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CATH Superfamily 1.10.510.10

Transferase(Phosphotransferase) domain 1

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Transferase(Phosphotransferase) domain 1
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 79169: Probable serine/threonine-protein kinase sky1

There are 10 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Dual-specificity kinase. [EC: 2.7.12.1]
ATP + a protein = ADP + a phosphoprotein.
  • This family of enzymes can phosphorylate both Ser/Thr and Tyr residues.
  • Formerly EC 2.7.1.37.
 166 A0A074T6N8 A0A074T6N8 A0A074TQA1 A0A074TQA1 A0A084G5L2 A0A084G5L2 A0A086JTU6 A0A086JTU6 A0A086K9Z5 A0A086K9Z5
(156 more...)
Non-specific serine/threonine protein kinase. [EC: 2.7.11.1]
ATP + a protein = ADP + a phosphoprotein.
  • This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analyzed to date.
  • Formerly EC 2.7.1.37 and EC 2.7.1.70.
 158 A0A024R704 A0A024R704 A0A060RSL0 A0A060RSL0 A0A060S047 A0A060S047 A0A061HUS7 A0A061HUS7 A0A061HWQ8 A0A061HWQ8
(148 more...)
RNA-directed DNA polymerase. [EC: 2.7.7.49]
Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).
  • Catalyzes RNA-template-directed extension of the 3'-end of a DNA strand by one deoxynucleotide at a time.
  • Cannot initiate a chain de novo.
  • Requires a RNA or DNA primer.
  • DNA can also serve as template.
  • See also EC 2.7.7.7.
 2 G0QZY0 G0QZY0
Guanylate cyclase. [EC: 4.6.1.2]
GTP = 3',5'-cyclic GMP + diphosphate.
  • Also acts on ITP and dGTP.
 2 A0A1A8NI66 A0A1A8NI66
Phenylalanine--tRNA ligase. [EC: 6.1.1.20]
ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + L-phenylalanyl- tRNA(Phe).
    		 2 G0QUT5 G0QUT5
    Type 1 galactoside alpha-(1,2)-fucosyltransferase. [EC: 2.4.1.69]
    GDP-beta-L-fucose + beta-D-galactosyl-(1->3)-N-acetyl-beta-D- glucosaminyl-R = GDP + alpha-L-fucosyl-(1->2)-beta-D-galactosyl-(1->3)-N- acetyl-beta-D-glucosaminyl-R.
    • The enzyme acts on a glycoconjugates where the substituent group is a glycoprotein or glycosphingolipid.
    • The recognized moiety of the substrate is known as a type 1 histo- blood group antigen precursor disaccharide, and the action of the enzyme produces an H type 1 antigen.
    • The enzyme from the bacterium Helicobacter pylori cannot act on type 2 substrates (see EC 2.4.1.344).
    • Formerly EC 2.4.1.89.
    		 2 G0R609 G0R609
    3-deoxy-7-phosphoheptulonate synthase. [EC: 2.5.1.54]
    Phosphoenolpyruvate + D-erythrose 4-phosphate + H(2)O = 3-deoxy-D- arabino-hept-2-ulosonate 7-phosphate + phosphate.
    • Formerly EC 4.1.2.15.
    		 2 A0A0W0G3T9 A0A0W0G3T9
    Mitogen-activated protein kinase. [EC: 2.7.11.24]
    ATP + a protein = ADP + a phosphoprotein.
    • Phosphorylation of specific tyrosine and threonine residues in the activation loop of this enzyme by EC 2.7.12.2 is necessary for enzyme activation.
    • Once activated, the enzyme phosphorylates target substrates on serine or threonine residues followed by a proline.
    • A distinguishing feature of all MAPKs is the conserved sequence Thr- Xaa-Tyr (TXY).
    • Mitogen-activated protein kinase (MAPK) signal transduction pathways are among the most widespread mechanisms of cellular regulation.
    • Mammalian MAPK pathways can be recruited by a wide variety of stimuli including hormones (e.g. insulin and growth hormone), mitogens (e.g. epidermal growth factor and platelet-derived growth factor), vasoactive peptides (e.g. angiotensin-II and endothelin), inflammatory cytokines of the tumor necrosis factor (TNF) family and environmental stresses such as osmotic shock, ionizing radiation and ischemeic injury.
    • Formerly EC 2.7.1.37.
    		 2 L0B177 L0B177
    Poly(A)-specific ribonuclease. [EC: 3.1.13.4]
    Exonucleolytic cleavage of poly(A) to 5'-AMP.
    • Cleaves poly(A) in either the single- or double-stranded form.
    		 2 G0R609 G0R609
    Holocytochrome-c synthase. [EC: 4.4.1.17]
    Holocytochrome c = apocytochrome c + heme.
    • In the reverse direction, the enzyme catalyzes the attachment of heme to two cysteine residues in the protein, forming thioether links.
    		 2 A0A075B069 A0A075B069