CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.20 | Alpha-Beta Barrel |
|
3.20.20 | TIM Barrel |
|
3.20.20.70 | Aldolase class I |
Domain Context
CATH Clusters
| Superfamily | Aldolase class I |
| Functional Family | 4-Hydroxy-2-oxoglutarate aldolase / 2-dehydro-3-deoxyphosphogluconate aldolase |
Enzyme Information
| 2.5.1.55 |
3-deoxy-8-phosphooctulonate synthase.
based on mapping to UniProt P0A955
Phosphoenolpyruvate + D-arabinose 5-phosphate + H(2)O = 3-deoxy-D-manno- octulosonate 8-phosphate + phosphate.
-!- Formerly EC 4.1.2.16.
|
| 4.1.3.16 |
4-hydroxy-2-oxoglutarate aldolase.
based on mapping to UniProt P0A955
4-hydroxy-2-oxoglutarate = pyruvate + glyoxylate.
-!- The enzymes from rat liver and bovine liver act on both enantiomers of 4-hydroxy-2-oxoglutarate. -!- Formerly EC 4.1.2.1 and EC 4.1.2.31.
|
| 4.1.2.14 |
2-dehydro-3-deoxy-phosphogluconate aldolase.
based on mapping to UniProt P0A955
2-dehydro-3-deoxy-6-phosphate-D-gluconate = pyruvate + D-glyceraldehyde 3-phosphate.
-!- The enzyme shows no activity with 2-dehydro-3-deoxy-6-phosphate-D- galactonate (cf. EC 4.1.2.55). -!- Also acts on 2-oxobutanoate.
|
| 4.1.1.3 |
Oxaloacetate decarboxylase.
based on mapping to UniProt P0A955
Oxaloacetate = pyruvate + CO(2).
-!- The enzyme from Klebsiella aerogenes is a biotinyl protein and also decarboxylates glutaconyl-CoA and methylmalonyl-CoA. -!- The process is accompanied by the extrusion of two sodium ions from cells. -!- Some animal enzymes require manganese.
|
UniProtKB Entries (1)
| P0A955 |
ALKH_ECOLI
Escherichia coli K-12
KHG/KDPG aldolase
|
PDB Structure
| PDB | 1EUN |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Covalent intermediate trapped in 2-keto-3-deoxy-6- phosphogluconate (KDPG) aldolase structure at 1.95-A resolution.
Proc.Natl.Acad.Sci.USA
|
