Homologous Superfamily: 2.60.40.10

Representative domain: 1u2hA00

Immunoglobulins

Classification Lineage (2.60.40.10)

CATH Code	Level Description	Links
2	Mainly Beta
2.60	Sandwich
2.60.40	Immunoglobulin-like
2.60.40.10	Immunoglobulins	Gene3D

Summary of Non-Redundant Representatives


-	-	-	-	293	442	1473	2174	9315

Non-Redundant Representatives (293)
Alignments (52)
Structural Neighbours ()
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What is a Non-Redundant Representative?

CATH is a tree-like organisation of nodes that begins with the class node (i.e. the first branch-point of the tree) and ends with the domain nodes (i.e. the leaves of the tree). Each node below the class have a parent that they belong to, e.g. the parent of the H level (Homologous superfamily) is the T (Topology). Additionally, each node above the domains have child nodes that belong to them, e.g. the child nodes of a given H (Homologous superfamily) level are the S35 families (domains clustered at > 35% sequence identity).

S35 Family Entries in Homologous Superfamily 2.60.40.10 (293)

CATH code	Representative Domain	Representative Keywords	Number of Domains
2.60.40.10.1	1u2hA00	Non-specific serine/threonine protein kinase.Striated muscle-specific serine/threonine protein kinase [EC:2.7.11.1]Muscle organ developmentNucleusStriated muscle preferentially expressed protein kinase	2
2.60.40.10.2	1k5nB00	Beta-2-microglobulinHomo sapiensBeta-2-microglobulinProtein bindingAntigen processing and presentation	622
2.60.40.10.3	3d9aL02		1147
2.60.40.10.4	3d9aL01		117
2.60.40.10.5	3esuF02		266
2.60.40.10.6	2q20A00		551
2.60.40.10.7	1k5nA02	HLA class I histocompatibility antigen, B-27 alpha chainMembrane fractionDefense responseHomo sapiens	527
2.60.40.10.8	2p45B00		40
2.60.40.10.9	3d9aH01		31
2.60.40.10.10	3d9aH02		313
2.60.40.10.11	1mjuL01		323
2.60.40.10.12	1ncwH02		448
2.60.40.10.13	1ogaD01	Homo sapiensT-cell receptor alpha chain C region	36
2.60.40.10.14	2nw2A01	TRA@ proteinHomo sapiens	5
2.60.40.10.15	1mjuH01		82
2.60.40.10.16	1my7A00	Pathways in cancerChagas diseaseChemokine signaling pathwayNeurotrophin signaling pathwayB cell receptor signaling pathway	5
2.60.40.10.17	1ogaE01	T-cell receptor beta-1 chain C regionHomo sapiensProtein binding	134
2.60.40.10.18	1edqA01	Chitinase ASerratia marcescens	15
2.60.40.10.19	2vxvH02		474
2.60.40.10.20	1smoB00	Receptor activityTriggering receptor expressed on myeloid cells 1Homo sapiensHumoral immune response	8
2.60.40.10.21	1k3iA03	Gibberella zeaeGalactose oxidaseGalactose oxidase.	13
2.60.40.10.22	1oaqL00		90
2.60.40.10.23	3bmvA04	Cyclomaltodextrin glucanotransferase.Cyclomaltodextrin glucanotransferaseThermoanaerobacterium thermosulfurigenes	65
2.60.40.10.24	1l6xA02	Ig gamma-1 chain C regionHomo sapiensProtein bindingAntigen binding	76
2.60.40.10.25	1kgcD01	Homo sapiensT-cell receptor alpha chain C region	11
2.60.40.10.26	1x9qA01		207
2.60.40.10.27	1pewA00	Ig lambda chain V-VI region SUTHomo sapiens	126
2.60.40.10.28	1v05A00	Plasma membraneFilamin-CHomo sapiens	5
2.60.40.10.29	1kgcE01	T-cell receptor beta-1 chain C regionHomo sapiensProtein binding	17
2.60.40.10.30	2q87C00	Homo sapiensCMRF35-like molecule 8CD300 antigen	5
2.60.40.10.31	2vxtH01		240
2.60.40.10.32	1ncwH01		290
2.60.40.10.33	2hftA01	Tissue factorPositive regulation of endothelial cell proliferationPositive regulation of platelet-derived growth factor receptor signaling pathwayPositive regulation of angiogenesisProtease binding	32
2.60.40.10.34	1q0xL02	Mus musculusIg lambda-1 chain V regionProtein binding	155
2.60.40.10.35	3bfoA00	Positive regulation of T cell cytokine productionActivation of NF-kappaB-inducing kinase activityPositive regulation of interleukin-2 productionNucleusB cell receptor signaling pathway	4
2.60.40.10.36	2hftA02	Tissue factorPositive regulation of endothelial cell proliferationPositive regulation of platelet-derived growth factor receptor signaling pathwayPositive regulation of angiogenesisProtease binding	35
2.60.40.10.37	1w8oA02	Exo-alpha-sialidase.Micromonospora viridifaciensSialidase	14
2.60.40.10.38	1cs6A01	Cell adhesion molecule bindingNeuron cell-cell adhesionContactin 2Gallus gallusContactin-2	5
2.60.40.10.39	1l6xA01	Ig gamma-1 chain C regionHomo sapiensProtein bindingAntigen binding	70
2.60.40.10.40	3bp6A00	Mus musculusExternal side of plasma membraneProgrammed cell death protein 1Protein bindingT cell receptor signaling pathway	5
2.60.40.10.41	1eajB00	Receptor activityIntegral to plasma membraneViral myocarditisCoxsackievirus and adenovirus receptorCoxsackievirus and adenovirus receptor	34
2.60.40.10.42	2rb8A00	TenascinCell adhesionSyndecan bindingECM-receptor interactionTenascin	3
2.60.40.10.43	1xauA00	Integral to plasma membraneReceptor activityNegative regulation of B cell proliferationProtein bindingMus musculus	3
2.60.40.10.44	1t2jA00	Homo sapiensSingle chain Fv	553
2.60.40.10.45	3b9eA01	Chitinase AVibrio harveyi	5
2.60.40.10.46	1my5A00	Pathways in cancerChemokine signaling pathwayChagas diseaseNeurotrophin signaling pathwayB cell receptor signaling pathway	25
2.60.40.10.47	1ogaD02	Homo sapiensT-cell receptor alpha chain C region	26
2.60.40.10.48	3k2mC00		11
2.60.40.10.49	2g5rA00	Sialic acid-binding Ig-like lectin 7Sialic acid binding Ig-like lectin 7Receptor activityIntegral to plasma membraneHomo sapiens	6
2.60.40.10.50	2rikA01	TitinOryctolagus cuniculus	4
2.60.40.10.51	1wwcA00	Integral to plasma membraneNT-3 growth factor receptorTransmembrane receptor protein tyrosine kinase signaling pathwayHomo sapiensReceptor protein-tyrosine kinase.	11
2.60.40.10.52	2rikA02	TitinOryctolagus cuniculus	4
2.60.40.10.53	1r6vA04	FervidolysinFervidobacterium pennivorans	1
2.60.40.10.54	1nkrA02	Integral to plasma membraneReceptor activityNatural killer cell inhibitory signaling pathwayHomo sapiensImmune response	27
2.60.40.10.55	3d85D02		8
2.60.40.10.56	1u3zA00	Protein homodimerization activityNegative regulation of interleukin-12 biosynthetic processLymph node developmentNucleusNuclear factor NF-kappa-B p105 subunit	30
2.60.40.10.57	2bk8A00	Non-specific serine/threonine protein kinase.Calcium ion bindingSarcomere organizationTelethonin bindingActin filament binding	1
2.60.40.10.58	1yc7A00		77
2.60.40.10.59	1mfaH01		29
2.60.40.10.60	1nkrA01	Receptor activityIntegral to plasma membraneHomo sapiensImmune responseNatural killer cell inhibitory signaling pathway	9
2.60.40.10.61	1vcaA02	Vascular cell adhesion protein 1MicrovillusPositive regulation of T cell proliferationMembrane to membrane dockingLeukocyte transendothelial migration	5
2.60.40.10.62	3b4nA01	Erwinia chrysanthemiPectate lyase.Endo-pectate lyase	4
2.60.40.10.63	1uvqA02		114
2.60.40.10.64	1clcA01	Clostridium thermocellumEndoglucanase DCellulase.	1
2.60.40.10.65	1eerB02	Jak-STAT signaling pathwayIntegral to plasma membraneHematopoietic cell lineageErythropoietin receptor activityErythropoietin receptor	15
2.60.40.10.66	2otuA00		12
2.60.40.10.67	1seqH02	Rattus norvegicusIghg protein	3
2.60.40.10.68	1vemA02	Beta-amylase.Bacillus cereusBeta-amylase	33
2.60.40.10.69	2rikA03	TitinOryctolagus cuniculus	3
2.60.40.10.70	2ialA01	Homo sapiensT-cell receptor alpha chain C region	13
2.60.40.10.71	1fltX00	Vascular endothelial growth factor receptor 1Integral to plasma membraneGrowth factor bindingFemale pregnancyVascular endothelial growth factor receptor activity	12
2.60.40.10.72	1pkoA00	Rattus norvegicusMyelin-oligodendrocyte glycoproteinPositive regulation of MyD88-dependent toll-like receptor signaling pathway	5
2.60.40.10.73	1cs6A03	Cell adhesion molecule bindingNeuron cell-cell adhesionContactin 2Gallus gallusContactin-2	5
2.60.40.10.74	1cfbA02	Calcium ion bindingNeuron cell-cell adhesionDrosophila melanogasterEpidermal growth factor receptor signaling pathwayNerve maturation	1
2.60.40.10.75	2qsqB01	Carcinoembryonic antigen-related cell adhesion molecule 5Integral to plasma membraneBasolateral plasma membraneHomo sapiens	9
2.60.40.10.76	1u58A02	Murine cytomegalovirus (strain K181)Immunoevasin	2
2.60.40.10.77	2bnuB02	T-cell receptor beta-1 chain C regionHomo sapiensProtein binding	110
2.60.40.10.78	3g08A02	Antigen-presenting glycoprotein CD1d1Endogenous lipid antigen bindingPositive thymic T cell selectionProtein bindingAntigen processing and presentation, exogenous lipid antigen via MHC class Ib	41
2.60.40.10.79	2r39A00	Vibrio parahaemolyticusFixG-related protein	1
2.60.40.10.80	1bquA02	Oncostatin-M receptor complexJak-STAT signaling pathwayResponse to cytokine stimulusPositive regulation of T cell proliferationPositive regulation of tyrosine phosphorylation of Stat1 protein	7
2.60.40.10.81	1fhgA00	TelokinMeleagris gallopavo	2
2.60.40.10.82	1fyhB02	Jak-STAT signaling pathwayInterferon gamma receptor 1Integral to plasma membraneChagas diseaseInterferon-gamma receptor activity	5
2.60.40.10.83	1ugnA01	Homo sapiensResponse to virusIntegral to membraneLeukocyte immunoglobulin-like receptor subfamily B member 1Protein phosphatase 1 binding	13
2.60.40.10.84	2v44A01	Prion diseasesNeural cell adhesion moleculePlasma membraneNeuron cell-cell adhesionNeural cell adhesion molecule 2	11
2.60.40.10.85	1fv1B02	HLA class II histocompatibility antigen, DR beta 5 chainMajor histocompatibility complex, class IIType I diabetes mellitusHematopoietic cell lineageAutoimmune thyroid disease	114
2.60.40.10.86	3edfA01	Cyclomaltodextrinase.CyclomaltodextrinaseFlavobacterium sp. 92	12
2.60.40.10.87	1qfoC00	Mus musculusSialoadhesinProtein binding	10
2.60.40.10.88	2v44A02	Prion diseasesNeural cell adhesion moleculePlasma membraneNeuron cell-cell adhesionNeural cell adhesion molecule 2	9
2.60.40.10.89	1eerC01	Jak-STAT signaling pathwayIntegral to plasma membraneHematopoietic cell lineageErythropoietin receptor activityErythropoietin receptor	15
2.60.40.10.90	1vjjA04	Calcium ion bindingCytoplasmGTPase activityPeptide cross-linkingHair follicle morphogenesis	17
2.60.40.10.91	1bquA01	Jak-STAT signaling pathwayOncostatin-M receptor complexResponse to cytokine stimulusPositive regulation of osteoblast differentiationPositive regulation of tyrosine phosphorylation of Stat1 protein	6
2.60.40.10.92	1cczA01	Homo sapiensLymphocyte function-associated antigen 3Protein binding	4
2.60.40.10.93	1waaC00	Calcium ion bindingNon-specific serine/threonine protein kinase.Sarcomere organizationTelethonin bindingActin filament binding	9
2.60.40.10.94	1qg3A02	Homo sapiensIntegrin complexIntegrin beta-4Protein binding	3
2.60.40.10.95	1cfbA01	Calcium ion bindingNeuron cell-cell adhesionNerve maturationEpidermal growth factor receptor signaling pathwayDrosophila melanogaster	1
2.60.40.10.96	2a38B01	Non-specific serine/threonine protein kinase.Calcium ion bindingTelethonin bindingSarcomere organizationActin filament binding	18
2.60.40.10.97	3dbxA02	CD1-2 antigenGallus gallus	6
2.60.40.10.98	1iamA02	Leukocyte migrationAdhesion to symbiontHeterophilic cell-cell adhesionRegulation of leukocyte mediated cytotoxicityT cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell	6
2.60.40.10.99	1ji1A01	Neopullulanase.Neopullulanase 1Thermoactinomyces vulgaris	10
2.60.40.10.100	1q72H02		6
2.60.40.10.101	2j8hA02	Non-specific serine/threonine protein kinase.Calcium ion bindingTelethonin bindingSarcomere organizationActin filament binding	6
2.60.40.10.102	2ny1B01	Zinc ion bindingMaintenance of protein location in cellT-cell surface glycoprotein CD4Signal transductionT cell receptor signaling pathway	32
2.60.40.10.103	1neuA00	Rattus norvegicusMyelin protein P0	1
2.60.40.10.104	1vjjA03	Calcium ion bindingHair follicle morphogenesisGTP bindingExtrinsic to internal side of plasma membraneTransglutaminase 3 [EC:2.3.2.13]	17
2.60.40.10.105	1axiB02	Jak-STAT signaling pathwayMulticellular organismal metabolic processCell surfaceGrowth hormone receptor complexInsulin-like growth factor receptor signaling pathway	13
2.60.40.10.106	2j8hA01	Non-specific serine/threonine protein kinase.Calcium ion bindingSarcomere organizationTelethonin bindingActin filament binding	6
2.60.40.10.107	3cafA01	Cell surfacePathways in cancerNucleusPositive regulation of cell proliferationFibroblast growth factor binding	33
2.60.40.10.108	1gsmA02	Membrane fractionIntestinal immune network for IgA productionCell adhesionSignal transductionMucosal vascular addressin cell adhesion molecule 1	2
2.60.40.10.109	1tvdA00	Homo sapiensHDV103S1	2
2.60.40.10.110	1lp9E01		49
2.60.40.10.111	1zxqA02	Intercellular adhesion molecule 2Integral to plasma membraneIntercellular adhesion molecule 2Homo sapiensNatural killer cell mediated cytotoxicity	1
2.60.40.10.112	1t0pB00	Integral to plasma membraneIntercellular adhesion molecule 3Intercellular adhesion molecule 3Homo sapiensIntegrin binding	2
2.60.40.10.113	3bmvA03	Cyclomaltodextrin glucanotransferaseCyclomaltodextrin glucanotransferase.Thermoanaerobacterium thermosulfurigenes	65
2.60.40.10.114	1cs6A04	Cell adhesion molecule bindingContactin 2Neuron cell-cell adhesionGallus gallusContactin-2	2
2.60.40.10.115	1ex0A03	Protein-glutamine gamma-glutamyltransferase activityHomo sapiensCoagulation factor XIII A chainProtein-glutamine gamma-glutamyltransferase.Blood coagulation	18
2.60.40.10.116	1cdcA00	T-cell surface antigen CD2Rattus norvegicusCell surfaceProtein homodimerization activityHematopoietic cell lineage	18
2.60.40.10.117	1fyhB01	Jak-STAT signaling pathwayIntegral to plasma membraneInterferon gamma receptor 1Interferon-gamma receptor activityChagas disease	6
2.60.40.10.118	1hkfA00	Integral to plasma membraneNatural cytotoxicity triggering receptor 2Cellular defense responseNatural killer cell mediated cytotoxicitySignal transduction	1
2.60.40.10.119	1m7xB01	Glycogen biosynthetic process1,4-alpha-glucan-branching enzyme1,4-alpha-glucan branching enzyme.1,4-alpha-glucan branching enzyme activityMetabolic pathways	4
2.60.40.10.120	2nqcA00	Plasma membraneFilamin-CHomo sapiens	7
2.60.40.10.121	1cs6A02	Cell adhesion molecule bindingNeuron cell-cell adhesionContactin 2Gallus gallusContactin-2	5
2.60.40.10.122	1vcaA01	MicrovillusVascular cell adhesion protein 1Positive regulation of T cell proliferationHeterophilic cell-cell adhesionFilopodium	5
2.60.40.10.123	2fcbA02	Low affinity immunoglobulin gamma Fc region receptor II-bImmune responseHomo sapiensSignal transduction	11
2.60.40.10.124	1ex0A04	Protein-glutamine gamma-glutamyltransferase activityHomo sapiensCoagulation factor XIII A chainProtein-glutamine gamma-glutamyltransferase.Blood coagulation	18
2.60.40.10.125	1qz1A03	Prion diseasesRattus norvegicusNeural cell adhesion moleculePlasma membraneFibroblast growth factor receptor binding	4
2.60.40.10.126	1g1cA00	Non-specific serine/threonine protein kinase.Calcium ion bindingTelethonin bindingSarcomere organizationActin filament binding	2
2.60.40.10.127	1ut9A01	Clostridium thermocellumCellulose 1,4-beta-cellobiosidase.Cellobiohydrolase	2
2.60.40.10.128	3h9yA02	Homo sapiensIg epsilon chain C region	20
2.60.40.10.129	1qfhA02	ThermotaxisPhagocytic cupMembrane fractionProtein homodimerization activityPhototaxis	4
2.60.40.10.130	2bc4D02	Major histocompatibility complex, class IIType I diabetes mellitusAutoimmune thyroid diseaseIntestinal immune network for IgA productionAllograft rejection	4
2.60.40.10.131	2fcbA01	Low affinity immunoglobulin gamma Fc region receptor II-bHomo sapiensImmune responseSignal transduction	25
2.60.40.10.132	1xiwA00	Hematopoietic cell lineageChagas diseaseReceptor signaling protein activitySH3 domain bindingT cell receptor signaling pathway	3
2.60.40.10.133	1fnfA01	FibronectinER-Golgi intermediate compartmentPeptide cross-linkingFibrinogen complexSubstrate adhesion-dependent cell spreading	1
2.60.40.10.134	3iagC03	Transcription factor bindingHeart developmentRegulation of timing of cell differentiationDefense response to bacteriumChromatin binding	7
2.60.40.10.135	3h9yB01	Homo sapiensIg epsilon chain C region	20
2.60.40.10.136	1iilG02	Cell surfacePathways in cancerPositive regulation of cell proliferationNucleusFibroblast growth factor binding	25
2.60.40.10.137	1u2cA01	Epithelial tube branching involved in lung morphogenesisDilated cardiomyopathyECM-receptor interactionHypertrophic cardiomyopathy (HCM)Sarcolemma	1
2.60.40.10.138	1gsmA01	Membrane fractionIntestinal immune network for IgA productionCell adhesionSignal transductionMucosal vascular addressin cell adhesion molecule 1	2
2.60.40.10.139	1dqtA00	Mus musculusExternal side of plasma membraneCytotoxic T-lymphocyte protein 4	10
2.60.40.10.140	2hp4A00	T-cell surface glycoprotein CD8 alpha chainHematopoietic cell lineageCD8A antigen, alpha polypeptidePrimary immunodeficiencyHomo sapiens	7
2.60.40.10.141	1qfhA01	ThermotaxisMembrane fractionPhagocytic cupPhototaxisProtein homodimerization activity	7
2.60.40.10.142	2bc4A02	HLA class II histocompatibility antigen, DM alpha chainHomo sapiensProtein binding	4
2.60.40.10.143	1t7vA02	Cell adhesionHomo sapiensZinc-alpha-2-glycoprotein	17
2.60.40.10.144	1n26A03	Jak-STAT signaling pathwayPositive regulation of smooth muscle cell proliferationResponse to cytokine stimulusAcute-phase responsePositive regulation of osteoblast differentiation	4
2.60.40.10.145	1rhfA01	Integral to plasma membraneReceptor signaling protein tyrosine kinase activityTyrosine-protein kinase receptor TYRO3Transmembrane receptor protein tyrosine kinase activityCell adhesion	2
2.60.40.10.146	2brqA00	Receptor clusteringTranscription factor bindingActin filament bindingActin cytoskeleton reorganizationCytoplasmic sequestering of protein	3
2.60.40.10.147	1n26A01	Positive regulation of smooth muscle cell proliferationJak-STAT signaling pathwayResponse to cytokine stimulusAcute-phase responsePositive regulation of osteoblast differentiation	2
2.60.40.10.148	1olzA03	Receptor bindingAnti-apoptosisSemaphorin-4DReceptor activityCell adhesion	2
2.60.40.10.149	3butA00	Archaeoglobus fulgidusPutative uncharacterized protein	1
2.60.40.10.150	1f97A02	Epithelial cell differentiationMus musculusJunctional adhesion molecule ACell adhesionTight junction	3
2.60.40.10.151	1jmxA04	Quinohemoprotein amine dehydrogenase 60 kDa subunitPseudomonas putida	4
2.60.40.10.152	1wzlA01	Neopullulanase 2Neopullulanase.Thermoactinomyces vulgaris	32
2.60.40.10.153	1fnfA03	Peptide cross-linkingFibronectinER-Golgi intermediate compartmentFibrinogen complexSubstrate adhesion-dependent cell spreading	5
2.60.40.10.154	1gl4B00	Chondrocyte differentiationCardiac muscle tissue developmentCartilage development involved in endochondral bone morphogenesisProtein localizationBrain development	1
2.60.40.10.155	1uadC00	ExocystRattus norvegicusExocyst complex component 2	3
2.60.40.10.156	2q8bH01		6
2.60.40.10.157	1itbB02	Platelet-derived growth factor receptor bindingIntegral to plasma membraneHematopoietic cell lineageInterleukin 1 receptor, type IInterleukin-1-mediated signaling pathway	3
2.60.40.10.158	1j0hA01	Neopullulanase.NeopullulanaseGeobacillus stearothermophilus	14
2.60.40.10.159	2aepL01		1
2.60.40.10.160	1uctA01	Immunoglobulin alpha Fc receptorIntegral to plasma membraneCD89 antigenHomo sapiensImmune response	5
2.60.40.10.161	1f6fB01	Rattus norvegicusProlactin receptor activityProlactin receptor	6
2.60.40.10.162	1f6fB02	Rattus norvegicusProlactin receptor activityProlactin receptor	6
2.60.40.10.163	1i1rA01	Jak-STAT signaling pathwayOncostatin-M receptor complexResponse to cytokine stimulusPositive regulation of T cell proliferationPositive regulation of osteoblast differentiation	2
2.60.40.10.164	3d85D01		8
2.60.40.10.165	1fnfA02	Peptide cross-linkingFibronectinER-Golgi intermediate compartmentFibrinogen complexSubstrate adhesion-dependent cell spreading	1
2.60.40.10.166	1nezH00	T-cell surface glycoprotein CD8 alpha chainProtein homodimerization activityHematopoietic cell lineageCD8A antigen, alpha polypeptideT cell receptor signaling pathway	13
2.60.40.10.167	1u3hA00	Mus musculusTRAV14-3	22
2.60.40.10.168	1y6kR02	Interleukin-10 receptor activityPlasma membraneInterleukin-10 receptor subunit alphaHomo sapiens	6
2.60.40.10.169	1iarB01	Jak-STAT signaling pathwayInterleukin 4 receptorIntegral to plasma membraneReceptor signaling protein activityInterleukin-4 receptor activity	4
2.60.40.10.170	3c8dA01	Shigella flexneriEnterochelin esteraseEnterochelin esterase and related enzymes	11
2.60.40.10.171	1qg3A01	Homo sapiensIntegrin complexProtein bindingIntegrin beta-4	3
2.60.40.10.172	1f97A01	Mus musculusEpithelial cell differentiationJunctional adhesion molecule ACell adhesionTight junction	3
2.60.40.10.173	3fruA02	Beta-2-microglobulin bindingIgG receptor FcRn large subunit p51Rattus norvegicusHumoral immune responseIgG receptor activity	8
2.60.40.10.174	1y6kR01	Interleukin-10 receptor activityPlasma membraneHomo sapiensInterleukin-10 receptor subunit alpha	6
2.60.40.10.175	1pbyA03	Paracoccus denitrificansQuinohemoprotein amine dehydrogenase 60 kDa subunit	2
2.60.40.10.176	1rhfA02	Integral to plasma membraneTyrosine-protein kinase receptor TYRO3Cell adhesionTYRO3 protein tyrosine kinase 3 [EC:2.7.10.1]Signal transduction	4
2.60.40.10.177	1dn0D02		14
2.60.40.10.178	1cczA02	Homo sapiensLymphocyte function-associated antigen 3Protein binding	5
2.60.40.10.179	1g0dA03	Protein-glutamine gamma-glutamyltransferase 2Protein-glutamine gamma-glutamyltransferase.Pagrus major	1
2.60.40.10.180	2ij0C00	Homo sapiensT cell receptor beta variable 20/OR9-2	7
2.60.40.10.181	3d85D03		8
2.60.40.10.182	1p7hL02	Nuclear factor of activated T-cells, cytoplasmic 2Sequence-specific DNA binding transcription factor activityTranscription activator activityNucleusHomo sapiens	21
2.60.40.10.183	1ti6B03	Pyrogallol hydroxytransferase.Pelobacter acidigalliciPyrogallol hydroxytransferase small subunit	36
2.60.40.10.184	2c4fT00	Tissue factorPositive regulation of endothelial cell proliferationPositive regulation of platelet-derived growth factor receptor signaling pathwayPositive regulation of angiogenesisProtease binding	3
2.60.40.10.185	1o0vA01	Homo sapiensIg epsilon chain C region	5
2.60.40.10.186	1cvrA03	Gingipain R [EC:3.4.22.37]Gingipain R.Gingipain R2Porphyromonas gingivalis	1
2.60.40.10.187	1axiB01	Jak-STAT signaling pathwayCell surfaceMulticellular organismal metabolic processGrowth hormone receptor complexInsulin-like growth factor receptor signaling pathway	13
2.60.40.10.188	1iarB02	Jak-STAT signaling pathwayInterleukin 4 receptorIntegral to plasma membraneInterleukin-4 receptor activityReceptor signaling protein activity	4
2.60.40.10.189	2jllA04	Prion diseasesNeural cell adhesion moleculePlasma membraneNeuron cell-cell adhesionNeural cell adhesion molecule 2	3
2.60.40.10.190	1fo0B00		6
2.60.40.10.191	1itbB03	Integral to plasma membranePlatelet-derived growth factor receptor bindingHematopoietic cell lineageInterleukin 1 receptor, type IInterleukin-1-mediated signaling pathway	3
2.60.40.10.192	1jmxA03	Quinohemoprotein amine dehydrogenase 60 kDa subunitPseudomonas putida	2
2.60.40.10.193	1g0dA04	Protein-glutamine gamma-glutamyltransferase 2Protein-glutamine gamma-glutamyltransferase.Pagrus major	7
2.60.40.10.194	3di2B02	Interleukin-7 receptor activityRegulation of DNA recombinationInterleukin-7 receptor subunit alphaHomo sapiensCell surface receptor linked signaling pathway	3
2.60.40.10.195	2ak4D01	Homo sapiensT-cell receptor alpha chain C region	13
2.60.40.10.196	2gysA02	Jak-STAT signaling pathwayGranulocyte macrophage colony-stimulating factor receptor complexCytokine receptor common subunit betaCytokine receptor common subunit betaCytokine-cytokine receptor interaction	5
2.60.40.10.197	1iamA01	Leukocyte migrationAdhesion to symbiontHeterophilic cell-cell adhesionRegulation of leukocyte mediated cytotoxicityT cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell	5
2.60.40.10.198	1sy6A01		2
2.60.40.10.199	1cidA01	Rattus norvegicusHematopoietic cell lineageT-cell surface glycoprotein CD4T cell receptor signaling pathwayCD4 antigen	5
2.60.40.10.200	1ncnA00	T-lymphocyte activation antigen CD86Positive regulation of cell proliferationImmune responseHomo sapiensProtein binding	4
2.60.40.10.201	1cd9D01	Mus musculusGranulocyte colony-stimulating factor receptorNeutrophil chemotaxis	7
2.60.40.10.202	1f2qA02	High affinity immunoglobulin epsilon receptor subunit alphaIntegral to plasma membraneHomo sapiensFc receptor, IgE, high affinity I, alpha polypeptideAsthma	14
2.60.40.10.203	2h32A00	Pre-B lymphocyte geneImmunoglobulin iota chainHomo sapiensProtein binding	1
2.60.40.10.204	1mcpH02	Mus musculusIg heavy chain V region M603	2
2.60.40.10.205	2gysB04	Jak-STAT signaling pathwayCytokine receptor common subunit betaCytokine-cytokine receptor interactionApoptosisGranulocyte macrophage colony-stimulating factor receptor complex	8
2.60.40.10.206	1imhC02	Nuclear factor of activated T-cells 5NucleusExcretionRNA polymerase II transcription factor activityProtein binding	2
2.60.40.10.207	1itbB01	Integral to plasma membranePlatelet-derived growth factor receptor bindingHematopoietic cell lineageInterleukin 1 receptor, type IInterleukin-1-mediated signaling pathway	3
2.60.40.10.208	2ny1B02	Zinc ion bindingMaintenance of protein location in cellT-cell surface glycoprotein CD4Signal transductionT cell receptor signaling pathway	32
2.60.40.10.209	2fbjH02	Mus musculusIg heavy chain V region J539	2
2.60.40.10.210	1kv3A01	Huntington's diseaseProtein-glutamine gamma-glutamyltransferase 2Protein-glutamine gamma-glutamyltransferase.Homo sapiensTransglutaminase 2 [EC:2.3.2.13]	23
2.60.40.10.211	1dr9A01	Type I diabetes mellitusAutoimmune thyroid diseaseIntestinal immune network for IgA productionAllograft rejectionT-lymphocyte activation antigen CD80	3
2.60.40.10.212	1je6A02	Response to heatMHC class I polypeptide-related sequence BGamma-delta T cell activationImmune response-activating cell surface receptor signaling pathwayResponse to retinoic acid	3
2.60.40.10.213	2gysA01	Jak-STAT signaling pathwayGranulocyte macrophage colony-stimulating factor receptor complexCytokine receptor common subunit betaCytokine receptor common subunit betaApoptosis	5
2.60.40.10.214	1cd9B02	Mus musculusNeutrophil chemotaxisGranulocyte colony-stimulating factor receptor	9
2.60.40.10.215	2ec8A03	Pathways in cancerProto-oncogene tyrosine-protein kinase Kit [EC:2.7.10.1]Hematopoietic cell lineageProtein bindingExtracellular space	3
2.60.40.10.216	1tdqA02	Nervous system developmentRattus norvegicusTenascinFocal adhesionProteinaceous extracellular matrix	1
2.60.40.10.217	2gy5A01	MicrovillusCell surfaceTransmembrane receptor protein tyrosine kinase signaling pathwaySignal transductionProtein binding	2
2.60.40.10.218	2gy5A04	MicrovillusCell surfaceTransmembrane receptor protein tyrosine kinase signaling pathwayProtein bindingSignal transduction	2
2.60.40.10.219	1hxmB02	Homo sapiensT-cell receptor gamma-2 chain C region	6
2.60.40.10.220	1qr4A01	TenascinGallus gallus	3
2.60.40.10.221	1bihA02	Hyalophora cecropiaHemolin	2
2.60.40.10.222	1xiwB00	Protein heterodimerization activityHematopoietic cell lineageChagas diseasePrimary immunodeficiencyHomo sapiens	3
2.60.40.10.223	1hzhH01		1
2.60.40.10.224	2ec8A04	Pathways in cancerHematopoietic cell lineageProto-oncogene tyrosine-protein kinase Kit [EC:2.7.10.1]Extracellular spaceProtein binding	3
2.60.40.10.225	1kv3A03	Huntington's diseaseProtein-glutamine gamma-glutamyltransferase 2Protein-glutamine gamma-glutamyltransferase.Homo sapiensTransglutaminase 2 [EC:2.3.2.13]	6
2.60.40.10.226	1ow0A02	Homo sapiensProtein bindingIg alpha-1 chain C region	4
2.60.40.10.227	2nziA03	Non-specific serine/threonine protein kinase.Calcium ion bindingSarcomere organizationTelethonin bindingActin filament binding	3
2.60.40.10.228	1n26A02	Positive regulation of smooth muscle cell proliferationJak-STAT signaling pathwayResponse to cytokine stimulusAcute-phase responsePositive regulation of osteoblast differentiation	1
2.60.40.10.229	1bihA03	Hyalophora cecropiaHemolin	2
2.60.40.10.230	1ow0A01	Homo sapiensProtein bindingIg alpha-1 chain C region	4
2.60.40.10.231	1fnhA01	Peptide cross-linkingFibronectinER-Golgi intermediate compartmentFibrinogen complexSubstrate adhesion-dependent cell spreading	1
2.60.40.10.232	1fnhA02	Peptide cross-linkingFibronectinER-Golgi intermediate compartmentFibrinogen complexSubstrate adhesion-dependent cell spreading	1
2.60.40.10.233	1p53A01	Leukocyte migrationAdhesion to symbiontHeterophilic cell-cell adhesionRegulation of leukocyte mediated cytotoxicityT cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell	2
2.60.40.10.234	2gysA03	Jak-STAT signaling pathwayGranulocyte macrophage colony-stimulating factor receptor complexCytokine receptor common subunit betaCytokine receptor common subunit betaCytokine-cytokine receptor interaction	5
2.60.40.10.235	1fnhA03	Peptide cross-linkingFibronectinER-Golgi intermediate compartmentFibrinogen complexSubstrate adhesion-dependent cell spreading	1
2.60.40.10.236	1dr9A02	Type I diabetes mellitusIntestinal immune network for IgA productionAutoimmune thyroid diseaseAllograft rejectionProtein binding	3
2.60.40.10.237	2c5dC01	Integral to plasma membraneTransmembrane receptor protein tyrosine kinase activityHomo sapiensTyrosine-protein kinase receptor UFOSignal transduction	2
2.60.40.10.238	2uzxB02	Basal plasma membraneHepatocyte growth factor receptor activityPathways in cancerEpithelial cell signaling in Helicobacter pylori infectionProto-oncogene tyrosine-protein kinase Met [EC:2.7.10.1]	2
2.60.40.10.239	1bihA01	Hyalophora cecropiaHemolin	2
2.60.40.10.240	2gy5A02	Cell surfaceMicrovillusTransmembrane receptor protein tyrosine kinase signaling pathwaySignal transductionProtein binding	2
2.60.40.10.241	2flbT00	Positive regulation of endothelial cell proliferationTissue factorPositive regulation of platelet-derived growth factor receptor signaling pathwayPositive regulation of angiogenesisProtease binding	5
2.60.40.10.242	2ec8A01	Pathways in cancerHematopoietic cell lineageProto-oncogene tyrosine-protein kinase Kit [EC:2.7.10.1]Acute myeloid leukemiaProtein binding	1
2.60.40.10.243	1g0dA01	Protein-glutamine gamma-glutamyltransferase 2Protein-glutamine gamma-glutamyltransferase.Pagrus major	1
2.60.40.10.244	3b43A02	Non-specific serine/threonine protein kinase.TitinOryctolagus cuniculus	1
2.60.40.10.245	1eh9A03	Sulfolobus solfataricusMalto-oligosyltrehalose trehalohydrolase4-alpha-D-((1->4)-alpha-D-glucano)trehalose trehalohydrolase.	2
2.60.40.10.246	2ec8A02	Pathways in cancerProto-oncogene tyrosine-protein kinase Kit [EC:2.7.10.1]Hematopoietic cell lineageExtracellular spaceAcute myeloid leukemia	3
2.60.40.10.247	1koaA03	Protein ZK617.1b, partially confirmed by transcript evidenceCaenorhabditis elegansLocomotionReproduction	1
2.60.40.10.248	1l6zA02	Mus musculusCarcinoembryonic antigen-related cell adhesion molecule 1	1
2.60.40.10.249	3k3qA00		1
2.60.40.10.250	1hxmA01		4
2.60.40.10.251	1bihA04	Hyalophora cecropiaHemolin	2
2.60.40.10.252	1hxmB01	Homo sapiensT-cell receptor gamma-2 chain C region	4
2.60.40.10.253	1hxmA02		6
2.60.40.10.254	1p53A03	Leukocyte migrationAdhesion to symbiontHeterophilic cell-cell adhesionRegulation of leukocyte mediated cytotoxicityT cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell	2
2.60.40.10.255	2ec8A05	Pathways in cancerHematopoietic cell lineageProto-oncogene tyrosine-protein kinase Kit [EC:2.7.10.1]Acute myeloid leukemiaProtein binding	3
2.60.40.10.256	1mh5B02		1
2.60.40.10.257	1bf2A01	Pseudomonas amyloderamosaIsoamylase.Isoamylase	1
2.60.40.10.258	2dtgE06	Insulin receptorInsulin receptor complexPhosphoinositide 3-kinase bindingPositive regulation of respiratory burstPositive regulation of nitric oxide biosynthetic process	1
2.60.40.10.259	2ifgA02	High affinity nerve growth factor receptorIntegral to plasma membraneTransmembrane receptor protein tyrosine kinase activityHomo sapiensReceptor protein-tyrosine kinase.	2
2.60.40.10.260	1cidA02	Rattus norvegicusHematopoietic cell lineageT-cell surface glycoprotein CD4T cell receptor signaling pathwayCD4 antigen	5
2.60.40.10.261	1ej6A05	MRNA guanylyltransferase.Outer capsid protein lambda-2Mammalian orthoreovirus 3 DearingMRNA (guanine-N(7)-)-methyltransferase.	1
2.60.40.10.262	1ypzF01		2
2.60.40.10.263	2dtgE05	Insulin receptorInsulin receptor complexPositive regulation of respiratory burstPositive regulation of nitric oxide biosynthetic processPhosphoinositide 3-kinase binding	1
2.60.40.10.264	2e9wA01	Pathways in cancerProto-oncogene tyrosine-protein kinase Kit [EC:2.7.10.1]Hematopoietic cell lineageAcute myeloid leukemiaProtein binding	2
2.60.40.10.265	1evuA01	Protein-glutamine gamma-glutamyltransferase activityHomo sapiensProtein-glutamine gamma-glutamyltransferase.Coagulation factor XIII A chainBlood coagulation	18
2.60.40.10.266	1p53A02	Leukocyte migrationAdhesion to symbiontHeterophilic cell-cell adhesionRegulation of leukocyte mediated cytotoxicityT cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell	2
2.60.40.10.267	2dtgE04	Insulin receptorInsulin receptor complexPositive regulation of respiratory burstPositive regulation of nitric oxide biosynthetic processPhosphoinositide 3-kinase binding	1
2.60.40.10.268	2uzyB03	Hepatocyte growth factor receptor activityBasal plasma membranePathways in cancerEpithelial cell signaling in Helicobacter pylori infectionProto-oncogene tyrosine-protein kinase Met [EC:2.7.10.1]	2
2.60.40.10.269	2uzyB04	Basal plasma membraneHepatocyte growth factor receptor activityPathways in cancerEpithelial cell signaling in Helicobacter pylori infectionProto-oncogene tyrosine-protein kinase Met [EC:2.7.10.1]	2
2.60.40.10.270	1ktkF02	T-cell receptor beta-1 chain C regionHomo sapiensProtein binding	1
2.60.40.10.271	2cumA00	Collagen metabolic processElastic fiber assemblyIntracellularHomo sapiensTenascin-X	2
2.60.40.10.272	1n6uA01	JAK-STAT cascadeIntegral to plasma membraneType I interferon receptor activityHomo sapiensResponse to virus	5
2.60.40.10.273	1n6uA02	JAK-STAT cascadeIntegral to plasma membraneType I interferon receptor activityResponse to virusHomo sapiens	5
2.60.40.10.274	1ac0A00	Starch and sucrose metabolismGlucoamylaseAspergillus nigerGlucan 1,4-alpha-glucosidase.Metabolic pathways	4
2.60.40.10.275	2dbjA01	Integral to plasma membraneSoluble fractionReceptor protein-tyrosine kinase.Cell-cell signalingProtein phosphorylation	1
2.60.40.10.276	2dm2A00	NucleusPalladinHomo sapiensActin filamentMuscle alpha-actinin binding	1
2.60.40.10.277	1f3rB02		2
2.60.40.10.278	1nctA00	Non-specific serine/threonine protein kinase.Calcium ion bindingSarcomere organizationTelethonin bindingActin filament binding	4
2.60.40.10.279	2cqvA00	Myosin light chain kinase activity[Myosin light-chain] kinase.Protein phosphorylationHomo sapiensMyosin light chain kinase, smooth muscle	1
2.60.40.10.280	2fnbA00	Peptide cross-linkingFibronectinER-Golgi intermediate compartmentFibrinogen complexSubstrate adhesion-dependent cell spreading	1
2.60.40.10.281	1ehxA00	Scaffolding proteinClostridium cellulolyticum	1
2.60.40.10.282	1j8kA00	ER-Golgi intermediate compartmentFibronectinPeptide cross-linkingFibrinogen complexSubstrate adhesion-dependent cell spreading	1
2.60.40.10.283	1pd6A00	Myosin-binding protein C, cardiac-typeVentricular cardiac muscle tissue morphogenesisHomo sapiensStriated muscle myosin thick filamentMyosin heavy chain binding	1
2.60.40.10.284	1uemA00	LuteolysisPositive regulation of axonogenesisIdentical protein bindingCell surfaceHomophilic cell adhesion	2
2.60.40.10.285	1owwA00	Peptide cross-linkingER-Golgi intermediate compartmentFibronectinFibrinogen complexSubstrate adhesion-dependent cell spreading	1
2.60.40.10.286	1witA00	Protein ZK617.1b, partially confirmed by transcript evidenceCaenorhabditis elegansLocomotionReproduction	2
2.60.40.10.287	1ujtA00	LuteolysisPositive regulation of axonogenesisIdentical protein bindingCell surfaceHomophilic cell adhesion	1
2.60.40.10.288	1jbjA01	Positive regulation of interferon-gamma productionPositive regulation of T cell anergyChagas diseaseAlpha-beta T cell receptor complexPositive regulation of alpha-beta T cell proliferation	2
2.60.40.10.289	1q38A00	Peptide cross-linkingER-Golgi intermediate compartmentFibronectinFibrinogen complexSubstrate adhesion-dependent cell spreading	1
2.60.40.10.290	2e7hA01	Cell surfaceIntegral to plasma membraneOrgan morphogenesisEph receptor B4 [EC:2.7.10.1]Receptor protein-tyrosine kinase.	2
2.60.40.10.291	1k85A00	Bacillus circulansChitinase.Chitinase A1	1
2.60.40.10.292	1uenA00	Neuronal cell adhesion moleculeAnkyrin bindingClustering of voltage-gated sodium channelsHomo sapiensSynapse assembly	1
2.60.40.10.293	1gxeA00	Myosin-binding protein C, cardiac-typeHomo sapiensVentricular cardiac muscle tissue morphogenesisStriated muscle myosin thick filamentStructural constituent of muscle	1

Close Structural Clusters (44)
Distant Structural Clusters (8)

What is an Close Structural Cluster?

A Close Structural Cluster describes a cluster of two or more CATH domains that have been grouped together due to their close structural similarity (SIMAX score < 5Å where SIMAX = RMSD x Number of residues in the larger domain/number of aligned residues).

Close Structural Clusters 2.60.40.10 (< 5Å)

Summary of "distant" structural clusters found within this level of CATH.
Cluster ID	Example Domain	Domains in Cluster	Structural Alignment (Core)	Structural Alignment (Expanded)
00002.00060.00040.00010/SSG5/1	1ac0A00	3	FASTA Jalview	FASTA Jalview
00002.00060.00040.00010/SSG5/2	1cvrA03	3	FASTA Jalview	FASTA Jalview
00002.00060.00040.00010/SSG5/3	1ut9A01	2	FASTA Jalview	FASTA Jalview
00002.00060.00040.00010/SSG5/4	3g08A02	14	FASTA Jalview	FASTA Jalview
00002.00060.00040.00010/SSG5/5	1t7vA02	5	FASTA Jalview	FASTA Jalview
00002.00060.00040.00010/SSG5/6	1edqA01	3	FASTA Jalview	FASTA Jalview
00002.00060.00040.00010/SSG5/7	1n26A01	4	FASTA Jalview	FASTA Jalview
00002.00060.00040.00010/SSG5/8	1m7xB01	2	FASTA Jalview	FASTA Jalview
00002.00060.00040.00010/SSG5/9	1qfhA01	5	FASTA Jalview	FASTA Jalview
00002.00060.00040.00010/SSG5/10	1axiB01	2	FASTA Jalview	FASTA Jalview
00002.00060.00040.00010/SSG5/11	1g0dA01	3	FASTA Jalview	FASTA Jalview
00002.00060.00040.00010/SSG5/12	1ex0A04	9	FASTA Jalview	FASTA Jalview
00002.00060.00040.00010/SSG5/13	2fcbA02	5	FASTA Jalview	FASTA Jalview
00002.00060.00040.00010/SSG5/14	1f3rB02	2	FASTA Jalview	FASTA Jalview
00002.00060.00040.00010/SSG5/15	1pd6A00	5	FASTA Jalview	FASTA Jalview
00002.00060.00040.00010/SSG5/16	2fnbA00	17	FASTA Jalview	FASTA Jalview
00002.00060.00040.00010/SSG5/17	1ypzF01	13	FASTA Jalview	FASTA Jalview
00002.00060.00040.00010/SSG5/18	1k85A00	5	FASTA Jalview	FASTA Jalview
00002.00060.00040.00010/SSG5/19	2ec8A01	4	FASTA Jalview	FASTA Jalview
00002.00060.00040.00010/SSG5/20	1cd9B02	14	FASTA Jalview	FASTA Jalview
00002.00060.00040.00010/SSG5/21	3h9yB01	5	FASTA Jalview	FASTA Jalview
00002.00060.00040.00010/SSG5/22	2q8bH01	8	FASTA Jalview	FASTA Jalview
00002.00060.00040.00010/SSG5/23	2ifgA02	4	FASTA Jalview	FASTA Jalview
00002.00060.00040.00010/SSG5/24	1rhfA02	4	FASTA Jalview	FASTA Jalview
00002.00060.00040.00010/SSG5/25	1iilG02	2	FASTA Jalview	FASTA Jalview
00002.00060.00040.00010/SSG5/26	3bmvA03	11	FASTA Jalview	FASTA Jalview
00002.00060.00040.00010/SSG5/27	1itbB02	2	FASTA Jalview	FASTA Jalview
00002.00060.00040.00010/SSG5/28	1wzlA01	3	FASTA Jalview	FASTA Jalview
00002.00060.00040.00010/SSG5/29	3c8dA01	2	FASTA Jalview	FASTA Jalview
00002.00060.00040.00010/SSG5/30	1uadC00	3	FASTA Jalview	FASTA Jalview
00002.00060.00040.00010/SSG5/31	2vxvH02	11	FASTA Jalview	FASTA Jalview
00002.00060.00040.00010/SSG5/32	2qsqB01	5	FASTA Jalview	FASTA Jalview
00002.00060.00040.00010/SSG5/33	3d85D01	2	FASTA Jalview	FASTA Jalview
00002.00060.00040.00010/SSG5/34	2flbT00	3	FASTA Jalview	FASTA Jalview
00002.00060.00040.00010/SSG5/35	2fcbA01	4	FASTA Jalview	FASTA Jalview
00002.00060.00040.00010/SSG5/36	1f97A02	16	FASTA Jalview	FASTA Jalview
00002.00060.00040.00010/SSG5/37	1qfhA02	2	FASTA Jalview	FASTA Jalview
00002.00060.00040.00010/SSG5/38	1ti6B03	2	FASTA Jalview	FASTA Jalview
00002.00060.00040.00010/SSG5/39	1sy6A01	2	FASTA Jalview	FASTA Jalview
00002.00060.00040.00010/SSG5/40	2gysA01	2	FASTA Jalview	FASTA Jalview
00002.00060.00040.00010/SSG5/41	1bihA02	5	FASTA Jalview	FASTA Jalview
00002.00060.00040.00010/SSG5/42	2gy5A04	26	FASTA Jalview	FASTA Jalview
00002.00060.00040.00010/SSG5/43	1cfbA01	12	FASTA Jalview	FASTA Jalview
00002.00060.00040.00010/SSG5/44	2ij0C00	25	FASTA Jalview	FASTA Jalview

What is a Distant Structural Cluster?

A Distant Structural Cluster describes a cluster of two or CATH domains that have been grouped together with a more relaxed structural similarity threshold to investigate more distant evolutionary similarities (SIMAX score < 5Å where SIMAX = RMSD x Number of residues in the larger domain/number of aligned residues).

Distant Structural Clusters 2.60.40.10 (< 9Å)

Summary of "distant" structural clusters found within this level of CATH.
Cluster ID	Example Domain	Domains in Cluster	Structural Alignment (Core)	Structural Alignment (Expanded)
00002.00060.00040.00010/SSGA9/1	3edfA01	16	FASTA Jalview	FASTA Jalview
00002.00060.00040.00010/SSGA9/2	3c8dA01	2	FASTA Jalview	FASTA Jalview
00002.00060.00040.00010/SSGA9/3	1dqtA00	3	FASTA Jalview	FASTA Jalview
00002.00060.00040.00010/SSGA9/4	1pd6A00	15	FASTA Jalview	FASTA Jalview
00002.00060.00040.00010/SSGA9/5	2rikA03	9	FASTA Jalview	FASTA Jalview
00002.00060.00040.00010/SSGA9/6	1ut9A01	4	FASTA Jalview	FASTA Jalview
00002.00060.00040.00010/SSGA9/7	1jmxA04	2	FASTA Jalview	FASTA Jalview
00002.00060.00040.00010/SSGA9/8	1ktkF02	2	FASTA Jalview	FASTA Jalview

What is a Structural Neighbour?

The term "structural neighbour" is used here to describe two CATH domains that share a degree of structural similarity. The SSAP algorithm is used to calculate this similarity and works by generating a structure-based pairwise alignment of the two domains then scoring this alignment using a RMSD score which has been normalised by the length of the larger domain divided by the number of aligned residues (SIMAX).

Structural Comparisons for Non-redundant S35 Representatives of 2.60.40.10 ( entries)

What is a Non-Redundant Representative?

Why can't I have a multiple structural alignment of the whole superfamily?

The simple answer is that some of the larger superfamilies in CATH comprise relatives which are very structurally diverse, having different secondary structure embellishments. Attempting to provide a global alignment of all domains in the superfamily would result in poor quality alignments. As a result, structural alignments in CATH are generated by first clustering together the structures that have at least some recognisable structural similarity using a normalised RMSD score (SIMAX = RMSDxNumber of residues in the largest domain/number of aligned residues) less than a given cutoff.

Homologous Superfamily: 2.60.40.10

Immunoglobulins

Classification Lineage (2.60.40.10)

Summary of Non-Redundant Representatives

What is a Non-Redundant Representative?

S35 Family Entries in Homologous Superfamily 2.60.40.10 (293)

What is an Close Structural Cluster?

Close Structural Clusters 2.60.40.10 (< 5Å)

What is a Distant Structural Cluster?

Distant Structural Clusters 2.60.40.10 (< 9Å)

What is a Structural Neighbour?

Structural Comparisons for Non-redundant S35 Representatives of 2.60.40.10 ( entries)

What is a Non-Redundant Representative?

Why can't I have a multiple structural alignment of the whole superfamily?

What is an Close Structural Cluster?

What is a Distant Structural Cluster?

What is a Structural Neighbour?

CATH Shortcuts