CATH Classification

Domain Context

CATH Clusters

Superfamily Aldolase class I
Functional Family Nicotinate-nucleotide diphosphorylase

Enzyme Information

2.4.2.19
Nicotinate-nucleotide diphosphorylase (carboxylating).
based on mapping to UniProt O25909
Beta-nicotinate D-ribonucleotide + diphosphate + CO(2) = pyridine-2,3- dicarboxylate + 5-phospho-alpha-D-ribose 1-diphosphate.
-!- The reaction is catalyzed in the opposite direction. -!- Since quinolinate is synthesized from L-tryptophan in eukaryotes, but from L-aspartate in some prokaryotes, this is the first NAD(+) biosynthesis enzyme shared by both eukaryotes and prokaryotes.

UniProtKB Entries (1)

O25909
NADC_HELPY
Helicobacter pylori 26695
Probable nicotinate-nucleotide pyrophosphorylase [carboxylating]

PDB Structure

PDB 2B7N
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Crystal structure of quinolinic acid phosphoribosyltransferase from Helicobacter pylori
Kim, M.K., Im, Y.J., Lee, J.H., Eom, S.H.
Proteins