CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.50 | Rossmann fold |
|
3.40.50.300 | P-loop containing nucleotide triphosphate hydrolases |
Domain Context
CATH Clusters
| Superfamily | P-loop containing nucleotide triphosphate hydrolases |
| Functional Family | Deoxythymidylate kinase (Thymidylate kinase) variant |
Enzyme Information
| 2.7.4.9 |
dTMP kinase.
based on mapping to UniProt P0A721
ATP + dTMP = ADP + dTDP.
|
| 2.7.4.9 |
dTMP kinase.
based on mapping to UniProt P23919
ATP + dTMP = ADP + dTDP.
|
UniProtKB Entries (2)
| P0A721 |
KTHY_SHIFL
Shigella flexneri
Thymidylate kinase
|
| P23919 |
KTHY_HUMAN
Homo sapiens
Thymidylate kinase
|
PDB Structure
| PDB | 1E9F |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Potentiating Azt Activation: Structures of Wildtype and Mutant Human Thymidylate Kinase Suggest Reasons for the Mutants' Improved Kinetics with the HIV Prodrug Metabolite Aztmp
J.Mol.Biol.
|