CATH Domain 2dn8A01

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.40	Beta Barrel
	2.40.50	OB fold (Dihydrolipoamide Acetyltransferase, E2P)
	2.40.50.100	RNA polymerase II/Efflux pump adaptor protein, barrel-sandwich hybrid domain

Domain Context

CATH Clusters

Superfamily	2.40.50.100
Functional Family	Acetyl-CoA carboxylase, isoform A

Enzyme Information

6.3.4.14	Biotin carboxylase. based on mapping to UniProt O00763 ATP + biotin-[carboxyl-carrier-protein] + HCO(3)(-) = ADP + phosphate + carboxy-biotin-[carboxyl-carrier-protein].
6.4.1.2	Acetyl-CoA carboxylase. based on mapping to UniProt O00763 ATP + acetyl-CoA + HCO(3)(-) = ADP + phosphate + malonyl-CoA. -!- Also catalyzes transcarboxylation; the plant enzyme also carboxylates propanoyl-CoA and butanoyl-CoA.

UniProtKB Entries (1)

ACACB_HUMAN

Homo sapiens

Acetyl-CoA carboxylase 2

PDB Structure

PDB	2DN8
External Links	PDBSum Proteopedia
Method	SOLUTION NMR
Organism
Primary Citation	Solution Structure of RSGI RUH-053, an Apo-Biotin Carboxy Carrier Protein from Human Transcarboxylase Ruhul Momen, A.Z.M., Hirota, H., Hayashi, F., Yokoyama, S. To be published