CATH Classification

Domain Context

CATH Clusters

Superfamily Immunoglobulins
Functional Family Hemocyte protein-glutamine gamma-glutamyltransferase, putative

Enzyme Information

2.3.2.13
Protein-glutamine gamma-glutamyltransferase.
based on mapping to UniProt P21980
Protein glutamine + alkylamine = protein N(5)-alkylglutamine + NH(3).
-!- The gamma-carboxymide groups of peptide-bound glutamine residues act as acyl donors, and the 6-amino-groups of protein- and peptide-bound lysine residues act as acceptors, to give intra- and inter-molecular N(6)-(5-glutamyl)lysine crosslinks.

UniProtKB Entries (1)

P21980
TGM2_HUMAN
Homo sapiens
Protein-glutamine gamma-glutamyltransferase 2

PDB Structure

PDB 1KV3
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Structural basis for the guanine nucleotide-binding activity of tissue transglutaminase and its regulation of transamidation activity.
Liu, S., Cerione, R.A., Clardy, J.
Proc.Natl.Acad.Sci.USA