CATH Classification

Domain Context

CATH Clusters

Superfamily NADP-dependent oxidoreductase domain
Functional Family Oxidoreductase, aldo/keto reductase family

Enzyme Information

1.1.1.317
Perakine reductase.
based on mapping to UniProt Q3L181
Raucaffrinoline + NADP(+) = perakine + NADPH.
-!- The biosynthesis of raucaffrinoline from perakine is a side route of the ajmaline biosynthesis pathway. -!- The enzyme is a member of the aldo-keto reductase enzyme superfamily from higher plants.

UniProtKB Entries (1)

Q3L181
PERR_RAUSE
Rauvolfia serpentina
Perakine reductase

PDB Structure

PDB 3UYI
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal structure of perakine reductase, founding member of a novel aldo-keto reductase (AKR) subfamily that undergoes unique conformational changes during NADPH binding.
Sun, L., Chen, Y., Rajendran, C., Mueller, U., Panjikar, S., Wang, M., Mindnich, R., Rosenthal, C., Penning, T.M., Stockigt, J.
J.Biol.Chem.