CATH Domain 2mwnB00

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.30	Roll
	2.30.29	PH-domain like
	2.30.29.30	Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)

Domain Context

CATH Clusters

Superfamily	Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)
Functional Family	Talin-1 isoform 2

Enzyme Information

UniProtKB Entries (1)

TLN1_HUMAN

Homo sapiens

Talin-1

PDB Structure

PDB	2MWN
External Links	PDBSum Proteopedia
Method	SOLUTION NMR
Organism
Primary Citation	Conformational activation of talin by RIAM triggers integrin-mediated cell adhesion. Yang, J., Zhu, L., Zhang, H., Hirbawi, J., Fukuda, K., Dwivedi, P., Liu, J., Byzova, T., Plow, E.F., Wu, J., Qin, J. Nat Commun