CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
2 | Mainly Beta |
|
2.30 | Roll |
|
2.30.29 | PH-domain like |
|
2.30.29.30 | Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB) |
Domain Context
CATH Clusters
| Superfamily | Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB) |
| Functional Family | Serine/threonine-protein kinase D1, putative |
Enzyme Information
| 2.7.11.13 |
Protein kinase C.
based on mapping to UniProt Q9BZL6
ATP + a protein = ADP + a phosphoprotein.
-!- A family of serine- and threonine-specific protein kinases that depend on lipids for activity. -!- They can be activated by calcium but have a requirement for the second messenger diacylglycerol. -!- Members of this group of enzymes phosphorylate a wide variety of protein targets and are known to be involved in diverse cell- signaling pathways. -!- Members of the protein kinase C family also serve as major receptors for phorbol esters, a class of tumor promoters. -!- Formerly EC 2.7.1.37.
|
UniProtKB Entries (1)
| Q9BZL6 |
KPCD2_HUMAN
Homo sapiens
Serine/threonine-protein kinase D2
|
PDB Structure
| PDB | 2COA |
| External Links | |
| Method | SOLUTION NMR |
| Organism | |
| Primary Citation |
Solution structure of the PH domain of protein kinase C, D2 type from human
To be Published
|