CATH Classification

Domain Context

CATH Clusters

Superfamily P-loop containing nucleotide triphosphate hydrolases
Functional Family ATP-dependent RNA helicase DeaD

Enzyme Information

3.6.4.13
RNA helicase.
based on mapping to UniProt P09052
ATP + H(2)O = ADP + phosphate.
-!- RNA helicases utilize the energy from ATP hydrolysis to unwind RNA. -!- Some of them unwind RNA with a 3' to 5' polarity, other show 5' to 3' polarity. -!- Some helicases unwind DNA as well as RNA. -!- May be identical with EC 3.6.4.12 (DNA helicase).
3.6.1.3
Adenosinetriphosphatase.
based on mapping to UniProt P09052
ATP + H(2)O = ADP + phosphate.
-!- Many enzymes previously listed under this number are now listed separately as EC 3.6.1.32 to EC 3.6.1.39. -!- The remaining enzymes, not separately listed on the basis of some function coupled with hydrolyzes of ATP, include enzymes dependent on Ca(2+), Mg(2+), anions, H(+) or DNA. -!- Formerly EC 3.6.1.4.
2.7.7.-
Nucleotidyltransferases.
based on mapping to UniProt P09052

UniProtKB Entries (1)

P09052
VASA1_DROME
Drosophila melanogaster
ATP-dependent RNA helicase vasa, isoform A

PDB Structure

PDB 2DB3
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Structural basis for RNA unwinding by the DEAD-box protein Drosophila Vasa.
Sengoku, T., Nureki, O., Nakamura, A., Kobayashi, S., Yokoyama, S.
Cell(Cambridge,Mass.)