CATH Classification

Domain Context

CATH Clusters

Superfamily Immunoglobulins
Functional Family Receptor protein-tyrosine kinase

Enzyme Information

2.7.10.1
Receptor protein-tyrosine kinase.
based on mapping to UniProt P09581
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
-!- The receptor protein-tyrosine kinases, which can be defined as having a transmembrane domain, are a large and diverse multigene family found only in metazoans. -!- In the human genome, 58 receptor-type protein-tyrosine kinases have been identified and these are distributed into 20 subfamilies. -!- Formerly EC 2.7.1.112.

UniProtKB Entries (1)

P07141
CSF1_MOUSE
Mus musculus
Macrophage colony-stimulating factor 1

PDB Structure

PDB 3EJJ
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structure of macrophage colony stimulating factor bound to FMS: diverse signaling assemblies of class III receptor tyrosine kinases.
Chen, X., Liu, H., Focia, P.J., Shim, A.H., He, X.
Proc.Natl.Acad.Sci.USA