The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
« Back to all FunFams

FunFam 1653: Nucleolar GTP-binding protein 2

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 13 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
GTPase activity GO:0003924
Catalysis of the reaction: GTP + H2O = GDP + phosphate.
5 G0SBX1 (/IDA) P40010 (/IDA) Q7JXU4 (/IDA) Q8MT06 (/IDA) Q9C923 (/IDA)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
4 P40010 (/IPI) P53742 (/IPI) Q9M8Z5 (/IPI) Q9NVN8 (/IPI)
RNA binding GO:0003723
Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
3 P40010 (/IDA) Q13823 (/IDA) Q9NVN8 (/IDA)
RNA binding GO:0003723
Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
2 Q6PGG6 (/ISO) Q99LH1 (/ISO)
GTP binding GO:0005525
Interacting selectively and non-covalently with GTP, guanosine triphosphate.
2 Q21086 (/ISS) Q8MT06 (/ISS)
RNA binding GO:0003723
Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
1 O74791 (/TAS)
GTPase activity GO:0003924
Catalysis of the reaction: GTP + H2O = GDP + phosphate.
1 O74791 (/ISM)
GTPase activity GO:0003924
Catalysis of the reaction: GTP + H2O = GDP + phosphate.
1 O14236 (/ISO)
GTPase activity GO:0003924
Catalysis of the reaction: GTP + H2O = GDP + phosphate.
1 P53742 (/ISS)
GTPase activity GO:0003924
Catalysis of the reaction: GTP + H2O = GDP + phosphate.
1 Q13823 (/NAS)
GTP binding GO:0005525
Interacting selectively and non-covalently with GTP, guanosine triphosphate.
1 O14236 (/ISO)
GTP binding GO:0005525
Interacting selectively and non-covalently with GTP, guanosine triphosphate.
1 Q13823 (/NAS)
ATPase activity GO:0016887
Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction.
1 Q8MT06 (/IDA)

There are 49 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Ribosomal large subunit export from nucleus GO:0000055
The directed movement of a ribosomal large subunit from the nucleus into the cytoplasm.
2 P40010 (/IMP) P53742 (/IMP)
Cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) GO:0000448
Endonucleolytic cleavage within ITS2 between the 5.8S rRNA and the LSU-rRNA of an rRNA molecule originally produced as a tricistronic rRNA transcript that contained the Small SubUnit (SSU) rRNA, the 5.8S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5' to 3' along the primary transcript.
2 A0A0R4IXF1 (/IMP) Q7ZVQ6 (/IMP)
Neural retina development GO:0003407
The progression of the neural retina over time from its initial formation to the mature structure. The neural retina is the part of the retina that contains neurons and photoreceptor cells.
2 A0A0R4IXF1 (/IMP) Q7ZVQ6 (/IMP)
RRNA processing GO:0006364
Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules.
2 O74791 (/IMP) Q7SZX9 (/IMP)
Regulation of exit from mitosis GO:0007096
Any process involved in the progression from anaphase/telophase to G1 that is associated with a conversion from high to low mitotic CDK activity.
2 A0A0R4IXF1 (/IMP) Q7ZVQ6 (/IMP)
Regulation of multicellular organism growth GO:0040014
Any process that modulates the frequency, rate or extent of growth of the body of an organism so that it reaches its usual body size.
2 Q21086 (/IMP) Q8MT06 (/IMP)
Positive regulation of multicellular organism growth GO:0040018
Any process that activates or increases the frequency, rate or extent of growth of an organism to reach its usual body size.
2 Q7JXU4 (/IMP) Q8MT06 (/IMP)
Regulation of neuron differentiation GO:0045664
Any process that modulates the frequency, rate or extent of neuron differentiation.
2 A0A0R4IXF1 (/IMP) Q7ZVQ6 (/IMP)
Ribosomal subunit export from nucleus GO:0000054
The directed movement of a ribosomal subunit from the nucleus into the cytoplasm.
1 O74791 (/IMP)
Ribosomal large subunit export from nucleus GO:0000055
The directed movement of a ribosomal large subunit from the nucleus into the cytoplasm.
1 P40010 (/IGI)
Ribosomal large subunit export from nucleus GO:0000055
The directed movement of a ribosomal large subunit from the nucleus into the cytoplasm.
1 P53742 (/IPI)
Ribosomal large subunit export from nucleus GO:0000055
The directed movement of a ribosomal large subunit from the nucleus into the cytoplasm.
1 O14236 (/ISO)
Maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) GO:0000463
Any process involved in the maturation of a precursor Large SubUnit (LSU) ribosomal RNA (rRNA) molecule into a mature LSU-rRNA molecule from the pre-rRNA molecule originally produced as a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, 5.8S rRNA, and Large Subunit (LSU) in that order from 5' to 3' along the primary transcript.
1 P40010 (/IMP)
Compound eye morphogenesis GO:0001745
The morphogenetic process in which the anatomical structures of the compound eye are generated and organized. The adult compound eye is a precise assembly of 700-800 ommatidia. Each ommatidium is composed of 20 cells, identified by cell type and position. An example of compound eye morphogenesis is found in Drosophila melanogaster.
1 Q7JXU4 (/IMP)
Nematode larval development GO:0002119
The process whose specific outcome is the progression of the nematode larva over time, from its formation to the mature structure. Nematode larval development begins with the newly hatched first-stage larva (L1) and ends with the end of the last larval stage (for example the fourth larval stage (L4) in C. elegans). Each stage of nematode larval development is characterized by proliferation of specific cell lineages and an increase in body size without alteration of the basic body plan. Nematode larval stages are separated by molts in which each stage-specific exoskeleton, or cuticle, is shed and replaced anew.
1 Q21086 (/IMP)
Phagocytosis GO:0006909
An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles.
1 Q7JXU4 (/IMP)
Germ cell development GO:0007281
The process whose specific outcome is the progression of an immature germ cell over time, from its formation to the mature structure (gamete). A germ cell is any reproductive cell in a multicellular organism.
1 Q21086 (/IMP)
Cellular response to starvation GO:0009267
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of nourishment.
1 Q8MT06 (/IEP)
Maintenance of inflorescence meristem identity GO:0010077
The process in which an organism retains a population of inflorescence meristem cells, preventing the commitment of all stem cell progeny to a differentiated cell fate.
1 Q9M8Z5 (/IMP)
Negative regulation of protein ubiquitination GO:0031397
Any process that stops, prevents, or reduces the frequency, rate or extent of the addition of ubiquitin groups to a protein.
1 Q9NVN8 (/IMP)
Negative regulation of protein ubiquitination GO:0031397
Any process that stops, prevents, or reduces the frequency, rate or extent of the addition of ubiquitin groups to a protein.
1 Q6PGG6 (/ISO)
Regulation of protein stability GO:0031647
Any process that affects the structure and integrity of a protein, altering the likelihood of its degradation or aggregation.
1 Q9NVN8 (/IDA)
Regulation of protein stability GO:0031647
Any process that affects the structure and integrity of a protein, altering the likelihood of its degradation or aggregation.
1 Q9NVN8 (/IMP)
Regulation of protein stability GO:0031647
Any process that affects the structure and integrity of a protein, altering the likelihood of its degradation or aggregation.
1 Q6PGG6 (/ISO)
Negative regulation of protein binding GO:0032091
Any process that stops, prevents, or reduces the frequency, rate or extent of protein binding.
1 Q9NVN8 (/IDA)
Negative regulation of protein binding GO:0032091
Any process that stops, prevents, or reduces the frequency, rate or extent of protein binding.
1 Q6PGG6 (/ISO)
Negative regulation of telomere maintenance via telomerase GO:0032211
Any process that stops, prevents, or reduces the frequency, rate or extent of the addition of telomeric repeats by telomerase.
1 Q9NVN8 (/IMP)
Negative regulation of telomere maintenance via telomerase GO:0032211
Any process that stops, prevents, or reduces the frequency, rate or extent of the addition of telomeric repeats by telomerase.
1 Q6PGG6 (/ISO)
Negative regulation of protein sumoylation GO:0033234
Any process that stops, prevents, or reduces the frequency, rate or extent of the addition of SUMO groups to a protein.
1 Q9NVN8 (/IMP)
Negative regulation of protein sumoylation GO:0033234
Any process that stops, prevents, or reduces the frequency, rate or extent of the addition of SUMO groups to a protein.
1 Q6PGG6 (/ISO)
Regulation of cell proliferation GO:0042127
Any process that modulates the frequency, rate or extent of cell proliferation.
1 Q8MT06 (/IMP)
Regulation of cell proliferation GO:0042127
Any process that modulates the frequency, rate or extent of cell proliferation.
1 Q21086 (/ISS)
Ribosome biogenesis GO:0042254
A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits; includes transport to the sites of protein synthesis.
1 Q9C923 (/IDA)
Ribosomal large subunit biogenesis GO:0042273
A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a large ribosomal subunit; includes transport to the sites of protein synthesis.
1 Q8MT06 (/IMP)
Response to drug GO:0042493
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease.
1 A0A1D8PMJ1 (/IMP)
Regulation of epidermal cell differentiation GO:0045604
Any process that modulates the frequency, rate or extent of epidermal cell differentiation.
1 Q9M8Z5 (/IMP)
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
1 Q9M8Z5 (/IMP)
Regulation of embryonic development GO:0045995
Any process that modulates the frequency, rate or extent of embryonic development.
1 Q9M8Z5 (/IMP)
Regulation of insulin receptor signaling pathway GO:0046626
Any process that modulates the frequency, rate or extent of insulin receptor signaling.
1 Q8MT06 (/IMP)
Floral organ morphogenesis GO:0048444
The process in which the anatomical structures of the floral organ are generated and organized.
1 Q9M8Z5 (/IGI)
Floral organ morphogenesis GO:0048444
The process in which the anatomical structures of the floral organ are generated and organized.
1 Q9M8Z5 (/IMP)
Cotyledon development GO:0048825
The process whose specific outcome is the progression of the cotyledon over time, from its formation to the mature structure. The cotyledon is the modified leaf (seed leaf), found as part of the embryo in plant seeds. It is involved in either storage or absorption of food reserves. Dicotyledonous seeds contain two cotyledons, while monocotyledonous seeds contain only one. The cotyledons may appear above ground and show photosynthetic activity in the seedling.
1 Q9M8Z5 (/IMP)
Positive regulation of protein homodimerization activity GO:0090073
Any process that increases the frequency, rate or extent of protein homodimerization, interacting selectively with an identical protein to form a homodimer.
1 Q9NVN8 (/IMP)
Positive regulation of protein homodimerization activity GO:0090073
Any process that increases the frequency, rate or extent of protein homodimerization, interacting selectively with an identical protein to form a homodimer.
1 Q6PGG6 (/ISO)
Mitotic spindle assembly GO:0090307
The aggregation, arrangement and bonding together of a set of components to form the spindle that contributes to the process of mitosis.
1 Q8MT06 (/IMP)
Positive regulation of protein localization to chromosome, telomeric region GO:1904816
Any process that activates or increases the frequency, rate or extent of protein localization to chromosome, telomeric region.
1 Q9NVN8 (/IDA)
Positive regulation of protein localization to chromosome, telomeric region GO:1904816
Any process that activates or increases the frequency, rate or extent of protein localization to chromosome, telomeric region.
1 Q9NVN8 (/IMP)
Positive regulation of protein localization to chromosome, telomeric region GO:1904816
Any process that activates or increases the frequency, rate or extent of protein localization to chromosome, telomeric region.
1 Q6PGG6 (/ISO)
Regulation of leaf development GO:2000024
Any process that modulates the frequency, rate or extent of leaf development.
1 Q9M8Z5 (/IMP)

There are 17 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Nucleolus GO:0005730
A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
11 A0A024R9Y6 (/IDA) O74791 (/IDA) P40010 (/IDA) P53742 (/IDA) Q13823 (/IDA) Q21086 (/IDA) Q5T0F3 (/IDA) Q7JXU4 (/IDA) Q8MT06 (/IDA) Q9M8Z5 (/IDA)
(1 more)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
6 A0A024R9Y6 (/IDA) O14236 (/IDA) O74791 (/IDA) P40010 (/IDA) P53742 (/IDA) Q9NVN8 (/IDA)
Nucleolus GO:0005730
A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
3 O14236 (/ISO) Q6PGG6 (/ISO) Q99LH1 (/ISO)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
2 O14236 (/ISO) Q6PGG6 (/ISO)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
2 P53742 (/IDA) Q21086 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
2 A0A024R9Y6 (/IDA) Q9NVN8 (/IDA)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
2 Q13823 (/IDA) Q9NVN8 (/IDA)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
2 Q6PGG6 (/ISO) Q99LH1 (/ISO)
Granular component GO:0001652
A structure found in the nucleolus, which contains nearly completed preribosomal particles destined for the cytoplasm.
1 Q8MT06 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 Q21086 (/ISS)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 Q13823 (/TAS)
Nucleolus GO:0005730
A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
1 Q21086 (/ISS)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 Q6PGG6 (/ISO)
Plasmodesma GO:0009506
A fine cytoplasmic channel, found in all higher plants, that connects the cytoplasm of one cell to that of an adjacent cell.
1 Q9M8Z5 (/IDA)
Preribosome, large subunit precursor GO:0030687
A preribosomal complex consisting of 27SA, 27SB, and/or 7S pre-rRNA, 5S rRNA, ribosomal proteins including late-associating large subunit proteins, and associated proteins; a precursor of the eukaryotic cytoplasmic large ribosomal subunit.
1 P40010 (/IGI)
Mitotic spindle pole body GO:0044732
The microtubule organizing center that forms as part of the mitotic cell cycle; functionally homologous to the animal cell centrosome.
1 O14236 (/IDA)
Mitotic spindle GO:0072686
A spindle that forms as part of mitosis. Mitotic and meiotic spindles contain distinctive complements of proteins associated with microtubules.
1 O14236 (/IDA)