Homologous Superfamily: 2.60.40.10

Representative domain: 1u2hA00

Immunoglobulins

Classification Lineage (2.60.40.10)

CATH Code	Level Description	Links
2	Mainly Beta
2.60	Sandwich
2.60.40	Immunoglobulin-like
2.60.40.10	Immunoglobulins	Gene3D

Summary of Non-Redundant Representatives


-	-	-	-	278	409	1273	1866	7674

Non-Redundant Representatives (278)
Alignments (46)
Structural Neighbours ()
Help

What is a Non-Redundant Representative?

CATH is a tree-like organisation of nodes that begins with the class node (i.e. the v5.0 of the tree) and ends with the domain nodes (i.e. the leaves of the tree). Each node below the class have a parent that they belong to, e.g. the parent of the H level (Homologous superfamily) is the T (Topology). Additionally, each node above the domains have child nodes that belong to them, e.g. the child nodes of a given H (Homologous superfamily) level are the S35 families (domains clustered at > 35% sequence identity).

S35 Family Entries in Homologous Superfamily 2.60.40.10 (278)

CATH code	Representative Domain	Number of Domains
2.60.40.10.1	1u2hA00	2
2.60.40.10.2	1k5nB00	505
2.60.40.10.3	3d9aL02	1004
2.60.40.10.4	3d9aL01	117
2.60.40.10.5	1k5nA02	432
2.60.40.10.6	2q20A00	551
2.60.40.10.7	2p45B00	68
2.60.40.10.8	1mexH01	240
2.60.40.10.9	1mjuL01	323
2.60.40.10.10	1ncwH02	277
2.60.40.10.11	1ogaD01	30
2.60.40.10.12	2nw2A01	5
2.60.40.10.13	1mjuH01	135
2.60.40.10.14	1my7A00	4
2.60.40.10.15	1ogaE01	126
2.60.40.10.16	1edqA01	11
2.60.40.10.17	1q9rB02	281
2.60.40.10.18	1smoB00	8
2.60.40.10.19	1k3iA03	12
2.60.40.10.20	3bmvA04	65
2.60.40.10.21	1oaqL00	210
2.60.40.10.22	1l6xA02	63
2.60.40.10.23	1kgcD01	8
2.60.40.10.24	1x9qA01	207
2.60.40.10.25	1v05A00	5
2.60.40.10.26	1kgcE01	17
2.60.40.10.27	2hftA01	31
2.60.40.10.28	1ncwH01	191
2.60.40.10.29	1ngzB02	205
2.60.40.10.30	1q0xL02	145
2.60.40.10.31	2hftA02	34
2.60.40.10.32	3bfoA00	4
2.60.40.10.33	1w8oA02	14
2.60.40.10.34	1l6xA01	60
2.60.40.10.35	1cs6A01	2
2.60.40.10.36	2rb8A00	3
2.60.40.10.37	1xauA00	3
2.60.40.10.38	3bp6A00	5
2.60.40.10.39	1eajB00	21
2.60.40.10.40	1t2jA00	352
2.60.40.10.41	3b9eA01	5
2.60.40.10.42	1my5A00	21
2.60.40.10.43	1ogaD02	26
2.60.40.10.44	2rikA01	4
2.60.40.10.45	2g5rA00	6
2.60.40.10.46	1wwcA00	11
2.60.40.10.47	2rikA02	4
2.60.40.10.48	1nkrA02	26
2.60.40.10.49	2bk8A00	1
2.60.40.10.50	3d85D02	7
2.60.40.10.51	1mfaH01	22
2.60.40.10.52	1nkrA01	8
2.60.40.10.53	1vcaA02	5
2.60.40.10.54	3b4nA01	4
2.60.40.10.55	1uvqA02	110
2.60.40.10.56	1clcA01	1
2.60.40.10.57	1eerB02	15
2.60.40.10.58	1uacH00	42
2.60.40.10.59	1seqH02	3
2.60.40.10.60	1vemA02	33
2.60.40.10.61	2otuA00	12
2.60.40.10.62	2rikA03	3
2.60.40.10.63	1fltX00	10
2.60.40.10.64	1cs6A03	2
2.60.40.10.65	2ialA01	13
2.60.40.10.66	1pkoA00	5
2.60.40.10.67	1cfbA02	1
2.60.40.10.68	2qsqB01	7
2.60.40.10.69	1u58A02	2
2.60.40.10.70	2bnuB02	106
2.60.40.10.71	2h26A02	23
2.60.40.10.72	1fhgA00	2
2.60.40.10.73	2r39A00	1
2.60.40.10.74	1fyhB02	5
2.60.40.10.75	1bquA02	7
2.60.40.10.76	1ugnA01	13
2.60.40.10.77	2v44A01	9
2.60.40.10.78	1fv1B02	110
2.60.40.10.79	3edfA01	12
2.60.40.10.80	1qfoC00	10
2.60.40.10.81	2v44A02	7
2.60.40.10.82	1eerC01	15
2.60.40.10.83	1vjjA04	17
2.60.40.10.84	1bquA01	6
2.60.40.10.85	1cczA01	4
2.60.40.10.86	1waaC00	8
2.60.40.10.87	1qg3A02	3
2.60.40.10.88	1cfbA01	1
2.60.40.10.89	2a38B01	18
2.60.40.10.90	1iamA02	6
2.60.40.10.91	2j8hA02	6
2.60.40.10.92	2ny1B01	29
2.60.40.10.93	1ji1A01	10
2.60.40.10.94	1axiB02	13
2.60.40.10.95	1neuA00	1
2.60.40.10.96	1vjjA03	17
2.60.40.10.97	2j8hA01	6
2.60.40.10.98	1fnaA00	9
2.60.40.10.99	3cafA01	29
2.60.40.10.100	1gsmA02	2
2.60.40.10.101	1tvdA00	2
2.60.40.10.102	1t0pB00	2
2.60.40.10.103	1lp9E01	49
2.60.40.10.104	3bmvA03	65
2.60.40.10.105	1zxqA02	1
2.60.40.10.106	1cs6A04	2
2.60.40.10.107	1cdcA00	18
2.60.40.10.108	1fyhB01	6
2.60.40.10.109	1ex0A03	18
2.60.40.10.110	2nqcA00	1
2.60.40.10.111	1hkfA00	1
2.60.40.10.112	1cs6A02	2
2.60.40.10.113	1vcaA01	5
2.60.40.10.114	2fcbA02	11
2.60.40.10.115	1m7xB01	4
2.60.40.10.116	1ex0A04	18
2.60.40.10.117	1qz1A03	2
2.60.40.10.118	1g1cA00	2
2.60.40.10.119	1ut9A01	2
2.60.40.10.120	1qfhA02	4
2.60.40.10.121	1op3H01	28
2.60.40.10.122	2fcbA01	25
2.60.40.10.123	1xiwA00	3
2.60.40.10.124	2bc4D02	4
2.60.40.10.125	1fnfA01	1
2.60.40.10.126	1u2cA01	1
2.60.40.10.127	1iilG02	25
2.60.40.10.128	1gsmA01	2
2.60.40.10.129	1dqtA00	10
2.60.40.10.130	2hp4A00	7
2.60.40.10.131	3brdA03	6
2.60.40.10.132	1qfhA01	7
2.60.40.10.133	1fp5A02	7
2.60.40.10.134	2bc4A02	4
2.60.40.10.135	1t7vA02	20
2.60.40.10.136	1n26A03	4
2.60.40.10.137	1rhfA01	2
2.60.40.10.138	2brqA00	6
2.60.40.10.139	1fp5A01	7
2.60.40.10.140	1n26A01	2
2.60.40.10.141	1olzA03	2
2.60.40.10.142	3butA00	1
2.60.40.10.143	1fnfA03	5
2.60.40.10.144	1gl4B00	1
2.60.40.10.145	1f97A02	3
2.60.40.10.146	1uadC00	3
2.60.40.10.147	1wzlA01	32
2.60.40.10.148	1itbB02	3
2.60.40.10.149	1uctA01	5
2.60.40.10.150	1f6fB01	4
2.60.40.10.151	1f6fB02	4
2.60.40.10.152	2aepL01	1
2.60.40.10.153	1i1rA01	2
2.60.40.10.154	3d85D01	7
2.60.40.10.155	1fnfA02	1
2.60.40.10.156	1y6kR02	6
2.60.40.10.157	1iarB01	4
2.60.40.10.158	1nezH00	12
2.60.40.10.159	1u3hA00	18
2.60.40.10.160	1qg3A01	3
2.60.40.10.161	1f97A01	3
2.60.40.10.162	3fruA02	8
2.60.40.10.163	1y6kR01	6
2.60.40.10.164	1rhfA02	4
2.60.40.10.165	1dn0D02	13
2.60.40.10.166	1cczA02	5
2.60.40.10.167	3d85D03	7
2.60.40.10.168	1ti6B03	36
2.60.40.10.169	1g0dA03	1
2.60.40.10.170	2c4fT00	3
2.60.40.10.171	2ij0C00	5
2.60.40.10.172	1p7hL02	21
2.60.40.10.173	1o0vA01	5
2.60.40.10.174	1cvrA03	1
2.60.40.10.175	1axiB01	13
2.60.40.10.176	1iarB02	4
2.60.40.10.177	1jmxA03	2
2.60.40.10.178	1fo0B00	6
2.60.40.10.179	1itbB03	3
2.60.40.10.180	1g0dA04	7
2.60.40.10.181	1moeA02	4
2.60.40.10.182	2gysA02	5
2.60.40.10.183	2ak4D01	9
2.60.40.10.184	1iamA01	5
2.60.40.10.185	1sy6A01	2
2.60.40.10.186	1cidA01	5
2.60.40.10.187	1ncnA00	4
2.60.40.10.188	1cd9D01	7
2.60.40.10.189	1f2qA02	14
2.60.40.10.190	1mcpH02	2
2.60.40.10.191	2gysB04	8
2.60.40.10.192	2h32A00	1
2.60.40.10.193	1imhC02	2
2.60.40.10.194	1itbB01	3
2.60.40.10.195	2ny1B02	29
2.60.40.10.196	2fbjH02	2
2.60.40.10.197	1kv3A01	23
2.60.40.10.198	1je6A02	3
2.60.40.10.199	1dr9A01	3
2.60.40.10.200	2gysA01	5
2.60.40.10.201	1cd9B02	9
2.60.40.10.202	2ec8A03	3
2.60.40.10.203	1tdqA02	1
2.60.40.10.204	2gy5A01	2
2.60.40.10.205	2gy5A04	2
2.60.40.10.206	1qr4A01	3
2.60.40.10.207	1hxmB02	6
2.60.40.10.208	1xiwB00	3
2.60.40.10.209	1bihA02	2
2.60.40.10.210	1hzhH01	1
2.60.40.10.211	2ec8A04	3
2.60.40.10.212	1kv3A03	6
2.60.40.10.213	1ow0A02	4
2.60.40.10.214	2nziA03	3
2.60.40.10.215	1n26A02	1
2.60.40.10.216	1bihA03	2
2.60.40.10.217	1ow0A01	4
2.60.40.10.218	1fnhA01	1
2.60.40.10.219	1fnhA02	1
2.60.40.10.220	1p53A01	2
2.60.40.10.221	2gysA03	5
2.60.40.10.222	1fnhA03	1
2.60.40.10.223	1dr9A02	3
2.60.40.10.224	2c5dC01	2
2.60.40.10.225	2uzxB02	2
2.60.40.10.226	1bihA01	2
2.60.40.10.227	2gy5A02	2
2.60.40.10.228	2ec8A01	1
2.60.40.10.229	2flbT00	5
2.60.40.10.230	1g0dA01	1
2.60.40.10.231	3b43A02	1
2.60.40.10.232	1eh9A03	2
2.60.40.10.233	2ec8A02	3
2.60.40.10.234	1koaA03	1
2.60.40.10.235	1l6zA02	1
2.60.40.10.236	1bihA04	2
2.60.40.10.237	1hxmA01	4
2.60.40.10.238	1hxmA02	6
2.60.40.10.239	1p53A03	2
2.60.40.10.240	2ec8A05	3
2.60.40.10.241	1hxmB01	4
2.60.40.10.242	1mh5B02	1
2.60.40.10.243	1bf2A01	1
2.60.40.10.244	2dtgE06	1
2.60.40.10.245	2ifgA02	2
2.60.40.10.246	1cidA02	5
2.60.40.10.247	1ypzF01	2
2.60.40.10.248	2dtgE05	1
2.60.40.10.249	2e9wA01	2
2.60.40.10.250	1evuA01	18
2.60.40.10.251	1p53A02	2
2.60.40.10.252	2dtgE04	1
2.60.40.10.253	2uzyB03	2
2.60.40.10.254	2uzyB04	2
2.60.40.10.255	1ktkF02	1
2.60.40.10.256	2cumA00	2
2.60.40.10.257	1n6uA01	3
2.60.40.10.258	1n6uA02	3
2.60.40.10.259	1ac0A00	4
2.60.40.10.260	2dbjA01	1
2.60.40.10.261	1f3rB02	2
2.60.40.10.262	1nctA00	4
2.60.40.10.263	1lwrA00	1
2.60.40.10.264	2cqvA00	1
2.60.40.10.265	2fnbA00	1
2.60.40.10.266	1ehxA00	1
2.60.40.10.267	1j8kA00	1
2.60.40.10.268	1pd6A00	1
2.60.40.10.269	1owwA00	1
2.60.40.10.270	1witA00	2
2.60.40.10.271	1uemA00	2
2.60.40.10.272	1ujtA00	1
2.60.40.10.273	1jbjA01	2
2.60.40.10.274	1q38A00	1
2.60.40.10.275	2e7hA01	2
2.60.40.10.276	1k85A00	1
2.60.40.10.277	1uenA00	1
2.60.40.10.278	1gxeA00	1

Close Structural Clusters (39)
Distant Structural Clusters (7)

What is an Close Structural Cluster?

A Close Structural Cluster describes a cluster of two or more CATH domains that have been grouped together due to their close structural similarity (SIMAX score < 5Å where SIMAX = RMSD x Number of residues in the larger domain/number of aligned residues).

Close Structural Clusters 2.60.40.10 (< 5Å)

Summary of "distant" structural clusters found within this level of CATH.
Cluster ID	Example Domain	Domains in Cluster	Structural Alignment (Core)	Structural Alignment (Expanded)
00002.00060.00040.00010/SSG5/1	1vemA02	3	FASTA Jalview	FASTA Jalview
00002.00060.00040.00010/SSG5/2	1cczA02	3	FASTA Jalview	FASTA Jalview
00002.00060.00040.00010/SSG5/3	1cfbA01	5	FASTA Jalview	FASTA Jalview
00002.00060.00040.00010/SSG5/4	1ut9A01	2	FASTA Jalview	FASTA Jalview
00002.00060.00040.00010/SSG5/5	2g5rA00	6	FASTA Jalview	FASTA Jalview
00002.00060.00040.00010/SSG5/6	1dn0D02	20	FASTA Jalview	FASTA Jalview
00002.00060.00040.00010/SSG5/7	2ec8A05	10	FASTA Jalview	FASTA Jalview
00002.00060.00040.00010/SSG5/8	3b9eA01	3	FASTA Jalview	FASTA Jalview
00002.00060.00040.00010/SSG5/9	1m7xB01	2	FASTA Jalview	FASTA Jalview
00002.00060.00040.00010/SSG5/10	1f6fB01	2	FASTA Jalview	FASTA Jalview
00002.00060.00040.00010/SSG5/11	1g0dA01	3	FASTA Jalview	FASTA Jalview
00002.00060.00040.00010/SSG5/12	1g0dA03	9	FASTA Jalview	FASTA Jalview
00002.00060.00040.00010/SSG5/13	1uctA01	5	FASTA Jalview	FASTA Jalview
00002.00060.00040.00010/SSG5/14	2h32A00	2	FASTA Jalview	FASTA Jalview
00002.00060.00040.00010/SSG5/15	1jbjA01	4	FASTA Jalview	FASTA Jalview
00002.00060.00040.00010/SSG5/16	1fnhA02	14	FASTA Jalview	FASTA Jalview
00002.00060.00040.00010/SSG5/17	1mjuH01	20	FASTA Jalview	FASTA Jalview
00002.00060.00040.00010/SSG5/18	1fyhB01	5	FASTA Jalview	FASTA Jalview
00002.00060.00040.00010/SSG5/19	2dtgE06	5	FASTA Jalview	FASTA Jalview
00002.00060.00040.00010/SSG5/20	2ec8A01	4	FASTA Jalview	FASTA Jalview
00002.00060.00040.00010/SSG5/21	2e7hA01	17	FASTA Jalview	FASTA Jalview
00002.00060.00040.00010/SSG5/22	1hxmA02	3	FASTA Jalview	FASTA Jalview
00002.00060.00040.00010/SSG5/23	1iamA01	4	FASTA Jalview	FASTA Jalview
00002.00060.00040.00010/SSG5/24	1iamA02	4	FASTA Jalview	FASTA Jalview
00002.00060.00040.00010/SSG5/25	1p53A02	2	FASTA Jalview	FASTA Jalview
00002.00060.00040.00010/SSG5/26	2uzxB02	4	FASTA Jalview	FASTA Jalview
00002.00060.00040.00010/SSG5/27	1itbB02	2	FASTA Jalview	FASTA Jalview
00002.00060.00040.00010/SSG5/28	1ji1A01	2	FASTA Jalview	FASTA Jalview
00002.00060.00040.00010/SSG5/29	1my7A00	9	FASTA Jalview	FASTA Jalview
00002.00060.00040.00010/SSG5/30	3d85D01	2	FASTA Jalview	FASTA Jalview
00002.00060.00040.00010/SSG5/31	2fcbA01	4	FASTA Jalview	FASTA Jalview
00002.00060.00040.00010/SSG5/32	1qfhA01	4	FASTA Jalview	FASTA Jalview
00002.00060.00040.00010/SSG5/33	1sy6A01	2	FASTA Jalview	FASTA Jalview
00002.00060.00040.00010/SSG5/34	2v44A02	16	FASTA Jalview	FASTA Jalview
00002.00060.00040.00010/SSG5/35	2gysA03	2	FASTA Jalview	FASTA Jalview
00002.00060.00040.00010/SSG5/36	1rhfA01	4	FASTA Jalview	FASTA Jalview
00002.00060.00040.00010/SSG5/37	1u2hA00	20	FASTA Jalview	FASTA Jalview
00002.00060.00040.00010/SSG5/38	3d85D02	7	FASTA Jalview	FASTA Jalview
00002.00060.00040.00010/SSG5/39	2hp4A00	29	FASTA Jalview	FASTA Jalview

What is a Distant Structural Cluster?

A Distant Structural Cluster describes a cluster of two or CATH domains that have been grouped together with a more relaxed structural similarity threshold to investigate more distant evolutionary similarities (SIMAX score < 5Å where SIMAX = RMSD x Number of residues in the larger domain/number of aligned residues).

Distant Structural Clusters 2.60.40.10 (< 9Å)

Summary of "distant" structural clusters found within this level of CATH.
Cluster ID	Example Domain	Domains in Cluster	Structural Alignment (Core)	Structural Alignment (Expanded)
00002.00060.00040.00010/SSGA9/1	1bf2A01	2	FASTA Jalview	FASTA Jalview
00002.00060.00040.00010/SSGA9/2	1n6uA01	15	FASTA Jalview	FASTA Jalview
00002.00060.00040.00010/SSGA9/3	2e9wA01	9	FASTA Jalview	FASTA Jalview
00002.00060.00040.00010/SSGA9/4	2uzyB03	8	FASTA Jalview	FASTA Jalview
00002.00060.00040.00010/SSGA9/5	2j8hA01	11	FASTA Jalview	FASTA Jalview
00002.00060.00040.00010/SSGA9/6	1g0dA01	2	FASTA Jalview	FASTA Jalview
00002.00060.00040.00010/SSGA9/7	1ogaD02	2	FASTA Jalview	FASTA Jalview

What is a Structural Neighbour?

The term "structural neighbour" is used here to describe two CATH domains that share a degree of structural similarity. The SSAP algorithm is used to calculate this similarity and works by generating a structure-based pairwise alignment of the two domains then scoring this alignment using a RMSD score which has been normalised by the length of the larger domain divided by the number of aligned residues (SIMAX).

Structural Comparisons for Non-redundant S35 Representatives of 2.60.40.10 ( entries)

What is a Non-Redundant Representative?

Why can't I have a multiple structural alignment of the whole superfamily?

The simple answer is that some of the larger superfamilies in CATH comprise relatives which are very structurally diverse, having different secondary structure embellishments. Attempting to provide a global alignment of all domains in the superfamily would result in poor quality alignments. As a result, structural alignments in CATH are generated by first clustering together the structures that have at least some recognisable structural similarity using a normalised RMSD score (SIMAX = RMSDxNumber of residues in the largest domain/number of aligned residues) less than a given cutoff.

Homologous Superfamily: 2.60.40.10

Immunoglobulins

Classification Lineage (2.60.40.10)

Summary of Non-Redundant Representatives

What is a Non-Redundant Representative?

S35 Family Entries in Homologous Superfamily 2.60.40.10 (278)

What is an Close Structural Cluster?

Close Structural Clusters 2.60.40.10 (< 5Å)

What is a Distant Structural Cluster?

Distant Structural Clusters 2.60.40.10 (< 9Å)

What is a Structural Neighbour?

Structural Comparisons for Non-redundant S35 Representatives of 2.60.40.10 ( entries)

What is a Non-Redundant Representative?

Why can't I have a multiple structural alignment of the whole superfamily?

What is an Close Structural Cluster?

What is a Distant Structural Cluster?

What is a Structural Neighbour?

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