CATH Classification

Domain Context

CATH Clusters

Superfamily Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)
Functional Family Phosphatidylinositol-3,4, 5-trisphosphate-dependent Rac exchange factor 1

Enzyme Information

UniProtKB Entries (1)

P63000
RAC1_HUMAN
Homo sapiens
Ras-related C3 botulinum toxin substrate 1

PDB Structure

PDB 4YON
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
The Phosphatidylinositol (3,4,5)-Trisphosphate-dependent Rac Exchanger 1Ras-related C3 Botulinum Toxin Substrate 1 (P-Rex1Rac1) Complex Reveals the Basis of Rac1 Activation in Breast Cancer Cells.
Lucato, C.M., Halls, M.L., Ooms, L.M., Liu, H.J., Mitchell, C.A., Whisstock, J.C., Ellisdon, A.M.
J.Biol.Chem.