CATH Classification

Domain Context

CATH Clusters

Superfamily P-loop containing nucleotide triphosphate hydrolases
Functional Family Adenylate kinase isoenzyme 1

Enzyme Information

2.7.4.6
Nucleoside-diphosphate kinase.
based on mapping to UniProt P30085
ATP + nucleoside diphosphate = ADP + nucleoside triphosphate.
-!- Many nucleoside diphosphates can act as acceptors. -!- Many ribo- and deoxyribonucleoside triphosphates can act as donors.
2.7.4.14
UMP/CMP kinase.
based on mapping to UniProt P30085
(1) ATP + (d)CMP = ADP + (d)CDP. (2) ATP + UMP = ADP + UDP.
-!- This eukaryotic enzyme is a bifunctional enzyme that catalyzes the phosphorylation of both CMP and UMP with similar efficiency. -!- dCMP can also act as acceptor. -!- Different from the monofunctional prokaryotic enzymes EC 2.7.4.25, CMP kinase and EC 2.7.4.22, UMP kinase. -!- This eukaryotic enzyme is a bifunctional enzyme that catalyzes the phosphorylation of both CMP and UMP with similar efficiency. -!- dCMP can also act as acceptor. -!- Different from the monofunctional prokaryotic enzymes EC 2.7.4.25 and EC 2.7.4.22. -!- Formerly EC 2.7.4.5.

UniProtKB Entries (1)

P30085
KCY_HUMAN
Homo sapiens
UMP-CMP kinase

PDB Structure

PDB 1TEV
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Substrate-induced Conformational Changes in Human UMP/CMP Kinase.
Sekulic, N., Ort, S., Konrad, M., Lavie, A.
J.Biol.Chem.