CATH Classification

Domain Context

CATH Clusters

Superfamily Immunoglobulins
Functional Family Protein-glutamine gamma-glutamyltransferase 5

Enzyme Information

2.3.2.13
Protein-glutamine gamma-glutamyltransferase.
based on mapping to UniProt P22735
Protein glutamine + alkylamine = protein N(5)-alkylglutamine + NH(3).
-!- The gamma-carboxymide groups of peptide-bound glutamine residues act as acyl donors, and the 6-amino-groups of protein- and peptide-bound lysine residues act as acceptors, to give intra- and inter-molecular N(6)-(5-glutamyl)lysine crosslinks.

UniProtKB Entries (1)

P22735
TGM1_HUMAN
Homo sapiens
Protein-glutamine gamma-glutamyltransferase K

PDB Structure

PDB 2XZZ
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal Structure of the Human Transglutaminase 1 Beta-Barrel Domain
Vollmar, M., Krysztofinska, E., Krojer, T., Yue, W.W., Cooper, C., Kavanagh, K., Allerston, C., Chaikuad, A., von Delft, F., Arrowsmith, C.H., Weigelt, J., Edwards, A., Bountra, C., Oppermann, U.
To be Published