transferase activity GO:0004842
Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages.
2 Q13489 (/IDA) Q13490 (/IDA)
Ubiquitin-protein transferase activity GO:0004842
Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages.
2 O08863 (/ISO) Q62210 (/ISO)
Ubiquitin-protein transferase activity GO:0004842
Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages.
2 Q13489 (/TAS) Q13490 (/TAS)
ATP binding GO:0005524
Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
2 Q9C000 (/IDA) Q9NPP4 (/IDA)
ATP binding GO:0005524
Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
2 Q2LKU9 (/ISS) Q3UP24 (/ISS)
Cysteine-type endopeptidase activator activity involved in apoptotic process GO:0008656
Increases the rate of proteolysis catalyzed by a cysteine-type endopeptidase involved in the apoptotic process.
2 Q9C000 (/NAS) Q9ULZ3 (/NAS)
Transferase activity GO:0016740
Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2.
2 Q13489 (/EXP) Q13490 (/EXP)
Transferase activity GO:0016740
Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2.
2 O08863 (/ISO) Q62210 (/ISO)
Enzyme binding GO:0019899
Interacting selectively and non-covalently with any enzyme.
2 Q9C000 (/IPI) Q9ULZ3 (/IPI)
Pyrin domain binding GO:0032090
Interacting selectively and non-covalently with a Pyrin (PAAD/DAPIN) domain, a protein-protein interaction domain that has the same fold as the Death domain.
2 Q9I9N6 (/IPI) Q9ULZ3 (/IPI)
Pyrin domain binding GO:0032090
Interacting selectively and non-covalently with a Pyrin (PAAD/DAPIN) domain, a protein-protein interaction domain that has the same fold as the Death domain.
2 Q8HXK9 (/ISS) Q9EPB4 (/ISS)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
2 Q9NPP4 (/IPI) Q9ULZ3 (/IPI)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
2 Q3UP24 (/ISO) Q9EPB4 (/ISO)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
2 Q3UP24 (/ISO) Q9EPB4 (/ISO)
Magnesium ion binding GO:0000287
Interacting selectively and non-covalently with magnesium (Mg) ions.
1 Q9NPP4 (/TAS)
Protease binding GO:0002020
Interacting selectively and non-covalently with any protease or peptidase.
1 Q9EPB4 (/ISO)
Transcription coactivator activity GO:0003713
Interacting selectively and non-covalently with a activating transcription factor and also with the basal transcription machinery in order to increase the frequency, rate or extent of transcription. Cofactors generally do not bind the template nucleic acid, but rather mediate protein-protein interactions between activating transcription factors and the basal transcription machinery.
1 Q13490 (/IMP)
Transcription coactivator activity GO:0003713
Interacting selectively and non-covalently with a activating transcription factor and also with the basal transcription machinery in order to increase the frequency, rate or extent of transcription. Cofactors generally do not bind the template nucleic acid, but rather mediate protein-protein interactions between activating transcription factors and the basal transcription machinery.
1 Q62210 (/ISO)
Transcription coactivator activity GO:0003713
Interacting selectively and non-covalently with a activating transcription factor and also with the basal transcription machinery in order to increase the frequency, rate or extent of transcription. Cofactors generally do not bind the template nucleic acid, but rather mediate protein-protein interactions between activating transcription factors and the basal transcription machinery.
1 Q62210 (/ISS)
Endopeptidase activity GO:0004175
Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain.
1 P29466 (/IDA)
Endopeptidase activity GO:0004175
Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain.
1 P29452 (/ISO)
Cysteine-type endopeptidase activity GO:0004197
Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile.
1 P29452 (/IDA)
Cysteine-type endopeptidase activity GO:0004197
Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile.
1 P29466 (/TAS)
Ubiquitin-protein transferase activity GO:0004842
Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages.
1 Q62210 (/ISS)
Interleukin-6 receptor binding GO:0005138
Interacting selectively and non-covalently with the interleukin-6 receptor.
1 Q9ULZ3 (/IPI)
Interleukin-6 receptor binding GO:0005138
Interacting selectively and non-covalently with the interleukin-6 receptor.
1 Q9EPB4 (/ISO)
Tropomyosin binding GO:0005523
Interacting selectively and non-covalently with tropomyosin, a protein associated with actin filaments both in cytoplasm and, in association with troponin, in the thin filament of striated muscle.
1 Q9ULZ3 (/IPI)
Tropomyosin binding GO:0005523
Interacting selectively and non-covalently with tropomyosin, a protein associated with actin filaments both in cytoplasm and, in association with troponin, in the thin filament of striated muscle.
1 Q9EPB4 (/ISO)
Peptidase activity GO:0008233
Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid.
1 P29452 (/IDA)
Zinc ion binding GO:0008270
Interacting selectively and non-covalently with zinc (Zn) ions.
1 Q13490 (/IDA)
Zinc ion binding GO:0008270
Interacting selectively and non-covalently with zinc (Zn) ions.
1 Q62210 (/ISO)
Zinc ion binding GO:0008270
Interacting selectively and non-covalently with zinc (Zn) ions.
1 Q62210 (/ISS)
Cysteine-type endopeptidase activator activity involved in apoptotic process GO:0008656
Increases the rate of proteolysis catalyzed by a cysteine-type endopeptidase involved in the apoptotic process.
1 Q9Y2G2 (/IDA)
Cysteine-type endopeptidase activator activity involved in apoptotic process GO:0008656
Increases the rate of proteolysis catalyzed by a cysteine-type endopeptidase involved in the apoptotic process.
1 P29466 (/TAS)
Peptidase activator activity involved in apoptotic process GO:0016505
Increases the activity of a peptidase that is involved in the apoptotic process.
1 Q9EPB4 (/ISO)
Myosin I binding GO:0017024
Interacting selectively and non-covalently with a class I myosin; myosin I heavy chains are single-headed, possess tails of various lengths, and do not self-associate into bipolar filaments.
1 Q9ULZ3 (/IPI)
Myosin I binding GO:0017024
Interacting selectively and non-covalently with a class I myosin; myosin I heavy chains are single-headed, possess tails of various lengths, and do not self-associate into bipolar filaments.
1 Q9EPB4 (/ISO)
Enzyme binding GO:0019899
Interacting selectively and non-covalently with any enzyme.
1 Q2LKU9 (/ISS)
Protein domain specific binding GO:0019904
Interacting selectively and non-covalently with a specific domain of a protein.
1 Q9C000 (/IPI)
NACHT domain binding GO:0032089
Interacting selectively and non-covalently with a NACHT (NAIP, CIITA, HET-E and TP1) domain. The NACHT domain consists of seven distinct conserved motifs, including an ATP/GTPase specific P-loop, a Mg(2+)-binding site and five more specific motifs.
1 Q9Y2G2 (/IPI)
Pyrin domain binding GO:0032090
Interacting selectively and non-covalently with a Pyrin (PAAD/DAPIN) domain, a protein-protein interaction domain that has the same fold as the Death domain.
1 Q9EPB4 (/ISO)
Ubiquitin binding GO:0043130
Interacting selectively and non-covalently with ubiquitin, a protein that when covalently bound to other cellular proteins marks them for proteolytic degradation.
1 Q13490 (/IDA)
Ubiquitin binding GO:0043130
Interacting selectively and non-covalently with ubiquitin, a protein that when covalently bound to other cellular proteins marks them for proteolytic degradation.
1 Q62210 (/ISO)
Ion channel binding GO:0044325
Interacting selectively and non-covalently with one or more specific sites on an ion channel, a protein complex that spans a membrane and forms a water-filled channel across the phospholipid bilayer allowing selective ion transport down its electrochemical gradient.
1 G3V8L1 (/IPI)
Protein dimerization activity GO:0046983
The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits.
1 Q9EPB4 (/IMP)
Protein N-terminus binding GO:0047485
Interacting selectively and non-covalently with a protein N-terminus, the end of any peptide chain at which the 2-amino (or 2-imino) function of a constituent amino acid is not attached in peptide linkage to another amino-acid residue.
1 Q13490 (/IPI)
Protein N-terminus binding GO:0047485
Interacting selectively and non-covalently with a protein N-terminus, the end of any peptide chain at which the 2-amino (or 2-imino) function of a constituent amino acid is not attached in peptide linkage to another amino-acid residue.
1 Q62210 (/ISO)
Chaperone binding GO:0051087
Interacting selectively and non-covalently with a chaperone protein, a class of proteins that bind to nascent or unfolded polypeptides and ensure correct folding or transport.
1 Q13490 (/IPI)
Chaperone binding GO:0051087
Interacting selectively and non-covalently with a chaperone protein, a class of proteins that bind to nascent or unfolded polypeptides and ensure correct folding or transport.
1 Q62210 (/ISO)
BMP receptor binding GO:0070700
Interacting selectively and non-covalently with a BMP receptor.
1 Q9ULZ3 (/IPI)
BMP receptor binding GO:0070700
Interacting selectively and non-covalently with a BMP receptor.
1 Q9EPB4 (/ISO)
FBXO family protein binding GO:0098770
Interacting selectively and non-covalently with any member of the FBXO protein family. Members of this family have an F-box protein motif of approximately 50 amino acids that functions as a site of protein-protein interaction.
1 Q13490 (/IPI)
FBXO family protein binding GO:0098770
Interacting selectively and non-covalently with any member of the FBXO protein family. Members of this family have an F-box protein motif of approximately 50 amino acids that functions as a site of protein-protein interaction.
1 Q62210 (/ISO)

There are 240 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Pyroptosis GO:0070269
A caspase-1-dependent cell death subroutine that is associated with the generation of pyrogenic mediators such as IL-1beta and IL-18.
5 A1Z198 (/IMP) P29452 (/IMP) Q2LKV5 (/IMP) Q2LKW6 (/IMP) Q3UP24 (/IMP)
Activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0006919
Any process that initiates the activity of the inactive enzyme cysteine-type endopeptidase in the context of an apoptotic process.
4 A1Z198 (/ISO) Q2LKV5 (/ISO) Q2LKW6 (/ISO) Q3UP24 (/ISO)
Defense response to bacterium GO:0042742
Reactions triggered in response to the presence of a bacterium that act to protect the cell or organism.
4 F1M649 (/ISS) F1MHT9 (/ISS) Q3UP24 (/ISS) Q9C000 (/ISS)
Regulation of apoptotic process GO:0042981
Any process that modulates the occurrence or rate of cell death by apoptotic process.
4 Q13489 (/IMP) Q13490 (/IMP) Q3UP24 (/IMP) Q9EPB4 (/IMP)
Activation of innate immune response GO:0002218
Any process that initiates an innate immune response. Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. Examples of this process include activation of the hypersensitive response of Arabidopsis thaliana and activation of any NOD or TLR signaling pathway in vertebrate species.
3 F1M649 (/ISS) F1MHT9 (/ISS) Q9NPP4 (/ISS)
Inflammatory response GO:0006954
The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages.
3 F1M649 (/ISS) F1MHT9 (/ISS) Q9NPP4 (/ISS)
Detection of bacterium GO:0016045
The series of events in which a stimulus from a bacterium is received and converted into a molecular signal.
3 F1M649 (/ISS) F1MHT9 (/ISS) Q3UP24 (/ISS)
Protein catabolic process GO:0030163
The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds.
3 A1Z198 (/IMP) Q2LKV5 (/IMP) Q2LKW6 (/IMP)
Interleukin-1 alpha production GO:0032610
The appearance of interleukin-1 alpha due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
3 A1Z198 (/IMP) Q2LKV5 (/IMP) Q2LKW6 (/IMP)
Interleukin-1 beta production GO:0032611
The appearance of interleukin-1 beta due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
3 A1Z198 (/IDA) Q2LKV5 (/IDA) Q2LKW6 (/IDA)
Interleukin-1 beta production GO:0032611
The appearance of interleukin-1 beta due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
3 A1Z198 (/IMP) Q2LKV5 (/IMP) Q2LKW6 (/IMP)
Negative regulation of apoptotic process GO:0043066
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
3 Q13489 (/TAS) Q13490 (/TAS) Q6P6S1 (/TAS)
Interleukin-1 beta secretion GO:0050702
The regulated release of interleukin 1 beta from a cell.
3 F1M649 (/ISS) F1MHT9 (/ISS) Q3UP24 (/ISS)
Positive regulation of interleukin-1 beta secretion GO:0050718
Any process that activates or increases the frequency, rate or extent of the regulated release of interleukin-1 beta from a cell.
3 Q2LKU9 (/IDA) Q9ULZ3 (/IDA) Q9Y2G2 (/IDA)
Positive regulation of interleukin-1 beta secretion GO:0050718
Any process that activates or increases the frequency, rate or extent of the regulated release of interleukin-1 beta from a cell.
3 P29452 (/IMP) P43527 (/IMP) Q9EPB4 (/IMP)
Positive regulation of interleukin-1 beta secretion GO:0050718
Any process that activates or increases the frequency, rate or extent of the regulated release of interleukin-1 beta from a cell.
3 Q8HXK9 (/ISS) Q9C000 (/ISS) Q9EPB4 (/ISS)
Protein homooligomerization GO:0051260
The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer.
3 F1M649 (/ISS) F1MHT9 (/ISS) Q9NPP4 (/ISS)
Protein heterooligomerization GO:0051291
The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of component monomers that are not all identical. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer.
3 F7FLN8 (/IPI) Q5XIW4 (/IPI) Q6P6S1 (/IPI)
Neuron apoptotic process GO:0051402
Any apoptotic process in a neuron, the basic cellular unit of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the nervous system.
3 A1Z198 (/ISO) Q2LKV5 (/ISO) Q2LKW6 (/ISO)
Pyroptosis GO:0070269
A caspase-1-dependent cell death subroutine that is associated with the generation of pyrogenic mediators such as IL-1beta and IL-18.
3 F1M649 (/ISS) F1MHT9 (/ISS) Q9NPP4 (/ISS)
Response to hypoxia GO:0001666
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level.
2 P43527 (/IDA) Q6P6S1 (/IDA)
Activation of innate immune response GO:0002218
Any process that initiates an innate immune response. Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. Examples of this process include activation of the hypersensitive response of Arabidopsis thaliana and activation of any NOD or TLR signaling pathway in vertebrate species.
2 Q3UP24 (/IMP) Q9EPB4 (/IMP)
Myeloid dendritic cell activation involved in immune response GO:0002277
The change in morphology and behavior of a myeloid dendritic cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response.
2 Q8HXK9 (/ISS) Q9ULZ3 (/ISS)
Positive regulation of antigen processing and presentation of peptide antigen via MHC class II GO:0002588
Any process that activates or increases the frequency, rate, or extent of antigen processing and presentation of peptide antigen via MHC class II.
2 Q8HXK9 (/ISS) Q9ULZ3 (/ISS)
Apoptotic process GO:0006915
A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died.
2 P29466 (/TAS) Q9ULZ3 (/TAS)
Activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0006919
Any process that initiates the activity of the inactive enzyme cysteine-type endopeptidase in the context of an apoptotic process.
2 Q9C000 (/IDA) Q9NPP4 (/IDA)
Activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0006919
Any process that initiates the activity of the inactive enzyme cysteine-type endopeptidase in the context of an apoptotic process.
2 Q2LKU9 (/ISS) Q3UP24 (/ISS)
Activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0006919
Any process that initiates the activity of the inactive enzyme cysteine-type endopeptidase in the context of an apoptotic process.
2 Q9C000 (/NAS) Q9ULZ3 (/NAS)
Inflammatory response GO:0006954
The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages.
2 Q3UP24 (/IMP) Q9EPB4 (/IMP)
Cell surface receptor signaling pathway GO:0007166
A series of molecular signals initiated by activation of a receptor on the surface of a cell. The pathway begins with binding of an extracellular ligand to a cell surface receptor, or for receptors that signal in the absence of a ligand, by ligand-withdrawal or the activity of a constitutively active receptor. The pathway ends with regulation of a downstream cellular process, e.g. transcription.
2 Q13489 (/TAS) Q13490 (/TAS)
I-kappaB kinase/NF-kappaB signaling GO:0007249
The process in which a signal is passed on to downstream components within the cell through the I-kappaB-kinase (IKK)-dependent activation of NF-kappaB. The cascade begins with activation of a trimeric IKK complex (consisting of catalytic kinase subunits IKKalpha and/or IKKbeta, and the regulatory scaffold protein NEMO) and ends with the regulation of transcription of target genes by NF-kappaB. In a resting state, NF-kappaB dimers are bound to I-kappaB proteins, sequestering NF-kappaB in the cytoplasm. Phosphorylation of I-kappaB targets I-kappaB for ubiquitination and proteasomal degradation, thus releasing the NF-kappaB dimers, which can translocate to the nucleus to bind DNA and regulate transcription.
2 Q13489 (/TAS) Q13490 (/TAS)
Spermatogenesis GO:0007283
The process of formation of spermatozoa, including spermatocytogenesis and spermiogenesis.
2 F7FLN8 (/IEP) Q5XIW4 (/IEP)
Response to bacterium GO:0009617
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a bacterium.
2 P29452 (/IMP) Q9EPB4 (/IMP)
Regulation of autophagy GO:0010506
Any process that modulates the frequency, rate or extent of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm.
2 P29452 (/IMP) Q9EPB4 (/IMP)
Regulation of tumor necrosis factor-mediated signaling pathway GO:0010803
Any process that modulates the rate or extent of the tumor necrosis factor-mediated signaling pathway. The tumor necrosis factor-mediated signaling pathway is the series of molecular signals generated as a consequence of tumor necrosis factor binding to a cell surface receptor.
2 Q13489 (/TAS) Q13490 (/TAS)
Protein deubiquitination GO:0016579
The removal of one or more ubiquitin groups from a protein.
2 Q13489 (/TAS) Q13490 (/TAS)
Positive regulation of actin filament polymerization GO:0030838
Any process that activates or increases the frequency, rate or extent of actin polymerization.
2 Q8HXK9 (/ISS) Q9ULZ3 (/ISS)
Regulation of protein stability GO:0031647
Any process that affects the structure and integrity of a protein, altering the likelihood of its degradation or aggregation.
2 Q8HXK9 (/ISS) Q9ULZ3 (/ISS)
Interleukin-1 beta production GO:0032611
The appearance of interleukin-1 beta due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
2 P29452 (/IGI) Q9EPB4 (/IGI)
Positive regulation of interferon-gamma production GO:0032729
Any process that activates or increases the frequency, rate, or extent of interferon-gamma production. Interferon-gamma is also known as type II interferon.
2 Q8HXK9 (/ISS) Q9ULZ3 (/ISS)
Positive regulation of interleukin-6 production GO:0032755
Any process that activates or increases the frequency, rate, or extent of interleukin-6 production.
2 Q8HXK9 (/ISS) Q9ULZ3 (/ISS)
Tumor necrosis factor-mediated signaling pathway GO:0033209
A series of molecular signals initiated by the binding of a tumor necrosis factor to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
2 Q13489 (/TAS) Q13490 (/TAS)
Regulation of toll-like receptor signaling pathway GO:0034121
Any process that modulates the frequency, rate, or extent of toll-like receptor signaling pathway.
2 Q13489 (/TAS) Q13490 (/TAS)
TRIF-dependent toll-like receptor signaling pathway GO:0035666
Any series of molecular signals generated as a consequence of binding to a toll-like receptor where the TRIF adaptor mediates transduction of the signal. Toll-like receptors directly bind pattern motifs from a variety of microbial sources to initiate innate immune response.
2 Q13489 (/TAS) Q13490 (/TAS)
NIK/NF-kappaB signaling GO:0038061
The process in which a signal is passed on to downstream components within the cell through the NIK-dependent processing and activation of NF-KappaB. Begins with activation of the NF-KappaB-inducing kinase (NIK), which in turn phosphorylates and activates IkappaB kinase alpha (IKKalpha). IKKalpha phosphorylates the NF-Kappa B2 protein (p100) leading to p100 processing and release of an active NF-KappaB (p52).
2 Q13489 (/TAS) Q13490 (/TAS)
Regulation of RIG-I signaling pathway GO:0039535
Any process that modulates the frequency, rate or extent of the series of molecular signals generated as a consequence of the cytoplasmic pattern recognition receptor (PRR) RIG-1 (also known as DDX58) binding to viral RNA.
2 Q13489 (/TAS) Q13490 (/TAS)
Positive regulation of activated T cell proliferation GO:0042104
Any process that activates or increases the rate or extent of activated T cell proliferation.
2 Q8HXK9 (/ISS) Q9ULZ3 (/ISS)
Defense response to bacterium GO:0042742
Reactions triggered in response to the presence of a bacterium that act to protect the cell or organism.
2 Q2LKU9 (/IDA) Q9NPP4 (/IDA)
Regulation of apoptotic process GO:0042981
Any process that modulates the occurrence or rate of cell death by apoptotic process.
2 O08863 (/ISO) Q62210 (/ISO)
Regulation of apoptotic process GO:0042981
Any process that modulates the occurrence or rate of cell death by apoptotic process.
2 P29466 (/TAS) Q9NPP4 (/TAS)
Positive regulation of apoptotic process GO:0043065
Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process.
2 Q9NPP4 (/IDA) Q9ULZ3 (/IDA)
Positive regulation of apoptotic process GO:0043065
Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process.
2 Q3UP24 (/ISO) Q9EPB4 (/ISO)
Negative regulation of apoptotic process GO:0043066
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
2 Q13490 (/IDA) Q90660 (/IDA)
Negative regulation of apoptotic process GO:0043066
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
2 F7FLN8 (/NAS) Q5XIW4 (/NAS)
Positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123
Any process that activates or increases the frequency, rate or extent of I-kappaB kinase/NF-kappaB signaling.
2 P29466 (/IEP) Q13490 (/IEP)
Negative regulation of I-kappaB kinase/NF-kappaB signaling GO:0043124
Any process that stops, prevents, or reduces the frequency, rate or extent of -kappaB kinase/NF-kappaB signaling.
2 Q9ULZ3 (/IDA) Q9Y2G2 (/IDA)
Positive regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043280
Any process that activates or increases the activity of a cysteine-type endopeptidase involved in the apoptotic process.
2 Q9ULZ3 (/IDA) Q9Y2G2 (/IDA)
Positive regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043280
Any process that activates or increases the activity of a cysteine-type endopeptidase involved in the apoptotic process.
2 Q8HXK9 (/ISS) Q9EPB4 (/ISS)
Regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043281
Any process that modulates the activity of a cysteine-type endopeptidase involved in apoptosis.
2 Q3UP24 (/IMP) Q9EPB4 (/IMP)
Macropinocytosis GO:0044351
An endocytosis process that results in the uptake of liquid material by cells from their external environment by the 'ruffling' of the cell membrane to form heterogeneously sized intracellular vesicles called macropinosomes, which can be up to 5 micrometers in size.
2 Q8HXK9 (/ISS) Q9ULZ3 (/ISS)
Regulation of innate immune response GO:0045088
Any process that modulates the frequency, rate or extent of the innate immune response, the organism's first line of defense against infection.
2 Q13489 (/TAS) Q13490 (/TAS)
Positive regulation of cytokine secretion GO:0050715
Any process that activates or increases the frequency, rate or extent of the regulated release of cytokines from a cell.
2 P29452 (/IMP) P43527 (/IMP)
Regulation of inflammatory response GO:0050727
Any process that modulates the frequency, rate or extent of the inflammatory response, the immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents.
2 P29452 (/IMP) Q9EPB4 (/IMP)
Regulation of inflammatory response GO:0050727
Any process that modulates the frequency, rate or extent of the inflammatory response, the immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents.
2 Q13489 (/TAS) Q13490 (/TAS)
Positive regulation of phagocytosis GO:0050766
Any process that activates or increases the frequency, rate or extent of phagocytosis.
2 Q8HXK9 (/ISS) Q9ULZ3 (/ISS)
Positive regulation of NF-kappaB transcription factor activity GO:0051092
Any process that activates or increases the frequency, rate or extent of activity of the transcription factor NF-kappaB.
2 Q9NPP4 (/IDA) Q9ULZ3 (/IDA)
Positive regulation of NF-kappaB transcription factor activity GO:0051092
Any process that activates or increases the frequency, rate or extent of activity of the transcription factor NF-kappaB.
2 Q3UP24 (/ISO) Q9EPB4 (/ISO)
Regulation of necroptotic process GO:0060544
Any process that modulates the rate, frequency or extent of a necroptotic process, a necrotic cell death process that results from the activation of endogenous cellular processes, such as signaling involving death domain receptors or Toll-like receptors.
2 Q13489 (/IMP) Q13490 (/IMP)
Regulation of necroptotic process GO:0060544
Any process that modulates the rate, frequency or extent of a necroptotic process, a necrotic cell death process that results from the activation of endogenous cellular processes, such as signaling involving death domain receptors or Toll-like receptors.
2 O08863 (/ISO) Q62210 (/ISO)
Regulation of necroptotic process GO:0060544
Any process that modulates the rate, frequency or extent of a necroptotic process, a necrotic cell death process that results from the activation of endogenous cellular processes, such as signaling involving death domain receptors or Toll-like receptors.
2 Q13489 (/TAS) Q13490 (/TAS)
Positive regulation of ERK1 and ERK2 cascade GO:0070374
Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade.
2 Q9EPB4 (/IMP) Q9ULZ3 (/IMP)
Regulation of nucleotide-binding oligomerization domain containing signaling pathway GO:0070424
Any process that modulates the frequency, rate, or extent of a nucleotide-binding oligomerization domain containing (NOD) pathway.
2 Q13489 (/TAS) Q13490 (/TAS)
Cellular response to tumor necrosis factor GO:0071356
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tumor necrosis factor stimulus.
2 O08863 (/IGI) Q62210 (/IGI)
Positive regulation of chemokine secretion GO:0090197
Any process that increases the rate, frequency or extent of chemokine secretion, the regulated release of chemokines from a cell.
2 Q9EPB4 (/IMP) Q9ULZ3 (/IMP)
Programmed necrotic cell death GO:0097300
A necrotic cell death process that results from the activation of endogenous cellular processes, such as signaling involving death domain receptors or Toll-like receptors.
2 P29452 (/IDA) Q2LKU9 (/IDA)
Regulation of NIK/NF-kappaB signaling GO:1901222
Any process that modulates the frequency, rate or extent of NIK/NF-kappaB signaling.
2 O08863 (/IGI) Q62210 (/IGI)
Positive regulation of protein polyubiquitination GO:1902916
Any process that activates or increases the frequency, rate or extent of protein polyubiquitination.
2 O08863 (/IGI) Q62210 (/IGI)
Regulation of cysteine-type endopeptidase activity GO:2000116
Any process that modulates the frequency, rate or extent of cysteine-type endopeptidase activity.
2 Q13489 (/TAS) Q13490 (/TAS)
Positive regulation of T cell migration GO:2000406
Any process that activates or increases the frequency, rate or extent of T cell migration.
2 Q8HXK9 (/ISS) Q9ULZ3 (/ISS)
Protein polyubiquitination GO:0000209
Addition of multiple ubiquitin groups to a protein, forming a ubiquitin chain.
1 Q13490 (/IDA)
Protein polyubiquitination GO:0000209
Addition of multiple ubiquitin groups to a protein, forming a ubiquitin chain.
1 Q62210 (/ISO)
Protein polyubiquitination GO:0000209
Addition of multiple ubiquitin groups to a protein, forming a ubiquitin chain.
1 Q62210 (/ISS)
Response to hypoxia GO:0001666
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level.
1 P29452 (/IMP)
Myeloid dendritic cell activation GO:0001773
The change in morphology and behavior of a dendritic cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor.
1 Q9ULZ3 (/IMP)
Myeloid dendritic cell activation GO:0001773
The change in morphology and behavior of a dendritic cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor.
1 Q9EPB4 (/ISO)
Microglial cell activation GO:0001774
The change in morphology and behavior of a microglial cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor.
1 P43527 (/IMP)
Placenta development GO:0001890
The process whose specific outcome is the progression of the placenta over time, from its formation to the mature structure. The placenta is an organ of metabolic interchange between fetus and mother, partly of embryonic origin and partly of maternal origin.
1 Q62210 (/IMP)
Activation of innate immune response GO:0002218
Any process that initiates an innate immune response. Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. Examples of this process include activation of the hypersensitive response of Arabidopsis thaliana and activation of any NOD or TLR signaling pathway in vertebrate species.
1 Q9ULZ3 (/IDA)
Activation of innate immune response GO:0002218
Any process that initiates an innate immune response. Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. Examples of this process include activation of the hypersensitive response of Arabidopsis thaliana and activation of any NOD or TLR signaling pathway in vertebrate species.
1 Q9EPB4 (/ISO)
Positive regulation of defense response to virus by host GO:0002230
Any host process that results in the promotion of antiviral immune response mechanisms, thereby limiting viral replication.
1 Q9EPB4 (/IMP)
Myeloid dendritic cell activation involved in immune response GO:0002277
The change in morphology and behavior of a myeloid dendritic cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response.
1 Q9EPB4 (/IMP)
Positive regulation of antigen processing and presentation of peptide antigen via MHC class II GO:0002588
Any process that activates or increases the frequency, rate, or extent of antigen processing and presentation of peptide antigen via MHC class II.
1 Q9EPB4 (/IMP)
Positive regulation of adaptive immune response GO:0002821
Any process that activates or increases the frequency, rate, or extent of an adaptive immune response.
1 Q9ULZ3 (/IMP)
Positive regulation of adaptive immune response GO:0002821
Any process that activates or increases the frequency, rate, or extent of an adaptive immune response.
1 Q9EPB4 (/ISO)
Proteolysis GO:0006508
The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.
1 P29466 (/IDA)
Proteolysis GO:0006508
The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.
1 P29452 (/ISO)
Proteolysis GO:0006508
The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.
1 P29466 (/TAS)
Apoptotic process GO:0006915
A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died.
1 P43527 (/IEP)
Apoptotic process GO:0006915
A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died.
1 Q9EPB4 (/ISO)
Apoptotic process GO:0006915
A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died.
1 Q9C000 (/NAS)
Activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0006919
Any process that initiates the activity of the inactive enzyme cysteine-type endopeptidase in the context of an apoptotic process.
1 Q9EPB4 (/IMP)
Signal transduction GO:0007165
The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.
1 Q9ULZ3 (/NAS)
Signal transduction GO:0007165
The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.
1 P29466 (/TAS)
Midgut development GO:0007494
The process whose specific outcome is the progression of the midgut over time, from its formation to the mature structure. The midgut is the middle part of the alimentary canal from the stomach, or entrance of the bile duct, to, or including, the large intestine.
1 P43527 (/IEP)
Myoblast fusion GO:0007520
A process in which non-proliferating myoblasts fuse to existing fibers or to myotubes to form new fibers. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers.
1 P43527 (/IMP)
Memory GO:0007613
The activities involved in the mental information processing system that receives (registers), modifies, stores, and retrieves informational stimuli. The main stages involved in the formation and retrieval of memory are encoding (processing of received information by acquisition), storage (building a permanent record of received information as a result of consolidation) and retrieval (calling back the stored information and use it in a suitable way to execute a given task).
1 P43527 (/IMP)
Response to toxic substance GO:0009636
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a toxic stimulus.
1 P43527 (/IEP)
Response to organonitrogen compound GO:0010243
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organonitrogen stimulus. An organonitrogen compound is formally a compound containing at least one carbon-nitrogen bond.
1 Q6P6S1 (/IEP)
Regulation of tumor necrosis factor-mediated signaling pathway GO:0010803
Any process that modulates the rate or extent of the tumor necrosis factor-mediated signaling pathway. The tumor necrosis factor-mediated signaling pathway is the series of molecular signals generated as a consequence of tumor necrosis factor binding to a cell surface receptor.
1 Q9ULZ3 (/IMP)
Regulation of tumor necrosis factor-mediated signaling pathway GO:0010803
Any process that modulates the rate or extent of the tumor necrosis factor-mediated signaling pathway. The tumor necrosis factor-mediated signaling pathway is the series of molecular signals generated as a consequence of tumor necrosis factor binding to a cell surface receptor.
1 Q9EPB4 (/ISO)
Response to organic cyclic compound GO:0014070
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic cyclic compound stimulus.
1 P43527 (/IDA)
Response to organic cyclic compound GO:0014070
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic cyclic compound stimulus.
1 Q6P6S1 (/IEP)
Detection of bacterium GO:0016045
The series of events in which a stimulus from a bacterium is received and converted into a molecular signal.
1 Q9NPP4 (/IDA)
Detection of bacterium GO:0016045
The series of events in which a stimulus from a bacterium is received and converted into a molecular signal.
1 Q3UP24 (/IMP)
Detection of bacterium GO:0016045
The series of events in which a stimulus from a bacterium is received and converted into a molecular signal.
1 Q3UP24 (/ISO)
Protein processing GO:0016485
Any protein maturation process achieved by the cleavage of a peptide bond or bonds within a protein. Protein maturation is the process leading to the attainment of the full functional capacity of a protein.
1 P29452 (/IDA)
Protein processing GO:0016485
Any protein maturation process achieved by the cleavage of a peptide bond or bonds within a protein. Protein maturation is the process leading to the attainment of the full functional capacity of a protein.
1 P29452 (/IMP)
Lung development GO:0030324
The process whose specific outcome is the progression of the lung over time, from its formation to the mature structure. In all air-breathing vertebrates the lungs are developed from the ventral wall of the oesophagus as a pouch which divides into two sacs. In amphibians and many reptiles the lungs retain very nearly this primitive sac-like character, but in the higher forms the connection with the esophagus becomes elongated into the windpipe and the inner walls of the sacs become more and more divided, until, in the mammals, the air spaces become minutely divided into tubes ending in small air cells, in the walls of which the blood circulates in a fine network of capillaries. In mammals the lungs are more or less divided into lobes, and each lung occupies a separate cavity in the thorax.
1 P43527 (/IEP)
Positive regulation of actin filament polymerization GO:0030838
Any process that activates or increases the frequency, rate or extent of actin polymerization.
1 Q9EPB4 (/IMP)
Positive regulation of protein ubiquitination GO:0031398
Any process that activates or increases the frequency, rate or extent of the addition of ubiquitin groups to a protein.
1 Q13489 (/IDA)
Positive regulation of protein ubiquitination GO:0031398
Any process that activates or increases the frequency, rate or extent of the addition of ubiquitin groups to a protein.
1 O08863 (/ISO)
Regulation of protein stability GO:0031647
Any process that affects the structure and integrity of a protein, altering the likelihood of its degradation or aggregation.
1 Q9EPB4 (/IMP)
Negative regulation of NF-kappaB transcription factor activity GO:0032088
Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of the transcription factor NF-kappaB.
1 B0V1H3 (/IDA)
Negative regulation of NF-kappaB transcription factor activity GO:0032088
Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of the transcription factor NF-kappaB.
1 Q9ULZ3 (/IMP)
Negative regulation of NF-kappaB transcription factor activity GO:0032088
Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of the transcription factor NF-kappaB.
1 Q9EPB4 (/ISO)
Response to muramyl dipeptide GO:0032495
Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a muramyl dipeptide stimulus. Muramyl dipeptide is derived from peptidoglycan.
1 Q2LKU9 (/IDA)
Response to muramyl dipeptide GO:0032495
Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a muramyl dipeptide stimulus. Muramyl dipeptide is derived from peptidoglycan.
1 Q9C000 (/ISS)
Response to lipopolysaccharide GO:0032496
Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria.
1 P29452 (/IDA)
Response to lipopolysaccharide GO:0032496
Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria.
1 P43527 (/IMP)
Negative regulation of interferon-beta production GO:0032688
Any process that stops, prevents, or reduces the frequency, rate, or extent of interferon-beta production.
1 Q9ULZ3 (/IMP)
Negative regulation of interferon-beta production GO:0032688
Any process that stops, prevents, or reduces the frequency, rate, or extent of interferon-beta production.
1 Q9EPB4 (/ISO)
Positive regulation of interferon-gamma production GO:0032729
Any process that activates or increases the frequency, rate, or extent of interferon-gamma production. Interferon-gamma is also known as type II interferon.
1 Q9EPB4 (/IMP)
Positive regulation of interleukin-6 production GO:0032755
Any process that activates or increases the frequency, rate, or extent of interleukin-6 production.
1 Q9EPB4 (/IMP)
Positive regulation of tumor necrosis factor production GO:0032760
Any process that activates or increases the frequency, rate, or extent of tumor necrosis factor production.
1 Q9ULZ3 (/IMP)
Positive regulation of tumor necrosis factor production GO:0032760
Any process that activates or increases the frequency, rate, or extent of tumor necrosis factor production.
1 Q9EPB4 (/ISO)
Response to ATP GO:0033198
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ATP (adenosine 5'-triphosphate) stimulus.
1 P29452 (/IMP)
Tumor necrosis factor-mediated signaling pathway GO:0033209
A series of molecular signals initiated by the binding of a tumor necrosis factor to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
1 Q9ULZ3 (/IDA)
Tumor necrosis factor-mediated signaling pathway GO:0033209
A series of molecular signals initiated by the binding of a tumor necrosis factor to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
1 Q9EPB4 (/ISO)
Positive regulation of activated T cell proliferation GO:0042104
Any process that activates or increases the rate or extent of activated T cell proliferation.
1 Q9EPB4 (/IMP)
Regulation of cell proliferation GO:0042127
Any process that modulates the frequency, rate or extent of cell proliferation.
1 Q13490 (/TAS)
Negative regulation of phosphorylation GO:0042326
Any process that stops, prevents or decreases the rate of addition of phosphate groups to a molecule.
1 O08863 (/IMP)
Response to drug GO:0042493
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease.
1 P43527 (/IDA)
Defense response to bacterium GO:0042742
Reactions triggered in response to the presence of a bacterium that act to protect the cell or organism.
1 Q3UP24 (/IMP)
Defense response to bacterium GO:0042742
Reactions triggered in response to the presence of a bacterium that act to protect the cell or organism.
1 Q3UP24 (/ISO)
Intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator GO:0042771
A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage, and ends when the execution phase of apoptosis is triggered.
1 Q9ULZ3 (/IMP)
Intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator GO:0042771
A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage, and ends when the execution phase of apoptosis is triggered.
1 Q9EPB4 (/ISO)
Positive regulation of apoptotic process GO:0043065
Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process.
1 P43527 (/IMP)
Negative regulation of apoptotic process GO:0043066
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
1 Q90660 (/IGI)
Negative regulation of apoptotic process GO:0043066
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
1 Q62210 (/ISO)
Regulation of GTPase activity GO:0043087
Any process that modulates the rate of GTP hydrolysis by a GTPase.
1 Q9EPB4 (/IMP)
Positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123
Any process that activates or increases the frequency, rate or extent of I-kappaB kinase/NF-kappaB signaling.
1 P29452 (/IDA)
Positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123
Any process that activates or increases the frequency, rate or extent of I-kappaB kinase/NF-kappaB signaling.
1 Q13489 (/TAS)
Negative regulation of I-kappaB kinase/NF-kappaB signaling GO:0043124
Any process that stops, prevents, or reduces the frequency, rate or extent of -kappaB kinase/NF-kappaB signaling.
1 Q9EPB4 (/ISO)
Proteasome-mediated ubiquitin-dependent protein catabolic process GO:0043161
The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome.
1 Q13490 (/IDA)
Proteasome-mediated ubiquitin-dependent protein catabolic process GO:0043161
The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome.
1 Q62210 (/ISO)
Proteasome-mediated ubiquitin-dependent protein catabolic process GO:0043161
The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome.
1 Q62210 (/ISS)
Positive regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043280
Any process that activates or increases the activity of a cysteine-type endopeptidase involved in the apoptotic process.
1 G3V8L1 (/IMP)
Positive regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043280
Any process that activates or increases the activity of a cysteine-type endopeptidase involved in the apoptotic process.
1 Q9I9N6 (/IPI)
Positive regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043280
Any process that activates or increases the activity of a cysteine-type endopeptidase involved in the apoptotic process.
1 Q9EPB4 (/ISO)
Neutrophil degranulation GO:0043312
The regulated exocytosis of secretory granules containing preformed mediators such as proteases, lipases, and inflammatory mediators by a neutrophil.
1 Q9ULZ3 (/TAS)
Macropinocytosis GO:0044351
An endocytosis process that results in the uptake of liquid material by cells from their external environment by the 'ruffling' of the cell membrane to form heterogeneously sized intracellular vesicles called macropinosomes, which can be up to 5 micrometers in size.
1 Q9EPB4 (/IMP)
Response to ethanol GO:0045471
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ethanol stimulus.
1 Q6P6S1 (/IEP)
Regulation of cell differentiation GO:0045595
Any process that modulates the frequency, rate or extent of cell differentiation, the process in which relatively unspecialized cells acquire specialized structural and functional features.
1 Q13490 (/TAS)
Positive regulation of circadian sleep/wake cycle, non-REM sleep GO:0046010
Any process that activates or increases the duration or quality of non-rapid eye movement (NREM) sleep.
1 P43527 (/IMP)
Positive regulation of JNK cascade GO:0046330
Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the JNK cascade.
1 Q9ULZ3 (/IMP)
Positive regulation of JNK cascade GO:0046330
Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the JNK cascade.
1 Q9EPB4 (/ISO)
Interleukin-1 beta secretion GO:0050702
The regulated release of interleukin 1 beta from a cell.
1 Q9NPP4 (/IDA)
Interleukin-1 beta secretion GO:0050702
The regulated release of interleukin 1 beta from a cell.
1 Q3UP24 (/IMP)
Interleukin-1 beta secretion GO:0050702
The regulated release of interleukin 1 beta from a cell.
1 Q3UP24 (/ISO)
Positive regulation of interleukin-1 alpha secretion GO:0050717
Any process that activates or increases the frequency, rate or extent of the regulated release of interleukin-1 alpha from a cell.
1 P29452 (/IMP)
Positive regulation of interleukin-1 beta secretion GO:0050718
Any process that activates or increases the frequency, rate or extent of the regulated release of interleukin-1 beta from a cell.
1 Q9EPB4 (/IGI)
Positive regulation of interleukin-1 beta secretion GO:0050718
Any process that activates or increases the frequency, rate or extent of the regulated release of interleukin-1 beta from a cell.
1 Q9EPB4 (/ISO)
Regulation of inflammatory response GO:0050727
Any process that modulates the frequency, rate or extent of the inflammatory response, the immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents.
1 Q9C000 (/IC)
Positive regulation of phagocytosis GO:0050766
Any process that activates or increases the frequency, rate or extent of phagocytosis.
1 Q9EPB4 (/IMP)
Defense response to Gram-negative bacterium GO:0050829
Reactions triggered in response to the presence of a Gram-negative bacterium that act to protect the cell or organism.
1 A0A060XPX2 (/IDA)
Defense response to Gram-negative bacterium GO:0050829
Reactions triggered in response to the presence of a Gram-negative bacterium that act to protect the cell or organism.
1 Q9ULZ3 (/IMP)
Defense response to Gram-negative bacterium GO:0050829
Reactions triggered in response to the presence of a Gram-negative bacterium that act to protect the cell or organism.
1 Q9EPB4 (/ISO)
Positive regulation of T cell activation GO:0050870
Any process that activates or increases the frequency, rate or extent of T cell activation.
1 Q9ULZ3 (/IMP)
Positive regulation of T cell activation GO:0050870
Any process that activates or increases the frequency, rate or extent of T cell activation.
1 Q9EPB4 (/ISO)
Positive regulation of sequence-specific DNA binding transcription factor activity GO:0051091
Any process that activates or increases the frequency, rate or extent of activity of a transcription factor, any factor involved in the initiation or regulation of transcription.
1 Q9ULZ3 (/IDA)
Positive regulation of sequence-specific DNA binding transcription factor activity GO:0051091
Any process that activates or increases the frequency, rate or extent of activity of a transcription factor, any factor involved in the initiation or regulation of transcription.
1 Q9EPB4 (/ISO)
Protein homooligomerization GO:0051260
The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer.
1 Q3UP24 (/IDA)
Neuron apoptotic process GO:0051402
Any apoptotic process in a neuron, the basic cellular unit of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the nervous system.
1 Q9C000 (/IDA)
Neuron apoptotic process GO:0051402
Any apoptotic process in a neuron, the basic cellular unit of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the nervous system.
1 Q2LKU9 (/ISS)
Response to cAMP GO:0051591
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate) stimulus.
1 Q6P6S1 (/IEP)
Defense response to virus GO:0051607
Reactions triggered in response to the presence of a virus that act to protect the cell or organism.
1 Q9ULZ3 (/IDA)
Defense response to virus GO:0051607
Reactions triggered in response to the presence of a virus that act to protect the cell or organism.
1 Q9EPB4 (/ISO)
Regulation of cell cycle GO:0051726
Any process that modulates the rate or extent of progression through the cell cycle.
1 Q13490 (/IDA)
Regulation of cell cycle GO:0051726
Any process that modulates the rate or extent of progression through the cell cycle.
1 Q62210 (/ISO)
Regulation of cell cycle GO:0051726
Any process that modulates the rate or extent of progression through the cell cycle.
1 Q62210 (/ISS)
Mitochondrial depolarization GO:0051882
The process in which the potential difference across the mitochondrial membrane is reduced from its steady state level.
1 P29452 (/IMP)
Membrane hyperpolarization GO:0060081
The process in which membrane potential increases with respect to its steady-state potential, usually from negative potential to a more negative potential. For example, during the repolarization phase of an action potential the membrane potential often becomes more negative or hyperpolarized before returning to the steady-state resting potential.
1 P29452 (/IMP)
Negative regulation of necroptotic process GO:0060546
Any process that decreases the rate, frequency or extent of a necroptotic process, a necrotic cell death process that results from the activation of endogenous cellular processes, such as signaling involving death domain receptors or Toll-like receptors.
1 Q62210 (/IGI)
Negative regulation of necroptotic process GO:0060546
Any process that decreases the rate, frequency or extent of a necroptotic process, a necrotic cell death process that results from the activation of endogenous cellular processes, such as signaling involving death domain receptors or Toll-like receptors.
1 O08863 (/IMP)
Necroptotic process GO:0070266
A programmed necrotic cell death process which begins when a cell receives a signal (e.g. a ligand binding to a death receptor or to a Toll-like receptor), and proceeds through a series of biochemical events (signaling pathways), characterized by activation of receptor-interacting serine/threonine-protein kinase 1 and/or 3 (RIPK1/3, also called RIP1/3) and by critical dependence on mixed lineage kinase domain-like (MLKL), and which typically lead to common morphological features of necrotic cell death. The process ends when the cell has died. The process is divided into a signaling phase, and an execution phase, which is triggered by the former.
1 O08863 (/IDA)
Necroptotic process GO:0070266
A programmed necrotic cell death process which begins when a cell receives a signal (e.g. a ligand binding to a death receptor or to a Toll-like receptor), and proceeds through a series of biochemical events (signaling pathways), characterized by activation of receptor-interacting serine/threonine-protein kinase 1 and/or 3 (RIPK1/3, also called RIP1/3) and by critical dependence on mixed lineage kinase domain-like (MLKL), and which typically lead to common morphological features of necrotic cell death. The process ends when the cell has died. The process is divided into a signaling phase, and an execution phase, which is triggered by the former.
1 Q62210 (/IMP)
Positive regulation of ERK1 and ERK2 cascade GO:0070374
Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade.
1 Q9EPB4 (/ISO)
Cellular response to lipopolysaccharide GO:0071222
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria.
1 Q9ULZ3 (/IDA)
Cellular response to lipopolysaccharide GO:0071222
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria.
1 Q9EPB4 (/ISO)
Cellular response to mechanical stimulus GO:0071260
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mechanical stimulus.
1 P29466 (/IEP)
Cellular response to organic substance GO:0071310
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic substance stimulus.
1 P29466 (/IDA)
Cellular response to organic substance GO:0071310
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic substance stimulus.
1 P29452 (/ISO)
Cellular response to interleukin-1 GO:0071347
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-1 stimulus.
1 Q9ULZ3 (/IDA)
Cellular response to interleukin-1 GO:0071347
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-1 stimulus.
1 Q9EPB4 (/ISO)
Cellular response to tumor necrosis factor GO:0071356
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tumor necrosis factor stimulus.
1 Q9ULZ3 (/IDA)
Cellular response to tumor necrosis factor GO:0071356
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tumor necrosis factor stimulus.
1 Q9EPB4 (/ISO)
Negative regulation of protein serine/threonine kinase activity GO:0071901
Any process that decreases the rate, frequency, or extent of protein serine/threonine kinase activity.
1 Q9ULZ3 (/IDA)
Negative regulation of protein serine/threonine kinase activity GO:0071901
Any process that decreases the rate, frequency, or extent of protein serine/threonine kinase activity.
1 Q9EPB4 (/ISO)
Intrinsic apoptotic signaling pathway by p53 class mediator GO:0072332
A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, and ends when the execution phase of apoptosis is triggered.
1 Q9ULZ3 (/IMP)
Intrinsic apoptotic signaling pathway by p53 class mediator GO:0072332
A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, and ends when the execution phase of apoptosis is triggered.
1 Q9EPB4 (/ISO)
Positive regulation of chemokine secretion GO:0090197
Any process that increases the rate, frequency or extent of chemokine secretion, the regulated release of chemokines from a cell.
1 Q9EPB4 (/ISO)
Positive regulation of release of cytochrome c from mitochondria GO:0090200
Any process that increases the rate, frequency or extent of release of cytochrome c from mitochondria, the process in which cytochrome c is enabled to move from the mitochondrial intermembrane space into the cytosol, which is an early step in apoptosis and leads to caspase activation.
1 Q9ULZ3 (/IDA)
Positive regulation of release of cytochrome c from mitochondria GO:0090200
Any process that increases the rate, frequency or extent of release of cytochrome c from mitochondria, the process in which cytochrome c is enabled to move from the mitochondrial intermembrane space into the cytosol, which is an early step in apoptosis and leads to caspase activation.
1 Q9EPB4 (/ISO)
Execution phase of apoptosis GO:0097194
A stage of the apoptotic process that starts with the controlled breakdown of the cell through the action of effector caspases or other effector molecules (e.g. cathepsins, calpains etc.). Key steps of the execution phase are rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died.
1 Q13490 (/TAS)
Activation of cysteine-type endopeptidase activity GO:0097202
Any process that initiates the activity of the inactive enzyme cysteine-type endopeptidase.
1 Q9EPB4 (/IMP)
Toxin transport GO:1901998
The directed movement of a toxin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
1 P29452 (/IMP)
Negative regulation of ripoptosome assembly involved in necroptotic process GO:1902443
Any process that stops, prevents or reduces the frequency, rate or extent of ripoptosome assembly involved in a necroptotic process.
1 Q62210 (/IGI)
Positive regulation of protein K63-linked ubiquitination GO:1902523
Any process that activates or increases the frequency, rate or extent of protein K63-linked ubiquitination.
1 Q13490 (/IDA)
Positive regulation of protein K63-linked ubiquitination GO:1902523
Any process that activates or increases the frequency, rate or extent of protein K63-linked ubiquitination.
1 Q62210 (/ISO)
Positive regulation of protein K63-linked ubiquitination GO:1902523
Any process that activates or increases the frequency, rate or extent of protein K63-linked ubiquitination.
1 Q62210 (/ISS)
Positive regulation of protein K48-linked ubiquitination GO:1902524
Any process that activates or increases the frequency, rate or extent of protein K48-linked ubiquitination.
1 Q13490 (/IDA)
Positive regulation of protein K48-linked ubiquitination GO:1902524
Any process that activates or increases the frequency, rate or extent of protein K48-linked ubiquitination.
1 Q62210 (/ISO)
Positive regulation of protein K48-linked ubiquitination GO:1902524
Any process that activates or increases the frequency, rate or extent of protein K48-linked ubiquitination.
1 Q62210 (/ISS)
Positive regulation of protein monoubiquitination GO:1902527
Any process that activates or increases the frequency, rate or extent of protein monoubiquitination.
1 Q13490 (/IDA)
Positive regulation of protein monoubiquitination GO:1902527
Any process that activates or increases the frequency, rate or extent of protein monoubiquitination.
1 Q62210 (/ISO)
Regulation of reactive oxygen species metabolic process GO:2000377
Any process that modulates the frequency, rate or extent of reactive oxygen species metabolic process.
1 Q62210 (/IMP)
Negative regulation of reactive oxygen species metabolic process GO:2000378
Any process that stops, prevents or reduces the frequency, rate or extent of reactive oxygen species metabolic process.
1 O08863 (/IMP)
Positive regulation of T cell migration GO:2000406
Any process that activates or increases the frequency, rate or extent of T cell migration.
1 Q9EPB4 (/IMP)
Positive regulation of interleukin-8 secretion GO:2000484
Any process that activates or increases the frequency, rate or extent of interleukin-8 secretion.
1 Q9ULZ3 (/IMP)
Positive regulation of interleukin-8 secretion GO:2000484
Any process that activates or increases the frequency, rate or extent of interleukin-8 secretion.
1 Q9EPB4 (/ISO)
Positive regulation of interleukin-6 secretion GO:2000778
Any process that activates or increases the frequency, rate or extent of interleukin-6 secretion.
1 Q9ULZ3 (/IMP)
Positive regulation of interleukin-6 secretion GO:2000778
Any process that activates or increases the frequency, rate or extent of interleukin-6 secretion.
1 Q9EPB4 (/ISO)
Positive regulation of cysteine-type endopeptidase activity GO:2001056
Any process that activates or increases the frequency, rate or extent of cysteine-type endopeptidase activity.
1 Q9ULZ3 (/IDA)
Positive regulation of cysteine-type endopeptidase activity GO:2001056
Any process that activates or increases the frequency, rate or extent of cysteine-type endopeptidase activity.
1 Q9EPB4 (/ISO)
Positive regulation of interleukin-10 secretion GO:2001181
Any process that activates or increases the frequency, rate or extent of interleukin-10 secretion.
1 Q9ULZ3 (/IMP)
Positive regulation of interleukin-10 secretion GO:2001181
Any process that activates or increases the frequency, rate or extent of interleukin-10 secretion.
1 Q9EPB4 (/ISO)
Positive regulation of extrinsic apoptotic signaling pathway GO:2001238
Any process that activates or increases the frequency, rate or extent of extrinsic apoptotic signaling pathway.
1 Q9ULZ3 (/IDA)
Positive regulation of extrinsic apoptotic signaling pathway GO:2001238
Any process that activates or increases the frequency, rate or extent of extrinsic apoptotic signaling pathway.
1 Q9EPB4 (/ISO)
Regulation of intrinsic apoptotic signaling pathway GO:2001242
Any process that modulates the frequency, rate or extent of intrinsic apoptotic signaling pathway.
1 Q9ULZ3 (/IDA)
Regulation of intrinsic apoptotic signaling pathway GO:2001242
Any process that modulates the frequency, rate or extent of intrinsic apoptotic signaling pathway.
1 Q9EPB4 (/ISO)

There are 47 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
9 B0V1H3 (/IDA) P43527 (/IDA) Q13489 (/IDA) Q13490 (/IDA) Q6P6S1 (/IDA) Q9C000 (/IDA) Q9EPB4 (/IDA) Q9ULZ3 (/IDA) Q9Y2G2 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
9 P29452 (/TAS) P29466 (/TAS) Q13489 (/TAS) Q13490 (/TAS) Q3UP24 (/TAS) Q9C000 (/TAS) Q9EPB4 (/TAS) Q9NPP4 (/TAS) Q9ULZ3 (/TAS)
IPAF inflammasome complex GO:0072557
A protein complex that consists of three components, IPAF, NAIP and caspase-1, and includes among its functions the sensing of flagellin derived from Legionella pneumophila, Salmonella typhimurium, Pseudomonas aeruginosa and Shigella flexneri.
9 F1M649 (/ISS) F1MHT9 (/ISS) P29466 (/ISS) P43527 (/ISS) Q9MZV6 (/ISS) Q9MZV7 (/ISS) Q9N2I1 (/ISS) Q9NPP4 (/ISS) Q9TV13 (/ISS)
NLRP3 inflammasome complex GO:0072559
A protein complex that consists of three components, NLRP3 (NALP3), PYCARD and caspase-1. It is activated upon exposure to whole pathogens, as well as a number of structurally diverse pathogen- and danger-associated molecular patterns (PAMPs and DAMPs) and environmental irritants. Whole pathogens demonstrated to activate the NLRP3 inflammasome complex include the fungi Candida albicans and Saccharomyces cerevisiae, bacteria that produce pore-forming toxins, including Listeria monocytogenes and Staphylococcus aureus, and viruses such as Sendai virus, adenovirus, and influenza virus.
9 P29452 (/ISS) P43527 (/ISS) Q5RAV7 (/ISS) Q8HXK9 (/ISS) Q9EPB4 (/ISS) Q9MZV6 (/ISS) Q9MZV7 (/ISS) Q9N2I1 (/ISS) Q9TV13 (/ISS)
AIM2 inflammasome complex GO:0097169
A protein complex that consists of AIM2, ASC, and caspase-1. AIM2 is a member of the HN-200 protein family that appears to be the sensor of cytosolic double-stranded DNA.
8 P29452 (/ISS) P43527 (/ISS) Q8HXK9 (/ISS) Q9EPB4 (/ISS) Q9MZV6 (/ISS) Q9MZV7 (/ISS) Q9N2I1 (/ISS) Q9TV13 (/ISS)
Protein complex GO:0043234
A stable macromolecular complex composed (only) of two or more polypeptide subunits along with any covalently attached molecules (such as lipid anchors or oligosaccharide) or non-protein prosthetic groups (such as nucleotides or metal ions). Prosthetic group in this context refers to a tightly bound cofactor. The component polypeptide subunits may be identical.
7 A0A0G2QC28 (/IDA) D9I2F9 (/IDA) F7FLN8 (/IDA) G3V8L1 (/IDA) P43527 (/IDA) Q5XIW4 (/IDA) Q6P6S1 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
6 A1Z198 (/ISO) O08863 (/ISO) Q2LKV5 (/ISO) Q2LKW6 (/ISO) Q62210 (/ISO) Q9EPB4 (/ISO)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
6 A1E2V0 (/ISS) O08863 (/ISS) Q2LKU9 (/ISS) Q62210 (/ISS) Q8HXK9 (/ISS) Q9ULZ3 (/ISS)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
6 Q13489 (/IDA) Q3UP24 (/IDA) Q9C000 (/IDA) Q9EPB4 (/IDA) Q9ULZ3 (/IDA) Q9Y2G2 (/IDA)
NLRP1 inflammasome complex GO:0072558
A protein complex that consists of two components, NLRP1 (NALP1) and caspase-1 or caspase-5. The exact mechanisms of NLRP1 activation remain obscure, but potassium ion efflux appears to be essential.
6 P29452 (/ISS) P43527 (/ISS) Q9MZV6 (/ISS) Q9MZV7 (/ISS) Q9N2I1 (/ISS) Q9TV13 (/ISS)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
5 P43527 (/IDA) Q13489 (/IDA) Q13490 (/IDA) Q9ULZ3 (/IDA) Q9Y2G2 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
5 A1Z198 (/ISO) O08863 (/ISO) Q2LKV5 (/ISO) Q2LKW6 (/ISO) Q9EPB4 (/ISO)
NLRP1 inflammasome complex GO:0072558
A protein complex that consists of two components, NLRP1 (NALP1) and caspase-1 or caspase-5. The exact mechanisms of NLRP1 activation remain obscure, but potassium ion efflux appears to be essential.
5 A1Z198 (/ISO) P29452 (/ISO) Q2LKV5 (/ISO) Q2LKW6 (/ISO) Q9EPB4 (/ISO)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
4 A1Z198 (/ISO) O08863 (/ISO) Q2LKV5 (/ISO) Q2LKW6 (/ISO)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
4 A1E2V0 (/ISS) O08863 (/ISS) Q8HXK9 (/ISS) Q9EPB4 (/ISS)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
3 Q13489 (/IDA) Q9C000 (/IDA) Q9Y2G2 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
3 O08863 (/ISO) Q62210 (/ISO) Q9EPB4 (/ISO)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
3 F1M649 (/ISS) F1MHT9 (/ISS) Q9NPP4 (/ISS)
Neuronal cell body GO:0043025
The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.
3 A0A0G2QC28 (/IDA) D9I2F9 (/IDA) G3V8L1 (/IDA)
Membrane raft GO:0045121
Any of the small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes. Small rafts can sometimes be stabilized to form larger platforms through protein-protein and protein-lipid interactions.
3 F7FLN8 (/IDA) Q5XIW4 (/IDA) Q6P6S1 (/IDA)
NLRP1 inflammasome complex GO:0072558
A protein complex that consists of two components, NLRP1 (NALP1) and caspase-1 or caspase-5. The exact mechanisms of NLRP1 activation remain obscure, but potassium ion efflux appears to be essential.
3 P29466 (/IDA) Q9C000 (/IDA) Q9ULZ3 (/IDA)
NLRP3 inflammasome complex GO:0072559
A protein complex that consists of three components, NLRP3 (NALP3), PYCARD and caspase-1. It is activated upon exposure to whole pathogens, as well as a number of structurally diverse pathogen- and danger-associated molecular patterns (PAMPs and DAMPs) and environmental irritants. Whole pathogens demonstrated to activate the NLRP3 inflammasome complex include the fungi Candida albicans and Saccharomyces cerevisiae, bacteria that produce pore-forming toxins, including Listeria monocytogenes and Staphylococcus aureus, and viruses such as Sendai virus, adenovirus, and influenza virus.
3 P29466 (/IDA) Q9ULZ3 (/IDA) Q9Y2G2 (/IDA)
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
2 P29452 (/IDA) Q9EPB4 (/IDA)
IPAF inflammasome complex GO:0072557
A protein complex that consists of three components, IPAF, NAIP and caspase-1, and includes among its functions the sensing of flagellin derived from Legionella pneumophila, Salmonella typhimurium, Pseudomonas aeruginosa and Shigella flexneri.
2 P29452 (/IDA) Q3UP24 (/IDA)
NLRP3 inflammasome complex GO:0072559
A protein complex that consists of three components, NLRP3 (NALP3), PYCARD and caspase-1. It is activated upon exposure to whole pathogens, as well as a number of structurally diverse pathogen- and danger-associated molecular patterns (PAMPs and DAMPs) and environmental irritants. Whole pathogens demonstrated to activate the NLRP3 inflammasome complex include the fungi Candida albicans and Saccharomyces cerevisiae, bacteria that produce pore-forming toxins, including Listeria monocytogenes and Staphylococcus aureus, and viruses such as Sendai virus, adenovirus, and influenza virus.
2 P29452 (/ISO) Q9EPB4 (/ISO)
AIM2 inflammasome complex GO:0097169
A protein complex that consists of AIM2, ASC, and caspase-1. AIM2 is a member of the HN-200 protein family that appears to be the sensor of cytosolic double-stranded DNA.
2 P29466 (/IDA) Q9ULZ3 (/IDA)
AIM2 inflammasome complex GO:0097169
A protein complex that consists of AIM2, ASC, and caspase-1. AIM2 is a member of the HN-200 protein family that appears to be the sensor of cytosolic double-stranded DNA.
2 P29452 (/ISO) Q9EPB4 (/ISO)
XY body GO:0001741
A structure found in a male mammalian spermatocyte containing an unpaired X chromosome that has become densely heterochromatic, silenced and localized at the nuclear periphery.
1 Q6P6S1 (/IDA)
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
1 Q9ULZ3 (/TAS)
Intracellular GO:0005622
The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.
1 Q9C000 (/IC)
Intracellular GO:0005622
The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.
1 Q9NPP4 (/NAS)
Cell GO:0005623
The basic structural and functional unit of all organisms. Includes the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope.
1 A0A060XPX2 (/IDA)
Nucleolus GO:0005730
A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
1 Q9ULZ3 (/IDA)
Nucleolus GO:0005730
A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
1 Q9EPB4 (/ISO)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 Q9ULZ3 (/NAS)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 P29452 (/TAS)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
1 Q9ULZ3 (/IDA)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
1 Q9EPB4 (/ISO)
IkappaB kinase complex GO:0008385
A trimeric protein complex that phosphorylates inhibitory-kappaB (I-kappaB) proteins. The complex is composed of two kinase subunits (alpha and beta) and a regulatory gamma subunit (also called NEMO). In a resting state, NF-kappaB dimers are bound to inhibitory IKB proteins, sequestering NF-kappaB in the cytoplasm. Phosphorylation of I-kappaB targets I-kappaB for ubiquitination and proteasomal degradation, thus releasing the NF-kappaB dimers, which can translocate to the nucleus to bind DNA and regulate transcription.
1 Q9ULZ3 (/TAS)
Cytoplasmic side of plasma membrane GO:0009898
The leaflet the plasma membrane that faces the cytoplasm and any proteins embedded or anchored in it or attached to its surface.
1 Q62210 (/IDA)
Cytoplasmic side of plasma membrane GO:0009898
The leaflet the plasma membrane that faces the cytoplasm and any proteins embedded or anchored in it or attached to its surface.
1 Q13490 (/ISS)
Secretory granule lumen GO:0034774
The volume enclosed by the membrane of a secretory granule.
1 Q9ULZ3 (/TAS)
Azurophil granule lumen GO:0035578
The volume enclosed by the membrane of an azurophil granule, a primary lysosomal granule found in neutrophil granulocytes that contains a wide range of hydrolytic enzymes and is released into the extracellular fluid.
1 Q9ULZ3 (/TAS)
CD40 receptor complex GO:0035631
A protein complex that contains at least CD40 (a cell surface receptor of the tumour necrosis factor receptor (TNFR) superfamily), and other signaling molecules.
1 Q62210 (/IDA)
CD40 receptor complex GO:0035631
A protein complex that contains at least CD40 (a cell surface receptor of the tumour necrosis factor receptor (TNFR) superfamily), and other signaling molecules.
1 Q13490 (/ISS)
Neuron projection GO:0043005
A prolongation or process extending from a nerve cell, e.g. an axon or dendrite.
1 P43527 (/IDA)
NLRP1 inflammasome complex GO:0072558
A protein complex that consists of two components, NLRP1 (NALP1) and caspase-1 or caspase-5. The exact mechanisms of NLRP1 activation remain obscure, but potassium ion efflux appears to be essential.
1 Q9C000 (/TAS)
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