CATH Classification

Domain Context

CATH Clusters

Superfamily Aldolase class I
Functional Family IMP dehydrogenase., GMP reductase

Enzyme Information

1.1.1.205
IMP dehydrogenase.
based on mapping to UniProt P12268
Inosine 5'-phosphate + NAD(+) + H(2)O = xanthosine 5'-phosphate + NADH.
-!- The enzyme acts on the hydroxy group of the hydrated derivative of the substrate. -!- Formerly EC 1.2.1.14.

UniProtKB Entries (1)

P12268
IMDH2_HUMAN
Homo sapiens
Inosine-5'-monophosphate dehydrogenase 2

PDB Structure

PDB 1B3O
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Crystal structure of human type II inosine monophosphate dehydrogenase: implications for ligand binding and drug design.
Colby, T.D., Vanderveen, K., Strickler, M.D., Markham, G.D., Goldstein, B.M.
Proc.Natl.Acad.Sci.USA