CATH Classification

Domain Context

CATH Clusters

Superfamily P-loop containing nucleotide triphosphate hydrolases
Functional Family ATP-dependent dethiobiotin synthetase BioD

Enzyme Information

6.3.3.3
Dethiobiotin synthase.
based on mapping to UniProt P9WPQ5
ATP + 7,8-diaminononanoate + CO(2) = ADP + phosphate + dethiobiotin.
-!- CTP has half the activity of ATP.

UniProtKB Entries (1)

P9WPQ5
BIOD_MYCTU
Mycobacterium tuberculosis H37Rv
ATP-dependent dethiobiotin synthetase BioD

PDB Structure

PDB 3FGN
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structural characterization of the Mycobacterium tuberculosis biotin biosynthesis enzymes 7,8-diaminopelargonic acid synthase and dethiobiotin synthetase .
Dey, S., Lane, J.M., Lee, R.E., Rubin, E.J., Sacchettini, J.C.
Biochemistry