CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.50 | Rossmann fold |
|
3.40.50.300 | P-loop containing nucleotide triphosphate hydrolases |
Domain Context
CATH Clusters
| Superfamily | P-loop containing nucleotide triphosphate hydrolases |
| Functional Family | Multidrug resistance-associated ABC transporter |
Enzyme Information
| 3.6.3.49 |
Channel-conductance-controlling ATPase.
based on mapping to UniProt P13569
ATP + H(2)O = ADP + phosphate.
-!- An animal enzyme that is active in forming a chloride channel, the absence of which brings about cystic fibrosis. -!- It is also involved in the functioning of other transmembrane channels.
|
| 3.6.3.19 |
Maltose-transporting ATPase.
based on mapping to UniProt P68187
ATP + H(2)O + maltose(Out) = ADP + phosphate + maltose(In).
-!- Comprises bacterial enzymes that import maltose and maltose oligosaccharides.
|
UniProtKB Entries (2)
| P68187 |
MALK_ECOLI
Escherichia coli K-12
Maltose/maltodextrin import ATP-binding protein MalK
|
| P13569 |
CFTR_HUMAN
Homo sapiens
Cystic fibrosis transmembrane conductance regulator
|
PDB Structure
| PDB | 3GD7 |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Crystal structure of human NBD2 complexed with N6-Phenylethyl-ATP (P-ATP)
To be Published
|