CATH Superfamily 1.10.533.10

Browse Functional Families

ID	Function Family (FunFam) Name	Total Sequences	Enzyme?	Structure?	Structural Representative	PDB Sites?	Alignment Diversity (0-100)
5156	Ankyrin-3 skin-specific splice variant	1254		3D	4d8oA04	-	95.2
5215	Netrin receptor UNC5D	985	EC	3D	1wmgA00	-	98.1
5221	Baculoviral IAP repeat-containing 2	963	EC	3D	2l9mA00	-	95.9
25	Astrocytic phosphoprotein PEA-15	603		3D	1n3kA00	-	23.4
5158	Caspase recruitment domain-containing protein 11	346		3D	4i16A00	-	80.0
5025	Ectodysplasin A1 receptor	222			-	-	46.8
5133	Myeloid differentiation primary response protein MyD88	210		3D	3mopA00	-	91.9
5203	PYD and CARD domain containing	207		3D	2n1fA00	-	92.2
5241	CASP8 and FADD-like apoptosis regulator	202		3D	2bbrA01	-	98.3
5014	Receptor-interacting serine/threonine-protein kinase 2	160	EC	3D	2n7zA00	-	63.3
5202	Cell death protein 3	154	EC		-	-	96.3
5107	Nuclear factor NF-kappa-B subunit	149		3D	2dbfA01	-	87.0
5038	SH3 domain-binding protein 4	147			-	-	68.9
4937	Tumor necrosis factor receptor superfamily member 21	134		3D	2dbhA01	-	41.7
3781	Tumor necrosis factor receptor superfamily member 25	132			-	-	39.5
5081	Interleukin-1 receptor-associated kinase 4	128	EC	3D	3mopG00	-	83.5
5093	CASP8 and FADD-like apoptosis regulator	126			-	-	74.3
1905	Death effector domain-containing protein	124			-	-	45.6
5170	Mutant B-cell CLL/lymphoma 10	123		3D	2mb9A00	-	85.8
1176	Tumor necrosis factor receptor superfamily member 21	119			-	-	74.7
4267	Nucleolar protein 3	117		3D	4uz0A00	-	78.4
5146	Caspase 9, isoform CRA_a	113	EC	3D	3ygsP00	-	76.2
5022	E3 ubiquitin-protein ligase TTC3	105	EC		-	-	51.8
5009	Death domain-containing protein CRADD	101		3D	3crdA00	-	41.1
1155	Caspase recruitment domain-containing protein 10	99			-	-	50.4
5169	FAS-associated death domain protein	99		3D	1e3yA00	-	80.7
5152	Tumor necrosis factor receptor superfamily member 6	98		3D	1ddfA00	-	88.5
5100	Nucleotide-binding oligomerization domain-containing protein 2	91			-	-	76.6
5164	Pyrin and HIN domain-containing protein 1	89			-	-	82.9
5110	TNFRSF1A-associated via death domain	87			-	-	64.9
1232	Interleukin-1 receptor-associated kinase-like 2	87		3D	3mopK00	-	59.9
5104	Pyrin variant	84		3D	2mpcA00	-	66.3
5145	Caspase 8, isoform CRA_a	84	EC	3D	4zbwA01	-	67.0
5020	Apoptotic protease-activating factor 1	83		3D	1c15A00	-	43.5
5117	Nucleotide-binding oligomerization domain-containing protein 2	82			-	-	59.7
2697	Interleukin-1 receptor-associated kinase 1	80	EC		-	-	31.9
5159	Nuclear factor NF-kappa-B p100 subunit	79		3D	2d96A01	-	78.3
5056	TNF receptor superfamily, member 1A	78		3D	1ichA00	-	70.2
5190	FAS-associated death domain protein	74		3D	1a1wA00	-	80.0
2497	Ankyrin 2, isoform K	72			-	-	14.4
2302	Ectodysplasin-A receptor-associated adapter protein	67			-	-	41.5
5002	RIKEN cDNA 1110007C09, isoform CRA_a	67		3D	4fh0A00	-	41.5
5049	Tumor necrosis factor receptor superfamily member 11B	64			-	-	66.8
5033	NACHT, LRR and PYD domains-containing protein 3	62		3D	2naqA00	-	34.3
5106	Tumor necrosis factor receptor superfamily member 11B	59			-	-	73.0
5029	IGF-like family receptor 1	56			-	-	49.0
5008	Death domain-containing protein CRADD	54		3D	2o71A00	-	50.7
5005	p53-induced death domain-containing protein 1	53		3D	2of5H00	-	29.7
1629	Tumor necrosis factor receptor superfamily member 16	53		3D	2n80A00	-	43.6
1034	UNC5C-like protein	51			-	-	41.8
3341	Disks large homolog 5	45			-	-	40.2
5155	Tumor necrosis factor receptor superfamily member 10B	43			-	-	78.9
5065	Interferon-induced helicase C domain-containing protein 1	43	EC		-	-	54.1
5037	Zinc finger and BTB domain-containing protein 40	42			-	-	60.6
5011	Nucleotide-binding oligomerization domain-containing protein 1	41		3D	2b1wA00	-	42.5
963	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	41		3D	2g7rA00	-	27.3
5103	Probable ATP-dependent RNA helicase DDX58	40	EC	3D	2lwdA00	-	47.2
5034	Probable ATP-dependent RNA helicase DDX58	37	EC	3D	4nqkA01	-	44.5
5000	Protein Tube	30		3D	1d2zB00	-	62.7
5012	Receptor-interacting serine/threonine-protein kinase 1	26	EC		-	-	34.0
5079	NACHT, LRR and PYD domains-containing protein 12	21		3D	2l6aA00	-	40.2
3111	Nucleotide-binding oligomerization domain protein 5	21		3D	4n1jA00	-	19.5
3615	Metastasis-associated in colon cancer protein 1	19			-	-	35.6
2890	NACHT, LRR and PYD domains-containing protein 2	19			-	-	8.3
5176	Caspase-4	19	EC		-	-	35.8
1270	Caspase recruitment domain-containing protein 6	19			-	-	9.3
1574	Interferon-induced helicase C domain-containing protein 1	18	EC		-	-	16.4
3738	Myeloid cell nuclear differentiation antigen	17		3D	2dbgA00	-	28.0
2891	NLR family pyrin domain-containing protein 9	17			-	-	3.8
763	Netrin receptor unc-5	16			-	-	13.8
5257	UNC-44, isoform b	15			-	-	75.7
5113	NACHT, LRR and PYD domains-containing protein 4F	15			-	-	45.2
2698	NACHT, LRR and PYD domains-containing protein 7	15		3D	2km6A00	-	17.0
813	Death-domain containing protein BG5	14			-	-	33.8
3517	NACHT, LRR and PYD domains-containing protein 1	13		3D	1pn5A00	-	10.0
3109	NACHT, LRR and PYD domains-containing protein 5	12			-	-	8.3
2060	Caspase 10, apoptosis-related cysteine peptidase	12	EC		-	-	10.8
2300	Caspase recruitment domain-containing protein 18	12		3D	1dgnA00	-	22.6
3381	Uncharacterized protein	11			-	-	17.8
5010	Cell death protein 4	11		3D	2a5yB01	-	21.7
3320	Interleukin-1 receptor-associated kinase 3	10	EC		-	-	22.5
3523	NACHT, LRR and PYD domains-containing protein 4	9			-	-	7.3
1751	Uncharacterized protein	8			-	-	13.1
5250	Viral CASP8 and FADD-like apoptosis regulator	8		3D	2bbrA02	-	51.5
2124	Fas-associated death domain protein	8			-	-	17.6
1362	NACHT, LRR and PYD domains-containing protein 13	7			-	-	8.5
1883	Melanoma differentiation-associated protein 5	7	EC		-	-	0.0
4121	Interferon-inducible protein AIM2	7		3D	4o7qA00	-	10.3
5198	Ovarian TNF receptor	7			-	-	40.2
4307	NACHT, LRR and PYD domains-containing protein 11	7			-	-	11.5
5054	NACHT, LRR and PYD domains-containing protein 9A	7			-	-	18.3
3522	Nucleotide-binding oligomerization domain protein 8	7		3D	2m5vA00	-	14.1
272	GD10085	6			-	-	12.9
4581	NACHT, LRR and PYD domains-containing protein 10	6		3D	2do9A01	-	11.6
1536	Caspase-2	6	EC		-	-	6.4
5052	Apoptosis-associated speck-like protein-containing a CARD	6			-	-	33.0
404	Hpr1	6			-	-	25.6
4120	Absent in melanoma 2	5		3D	2n00A00	-	14.1
1715	Apoptotic protease-activating factor 1	5			-	-	0.0
1238	Melanoma differentiation associated protein-5	5	EC		-	-	8.5
3316	Tumor necrosis factor receptor type 1-associated DEATH domain protein	5			-	-	5.8
3736	NACHT, LRR and PYD domains-containing protein 8	4			-	-	2.6
3976	Uncharacterized protein	4			-	-	0.0
605	Fas-associated death domain protein	4			-	-	0.0
3311	Mitochondrial antiviral signaling protein	4			-	-	0.0
869	Melanoma differentiation associated protein-5	4	EC		-	-	9.8
2704	NACHT, LRR and PYD domains-containing protein 5	4			-	-	13.6
1537	Death-associated protein kinase dapk-1	4	EC		-	-	0.0
3314	NLR family, pyrin domain containing 9B	4			-	-	0.0
3110	Tumor necrosis factor receptor superfamily member 16	3			-	-	1.3
5046	Death domain-containing membrane protein NRADD	3			-	-	13.0
535	Caspase Nc	3			-	-	8.9
2315	Caspase 8	3			-	-	2.5
2064	NLR family CARD domain-containing protein 4	2			-	-	0.0
1892	Tumor necrosis factor receptor-interacting protein-1	2			-	-	0.0
3583	Caspase-8	2			-	-	0.0
5024	Mitochondrial antiviral-signaling protein	2			-	-	11.3
2413	Fas-associated death domain protein	2			-	-	1.3
3526	NACHT, LRR and PYD domains-containing protein 9	2			-	-	0.0
993	Protein Card6	2			-	-	0.0
2701	Fas-associated death domain protein	2			-	-	8.2
2928	Caspase b	2			-	-	1.3
690	Tumor necrosis factor receptor superfamily, member 1a	1			-	-	0.0
3759	NOD2a protein	1			-	-	0.0
701	Caspase-8	1			-	-	0.0
3993	NOD2a protein	1			-	-	0.0
1947	Fas	1			-	-	0.0
3953	NLR family, pyrin domain containing 4B	1			-	-	0.0
2100	Irak3 protein	1			-	-	0.0
1741	Death receptor 6	1			-	-	0.0
381	Uncharacterized protein	1			-	-	0.0
3261	IKB-1	1			-	-	0.0
4999	Uncharacterised protein	1			-	-