CATH Domain 1xmiA00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.50	Rossmann fold
	3.40.50.300	P-loop containing nucleotide triphosphate hydrolases

Domain Context

CATH Clusters

Superfamily	P-loop containing nucleotide triphosphate hydrolases
Functional Family	Cystic fibrosis transmembrane conductance regulator

Enzyme Information

3.6.3.49

Channel-conductance-controlling ATPase.

based on mapping to UniProt P13569

ATP + H(2)O = ADP + phosphate.

-!- An animal enzyme that is active in forming a chloride channel, the absence of which brings about cystic fibrosis. -!- It is also involved in the functioning of other transmembrane channels.

UniProtKB Entries (1)

P13569

CFTR_HUMAN

Homo sapiens

Cystic fibrosis transmembrane conductance regulator

PDB Structure

PDB	1XMI
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Escherichia
Primary Citation	Impact of the delta-F508 Mutation in First Nucleotide-binding Domain of Human Cystic Fibrosis Transmembrane Conductance Regulator on Domain Folding and Structure Lewis, H.A., Zhao, X., Wang, C., Sauder, J.M., Rooney, I., Noland, B.W., Lorimer, D., Kearins, M.C., Conners, K., Condon, B., Maloney, P.C., Guggino, W.B., Hunt, J.F., Emtage, S. J.Biol.Chem.