CATH Classification

Domain Context

CATH Clusters

Superfamily Immunoglobulins
Functional Family Kinase insert domain receptor

Enzyme Information

2.7.10.1
Receptor protein-tyrosine kinase.
based on mapping to UniProt P35968
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
-!- The receptor protein-tyrosine kinases, which can be defined as having a transmembrane domain, are a large and diverse multigene family found only in metazoans. -!- In the human genome, 58 receptor-type protein-tyrosine kinases have been identified and these are distributed into 20 subfamilies. -!- Formerly EC 2.7.1.112.

UniProtKB Entries (1)

P35968
VGFR2_HUMAN
Homo sapiens
Vascular endothelial growth factor receptor 2

PDB Structure

PDB 3KVQ
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Direct contacts between extracellular membrane-proximal domains are required for VEGF receptor activation and cell signaling
Yang, Y., Xie, P., Opatowsky, Y., Schlessinger, J.
Proc.Natl.Acad.Sci.USA