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CATH Superfamily 1.10.1580.10

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 1653: Nucleolar GTP-binding protein 2

There are 5 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Heterotrimeric G-protein GTPase. [EC: 3.6.5.1]
GTP + H(2)O = GDP + phosphate.
  • This group comprises GTP-hydrolyzing systems, where GTP and GDP alternate in binding.
  • This group includes stimulatory and inhibitory G-proteins such as G(s), G(i), G(o) and G(olf), targeting adenylate cyclase and/or K(+) and Ca(2+) channels; G(q) stimulating phospholipase C; transducin activating cGMP phosphodiesterase; gustducin activating cAMP phosphodiesterase.
  • G(olf) is instrumental in odor perception, transducin in vision and gustducin in taste recognition.
  • At least 16 different alpha subunits (39-52 kDa), 5 beta subunits (36 kDa) and 12 gamma subunits (6-9 kDa) are known.
  • Formerly EC 3.6.1.46.
 24 A0A024V283 A0A024VZM8 A0A024WI65 A0A088RHN2 A0A088RZF9 A0A1A8W8B6 A0A1A8WEH3 A0A1C3KF94 A0A1C3KX90 A0A1D3TMK4
(14 more...)
L-glutamate gamma-semialdehyde dehydrogenase. [EC: 1.2.1.88]
L-glutamate 5-semialdehyde + NAD(+) + H(2)O = L-glutamate + NADH.
  • This enzyme catalyzes the irreversible oxidation of glutamate-gamma- semialdehyde to glutamate as part of the proline degradation pathway.
  • (S)-1-pyrroline-5-carboxylate, the product of the first enzyme of the pathway (EC 1.5.5.2) is in spontaneous equilibrium with its tautomer L-glutamate gamma-semialdehyde.
  • In many bacterial species, both activities are carried out by a single bifunctional enzyme.
  • The enzyme can also oxidize other 1-pyrrolines, e.g. 3-hydroxy-1- pyrroline-5-carboxylate is converted into 4-hydroxyglutamate and (R)- 1-pyrroline-5-carboxylate is converted into D-glutamate.
  • NADP(+) can also act as acceptor, but with lower activity.
  • Formerly EC 1.5.1.12.
 1 A0A0L1HRW1
Tyrosine--tRNA ligase. [EC: 6.1.1.1]
ATP + L-tyrosine + tRNA(Tyr) = AMP + diphosphate + L-tyrosyl-tRNA(Tyr).
    		 1 V5F051
    DNA-directed DNA polymerase. [EC: 2.7.7.7]
    Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).
    • Catalyzes DNA-template-directed extension of the 3'-end of a DNA strand by one nucleotide at a time.
    • Cannot initiate a chain de novo.
    • Requires a primer which may be DNA or RNA.
    • See also EC 2.7.7.49.
    		 1 B0E5H9
    DNA topoisomerase. [EC: 5.99.1.2]
    ATP-independent breakage of single-stranded DNA, followed by passage and rejoining.
    • Brings about the conversion of one topological isomer of DNA into another, e.g. the relaxation of superhelical turns in DNA, the interconversion of simple and knotted rings of single-stranded DNA, and the intertwisting of single-stranded rings of complementary sequences (cf. EC 5.99.1.3).
    		 1 G7YI59
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