CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.50 | Rossmann fold |
|
3.40.50.300 | P-loop containing nucleotide triphosphate hydrolases |
Domain Context
CATH Clusters
| Superfamily | P-loop containing nucleotide triphosphate hydrolases |
| Functional Family | ABC transporter ATP-binding protein/permease |
Enzyme Information
| 3.6.3.44 |
Xenobiotic-transporting ATPase.
based on mapping to UniProt P21447
ATP + H(2)O + xenobiotic(In) = ADP + phosphate + xenobiotic(Out).
-!- Enzymes of Gram-positive bacteria and eukaryotic cells that export a number of drugs, with unusual specificity, covering various groups of unrelated substances, while ignoring some that are closely related structurally. -!- Several distinct enzymes may be present in a single eukaryotic cell. -!- Many of them transport glutathione conjugates with drugs. -!- Some also show some 'flippase' (EC 3.6.3.1) activity. -!- Formerly EC 3.6.3.45.
|
UniProtKB Entries (1)
| P21447 |
MDR1A_MOUSE
Mus musculus
Multidrug resistance protein 1A
|
PDB Structure
| PDB | 3G5U |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Structure of P-glycoprotein reveals a molecular basis for poly-specific drug binding.
Science
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