CATH Classification

Domain Context

CATH Clusters

Superfamily ATP-grasp fold, B domain
Functional Family Phosphoribosylaminoimidazole-succinocarboxamide synthase (SAICAR synthetase)

Enzyme Information

6.3.2.6
Phosphoribosylaminoimidazolesuccinocarboxamide synthase.
based on mapping to UniProt P27616
ATP + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-aspartate = ADP + phosphate + (S)-2-(5-amino-1-(5-phospho-D- ribosyl)imidazole-4-carboxamido)succinate.
-!- Forms part of the purine biosynthesis pathway.

UniProtKB Entries (1)

P27616
PUR7_YEAST
Saccharomyces cerevisiae S288C
Phosphoribosylaminoimidazole-succinocarboxamide synthase

PDB Structure

PDB 1A48
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
The structure of SAICAR synthase: an enzyme in the de novo pathway of purine nucleotide biosynthesis.
Levdikov, V.M., Barynin, V.V., Grebenko, A.I., Melik-Adamyan, W.R., Lamzin, V.S., Wilson, K.S.
Structure